Journal of Energy Storage
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2025
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IF 9.8
Tiandong Zhang,Haixin Ma,Tianyuan Yin,Zining Pu,Xue Zhang,Lin Li,Chao Yin,Changhai Zhang,Qingguo Chi
Biaxially oriented polypropylene (BOPP) are the most popular dielectric materials that used in the film capacitors products, however, the maximum operating temperature of BOPP films is only 105 °C, which limits its application in the extreme high-temperature and high-field conditions. Thus, it is urgent to develop the new-typed dielectric films with excellent energy storage performance at elevated temperature for meeting the requirements of new energy vehicles and high-voltage-direct transmission engineering. Recently, non-polar polyolefin poly (4-methyl-1-pentene) (PMP) dielectrics with superior high-temperature endurance and exhibit great potential to replace BOPP. In this work, PMP films have been successfully fabricated by melt casting technique and achieved mass-production. To further improve the high-temperature energy storage performance of PMP dielectric films, we propose a cooperative modulation of the multiscale structures including molecular chains and surfaces. In detail, UV-irradiation grafting of trifluoroethyl methacrylate (TFEMA) onto PMP molecular chains creates “bulk-traps” through polar group effects, which can effectively trap electric charges and reduce conduction loss at high-temperature. Meanwhile, the AlN/PZT heterostructured inorganic barrier layers are deposited onto the surfaces of TFEMA-grafted-PMP films via magnetron sputtering technique. The energy band structure differences between AlN/metal electrodes and AlN/PZT interfaces were utilized to construct interface barriers, thereby suppressing charge injection from metal electrodes and reducing high-temperature conduction losses. The results demonstrate that the high-temperature energy storage performances of the films have been significantly improved by optimizing UV irradiation duration and inorganic barrier layer thickness. At 150 °C, a discharged energy density of 4.23 J/cm 3 with η maintained above 91 % has been achieved, while the films exhibit excellent cycling stability of charge-discharge performances.
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Materials Today Bio
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2026
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IF 11
Zhaoyou Chu,Shu Fang,Wanyue Fu,Jun Liang,Yayun Wu,Ling Xu,Hanqing Zhang,Jiyang Wang,Haisheng Qian,Min Shao
New Delhi metallo-β-lactamase (NDM)-producing drug-resistant bacteria often form stubborn biofilms and cause severe pneumonia, resulting in conventional antibiotic failure. In this study, we developed gelatin-genipin microspheres co-loaded with EDTA and meropenem (GEM) for targeted treatment of NDM pneumonia. EDTA exerted dual functions: it chelated Zn 2+ to inactivate NDM enzyme and restore meropenem activity (FIC = 0.046875), while also disrupting bacterial biofilms through chelation. GEM microspheres enable accelerated drug release in the artificial phlegm environment. In a mouse model of NDM pneumonia, GEM microspheres can enhance the recruitment of neutrophils and M1 cells at the early stage (12 h) through bacterial clearance, modulate the secretion of interferon-γ by CD8 + T cells and natural killer cells, and reshape the pulmonary immune microenvironment. Furthermore, GEM treatment reduced pathological pulmonary immune cell infiltration and excessive inflammation at late time points (days 3-7). Taken together, GEM microspheres integrate biofilm disruption, enzyme inhibition, synergistic bactericidal effects, and immunoregulation, representing a promising strategy against NDM drug-resistant bacterial pneumonia.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Xiaojun Yan,Yulin Zhang,Wen Zeng,Yang Li,Chenhui Zhu
Tendon repair remains a major clinical challenge, largely because current strategies often fail to simultaneously achieve early inflammatory control and subsequent matrix remodeling. To address this problem, we developed a dynamically responsive nano-hydrogel, CAPP@IGF-1, composed of 3-carboxyphenylboronic acid-modified chitosan, polyvinyl alcohol, and IGF-1-loaded PLGA microspheres, which were integrated through phenylborate ester crosslinking. The hydrogel exhibited favorable self-healing behavior together with enhanced mechanical properties, with an elastic modulus of 4.5 MPa and a toughness of 15.3 MJ/m³, enabling it to maintain local structural stability under the complex dynamic conditions of tendon repair. Under the acidic inflammatory microenvironment, CAPP@IGF-1 enabled controlled local release of IGF-1 and activated the IGF-1R/AKT signaling pathway, thereby markedly promoting macrophage reprogramming from the pro-inflammatory M1 state to the pro-reparative M2 state. This was accompanied by suppression of IL-6, IL-2, and TNF-α and upregulation of IL-10, leading to the establishment of a local immune microenvironment favorable for repair. On this basis, the hydrogel further promoted tendon stem/progenitor cell migration, proliferation, extracellular matrix remodeling, and more ordered collagen deposition. In a rabbit tendon injury model, CAPP@IGF-1 notably reduced peritendinous adhesion, and enhanced the mechanical recovery of repaired tendons. Collectively, CAPP@IGF-1 achieves stage-specific intervention during tendon healing through the combined effects of a dynamically crosslinked network, enhanced mechanical properties, and intelligent IGF-1 release. This study demonstrates the feasibility of using materials design to connect inflammatory microenvironment regulation with tissue regeneration and provides a new strategic basis for the precise repair of complex tendon injuries.
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ACS Sensors
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2026
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IF 10.9
Yiwen Zhou,Zichen Zheng,Kewei Liu,Marc Debliquy,Carla Bittencourt,Chao Zhang
Chemiresistive gas sensors designed for the detection of agricultural volatile organic compounds (VOCs) play a crucial role in monitoring crop growth and ensuring the quality of agricultural products. However, conventional metal oxide gas sensors continue to encounter challenges related to high power consumption and limited detection capabilities. In this study, bismuth stannate oxide Bi2Sn2O7 (BSO) quantum dots were synthesized via a hydrothermal method to facilitate room-temperature detection of 1-octanol. A systematic investigation was conducted to elucidate the relationship between the gas sensing performance of the material and its microstructure, surface valence states, and electronic structure. The BSO-8 sensor, characterized by an exceptionally high specific surface area (BET = 143.57 m2 g−1), demonstrated a wide detection range of 1−50 ppm, exhibiting a remarkable response of 75.06 ± 1.25 at 50 ppm under 30% relative humidity. Additionally, the sensor displayed excellent reproducibility, long-term stability, and significant selectivity toward 1-octanol. Further mechanistic insights were obtained through valence band spectroscopy and density functional theory calculations, which provided a comprehensive understanding of the evolution of the electronic structure and gas adsorption behavior. These findings demonstrate the potential of BSO-based sensors for practical applications in detecting 1-octanol at 30% RH, highlighting its significance as a key biomarker for agricultural VOCs.
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NATURAL PRODUCT RESEARCH
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2026
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IF 1.8
Qiao-Long Hao,Han-Mei Bai,Lei Miao,Shuang Yao,Chuan-Rui Zhang
The first phytochemical investigation of Tarlmounia elliptica (the sole species of its genus) led to the isolation of eight compounds from its aerial parts, including a previously undescribed seco-norlignan, tarlelliptin A (1), and a rare ring B aromatic 1(10→6)abeo-ergostane-type steroid, tarlelliptin B (2). Their structures were fully characterised by comprehensive spectroscopic analysis (HRESIMS, 1D/2D NMR) and corroborated by quantum chemical calculations (including ECD and NMR computations). Biological evaluation for cytotoxic, anti-inflammatory, and antibacterial activities indicated that only the known compound 7-oxo-β-sitosterol (8) exhibited weak antibacterial activity (MIC = 64.0 μg/mL) against methicillin-resistant Staphylococcus aureus (MRSA) strain 252.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Yusen Xing,Rugeng Liu,Mei Li,Wei Han
To lower the reaction temperature and enhance the waste incorporation rate of ZrSiO 4 , this study developed a novel low-temperature synthesis strategy. MgF 2 was used as a mineralizer to optimize the synthesis of ZrSiO 4 . Ceramics are successfully prepared by sintering at 1000 °C for 6 h. The role of MgF 2 in promoting the reaction is also investigated. At 1000 °C, MgF 2 reacts with SiO 2 to form amorphous Mg 2 SiO 4 . The Mg 2 + ions released in this process promote the phase transformation from m-ZrO 2 to t-ZrO 2 . The t-ZrO 2 then reacts with SiO 4 4- , thereby forming ZrSiO 4 . Under the same conditions, Nd x Zr (1-x) SiO 4 ceramic waste forms are synthesized for the immobilization of Nd 2 O 3 , which simulates high-level radioactive waste. XRD results show that a single-phase zircon structure is maintained when x ≤ 0.35. However, when x > 0.35, a small amount of Mg 2 SiO 4 is detected as a secondary phase. This indicates that some SiO 2 remains unreacted, and part of the Nd 2 O 3 is not incorporated into the crystal structure. Based on these findings, the sample with the maximum solid solution (x = 0.35) is selected and combined with lead-containing borosilicate glass to produce glass-ceramic waste forms. Leaching tests show that the normalized release rate of Nd 3+ gradually decreases as the glass content increases. With a glass content of 90 wt%, the material exhibits outstanding aqueous durability, as evidenced by a negligible Nd 3+ leaching rate of merely 1.57 × 10 −6 g·m −2 ·d −1 after 2 8 days. In conclusion, MgF 2 acts as an effective mineralizer, enabling a substantial reduction in both the synthesis temperature and duration required for ZrSiO 4 formation.
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Frontiers in Pharmacology
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2026
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IF 5.4
Shan Luo,Yake Lan,Ruoqi Zhang,Zhongqiu Luan
Introduction Diabetic nephropathy (DN), as a complication of diabetes, is one of the major causes of end-stage renal disease. Licochalcone B (LCB), a flavonoid active component derived from licorice, is well known for its anti-inflammatory and antioxidant properties. However, the influence of LCB on DN remains unclear. This research investigated the effect of LCB on DN and elucidated the regulatory mechanism. Methods We employed male C57BL/6 mice to construct a DN mouse model induced by a high-fat diet (HFD)/streptozotocin (STZ). In vitro , a high glucose (HG)-induced injury model in HK-2 (human renal tubular epithelial) cells was used to further confirm the protective effects of LCB. Results LCB treatment (20 mg/kg and 40 mg/kg) decreased blood glucose levels, kidney injury, glycogen deposition, and collagen accumulation in the DN mice. Moreover, LCB at a dosage of 40 mg/kg reduced albumin, creatinine, and blood urea nitrogen levels by about 70.7%, 33.4%, and 45.6%, respectively, indicating an improvement in kidney function. In renal tissues, LCB suppressed oxidative stress and apoptosis in HFD/STZ-induced mice. Consistent with in vivo findings, LCB alleviated HG-induced oxidative stress and apoptosis in HK-2 cells. Transcriptome analysis revealed that LCB affects oxidative stress and renal function-related pathways to alleviate DN. Further mechanistic studies demonstrated that LCB treatment upregulates the expressions of heme oxygenase-1 (HO-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2), suggesting activation of the Nrf2/HO-1 signaling pathway. Conclusion Taken together, this research demonstrates that LCB suppresses oxidative stress and apoptosis accompanied by modulating the Nrf2/HO-1 pathway to ameliorate DN, which provides a promising strategy for DN treatment.
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JOURNAL OF ETHNOPHARMACOLOGY
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2026
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IF 6.8
Shuxian Zang,Ziyun Ban,Lingchen Hou,Yuxuan Zhang,Yuanyuan Wang,Yuanyuan Zhang,Chaonan Wang,Depei Li,Feiyu An,Yuqi Liu,Yunyun Geng,Yonggang Gao
Ethnopharmacological relevance The herbal combination of Bupleurum chinense DC (Chaihu) and Paeonia lactiflora Pall (Baishao), collectively referred to as Chaihu-Baishao (CB), has been historically utilized in traditional Chinese medicine for the treatment of depression. However, the mechanisms underlying its therapeutic benefits have not been clearly defined. Aim of the study This study investigated whether CB alleviates depressive symptoms by modulating the interaction between the voltage-gated calcium channel subunit α2δ-1 and the N-methyl-D-aspartate receptor (NMDAR) subunit NMDAR2B (NR2B), thereby restoring hippocampal synaptic plasticity. Materials and methods In vivo , the chronic social defeat stress (CSDS) mouse model was employed to assess the impact of CB on depression-like behaviors, hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, impairments in hippocampal neuronal and synaptic plasticity, as well as the expression and interaction of α2δ-1 and NR2B. In vitro , corticosterone (CORT) was utilized to induce cellular injury. In PC12 cells, the therapeutic effects of CB-containing serum and the α2δ-1 inhibitor gabapentin (GBP) were assessed, focusing on the interaction between α2δ-1 and NR2B, as well as the expression levels of synaptic proteins postsynaptic density protein 95 (PSD95) and synaptophysin (SYN). The role of CB was further corroborated using Cacna2d1 gene knockout cells. Molecular docking techniques were employed to predict the key active components within CB that target α2δ-1 and NR2B, hereby exerting antidepressant effects. Results In vivo studies demonstrated that CB significantly alleviated depression-like behaviors in mice, decreased levels of adrenocorticotropic hormone (ACTH) and CORT. Furthermore, CB relieved structural damage to hippocampal neurons and synapses, downregulated the expression of α2δ-1 and NR2B, inhibited their interaction and restored synaptic protein expression. In vitro experiments revealed that CB mitigated CORT-induced cellular damage, suppressed the α2δ-1-NR2B interaction, and enhanced synaptic proteins expression. Additionally, studies involving GBP treatment and Cacna2d1 -knockout confirmed that α2δ-1 plays a regulatory role in NR2B expression and synaptic plasticity. Molecular docking analyses identified Saikosaponin C, Saikosaponin B4, and Bupleuroside I as potential key components. Conclusion The findings of this study elucidate a novel mechanism through which CB exerts its antidepressant effects, specifically by modulating the α2δ-1-NR2B interaction and restoring of synaptic plasticity within the hippocampus.
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ACS Catalysis
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2026
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IF 13.6
Qiliang Liu,Wenxing Yang
Recently, an intense Raman peak at approximately 520–544 cm–1 (briefly named as *530 in this study) has been widely observed and discussed during in situ spectroscopic studies of electrochemical CO2 or CO reduction reaction (CO(2)RR). Several mechanisms were proposed to explain the nature of this peak, most notably attributing it to Cu–OHad or CuOx(OH)y, which was then utilized as a key spectroscopic indicator in various mechanistic discussions. Herein, by systematic isotopic-labeled spectroscopic studies, we show that the nature of the *530 peak may not be the previously proposed species, but more likely a surface species containing (C, O) in equilibrium with inert bridging-type adsorbed CO (*CObridge). Both the formation of *530 and *CObridge is shown to be associated with the spontaneous reconstruction of Cu. The *CObridge and *530 Raman modes share the same adsorption sites and can interconvert into each other via the variation of electrochemical potentials. Finally, the appearance of both peaks is shown to signalize a deteriorated C2+ products performance of CO2RR and CORR. These results update the current understandings of the role of *530 for CO(2)RR. It also highlights that the emerging-recognized electrocatalyst reconstruction phenomenon can be accompanied by the formation of diverse surface adsorbates, casting challenges, and necessitating rigorous spectroscopic studies for better mechanistic understanding.
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FOOD CHEMISTRY
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2026
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IF 10.4
Zhi Hu,Jiapeng Chen,Hengyong Xu,Xuyang Ji,Jiajun Zhu,Longge Guo,Xinqi Wang,Yiping Liu,Chaowu Yang,Chunlin Yu,Zengrong Zhang,Mohan Qiu,Yan Wang
Understanding the biochemical basis of chicken meat flavor is important for improving meat quality. An integrated metabolomic, lipidomic, and transcriptomic approach was applied to compare breast (BM) and leg meat (LM) of 120-day-old Tianfu broilers. Compared with BM, LM showed higher pH values, a 43.05% lower drip loss, and markedly higher intramuscular fat (IMF) content (6.217% vs. 1.954%), whereas BM contained more inosine monophosphate and exhibited greater shear force. GC–MS and lipidomics identified 147 volatile compounds and 1972 lipid species, respectively, with glycerophospholipids, particularly phosphatidylethanolamine and phosphatidylcholine, closely associated with flavor differences between muscles. Multi-omics factor analysis indicated circ_015424 as a key molecular feature correlated with lipid metabolism and flavor-related pathways. Functional assays further showed that circ_015424 enhanced lipid droplet accumulation in intramuscular adipocytes via the miR-196-1-3p/MOGAT1 axis. These results clarify lipid-related mechanisms underlying muscle-specific flavor formation in chicken.
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ACS Nano
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2026
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IF 17.3
Gang Zhao,Xiaodong Liu,Xiaodong Wen,Xujun Zhao,Chenchen Hang,Lei Wang,Yuchen Ding,Liming Zhang,Liang Zhang,Yude Su
The tandem strategy for electrochemical CO2 reduction (ECO2R), which utilizes CO gas as the essential intermediate, offers a promising route for converting CO2 into multicarbon (C2+) products. However, inefficient retention and utilization of the CO intermediate remain fundamental issues limiting the practical viability of these tandem systems. Here, we introduce a proof-of-concept “CO reservoir” strategy to directly address this bottleneck. With a well-defined bilayer tandem ECO2R system, we show that incorporating N-doped carbon nanotube (NCNT) as a CO reservoir into the downstream Cu catalyst layer simultaneously enhances the retention time, local concentration, and utilization efficiency of the CO intermediate, a discovery validated by COMSOL simulations, potential-step chronoamperometry, theoretical calculations, and in situ Raman spectroscopy. Enabled by this reservoir effect, the tandem electrocatalyst demonstrates exceptional CO2-to-C2+ performance, achieving a peak C2+ Faradaic efficiency (FEC2+) of 87.1 ± 2.7% and, notably, an optimal C2+ partial current density (jC2+) exceeding 1 A cm–2. The CO reservoir strategy constitutes a promising approach for effective intermediate management in tandem ECO2R systems, establishing a viable tandem route toward industrial-level C2+ production from CO2.
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NEW JOURNAL OF CHEMISTRY
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2026
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IF 2.6
Xingbo Qi,Lei Ni,Ziyan He,Xu Sun,Hejie Lu,Haiqiang Li,Ruixi Meng,Maosen Fu,Xiao Ma
Cobalt-free, nickel-rich layered oxide cathode material LiNixMn1-xO2 (NM) has attracted much attention due to its high specific capacity and low cost. However, cobalt-free cathode materials have more serious problems such as Li/Ni disorder and structural degradation compared to ternary LiNixCOyMn1-x-yO2 (x ≥0.5, NCM) cathodes. To address these challenges, LiNi0.6Mn0.4O2 (NM64) and a series of Mo-doped Li(Ni0.6Mn0.4)(1-x)MoxO2 (x = 0, 0.01, 0.02, 0.03, 0.04, 0.05) cathode materials were designed and prepared by high-temperature solid-phase method, and the effect of Mo doping on the structure and electrochemical performance of NM64 cathodes was systematically investigated. Mo doping not only suppresses Li/Ni mixing and enlarges interlayer spacing but also effectively inhibits primary particle overgrowth, resulting in refined particle morphology that enhances structural stability and Li+ transport kinetics. Consequently, the Mo-doped NMM cathodes exhibit more stable interface with significantly suppressed side reactions. Li(Ni0.6Mn0.4)0.98Mo0.02O2 cathode exhibited superior capacity retention of 86.83% after 100 cycles at 1.0 C (at 25℃ and 2.8-4.3 V), surpassing the NM matrix by 8.98% and demonstrating the remarkable cycling stability improvement. This work elucidates the structural and interfacial stabilization mechanisms induced by high-valent Mo doping, providing an effective approach to developing high-performance Co-free layered oxide cathodes.
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