INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.5
Linru Huang,Fengping Liao,Kuntai Li,Yinyin Cao,Minghui Tan
The development of multifunctional and biodegradable composite films represents a promising approach to enhancing food preservation. Herein, a chitosan-based composite film was designed by incorporating bacterial cellulose (as a mechanical reinforcement agent) and Bacillus amyloliquefaciens HY2–1 lipopeptides (as an antimicrobial component), with the aim of enabling its potential application in food packaging. A systematic investigation was conducted to evaluate the influence of varying HY2–1 lipopeptides concentrations on the key performance metrics of the composite films, including mechanical strength, barrier properties, antioxidant capacity, antimicrobial activity, and practical efficacy in fruit preservation. The results revealed a concentration-dependent enhancement in functional properties of the composite films with increasing of HY2–1 lipopeptides incorporation. At the optimal HY2–1 lipopeptides concentration of 2.4 mg/mL, the composite film demonstrated significantly improved antioxidant activity, with DPPH radical scavenging of 48.21% (8-fold that of the control) and ABTS radical scavenging of 60.73% (3-fold that of the control). Besides, the composite film exhibited significantly enhanced antimicrobial activities against a broad spectrum of pathogens, including Gram-positive bacteria ( Listeria monocytogenes and Staphylococcus aureus ), Gram-negative bacteria ( Escherichia coli ), and the fungal Penicillium digitatum , compared to the control film. Furthermore, the lipopeptides-incorporated composite film effectively preserved critical shelf-life indicators of citrus and strawberry under ambient storage conditions, including color retention, firmness maintenance, and nutritional content preservation, thereby demonstrating excellent practical preservation efficacy. Overall, this study designs a high-performance, fully bio-based composite film by integrating multifunctional lipopeptides into a chitosan matrix, presenting a potent and natural strategy to extend the shelf-life of perishable foods.
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ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
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2017
·Vol. 643
·期 7
·471-476
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IF 1.144
Lingyun Dong,Jiao Yang,Shigang Shen,Zhenzhen Liu,Xiaojing Chen,Sufang Sun
Through extensive research on the PbO / PbBr 2 / B 2 O 3 system, a new single crystal of yellow lead-containing oxyborate bromine, [O 2 Pb 3 ] 2 (BO 3 )Br, was grown from the melt. It crystallizes in the centrosymmetric space group Cmcm (no. 63) of the orthorhombic system with the following unit cell dimensions: a = 9.5748(8) Å, b = 20.841(2) Å, c = 5.7696(5) Å, and Z = 4. The whole structure is characterized by an infinite one-dimensional (1D) ∞ 1 [O 2 Pb 3 ] double chain, which is based on the OPb 4 oxocentered tetrahedra and considered as the derivative of the continuous sheet of OPb 4 tetrahedra from the tetragonal modification of α-PbO. The 1D ∞ 1 [O 2 Pb 3 ] double chains are further bridged by the BO 3 units through common oxygen atoms to form two-dimensional (2D) ∞ 1 [[(O 2 Pb 3 )(BO 3 )] layers, with Br atoms situated between the layers. IR spectroscopy, UV/Vis/NIR diffuse reflectance spectroscopy, and thermal analysis were also performed on the reported material.
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Materials Science & Engineering C-Materials for Biological Applications
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2017
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IF 4.164
Zhijia Zhang,Xiaole Zhao,Yingchun Su,Defeng Xing,Xiaojun Han
We demonstrate that antibacterial agent N , N′ -[(4, 5-dihydroxy-1, 2-phenylene)bis(methylene)]bisacrylamide (OHABA) can be assembled on the surface of vinyl organosilicon nanospheres (VOSNs) by atom transfer radical polymerization (ATRP). Chemically cross-linked vinyl organosilicon cores were facilely fabricated by sol-gel method as support, which densely grafted poly-OHABA (POHABA) as shells. Antibacterial assessment test results revealed that POHABA-based core@shell structure displayed high antibacterial performance, long-term stability, and kept broad-spectrum antibacterial effect of against Gram-negative and Gram-positive bacteria.
研究领域:
材料科学
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纳米医学
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抗菌材料
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高分子化学
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表面功能化
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 2
·121277
·
IF 7.2
Caifeng Xia,Siyuan Liu,Qikang Yin,Sen Liu,Bo Liao,Shuxian Wei,Zhaojie Wang,Zhe Sun,Xiaoqing Lu
The performance of mixed matrix membranes (MMMs) depends largely on the structure and composition of incorporated nanofillers. However, it remains challenging to achieve efficient separation performance with uniform filler dispersion and strong interfacial compatibility within the polymer matrix. In this study, an ionic liquid-modified hollow microsphere of tartaric acid anion-intercalated layered double hydroxide (IL@HMS TA-LDH) was designed and embedded into a PIM-1 matrix to fabricate IL@HMS TA-LDH/PIM-1 MMMs for efficient CO 2 separation. The hollow microstructure and anion-rich interlayers of LDH provide multiple facilitated transport pathways for CO 2 significantly enhancing both permeability and selectivity. Experimental and theoretical calculation results confirm that IL modification on HMS TA-LDH not only improved the interfacial compatibility between the polymer and the filler but also enhanced CO 2 affinity and the CO 2 /N 2 selectivity. The resulting MMMs surpassed the 2019 Robeson upper bound and showed good stability. The separation efficiency of the optimal 5.0 % IL@HMS TA-LDH/PIM-1 MMMs was the best (CO 2 permeability was 8550.73 ± 367.54 Barrer, CO 2 /N 2 selectivity was 40.75 ± 1.83), outperforming most of the other reported MMMs. This work offers a new strategy for designing high-performance CO 2 capture membranes by combining hollow-structured LDH with functionalized ionic liquids.
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ACS Sensors
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2026
·
IF 10.9
Yiwen Zhou,Zichen Zheng,Kewei Liu,Marc Debliquy,Carla Bittencourt,Chao Zhang
Chemiresistive gas sensors designed for the detection of agricultural volatile organic compounds (VOCs) play a crucial role in monitoring crop growth and ensuring the quality of agricultural products. However, conventional metal oxide gas sensors continue to encounter challenges related to high power consumption and limited detection capabilities. In this study, bismuth stannate oxide Bi2Sn2O7 (BSO) quantum dots were synthesized via a hydrothermal method to facilitate room-temperature detection of 1-octanol. A systematic investigation was conducted to elucidate the relationship between the gas sensing performance of the material and its microstructure, surface valence states, and electronic structure. The BSO-8 sensor, characterized by an exceptionally high specific surface area (BET = 143.57 m2 g−1), demonstrated a wide detection range of 1−50 ppm, exhibiting a remarkable response of 75.06 ± 1.25 at 50 ppm under 30% relative humidity. Additionally, the sensor displayed excellent reproducibility, long-term stability, and significant selectivity toward 1-octanol. Further mechanistic insights were obtained through valence band spectroscopy and density functional theory calculations, which provided a comprehensive understanding of the evolution of the electronic structure and gas adsorption behavior. These findings demonstrate the potential of BSO-based sensors for practical applications in detecting 1-octanol at 30% RH, highlighting its significance as a key biomarker for agricultural VOCs.
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NATURAL PRODUCT RESEARCH
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2026
·
IF 1.8
Qiao-Long Hao,Han-Mei Bai,Lei Miao,Shuang Yao,Chuan-Rui Zhang
The first phytochemical investigation of Tarlmounia elliptica (the sole species of its genus) led to the isolation of eight compounds from its aerial parts, including a previously undescribed seco-norlignan, tarlelliptin A (1), and a rare ring B aromatic 1(10→6)abeo-ergostane-type steroid, tarlelliptin B (2). Their structures were fully characterised by comprehensive spectroscopic analysis (HRESIMS, 1D/2D NMR) and corroborated by quantum chemical calculations (including ECD and NMR computations). Biological evaluation for cytotoxic, anti-inflammatory, and antibacterial activities indicated that only the known compound 7-oxo-β-sitosterol (8) exhibited weak antibacterial activity (MIC = 64.0 μg/mL) against methicillin-resistant Staphylococcus aureus (MRSA) strain 252.
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Materials Today Bio
·
2026
·
IF 11
Zhaoyou Chu,Shu Fang,Wanyue Fu,Jun Liang,Yayun Wu,Ling Xu,Hanqing Zhang,Jiyang Wang,Haisheng Qian,Min Shao
New Delhi metallo-β-lactamase (NDM)-producing drug-resistant bacteria often form stubborn biofilms and cause severe pneumonia, resulting in conventional antibiotic failure. In this study, we developed gelatin-genipin microspheres co-loaded with EDTA and meropenem (GEM) for targeted treatment of NDM pneumonia. EDTA exerted dual functions: it chelated Zn 2+ to inactivate NDM enzyme and restore meropenem activity (FIC = 0.046875), while also disrupting bacterial biofilms through chelation. GEM microspheres enable accelerated drug release in the artificial phlegm environment. In a mouse model of NDM pneumonia, GEM microspheres can enhance the recruitment of neutrophils and M1 cells at the early stage (12 h) through bacterial clearance, modulate the secretion of interferon-γ by CD8 + T cells and natural killer cells, and reshape the pulmonary immune microenvironment. Furthermore, GEM treatment reduced pathological pulmonary immune cell infiltration and excessive inflammation at late time points (days 3-7). Taken together, GEM microspheres integrate biofilm disruption, enzyme inhibition, synergistic bactericidal effects, and immunoregulation, representing a promising strategy against NDM drug-resistant bacterial pneumonia.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Xiaojun Yan,Yulin Zhang,Wen Zeng,Yang Li,Chenhui Zhu
Tendon repair remains a major clinical challenge, largely because current strategies often fail to simultaneously achieve early inflammatory control and subsequent matrix remodeling. To address this problem, we developed a dynamically responsive nano-hydrogel, CAPP@IGF-1, composed of 3-carboxyphenylboronic acid-modified chitosan, polyvinyl alcohol, and IGF-1-loaded PLGA microspheres, which were integrated through phenylborate ester crosslinking. The hydrogel exhibited favorable self-healing behavior together with enhanced mechanical properties, with an elastic modulus of 4.5 MPa and a toughness of 15.3 MJ/m³, enabling it to maintain local structural stability under the complex dynamic conditions of tendon repair. Under the acidic inflammatory microenvironment, CAPP@IGF-1 enabled controlled local release of IGF-1 and activated the IGF-1R/AKT signaling pathway, thereby markedly promoting macrophage reprogramming from the pro-inflammatory M1 state to the pro-reparative M2 state. This was accompanied by suppression of IL-6, IL-2, and TNF-α and upregulation of IL-10, leading to the establishment of a local immune microenvironment favorable for repair. On this basis, the hydrogel further promoted tendon stem/progenitor cell migration, proliferation, extracellular matrix remodeling, and more ordered collagen deposition. In a rabbit tendon injury model, CAPP@IGF-1 notably reduced peritendinous adhesion, and enhanced the mechanical recovery of repaired tendons. Collectively, CAPP@IGF-1 achieves stage-specific intervention during tendon healing through the combined effects of a dynamically crosslinked network, enhanced mechanical properties, and intelligent IGF-1 release. This study demonstrates the feasibility of using materials design to connect inflammatory microenvironment regulation with tissue regeneration and provides a new strategic basis for the precise repair of complex tendon injuries.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 6
·387
·
IF 5.4
Yu Zengshan,Wu Yanjun,Guo Shan,Li Zelong,Cui Jiahao,Shi Guochao
Chronic kidney disease (CKD) has become a major global public health issue. Due to its insidious onset and atypical early symptoms, patients often fail to detect it in time and receive effective intervention. Therefore, conducting early screening and diagnosis is of great significance for delaying the progression of renal failure and reducing the burden on patients and society. Combining surface-enhanced Raman scattering (SERS) technology, immunochromatography and artificial intelligence algorithm, this study utilized serum kidney injury molecule-1 (KIM-1) molecule as a key biomarker to construct a serum-based CKD diagnostic model, aiming to achieve efficient and accurate CKD screening. A total of six models were included for comparative analysis, among which the extreme gradient boosting (XGBoost) model successfully achieved precise classification of CKD, with a classification accuracy of 98.42% and an area under the curve (AUC) of 99.96%. Furthermore, leave-one-out cross-validation was used to validate this model, with an overall classification accuracy of 96.79%. These results indicated that the model exhibited good stability and strong robustness. In conclusion, the artificial intelligence-driven immunochromatography SERS biosensing technology with serum KIM-1 molecule as the early warning radar is expected to become a new technical strategy for intelligent early screening and auxiliary diagnosis of CKD. Graphical The alternative text for this image may have been generated using AI.
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TOXICOLOGY AND APPLIED PHARMACOLOGY
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2026
·
IF 3.6
Lina Li,Haotian Chen,Yang Zhu,Ren-shan Ge,Chao Chen,Shangqin Chen
Parabens are extensively employed as antimicrobial preservatives in cosmetics, personal care items, and pharmaceuticals. However, their potential metabolism regulating effects, particularly regarding the inhibition of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), remains unknown. This study assessed 4-hydroxybenzoic acid and 9 parabens for their ability to inhibit human and rat liver 11β-HSD1, investigating their mechanism of action, structure-activity relationship (SAR), molecular interactions (via in silico docking), and influence on cortisol metabolism in LX-2 cells. Nonylparaben emerged as the most potent inhibitor, demonstrating the lowest IC 50 values (human: 6.29 μM) and strongest binding affinity (ΔG: human: −6.84 kcal/mol). The inhibitor trend followed nonyl > heptyl (IC 50 = 11.37 μM) > hexyl (15.32 μM) > benzyl (29.99 μM) > phenyl (53.27 μM) > butyl (58.87 μM) paraben. Short-chain parabens (
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Materials Today Nano
·
2026
·
IF 7.6
Yue Zhao,Xin-Ya Zhou,Qing-Yin Li,Zheng-Hui Qiu,Zhi-Yong Sun,Guang-Long Zhang,Jin-Wei Zhang,Cun-Guo Lin
A carboxylic acid molecular bridging strategy for modifying M-HOFs is developed. • Synergistic “rigidity-flexibility” balance enhances structure and charge transport. • Charge recombination is significantly suppressed per time-resolved spectroscopy. • Improved photocatalytic degradation and antibacterial performance are achieved. • This work provides a design principle for HOF-based photocatalysts. High-performance photocatalysts are significant for overcoming contemporary energy and environmental challenges. Metal-complex hydrogen-bonded frameworks (M-HOFs) are promising materials, yet they often face the problem of poor charge separation. Herein we suggest a strategy of molecular design to enhance the photocatalytic activity of a standard M-HOF, which is MPM-1-TIFSIX that can be modified by trimesic acid. In this approach, trimesic acid acts as a molecular glue. It comprises both coordination bonds and hydrogen bonds, creating an equilibrium between rigidity and flexibility within the structure. This modification improves the structural ordering and arrangement, and also facilitates charge transport through the material. The experimental results indicate evident lower photoluminescence and longer carrier lifetime which confirms that charge recombination is highly curtailed. This work enhances the performance of M-HOFs in the areas of pollutants degradation, antibiofouling and antibacterial. It also offers the basic guidelines to the directed rationale approach in designing next generation HOF-based photocatalysts. Download: Download high-res image (284KB) Download: Download full-size image
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Frontiers in Immunology
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2026
·
IF 7
Tianyi Xu,Qilei Yang,Yue Peng,Congcong Xie,Huimin Yu
Rheumatoid arthritis (RA) therapy demands agents that are both effective and safe, yet many natural products with promising bioactivity, such as curcumin, face major translational challenges due to poor solubility and bioavailability. To overcome these limitations, we designed and synthesized a series of dual-functional curcumin-borneol prodrugs via a succinate ester linkage, including the parent ester (CBS), its water-soluble sodium salt (CBS-Na), and a disubstituted analog (DCBS), to enhance delivery and synergize therapeutic action. These derivatives markedly improved cellular uptake and nuclear localization, potently scavenged reactive oxygen species, and effectively suppressed the MAPK/AP-1 signaling axis by inhibiting ERK and p38 phosphorylation and c-Fos expression, leading to downregulation of matrix metalloproteinase MMP9 and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β). In a collagen-induced arthritis rat model, the derivatives demonstrated superior efficacy over native curcumin in alleviating joint inflammation and destruction, while exhibiting an excellent safety profile, thus representing a novel and promising therapeutic strategy for RA.
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