MICROCHIMICA ACTA
·
2023
·Vol. 191
·期 1
·1-10
·
IF 5.7
Li Wenjie,Xu Zhenjuan,Li Peipei,Liu Xiang,Chen Chao,Zhang Youyu,Liu Meiling,Yao Shouzhuo
An electrochemical sensor capable of detecting glutathione (GSH) with high sensitivity and selectivity was developed based on the unique novel electroactive silver-based metal organic framework (Ag-MOF). The Ag-MOF obtained by silver nitrate and 1,3,5-benzoic acid (H 3 BTC) was thoroughly characterized and was modified onto the electrode via facile drop-casting method. The electrochemical response of GSH on the Ag-MOF modified electrode showed a significant reduction in the current signal because the Ag-GSH complex had stronger specific affinity than Ag-H 3 BTC and resulted in the collapse of the Ag-MOF. This sensor demonstrated an extensive linear dynamic range of 0.1 nM-1 µM, along with the low detection limit of 0.018 nM. Additionally, it exhibited good reproducibility, stability, and resistance to interfering compounds. The Ag-MOF modified electrode demonstrated superior performance attributed to its rapid electron transfer rate, outstanding electrochemical redox activity, and specific recognition/competitive reaction. These factors improved both sensitivity and selectivity. The high anti-interference ability allowed for the selective detection of GSH in intricate surroundings. In the real sample testing, the RSD was lower than 3.1% and the recovery was between 98.1 and 103%. This research highlights the potential of Ag-MOFs in developing electrochemical sensors and their promising applications in determining GSH for food screening and early disease diagnosis.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2024
·Vol. 40
·期 2
·293-304
·
IF 3.1
Chen Peiyu,Zhang Guoyang,Li Jiguang,Ma Lijun,Zhou Jiaying,Zhu Mingguang,Li Shuo,Wang Zhuo
The combination of near-infrared (NIR) fluorescence imaging (FLI) and photoacoustic imaging (PAI) can effectively compensate for each other’s inherent limitations, which can provide reliable and rich information on tumor biology. Therefore, the development of FL/PA dual-modality imaging probes is beneficial for achieving precision cancer diagnosis and treatment. Herein, we designed an efficient phototherapy agent methoxy bithiophene indene (OTIC), which was based on aggregation-induced emission (AIE) active fluorophores. To improve the water dispersion and enrichment of OTIC at the tumor site, OTIC nanoparticles (OTIC NPs) were prepared by a nanoprecipitation method. The balance between radiation and non-radiation energy dissipation was regulated by the strong donor-acceptor interaction and intramolecular motion. So OTIC NPs exhibited bright NIR fluorescence, photoacoustic signals, efficient generation of reactive oxygen species, and high photothermal conversion efficiency under NIR irradiation. Accurate imaging of the tumor and mice sentinel lymph nodes (SLNs) with OTIC NPs was visualized by NIR FL/PA dual-modal imaging. With the comprehensive imaging information provided by OTIC NPs in vivo , tumors were ablated under laser irradiation, which greatly improved the therapeutic efficacy. OTIC NPs would be possible to realize the precise guidance of FL/PA imaging for tumor treatment in the future clinical application.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 35
·1-11
·
IF 2.8
Sui Meirong,Gu Xiuquan
In this work, a facile metal organic decomposition route was developed for synthesizing the ZnO quantum dots (QDs), which were then in situ deposited onto a BiVO 4 nanoporous films for enhancing its photoelectrochemical (PEC) water oxidization activity. The results shows that there aren’t significant changes in both the color and surface morphology of the BiVO 4 membrane after QD modification. Nevertheless, the ZnO/BiVO 4 photoanode demonstrates a maximum photocurrent density of 2.56 mA/cm 2 at a bias of 1.23 V RHE with simulated solar irradiation, which is almost 2 times higher than that of the unmodified BiVO 4 one. The enhanced PEC performance is attributed to the formation of type II heterojunction, which promotes charge transfer/separation. This work might shield light on enhancing the PEC performance of BiVO 4 towards water oxidization.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2024
·Vol. 42
·期 5
·570-578
·
IF 4.1
Sun Xiao-Fei,Zhang Xu,Song Shu-Ping,Yao Ya-Qun,Zhang Yan,Wang Cheng-Liang,Sun Jing-Jiang,Wang Qing-Fu
L -glutamic acid (LA) is a bio-based, non-toxic, environmentally friendly material derived from biomass. The present study reports the application of Passerini three-component polymerization (P-3CP) for the straightforward preparation of LA-based light-responsive polyesters (PLTDs) under mild conditions. PLTDs with molar masses up to 8500 g/mol and high yields exceeding 90% are obtained. The chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible (UV-Vis) spectroscopy, size exclusion chromatography (SEC), nuclear magnetic resonance (NMR) spectroscopy, and liquid chromatography mass spectrometry (LC-MS). Meanwhile, monodisperse PLTD-based doxorubicin-loaded nanoparticles (PLTD-DOX-NP) (size=193 nm, PDI=0.018) are formulated by nanoprecipitation method. Upon light-induced depolymerization, the PLTD-DOX-NP undergoes rapid decomposition, resulting in a burst release of 80% cargo within 13 s. Furthermore, according to biological toxicity tests, the PLTD-NP possesses adequate biosafety, both before and after irradiation. Overall, the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry, significantly simplifying the synthetic pathway of light-responsive polymers.
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Science China-Chemistry
·
2024
·
IF 10.4
Chen Zhi-Wei,Wang Hong-Juan,Liu Chang,Lu Xiu-Li,Lu Tong-Bu
Nitrogen-doped carbon materials have been widely used for the constructions of single-atom catalysts, while the effect of different species of doped nitrogen on the catalytic activity of CO 2 electroreduction has rarely been investigated. Here we found that pyrrolic-N coordinated Ni 2+ catalysts display much higher electrocatalytic CO 2 -to-CO activity and selectivity than the corresponding pyridinic-N coordinated low valent Ni (0−+2) catalysts, and pyrrolic-N coordinated Ni 2 dual-atoms catalyst of Ni 2 /N-CNTs exhibits the best electrocatalytic performance, with over 90% Faradaic efficiencies in a broad potentials from −0.6 to −1.2 V vs. reversible hydrogen electrode, as well as an outstanding CO specific current of 56.2 A/mg Ni and high turnover frequency of 6.2 × 10 4 h −1 , over 7-times higher than those of pyridinic-N coordinated Ni catalysts. Electrochemical results indicate the weak electron-donor nature of pyrrolic-N facilitates the generation of a reduced active site at low overpotential for boosting CO 2 electroreduction. Density functional theory calculations reveal that the reaction free energy for the *COOH formation on pyrrolic-N coordinated Ni catalysts are lower than those on pyridinic-N coordinated Ni catalysts, and a H 2 O-adsorbed Ni 2 /N-CNTs displays the optimized reaction free energy for both *COOH formation and CO desorption, which derive the best catalytic performance.
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Frontiers of Materials Science
·
2024
·Vol. 18
·期 4
·1-10
·
IF 2.5
Zhang Jingjing,Zhong Daliang,Zheng Zhijian,Li Qier,Yang Xinyan,Ma Zaiqiang,Zhang Quan,Kong Xiangdong,Zhao Ruibo
Although Prussian blue (PB) has been widely investigated as a biocompatible photothermal agent with significant potential in cancer treatment, its further application is still hindered by low photothermal conversion efficiency (PCE) and poor stability. In this study, a biomimetic mineralization approach is employed to improve properties of PB by binding it with manganese phosphate through manganese ions, resulting in the formation of nanocomposite manganese phosphate mineralized Prussian blue (MnP&PB). Compared to PB alone, MnP&PB can significantly enhance the PCE, increasing it to 44.46%, which is attributed to the manganese-induced redshift absorption and the bandgap narrowing in the near-infrared (NIR) region. Meanwhile, MnP&PB demonstrates a significant increase in temperature compared to that of either MnP or PB alone, further enhancing the inhibition effect against cancer under the NIR irradiation. It is revealed that the incorporation of manganese phosphate into PB via biomimetic mineralization lead to the enhancement of both PCE and therapeutic efficacy, thus presenting a promising alternative approach for the improvement of cancer photothermal therapy.
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BMC Cardiovascular Disorders
·
2024
·Vol. 24
·期 1
·1-12
·
IF 2
Qian Kai,Song Li,Guo Jia-Min,Fu Dan,Shi Jia,Ma Yu,Ge Zi-Jie,Li Lei,Zhang Su-qin
Background Cardiovascular disease carries the highest mortality rate among diseases, and pharmacological interventions have limited efficacy. Baicalin (Bai) promotes biological metabolic processes, eliminates oxygen free radicals, and is anti-inflammatory. This study aimed to investigate the effect of Bai on the cardiac injury model induced by isoproterenol in mice.Methods and ResultIn this study, all groups except the control received intraperitoneal injections of isoproterenol (ISO) to induce a cardiac injury model, with the drug administered continuously for 14 days. hematoxylin and eosin staining and Masson’s trichrome staining revealed that Bai significantly mitigated ISO-induced pathological changes in mouse heart tissue and alleviated myocardial hypertrophy. Echocardiography assessments demonstrated that Bai preserved cardiac function in ISO-treated mice. Furthermore, our findings indicated that Bai activated the Nrf2 signaling pathway in vivo and in vitro. To delve deeper, mice were further treated with ML385 (ML) via intraperitoneal injection to inhibit the Nrf2 pathway. Results showed that ML385 blocked the cardioprotective effects of Bai in mouse heart tissue.Conclusion Bai protects against ISO-induced cardiac injury, and its mechanism is related to activating the Nrf2/HO-1 signaling pathway to regulate cardiac ferroptosis and improve cardiac remodeling.
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PubMed
高影响因子
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2015
·Vol. 82
·期 3
·453-460
·
IF 1.488
Li Shujing,Yue Junzhi,Zhou Wei,Li Li
The inclusion complexes between puerarin and three cyclodextrins (CDs), namely β-cyclodextrin (β-CD), (2-hydroxy)propyl-β-cyclodextrin (HP-β-CD, DS = 4.2) and methyl-β-cyclodextrin (Me-β-CD, DS = 12.5) were prepared. The effects of the complexation on the stability of puerarin were investigated in both solution and the solid state by methods of phase solubility study, XRD, DSC and SEM. Furthermore, the antioxidant activities of puerarin and puerarin/CDs inclusion complexes were determined by reducing power and 1,1-diphenyl-2-picryl-hydrazyl methods. Results showed that puerarin formed 1:1 stoichiometric inclusion complexes with β-CD, HP-β-CD and Me-β-CD. Additionally, the solubility and thermal stability of puerarin was improved after encapsulating by CDs. Antioxidant activity studies showed that the antioxidant performance of the inclusion complex was better than the native puerarin, and puerarin/Me-β-CD complex was the most effective form. It can be a potentially promising way to develop a new formulation of puerarin for herbal medicine or healthcare products.
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CHROMATOGRAPHIA
·
2014
·Vol. 77
·期 23
·1653-1660
·
IF 1.37
Lv Tao,Zhao Xian-En,Zhu Shuyun,Ji Zhongyin,Chen Guang,Sun Zhiwei,Song Cuihua,You Jinmao,Suo Yourui
A novel hyphenated technique based on ultrasonic-assisted dispersive liquid–liquid microextraction (UA-DLLME) coupled with derivatization has been established for the determination of brassinolide (BL, a representative of brassinosteroids) by HPLC fluorescence detection. 9-Phenanthreneboronic acid is used as labeling reagent of BL. UA-DLLME parameters containing type and volume of extraction and disperser solvent, pH and ultrasonication time are optimized. Derivatization parameters are optimized included amount of 9-phenanthreneboronic acid, volume ratio of pyridine, derivatization time and temperature. Under optimal conditions, quantitative linear range of BL is 50–1,000 ng L −1 and excellent linear response is observed with correlation coefficient of 0.9996. Limit of detection and limit of quantification are calculated as 8.0 and 25.0 ng L −1 , respectively. RSDs of retention time and peak area are in the range of 0.68–0.97 % and 4.61–6.54 % for intra-day precision, 1.32–1.94 % and 7.28–9.75 % for inter-day precision, respectively. Accuracy is satisfactory in the range of 82.3–125.1 %. RSDs’ values of repeatability are in the range of 0.82–1.79 and 3.95–8.53 % for retention time and peak area, respectively. Enrichment factor for BL is 189. The results of recovery and matrix effect are in the range of 82.0–108.6 and 90.0–115.3 %, respectively. The proposed method has been applied for the determination of BL in Arabidopsis thaliana , Daucus carota and Brassica campestris L. leaves with much higher sensitivity than many other methods.
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Bioresources and Bioprocessing
·
2024
·Vol. 11
·期 1
·1-14
·
IF 4.3
Chen Ming,She Weina,Zhao Xin,Chen Cheng,Zhu Benwei,Sun Yun,Yao Zhong
The Thermomyces lanuginosus lipase (TLLs) was successfully immobilized within a novel hydrogel matrix through a two-step crosslinking method. TLLs were initially crosslinked through the Schiff base reaction by oxidized carboxymethyl cellulose (OCMC). The water-soluble OCMC@TLLs complex was subsequently crosslinked by carboxymethyl chitosan (CMCSH) in a microfluidic apparatus to form the CMCHS/OCMC@TLLs microspheres. The CD (Circular Dichroism, CD) and FT-IR (Fourier Transform infrared spectroscopy, FT-IR) spectra demonstrated that the crosslinking of TLLs with OCMC resulted in a less significant impact on their structure compared to that with glutaraldehyde. CMCHS/OCMC@TLLs showed decreased catalytic performance due to the mass transfer resistance, while its thermal stability was greatly improved. The CMCHS/OCMC@TLLs were used to catalyze the lauroylation of arbutin in tetrahydrofuran. After 12 h of reaction under optimal conditions, the yield of 6′-O-lauryl arbutin reached an impressive 92.12%. The prepared 6′-O-lauryl arbutin has high lipophilicity and exhibits similar tyrosinase inhibitory activity and higher antioxidant activity compared to its parent compound.
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PubMed
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JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 54
·期 9
·6841-6852
·
IF 3.442
Wei Zhan,Chen Ying,Lin Pengcheng,Yan Qi,Fan Yufeng,Cheng Zhengdong
All inorganic perovskite nanocrystals (AIPNCs) have attracted tremendous research interest due to their fascinating properties in the field of photoelectron. Conventional synthesis of AIPNCs is usually conducted by using batch reactions under gas protection at high temperatures. Herein, an automated microreactor platform consisting of flow-focusing microfluidics is firstly applied to synthesize AIPNCs without gas protection at room temperature. The nucleation and growth is based on the ultrafast mixing and phase separation in low-toxicity solvent. The AIPNCs formed in the microreactor have good crystallinity and narrow size distribution. Meanwhile, the flow-focusing microfluidics also can be used to encapsulate AIPNCs into templated microspheres to improve their stability against temperature, light and water. Furthermore, the as-constructed AIPNC spheres exhibiting linear temperature response represent their promising microthermometer application. It is envisioned that the microfluidic technique provides another alternative to synthesize Ni 2+ -doped, Ce 3+ -doped, Yb 3+ -doped, Bi 3+ -substituted AIPNCs or organic–inorganic hybrid perovskite nanocrystals and to fabricate templated AIPNC materials and devices.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2018
·Vol. 88
·期 1
·227-235
·
IF 1.745
Gao Qiuyue,Jin Yani,Jin Yiming,Wang Xiaoqing,Ye Ziran,Hong Zhanglian,Zhi Mingjia
Abstract This work reported the preparation of amorphous MoS x aerogel and MoS x /carbon nanotubes composite aerogels by a modified epoxide addition sol–gel method. In this process, propylene epoxide scavenged the protons from a S–H-contained organic acid ( dl -Mercaptosuccinic acid) and promoted the interactions between (NH 4 ) 6 Mo 7 O 24 •4H 2 O and the functional groups in the organic acid to form a gel. The sulfur and molybdenum contained a wet gel turned into an amorphous MoS x aerogel after supercritical drying in ethanol. Carbon nanotubes can be further incorporated into the aerogel backbone, which can extend the specific surface area and alter the pore structures in the composite aerogels. Such composite aerogels showed good catalytic performance in electrochemical hydrogen evolution reactions.
MoS x aerogels can be prepared by the modified epoxide-adding method and showed good catalytic activity toward HER.
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