INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yanzhi Chen,Jiawen Zhang,Xinnuo Wang,Molan Zhang,Lijun You,Kseniya Hileuskaya
Agaricus bisporus chitosan coated metformin-encapsulated nanoliposomes. • ACS coating improved nanoliposome stability and encapsulation retention. • A-M-L improved glycemic control and lipid metabolic profiles in T2DM mice. • A-M-L mitigated gastrointestinal inflammation and preserved mucosal integrity. • ACS modification enhanced intestinal mucoadhesion and ileal retention. Gastrointestinal intolerance and limited intestinal residence remain important challenges in the long-term oral use of metformin (MET) for type 2 diabetes mellitus (T2DM). Although liposomal encapsulation can improve drug delivery, unmodified MET-encapsulated liposomes remain vulnerable to gastrointestinal disruption and premature leakage, which undermines their therapeutic potential. To address this limitation, Agaricus bisporus -derived chitosan (ACS) was employed as a bioactive macromolecular coating to construct MET-encapsulated liposomes (MET-LP). The ACS coating reversed the surface charge of MET-LP, improved colloidal dispersion, and enhanced storage stability, with 0.5% ACS-modified MET-encapsulated liposomes (A-M-L) retaining 83.1% encapsulation efficiency after 21 days at 4 °C. In T2DM mice, 1.0% A-M-L produced stronger glycemic control, lowering fasting blood glucose from 14.3 to 8.6 mmol/L, reducing HbA1c by approximately 32.9%, and decreasing the area under the curve (AUC) of the oral glucose tolerance test (OGTT) by 37.7%. Moreover, A-M-L improved serum lipid profiles and hepatic oxidative-stress-related indicators and was associated with lower ileal inflammatory cytokine levels and better-maintained gastrointestinal tissue morphology in T2DM mice. ACS modification also enhanced the intestinal retention of labelled liposomal carriers, as indicated by a 233.3% higher ileal fluorescence intensity of 0.5% A-M-L than unmodified MET-LP in SD rats. Collectively, these findings indicate that ACS modification improved the formulation stability, intestinal retention of labelled liposomal carriers, and hypoglycemic performance of MET-encapsulated liposomes.
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高影响因子
FIBERS AND POLYMERS
·
2026
·
IF 3.1
Tang Ci,Liu Siying,Li Xuan,Yang Jing
Herbal extracts possess antioxidant and broad-spectrum antibacterial activity, which can efficiently inhibit the growth of multiple pathogenic microorganisms. However, their inherent disadvantages, including poor aqueous solubility and inferior physicochemical stability, severely hinder their practical application. Herein, a co-loaded dual-network polysaccharide hydrogel was engineered to tackle these challenges. Baicalin (BA) was first encapsulated into cyclodextrin to yield a BA inclusion complex, which was embedded within a crosslinked hydrogel network built from chondroitin sulfate and carboxymethyl chitosan. Berberine hydrochloride (BH), a synergistic antibacterial candidate, was co-loaded in situ during hydrogel synthesis to attain combined antibacterial effects of baicalin and berberine hydrochloride. The antibacterial results confirm that the BH-BA inclusion complex effectively lowers the individual effective antibacterial concentrations of both agents, showing prominent synergistic activity against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). The resultant hydrogel displayed enhanced structural stability, favorable mechanical properties, excellent biocompatibility, as well as pH-responsive drug release profiles. After incubation with the dual-network hydrogel, the survival rates of Escherichia coli and Staphylococcus aureus reached 12.67 ± 3.06% and 7.33 ± 2.08%, respectively, accompanied by a DPPH radical scavenging capacity of 82.08± 6.99%. Among all tested groups, the OCBBC group displayed the most pronounced effect in promoting cell migration, achieving a cell scratch wound healing rate of 72.46 ± 1.75%. This dual-network hydrogel provides a feasible avenue to construct high-efficiency antibacterial biomaterials and paves the way for innovative antibacterial treatment modalities.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Hao-Ze Li,Ru-Meng Liu,Jia-Si Zhang,Chen-Yan Zheng,Jin-E Wu,Chao Chang,Zhi-Yong Gong,Yong-Ning Wu,Kai Zhang,Xin Liu
The persistent environmental threat posed by diclofenac sodium (DCF), a low-biodegradability pharmaceutical contaminant in aquatic systems, necessitates advanced adsorbents capable of overcoming the capacity, kinetics, and recyclability limitations of conventional materials. To address this, we synthesized a novel cationic covalent organic framework/chitosan (iCOF/CS) aerogel. This was achieved first through the Schiff base condensation of 1,2,3-triaminoguanidinium chloride (TG Cl ) and 6-dihydroxynaphthalene-1,5-dicarbaldehyde (DHNDA) to form the iCOF. Subsequently, the iCOF was integrated into a chitosan matrix that was cross-linked with 1,3,5-triformylphloroglucinol (Tp), resulting in a hierarchical pore structure. The composite demonstrated exceptional DCF adsorption performance with ultrafast equilibrium within 10 min (98 % removal in 2 min) and a record capacity of 557.1 mg·g −1 , surpassing pure iCOF (473.1 mg·g −1 ) and CS aerogel (381.6 mg·g −1 ), attributed to synergistic ion exchange (Cl − /DCF − ), electrostatic attraction, π-π stacking, and hydrogen bonding, as validated by spectroscopy and theoretical calculation. The pioneering cationic COF/CS aerogel was engineered to overcome inherent recyclability limitations of powdered iCOF. The iCOF/CS aerogel gave above 97 % DCF removal in real aqueous matrices (tap, river and lake water) and over 91 % adsorption capacity after four regeneration cycles, thereby establishing a scalable remediation platform for pharmaceutical contaminants via engineered iCOF composites.
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高影响因子
ELECTROCHIMICA ACTA
·
2014
·
IF 4.086
Minghao Sun,Haoxiang Zhong,Shuren Jiao,Hanqi Shao,Lingzhi Zhang
Carboxymethyl chitosan (C-CTS) was firstly reported as a water soluble binder for LiFePO 4 cathode in Li-ion batteries. The electrochemical performances of LiFePO 4 cathode with C-CTS binder was investigated and compared with the conventional water-soluble sodium carboxymethyl cellulose (CMC) and the commercial non-aqueous polyvinylidene difluoride (PVDF). LiFePO 4 cathode with C-CTS exhibited a comparable cycling performance, but better rate capability than that of CMC and PVDF, retaining 65% capacity of C/5 at 5 C rate as compared with 55.9% and 39.4% for CMC and PVDF, respectively. In addition, LiFePO 4 cathode with C-CTS exhibited excellent cycling performance at 60 °C, retaining 91.8%/62.1% capacity after 80 cycles at 1 C/10 C, respectively.
研究领域:
材料科学
·
电化学
·
能源存储
·
高分子化学
·
电池技术
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Ruxia Ning,Xichuang Cheng,Fuhou Lei,Jiufang Duan,Kun Wang,Jianxin Jiang
Natural and high-quality biomass-based coating films are considered promising packaging to consumers. However, the poor mechanical properties and weak antimicrobial activity of biomass materials have limited their practical application. A cleaner and low-cost strategy is used to prepare antimicrobial, self-recovery, and biocompatible coating films using tamarind kernel powder (TKP) and chitosan (CS). The TKP protein and chitosan chains were covalently cross-linked with tetrakis(hydroxymethyl)phosphonium chloride (THPC) to form a three-dimensional network based on THPC-amine dynamic bonds, and act as a sacrificial bond. Then, the hydrogen bond forms an interpenetrating network to build a strong multi-network film. Thus, the THPC multi-crosslinking TKP based films showed enhanced stretchable property (increased from 3.23 % to 77.54 %), and self-recovery after 30 min of recovery. Additionally, the film has been found to exhibit low water vapor permeability, low oxygen transmittance rate, and excellent antimicrobial efficiency (maximum inhibition zones: 24.39 mm). Moreover, the prepared films were demonstrated to be biocompatible and non-hemolytic based on cell viability and hemolytic activity assays. The method described herein could broaden the scope of biomass-based materials in the realm of antimicrobial coating films.
研究领域:
高分子材料科学
·
食品包装工程
·
生物医学材料
·
天然高分子化学
·
抗菌材料
·
可再生资源利用
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xinghai Huang,Jianmin Li,Jingjin He,Jianwei Luo,Jinyun Cai,Jianhua Wei,Peiyuan Li,Haiyi Zhong
To fulfill the current need for intelligent active food packaging. This study incorporated the curcumin inclusion complexes (CUR-CD) into chitosan/polyvinyl alcohol polymer to develop a new intelligent active film. The structures of films were analyzed by Fourier-transform infrared (FT-IR), scanning electron microscope (SEM), and so on. The CP-Cur150 film displays exceptional mechanical properties, water vapor barrier, and UV blocking capabilities as demonstrated by physical analysis. The CP-Cur150 film exhibited free radical scavenging rates on 2,2-diazo-di-3-ethylbenzothiazolin-6-sulfonic (ABTS) (98 %) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) (87 %). Additionally, it showed inhibitory effects on Gram-positive bacteria ( Staphylococcus aureus ) and Gram-negative bacteria ( Escherichia coli ), reducing live colony counts by approximately 2.7 and 1.3 Log 10 CFU/mL, respectively. The films were used to monitor the shrimp's freshness in real time. With the spoilage of shrimp, the film exhibited clear color fluctuations, from light yellow to red. In addition, the evaluation of the impact of films on pork pH, total volatile basic nitrogen, and total bacterial counts demonstrated that the CP-Cur150 film displayed the most significant effectiveness in preserving freshness, thereby extending the shelf life of pork.
研究领域:
食品科学与技术
·
高分子材料
·
活性与智能包装
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食品保鲜
·
纳米复合材料
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Haoting Niu,Shuo Tang,Moyong Li,Lilu Guo,Lulu Qin,Liuyun Jiang,Anji Chen,Xiang Hu
A novel multifunctional double-network hydrogel composed of carboxymethyl chitosan-oxidized sodium alginate-poloxamer (PF127) loaded with Panax notoginseng saponins (OSA/CM/PF127@PNS) was developed for intrauterine adhesion therapy. FT-IR spectroscopy confirmed acetalation crosslinking between OSA and CMC, as evidenced by characteristic imine peak (1636 cm⁻ 1 ). SEM observations revealed the hydrogel possessed a porous microstructure, with robust self-healing capability validated (by rheological cyclic strain tests), a maximum swelling ratio of 1155%, and sustained PNS release reaching 52.2% at 24 h. In vitro degradation studies indicated the stability under physiological pH (7.4) was enhanced due to the dual-crosslinked network. Moreover, the hydrogel exhibited potent antibacterial activity (> 90% inhibition against E. coli and S. aureus ), antioxidant capacity, and excellent hemocompatibility (< 5% hemolysis). The hydrogel showed exceptional biocompatibility in cellular assays. Notably, PNS loading significantly suppressed pro-inflammatory cytokines (TNF- α , IL-1 β , IL-6) at the mRNA level and inhibited NF- κ B signaling at the protein level. Furthermore, it promoted angiogenesis in vitro, evidenced by upregulated angiogenesis-related proteins. Therapeutically, the hydrogel significantly accelerated wound healing in a murine model (> 90% closure by day 9) and effectively promoted endometrial regeneration in a rat IUA model. This work provides a novel and promising strategy based on natural polymer-based hydrogels, demonstrating its potential for the treatment of intrauterine adhesions and regenerative medicine.
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高影响因子
Materials Today Communications
·
2026
·
IF 4.9
Xinchen Du,Yafang Chen,Peng Zhang,Xuelei Li,Jilite Wang,Sheng Yang,Binhong Teng,Yadong Liu
Developing a diabetic wound dressing that integrates immunomodulation, angiogenesis, and anti-infection effects remains a challenge. Herein, we prepared a novel hydrogen sulfide (H 2 S) donor-modified quaternized chitosan sponge. The sponge enabled controlled H 2 S release in response to reactive oxygen species (ROS), decreasing intracellular ROS while increasing H 2 S levels. The sponge modulated Raw 264.7 macrophage polarization toward the M2 phenotype by inhibiting NF-κB activation, thereby reducing inflammatory cytokine expression and excessive inflammation. The sponge enhanced human umbilical vein endothelial cell migration and angiogenesis by upregulating the vascular endothelial growth factor and endothelial nitric oxide synthase expression. The sponge showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Escherichia coli , reducing wound inflammatory responses. The biocompatible sponge accelerated diabetic wound healing by synergistically promoting re-epithelialization, collagen deposition, and angiogenesis, while attenuating inflammation, superior to commercial 3 M™ dressing. Our ROS-responsive H 2 S-releasing cationic chitosan sponge exhibits significant potential for advanced diabetic wound care.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Xiangyu Sun,Jiaming Yu,Qifeng Wei,Xiulian Ren
Bacterial infection is still one of the main problems observed in the clinical process of wound healing, so the development of new multifunctional biocompatible materials is an urgent clinical need. A kind of supramolecular biofilm crosslinked by hydrogen bond between natural deep eutectic solvent and chitosan was studied and successfully prepared to reduce bacterial infection. Its killing rates of Staphylococcus aureus and Escherichia coli can reach 98.86 % ± 1.90 % and 99.69 % ± 0.53 %, and it can be degraded in both soil and water, showing excellent biocompatibility and biodegradability . In addition, the supramolecular biofilm material also has the UV barrier property, which can effectively avoid the secondary injury of UV to the wound. Interestingly, the cross-linking effect of hydrogen bond makes the biofilm have a more compact structure and rough surface, and gives the biofilm strong tensile properties. Overall, owing to these unique advantages, NADES-CS supramolecular biofilm has great potential for medical applications, laying the foundation for the realization of sustainable polysaccharide materials.
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Fengsong Liu,Xiaowei Zhang,Xinglong Xiao,Qingfei Duan,Hong Bai,Yifang Cao,Yan Zhang,Mahafooj Alee,Long Yu
Polyvinyl alcohol (PVA) and chitosan (CS) are attractive polymeric feedstocks for developing eco-environmental materials. In this work, a biodegradable and antibacterial film was developed based on PVA blending with different long-chain alkyl and different contents of quaternary chitosan through solution casting, in which quaternary chitosan not only acted as an antibacterial agent but also improved hydrophobicity and mechanical properties. A novel peak appeared at 1470 cm −1 in Transform Infrared Spectroscopy (FTIR) and a new C Cl bond spectral peak at 200 eV in X-ray photoelectron spectroscopy (XPS) spectra suggested that CS was successfully modified by quaternary. Besides, the modified films have better antibacterial effects against Escherichia ( E. coli ) and Staphylococcus ( S. aureus ) and present stronger antioxidant properties. Optical properties demonstrated that the light transmittance on both UV and visible light showed a decreasing trend with the increase of the quaternary chitosan contents. Whereas the composite films have enhanced hydrophobicity than PVA film. Furthermore, the composite films had higher mechanical properties, in which Young's modulus , tensile strength , and elongation at break were 344.99 MPa, 39.12 MPa, and 507.09 %, respectively. This research demonstrated that the modified composite films could extend the shelf of life on antibacterial packaging.
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PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Jun Wu,Fangtian Liu,Chaoji Chen,Ze Zhao,Yumin Du,Xiaowen Shi,Yang Wu,Hongbing Deng
Biosafe antibacterial agents are urgently demanded in treating infection especially chronic infection. However, efficient and controlled release of those agents remains great challenging. Two nature-derived agents, lysozyme (LY) and chitosan (CS), are selected to establish a facile method for long-term bacterial inhibition. We incorporated LY into the nanofibrous mats, then deposited CS and polydopamine (PDA) on the surface by layer-by-layer (LBL) self-assembly. In this vein, LY is gradually released with the degradation of nanofibers , and CS is rapidly disassociated from the nanofibrous mats to synergistically result in a potent inhibition against Staphylococcus aureus ( S. aureus) and Escherichia coli ( E. coli) over a period of 14 days. Besides long-term antibacterial capacity, LBL-structured mats could readily achieve a strong tensile stress of 6.7 MPa with an increase percentage of up to 103%. The enhanced proliferation of L929 cells arrives at 94% with help of CS and PDA on the surface of nanofibers. In this vein, our nanofiber has a variety of advantages including biocompatibility, strong long-term antibacterial effect , and skin adaptability, revealing the significant potential to be used as highly safe biomaterial for wound dressings.
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PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2023
·Vol. 332
·期 6
·1953-1960
·
IF 1.6
Luo Qingyun,Wang Chongshi,Zhu Wei,Yu Hongchao,Wang Chunyan,Chen Chuanhong
Due to its high adsorption capacity and adsorption efficiency, polymer gel shows excellent performances in the treatment of wastewater containing thorium. In this work, glutaraldehyde cross-linked N -(4-Aminobenzoyl)-ʟ-glutamic acid modified chitosan (CCS-AGA) was used to adsorb Th(IV) ions from aqueous solutions for the first time. FT-IR and SEM results revealed the chemical structure and surface morphology of this material. The influence of solution pH, contact time and initial concentration of Th ions on the adsorption of Th(IV) by CCS-AGA was investigated. The experimental data suggest that the adsorption behavior of CCS-AGA could be accurately predicted by the Langmuir model. The maximum theoretical adsorption capacity of CCS-AGA for Th(IV) was 162 mg/g. Moreover, this material exhibited excellent reusability and adsorption selectivity for Th(IV).
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高影响因子
危险品化学品经营许可证（带存储）