Journal of Physical Chemistry C
·
2024
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IF 3.3
Xiao-Cong Ma,Zhou Yu,Ya-Li Zhang,Jian-Ang Jin,Jian-Ping Li,Xu-Liang Fan,Qiang Wan,Ju-Fang Zheng,Xiao-Shun Zhou,Ya-Hao Wang
Nickel foam is a prevalent material for the oxygen evolution reaction (OER) in alkaline media. Herein, we employed a one-step electrodeposition technique to effectively fabricate a Ni(OH)2/Au/nickel foam (denoted as a Ni(OH)2/Au/NF) catalyst. This catalyst exhibits both surface-enhanced Raman scattering (SERS) activity and catalytic activity. The electrochemical SERS technique is employed for in situ monitoring of surface structure changes and intermediates during the OER process. The molecular evidence reveals that the electro-driven initial Ni(OH)2 first becomes disordered and finally is oxidized to NiOOH. When the OER occurs, the active oxygen species of NiOO* is observed to release O2. Compared with that of bare NF, the more disordered NiOOH from Ni(OH)2/Au/NF has a greater OER activity. These findings significantly advance the understanding of the OER mechanism on Ni-based catalysts, providing guidelines for the elaboration and optimization of future catalytic systems.
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MICROCHEMICAL JOURNAL
·
2024
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IF 4.9
Yue Gao,Xiangyi He,Rong Hu,Qing Li
In this study, we synthesized Ag-doped Au/Ag nanoclusters (GSH-Au/Ag NCs) with enhanced luminescence. We conducted a comprehensive investigation into the mechanism behind KMnO 4 -induced fluorescence (FL) quenching of these bimetallic nanoclusters and, leveraging this understanding, developed a sensitive fluorescent method for determining acid phosphatase activity (ACP). The fluorescence quenching mechanism was attributed to a combination of the inner filter effect (IFE) and redox reactions. Subsequently, ascorbic acid (AA) was generated from L-ascorbic acid 2-phosphate trisodium salt (AAP), which was selectively hydrolyzed by ACP . The released AA then reduced KMnO 4 , leading to the inhibition of fluorescence quenching of GSH-Au/Ag NCs by KMnO 4 . This innovative approach exhibited higher sensitivity, with a lower limit of detection of 0.0085 U/L (S/N = 3) for ACP activity sensing. Our proposed strategy was successfully applied to analyze ACP activity in human serum samples, demonstrating promising potential for the widespread utilization of metal nanoclusters in various applications.
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ELECTROCHIMICA ACTA
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2010
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IF 3.325
Xianggang Liu,Xiangjin Qu,Hai Fan,Shiyun Ai,Ruixia Han
An electrochemical method for the detection of DNA hybridization using a novel electroactive, cationic, and water-soluble branched polyethyleneimine (BPEI)–cobalt(III)–phenanthroline(phen) polymeric indicator and single-stranded neutral peptide nucleic acid (PNA) probe on the Au electrode was developed. The indicator possesses some free amine groups, as well as cationic cobalt complexes in the polymer chain. It does not bind to neutral PNA capture probe alone. However, the indicator strongly interacts with the negatively charged backbone of the complementary oligonucleotide bound to the PNA probe through electrostatic interactions . The coordination spherical moieties also interact with the probe by embedding into the double-helix structure of PNA–DNA. These two interactions enable transduction of hybridization, producing a clear electrical signal in differential pulse voltammetry (DPV). The correlation against non-complementary DNA, three-base and one-base mismatch DNA was sharp, and the signal of indicator for the target DNA demonstrated a linear relationship within the concentration range of 5.0 × 10 −9 to 2.5 × 10 −7 M ( R = 0.9940) with a detection limit of 5.6 × 10 −10 M. These studies showed that the novel polymeric indicator and single-stranded PNA probe could be used to fabricate an electrochemical biosensor for DNA detection. This technique can provide an alternative route for expanding the range of detection methods available for DNA hybridization.
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TALANTA
·
2025
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IF 6.1
Gao-Feng Wu,Jian Zhu,Guo-Jun Weng,Jian-Jun Li,Jun-Wu Zhao
To enhance the efficacy of Surface-enhanced Raman spectroscopy (SERS), noble metal nanoparticles (NMNPs) can be organized onto three-dimensional (3D) hierarchical nanostructures. This study involved constructing a 3D solid SERS substrate by layering Au–Ag core-satellite nanoparticle monolayer films (MF) on a polystyrene sphere (PS) array, termed Au–Ag core-satellite NPs-MF-PS. Optimizing the PS size was essential to maximize SERS substrate activity, with the 500 nm PS providing the best SERS enhancement factor of 1.03 × 10 7 a two-fold increase over Au–Ag core-satellite NPs MF alone. Additionally, cotinine detection was improved by using a ratio between the target molecules and internal Raman signals from the SERS substrate. Compared to conventional methods relying on the target molecule's Raman signal, this ratiometric SERS method expanded the detection range from 10 −8 - 10 −1 M to 10 −9 - 10 −1 M and reduced the detection limit from 3.67 × 10 −9 M to 1.68 × 10 −10 M. This approach represents a novel direction in creating ultra-sensitive SERS platforms with broad applications, suggesting that ratiometric SERS could further promote SERS technology advancements.
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NANOTECHNOLOGY
·
2020
·Vol. 31
·期 47
·475102
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IF 3.551
Lei Zhang,Feng Wei,Abdulrahman Al-Ammari,Dongping Sun
To date, numerous drug delivery systems based on mesoporous silica nanoparticles (MSNs) have been explored, but little has been done on optimizing the structure and composition of MSNs to achieve effective drug delivery for cancer cells. Ideal mesoporous drug carriers should incorporate drugs in a way that prevents pre-release in biological surroundings before reaching the targeted area, which usually requires the capping of the open ends on the surface and the incorporation of targeting ligands on the exterior of nanocarriers. In this study, an MSN-based drug carrier system was synthesized with biocompatible Au nanoparticles (NPs) as the 'hard caps', and folic acid conjugated to the surface for targeting folate receptor-overexpressed cancer cells. Disulfide bonds linking Au and MSN NPs were introduced to the MSN surface as the redox-sensitive and chemically removable components. To study the effect of structures of MSNs in drug release, three types of MSNs were compared, including hollow mesoporous silica NPs, large-pore hollow mesoporous silica NPs and typical nano-sized pores on the surface (MSN). To achieve optimal coverage of thiol groups, two methods of functionalization were compared in effecting drug loading and release in vitro. Finally, the effect of residual surfactant was also discussed in anticancer studies. Therefore, the appropriate MSN nanostructure for redox-sensitive and targeted drug delivery was optimized.
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Food Bioscience
·
2024
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IF 4.8
Qian Zhao,Xinhui Xie,Liye Chen,Jiahao Wu,Ziping Jiang,Xingbo Shi
Aflatoxin B1 (AFB1), one of the most toxic mycotoxins, is commonly found in various food. This study develops a dual-mode biosensor integrating smartphone analysis and dark-field microscopy (DFM) observation for AFB1 detection based on the disintegration of core-shell Ag@Au nanoparticles (Ag@Au NPs). Employing a sandwich assay format, AFB1 aptamer assembled Ag@Au NPs are anchored on 96-well plate and disintegrated by nitric acid. Thereafter, the Ag core is etched, releasing Ag + that serve as colorimetric signal regulators upon the introduction of the glutathione-manganese dioxide nanosheets-3,3′,5,5′-tetramethylbenzidine substrate. The color signal is analyzed using a smartphone based on red-green-blue value analysis. Furthermore, the collapsed Au shell releases individual Au NPs that serve as dark-field scattering nanoprobes, producing a high-intensity green dark-field scattering signal under DFM observation. The detection limit (3.67 fg/mL) is 199/8174/2180-fold lower than those of colorimetric signal, commercial enzyme-linked immunosorbent assay kit, and high-performance liquid chromatography, respectively. Overall, smartphone analysis enables on-site preliminary screening without sophisticated instrumentation. DFM observation allows the ultra-sensitive quantitative detection in a laboratory. The proposed dual-mode biosensor will not only reduce false-positive/negative rate through the bidirectional signal readout, but also offer a practical, stable, and ultrasensitive strategy for AFB1 detection in food.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Xinrong Li,Shuliang Chen,Zihui Dai,Xianzhi Hu,Futing Zi
The selective recovery of gold ions from gold leaching solutions limits the industrial application of the copper-ammonia (Cu 2+ –NH 3 )-thiosulfate system. Here, the influence of the carbon chain length of organic phosphines on the selective recovery of gold ions was studied, and an extractant (trihexylphosphine, THP) that is suitable for the selective recovery of gold ions from a Cu 2+ –NH 3 -thiosulfate leaching solution was screened. The selectivity of organic phosphines with different carbon chain lengths for gold ions was C 8 = C 6 > C 4 > C 3 > C 2 , and when the number of carbon atoms in a single carbon chain was at least six, the selective recovery of gold ions from the Cu 2+ –NH 3 -thiosulfate solution was realized. THP completely recovered low concentration gold ions (6.73 mg/L) in the Cu 2+ –NH 3 -thiosulfate gold leaching solution regardless of the pH. The mechanism of gold ion extraction into the organic phase mainly involved ligand exchange between THP and [Au(S 2 O 3 ) 2 ] 3− . Job’s method and density functional theory calculations confirmed that the composition ratio of the complex formed by THP and Au was 2:1 at the practical and theoretical levels, respectively. Finally, Multiwfn and VMD were used to visually predict the possible reaction sites in THP. This study provides an exact method for the selective recovery of gold ions from thiosulfate-based gold leaching solutions, which will promote the development of thiosulfate-based gold leaching systems.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2024
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IF 4.1
Shuting Jiang,Yifan Wang,Haoran Cheng,Gongliang Zhang,Hongman Hou,Jingran Bi,Shuang Yan,Hongshun Hao
A unique multifunctional photoelectrochemical(PEC) platform for the simultaneous detection and inactivation of Salmonella enteritidis (SE) was proposed. The photoactive material in the platform was a Bi 2 MoO 6 /V 2 CTx composite, and gold nanoparticles were modified to link the aptamer via Au-S bonds. The aptamer was to link the complementary DNA (cDNA) to the electrode surface via base complementarity. In the presence of SE, the aptamer attached to Salmonella enteritidis selectively and then the cDNA was released from the aptamer electrode, the photocurrent signal was amplified, allowing for quantitative detection of Salmonella enteritidis . The linear range of the method was 1.82 × 10 2 CFU/mL to 1.82 × 10 8 CFU/mL based on the specific recognition of Salmonella enteritidis by aptamer. The detection limit was 26 CFU/mL. Furthermore, due to its photoelectrocatalytic action, the PEC platform demonstrated strong antibacterial activity (99.99 %). The new technique was created to detect and inactivate Salmonella enteritidis in a timely and sensitive manner.
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ANALYTICA CHIMICA ACTA
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2024
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IF 5.7
Qiuwen Huang,Na Zhou,Jiayi Peng,Xuanjiang Zeng,Lijuan Du,Yan Zhao,Xiaojun Luo
Background The COVID-19 pandemic, caused by the novel coronavirus, has had a profound impact on global health and economies worldwide. This unprecedented crisis has affected individuals, communities, and nations in diverse manners. Developing simple and accurate diagnostic methods is an imperative task for frequent testing to mitigate the spread of the virus. Among these methods, SARS-CoV-2 antigen tests in clinical specimens have emerged as a promising diagnostic method for COVID-19 due to their sensitive and accurate detection of spike (S) protein, which plays a crucial role in viral infection initiation. Results In this work, a dual-signal amplification surface enhanced Raman scattering (SERS)-based S protein biosensor was constructed based on Au NPs/COFs and enzyme-free catalytic hairpin assembly (CHA) amplification method. The approach relies on a released free DNA sequence (T), which is generated from the competition reaction between Aptamer/T and Aptamer/S protein, to trigger a CHA reaction. Due to the high binding affinity and selectivity between the S protein and its aptamer, CHA process was triggered with the maximum SERS tags (H2-conjugated Au@4-mercaptobenzonitrile@Ag) anchored onto Au NPs/COFs substrate surface. This SERS platform could detect the S protein at concentrations with high sensitivity (limit of detection = 3.0 × 10 −16 g/mL), wide detection range (1 × 10 −16 to 1 × 10 −11 g/mL), acceptable reproducibility (relative standard deviation = 7.01 %) and excellent specificity. The biosensor was also employed to detect S protein in artificial human salivas. Significance Thus, this study not only developed a novel Au NPs/COFs substrate exhibiting strong SERS enhancement ability and high reproducibility, but also proposed a promising dual-signal amplification SERS-based diagnostic method for COVID-19, holding immense potential for the detection of a wide range of antigens and infectious diseases in future applications.
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ACS Applied Nano Materials
·
2024
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IF 5.3
Kun Wang,Yingru Tang,Kangli Xing,Xiaoming Mou,Xiaoyan Yang,Zhenlan Quan
Protein self-assembly has attracted extensive interest in the field of biomaterials and biomedicine due to its inherent biocompatibility and flexible designability. In this paper, we propose a potential route to generate a photoelectrochemical (PEC) sensing platform through Sn-triggered protein self-assembly. Specifically, Sn2+ ion was used to trigger the self-assembly of bovine serum albumin (BSA) to form in situ Sn/BSA film on the indium tin oxide (ITO) glass. Then, a CdS thin film as a PEC active material was electrodeposited on the Sn/BSA modified ITO electrode. The hybrid Sn/BSA film was demonstrated to stabilize the PEC response of the CdS. A dual-electrode PEC cell comprised a graphene oxide (GO)-modified photocathode and a Sn/BSA hybrid film/CdS-loaded photoanode. Pb2+-response deoxyribozymes (DNAzymes) were hybridized with the substrate strands tagged with Au nanoparticles (Au NPs) and then immobilized on the photocathode. Upon Pb2+-induced cleavage, Au NP-linked oligonucleotide fragment dislocated from the photocathode surface, resulting in a decrease in the PEC response. The present PEC biosensor showed highly sensitive detection of Pb2+ with a wide detection range from 10.0 fM to 0.1 μM and a low detection limit of 4.0 fM. This work demonstrates that the Sn/BSA hybrid film has potential application prospects in PEC sensing, thereby providing a new way of thinking for the design and development of the bioinspired biosensor.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Mengyue Gao,Qiao Chen,ZhiHao Li,YiFang Zhan,LiHua Wang,Ting He,Qi Yao,Fengmei Jin,Jiming Hu
A SPE-SERS method was developed for the detection of several antibiotic residues in dairy products. Gold nanoparticles (Au NPs) encapsulated with an ultrathin Cr-MIL-101 shell (Au@Cr-MIL-101 NPs) have been synthesized, and the thickness of Cr-MIL-101 shell can be precisely controlled to 3 nm. As a superior solid phase extraction (SPE) adsorbent, Cr-MIL-101 acts as a shell layer to effectively enrich antibiotics within the localized surface plasmon resonance (LSPR) field of Au NPs, which enhances the SERS signal and eliminates background interference. The method can achieve highly sensitive and high-throughput detection for tetracycline hydrochloride, sulfapyridine and benzylpenicillin sodium in dairy products, and the detection limits (LOD) are as low as 2.237, 2.644 and 4.662 ppb respectively. The recoveries of antibiotic residues in spiked dairy products ranged from 72.31 % to 146.7 % with matrix effects (ME) of −15.13 % to 28.68 %. Thus, this method holds significant promise for rapid detection of antibiotics in milk.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Zhongshun Wang,Qunyan Zhu,Chang Liu,Kun Chen,Yuheng Fu,Bingbing Xie,Lin Zhang,Wensheng Yang
Achieving highly sensitive surface-enhanced Raman scattering (SERS) detection requires precise collection of trace target analyte molecules into small hot spot regions. In this study, we propose a convenient and cost-effective method to construct a high-performance SERS platform based on the super-hydrophobic delivery (SHD) effect to overcome the diffusion limit during sample evaporation. A paper based super-hydrophobic substrate (PBSH substrate) was employed as a concentrator to enrich the analytes, along with SiO 2 @Au core-satellite structures (SiO 2 @Au CSSs) to form “molecule in hot spot” matrices. Benefiting from the SHD effect and the high SERS activity of SiO 2 @Au CSSs in three-dimensional space, we achieved excellent SERS sensitivity and reproducibility. This platform exhibits a good linear response for detecting Rhodamine 6G (R6G) across concentration ranges from nanomolar (10 −7 M) to femtomolar (10 −13 M) levels, with a low relative standard deviation (RSD) of 6.42 % observed across 30 randomly selected spots. Moreover, the platform enables sensitive detection of various contaminants and multicomponent residues of pesticides and organic dyes in real samples, exhibiting great practical potential in the field of food safety.
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