JOURNAL OF CHROMATOGRAPHY A
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2023
·
IF 4.1
Yehong Han,Mingyu Wang,Chunliu Yang,Zihui Zhao,Yanan Yuan,Hongyuan Yan
Osimertinib (OSIM) is widely used as a mainstream drug for the treatment of non-small cell lung cancer (NSCLC). However, the lack of a rapid extraction and detection method for OSIM and its metabolite, AZ-5104, has limited clinical drug metabolism and drug resistance research because the drug is unstable. In this study, a new ionic liquid hybrid hierarchical porous material (IL-HHPM) was synthesized with hierarchical porous structures, including micropores (1.6–2.0 nm), mesopores (2.0–50.0 nm), macropores (50.0–148.7 nm), and multiple functional groups via a one-step hydrothermal method using silanized ionic liquids (IL) as functionalized hybrid monomer. The IL-HHPM has the advantages of a high specific surface area (437.4 ± 4.6 m 2 g −1 ), sizable pore volume (0.74 cm 3 g −1 ), and fast mass transfer, additionally, the IL-HHPM adsorbed OSIM and AZ-5104 via π-π interactions and hydrogen bonding. OSIM and AZ-5104 were rapidly extracted and measured in human urine using rapid and miniaturized centrifugal spin-column extraction (MCSCE), which was based on the IL-HHPM. The optimized factors for the extraction recoveries of OSIM and AZ-5104 were adsorbent dosage (8.0 mg), sample volume (0.5 mL), and operation time (9.0 min), and markedly reduced the adsorbent dosage and operation time. The IL-HHPM-MCSCE-HPLC method displayed good linearity (0.02−5.00 μg mL −1 , r ≥ 0.9997), satisfying accuracy (spiked recoveries of 87.7%−100.0%), and good precision (RSDs ≤ 7.0%). The developed method is rapid, sensitive, and reproducible for the simultaneous determination of trace level of OSIM and AZ-5104 in human urine.
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高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Boying Yue,Xiyue Wang,Lili Lian,Yanyan Wang,Wenxiu Gao,Hao Zhang,Jinfeng Zhao,Dawei Lou
A needle-type extraction device (NTED) packed with ionic liquid-based molecularly imprinted polymers (MIP) coated copper fiber was produced for extraction of chlorobenzenes (CBs) in the aqueous environment followed by detection with GC-FID. Precipitation polymerization was performed to synthesize CBs imprinted polymers (CBs-MIP) with CBs as a mixed template, and 1-vinyl-3-aminoformylmethyl imidazolium chloride ionic liquid ([VAFMIM]Cl) as a functional monomer. Then CBs-MIP was coated on the braided copper fiber surface by sol–gel technology, which was served as a coated fiber to extract five trace CBs in drinking water, river water and industrial wastewater. The effects of several experimental conditions on extraction, including extraction time and temperature, pump flow rate, stirring speed, desorption time and temperature were studied by the single factor and experimental design method. A Plackett-Burman design (PBD) was used to screen the significant factors and a Box-Behnken design (BBD) was applied to optimize the significant variables to obtain the optimum extraction conditions. The limits of detection (0.0073–0.0130 μg L −1 ) and enrichment factors (2158–4087) for studied CBs were obtained after optimization. Moreover, the recoveries of CBs spiked in real water samples were 80.01–97.10% with RSD less than 7.70%. The experimental results confirmed that the NTED packed with CBs-MIP coated fiber is a promising device for extracting trace CBs from the water matrix.
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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2019
·Vol. 94
·期 7
·2355-2363
·
IF 2.659
Hui-Fang Ren,Dan Zhu,Ji-Fan Li,Chun-Ling Liu,Rong-Zhen Yang,Wen-Sheng Dong
BACKGROUND The chemical catalytic conversion of carbohydrates into γ-valerolactone (GVL) is a sustainable alternative to the petrochemical process starting from the depleting fossil resources. Direct conversion of carbohydrates (fructose, glucose, starch and cellulose) into GVL was achieved via the combined heteropoly acid based SO 3 H-functionalized ionic liquid (HAIL) and supported ruthenium (Ru) catalyst system in one pot and in water media. RESULTS A 63% GVL yield (based on fructose) was obtained under the catalysis of 1-methyl-3-(3-sulfopropylimidazolium)silicotungstate ([MIMPS] 4 SiW) and Ru/ZrO 2 at 180 °C, first in 0.1 MPa nitrogen (N 2 ) for 3 h (dehydration), and then in 4 MPa hydrogen (H 2 ) for 10 h (hydrogenation). Under the same reaction conditions, the GVL yields from glucose, starch and cellulose were 68%, 60% and 60%, respectively. The recyclability of the catalytic system consisting of [MIMPS] 4 SiW and Ru/ZrO 2 was investigated in four runs. The activity for [MIMPS] 4 SiW did not change after use. Partial deactivation of Ru/ZrO 2 was observed, which was ascribed to the severe carbon deposition. CONCLUSIONS In the present method, HAIL and Ru/ZrO 2 catalysts were loaded together. No separation and/or neutralization step reported in the literature was needed and only an atmosphere change (from N 2 to H 2 ) step was involved. Therefore, we provide a promising method for efficient conversion of carbohydrates into GVL. © 2019 Society of Chemical Industry
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INORGANIC CHEMISTRY
·
2018
·
IF 4.7
Fang-Li Fan,Zhi Qin,Shi-Wei Cao,Cun-Min Tan,Qing-Gang Huang,De-Sheng Chen,Jie-Ru Wang,Xiao-Jie Yin,Chao Xu,Xiao-Gui Feng
Here, we propose the use of carboxyl-functionalized ionic liquid, [Hbet][Tf2N], to separate the fission products from spent nuclear fuels. This innovative method allows the selective dissolution of neutron poisons, lanthanides oxide, as well as some fission products with high yield, leaving most of the UO2 matrix and minor actinides behind in the spent nuclear fuel and accomplishing the actinides recovery as a group. Water-saturated [Hbet][Tf2N] can dissolve lanthanides oxide from simulated spent nuclear fuel with a dissolution ratio of 100% at 40 °C. However, the dissolution of uranium is almost negligible (<1%) under the same conditions. This big difference in dissolution provides a novel separation approach to spent nuclear fuel recycling and may open new perspectives for spent nuclear fuel reprocessing. The recovery of Nd and U from metal-loaded ionic liquids and the recyclability of the ionic liquid [Hbet][Tf2N] have also been investigated. Furthermore, a U/x value related to the lattice energy U of metal compound MxOy is used to elaborate the solubility. This work represents the first case for efficient fission products removal by selective dissolution, avoiding the complete dissolution of spent nuclear fuel, the producing of the large high-level radioactive waste, and reducing environmental hazards.
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TALANTA
·
2019
·
IF 4.916
Di Cao,Xu Xu,Shan Xue,Xue Feng,Lei Zhang
A simple, rapid and sensitive method based on in situ derivatization combined with magnetic ionic liquid (MIL)-dispersive liquid-liquid microextraction (DLLME) was developed for the determination of biogenic amines (BAs). Six BAs (tryptamine, phenylethylamine , histamine, tyramine , spermidine , and spermine) were in situ derivatized with dansyl chloride (DNS-Cl), extracted by MIL-DLLME, and then chromatographed by high-performance liquid chromatography with ultraviolet detection (HPLC-UV). This MIL trihexyltetradecylphosphonium tetrachlorocobalt (II) [P 6,6,6,14 + ] 2 [CoCl 4 2- ] was explored as the extraction solvent with the advantages of magnetic susceptibility , hydrophobicity and mobile phase compatibility. Furthermore, the MIL was designed to reduce hydrolysis in aqueous solvent as well as decrease absorbance when submitted to HPLC. In order to obtain optimized extraction efficiency, the MIL mass, the volume of derivatizing agent, the type and volume of disperser, the derivatizing and extraction time, and pH of sample solution were investigated. The proposed method was successfully applied for the analysis of wine and fish samples, and the recoveries of analytes achieved were in the range of 93.2–103.1% and 94.5–102.3%, respectively. The limits of detection/quantification for wine and fish samples were in the range of 1.3–3.9/4.1–9.9 μg/L and 1.2–3.8/3.9–9.6 μg/kg, respectively. Additionally, good reproducibility with relative standard deviations lower than 4.9% (n = 5) was obtained for the analysis of wine and fish samples. The in situ DNS-Cl derivatization and MIL-DLLME method was an efficient, rapid, environmental friendly microextraction approach for the determination of BAs in foodstuffs.
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高影响因子
CHROMATOGRAPHIA
·
2018
·Vol. 81
·期 4
·595-610
·
IF 1.401
Liu Wei,Quan Ji
In this work, a quantitative structure–property relationship (QSPR) model based on atom-type electrotopological state (E-state) indices has been developed for predicting the dispersive liquid–liquid microextraction (DLLME) enrichment effect for aromatic organics by using 1-octyl-3-methylimidazolium hexafluorophosphate ([OMIM][PF 6 ]) ionic liquid as extractant. The enrichment factors of the aromatic organics obtained through DLLME-IL process were used as the dependent variable of the multiple linear regression (MLR) equation. The E-state indices of those organic compounds which combined together both electronic and topological characteristics of the analyzed molecules were used as molecular structure descriptors and the independent variable of the equation. The squared correlation coefficient R 2 for the MLR was 0.992 for the training set of 33 compounds. For the test set of 8 compounds, the linear regression coefficient was R 2 = 0.985. The results of this study showed that it can successfully predict enrichment factors of [OMIM][PF 6 ] in DLLME by using atom-type E-state indices, which can provide one more way for predicting the ability of ionic liquid to extract organic compounds based on their molecular structures.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2018
·
IF 2.441
Xiaoling Yang,XiWen Lin,YiDuo Mi,Haixiang Gao,Jing Li,Sanbing Zhang,Wenfeng Zhou,Runhua Lu
In this study, a novel ionic liquid-type surfactant modified attapulgite named as 1-dodecyl-3-methylimidazolium bromide-attapulgite (C 12 MIM-ATP) is successfully prepared and applied in dispersive solid phase extraction (dSPE) for the fast determination of pyrethroid residues in tea drinks. The primary factors that influenced the extraction efficiency, including sorbent type, amount of sorbent, extraction time, desorption conditions, pH and ionic strength , are investigated. The optimized results reveal that the extraction and desorption equilibria are rapidly obtained within 1 min. Under the optimized conditions, good linearity (2–500 μg/L) is observed for four pyrethroids in tea drinks with determination coefficients (r 2 ) ranged from 0.9992 to 1.0000. The limits of detection (LODs) are 0.6 μg/L for all pesticides. Acceptable extraction recoveries of target analytes are found from 90.28 to 107.56% with relative standard deviations (RSDs) less than 8.30% in real tea drink samples. The batch-to-bath repeatability is evaluated by recovery test on five independent synthesized C 12 MIM-ATP sorbents. Satisfactory batch-to-batch repeatability is obtained with the recovery factors varied in 15%. A small matrix effect is observed using C 12 MIM-ATP as the sorbent for detection pyrethroids in tea drinks.
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CARBON
·
2018
·
IF 7.082
Yanli Huang,Qiuli Wei,Yuanyuan Wang,Liyi Dai
In this work, three-dimensional (3D) amine-terminated ionic liquid (IL) covalently functionalized graphene/Pd composite aerogels are successfully fabricated via a facile and green reduction-inducing self-assembly method. The morphology and composition of the obtained 3D IL-rGO/Pd composite aerogels are studied by means of TEM , SEM , XRD , FTIR , XPS , BET, and Raman spectroscopy . In those composites, the cations of NH 2 -IL introduced to the surface of graphene sheets can avoid the restacking of graphene sheets and enlarge the specific surface area, which provide efficient transport pathways for improving the catalytic performance. The negatively charged Pd precursors (PdCl 4 2− ) are adsorbed on positively charged imidazolium ring moiety of NH 2 -IL to engender Pd NPs with small particle sizes uniformly distributed on the graphene sheets, which can maximize the active surface area of catalysts and enhance their catalytic activity . The catalytic studies show that the 3D IL-rGO/Pd composite aerogels can be used as efficient, easy separation, recyclable, and stable catalysts for the Suzuki cross-coupling reactions under mild conditions, and the catalytic efficiency shows no obvious loss even after ten repeated cycles.
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POLYMER SCIENCE SERIES A
·
2018
·Vol. 60
·期 3
·381-390
·
IF 0.729
Yang Dongyu,Yuan Chaosheng,Yang Kun,Shao Chunguang,Wang Yongqiang,Cheng Xuerui,Su Lei
Isothermal crystallization behavior of Pluronic F127 blended with and without an ionic liquid (IL) was investigated by in situ polarized optical microscopy (POM) and Fourier transform infrared spectroscopy (FTIR). For the pure F127, the POM and FTIR results showed that the spherulite size and crystallinity of F127 increased with the melting temperature increasing to 60, 80, and 135°C. This could be explained by the flexibility of the polymer chain at high melting temperatures. For the F127 blended with IL, the POM results showed that the morphology of F127 evolved from spherulite to dendritic segregation and fibrous crystal with the increasing IL content. FTIR results indicated that hydrogen bonds were formed between F127 and IL, and the intensity of the hydrogen bonds became strengthened gradually with increasing IL content. The effect of hydrogen bonds on the morphology evolution of F127/IL is discussed.
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IONICS
·
2015
·Vol. 21
·期 9
·2567-2574
·
IF 1.754
Liu Guishen,Ma Yanhui,Hou Xiaodong,huang Yina,Chen Jianpeng,Zhan Guoqing,Li Chunya
1-[3-(N-Pyrrole)propyl]-3-[1-tert-butoxy-carbonylamino-propyl]imidazolium tetrafluoroborate ionic liquid was successfully synthesized and characterized. The ionic liquid was electrochemically polymerized onto a glassy carbon electrode surface using a multi-potential step technique. Morphology and electrochemical properties of the polymerized ionic liquid film electrode were studied with scanning electronic microscopy and electrochemical impedance spectroscopy. Using the polymerized ionic liquid film as a sensing platform, electrochemical behaviors of magnolol were investigated by voltammetry. Under optimal experimental conditions, the oxidation peak currents were linearly related to magnolol concentrations in the range from 5.0 × 10 −8 to 1.0 × 10 −5 mol L −1 . The detection limit calculated from the standard deviation of the intercept was 2.3 × 10 −7 mol L −1 . Practical application of the polymerized ionic liquid film electrode was demonstrated by determining magnolol in the traditional Chinese medicine. The result is consistent with that obtained using high performance liquid chromatography.
Polymerized ionic liquid film electrode fabricated with potential step technique and application in voltammetric sensing of magnolol
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FOOD CHEMISTRY
·
2015
·
IF 3.391
Meiling Wang,Yinlu Sun,Xiongbo Yang,Jianwei Zhao
Graphene oxide (GO) is a pH-dependent amphiphile. In this paper, it was found that carbon nanotubes (CNTs) can be highly dispersed in graphene oxide “water” with the aid of prototype ionic liquid of 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF 6 ]). The introduction of [BMIM][PF 6 ] not only can minimize the defects of poor electrical conductivity of GO, but also can improve the dispersibility of CNT in water. Hence, a new composite of CNT/GO-[BMIM][PF 6 ] with high dispersibility and strong conductivity was presented for the first time and employed in the sensitive determination of Amaranth in soft drinks. The detection limit achieved (0.1 nM) is much lower than the guideline values in soft drinks. The ease of preparation, low background current, high sensitivity and stability can create novel avenues and applications for fabricating robust sensors for determination of other azo dyes in foods.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Liwei Qian,Yuhao Zhang,Wenqi Song,Sufeng Zhang,Nan Zhang,Valentin Nica
Glycoproteins are essential in biological systems, yet their complex structures and diverse glycosylation patterns present challenges for efficient and specific recognition. Herein, molecularly imprinted polymers (MIPs) with high selectivity and adsorption capacity for glycoproteins were developed using two synergistic strategies. One strategy was to synthesize a boronic acid-containing ionic liquid (PBA-IL) functional monomer that combines long-range non-covalent interactions with short-range covalent bonds, enhancing the interaction modes with ovalbumin (OVA) to improve imprinting efficiency. The other strategy entailed constructing a composite carrier with high specific surface area (50.3 m 2 /g) and abundant active sites by in-situ growth of UiO-66 metal–organic framework crystals on a wood-derived cellulose sponge (WCS). This composite (WCS@UiO-66) was utilized in a template immobilization method combined with surface imprinting technique (TIM-SIT) to prepare the MIPs (WCS@UiO-66@MIPs). Molecular simulations indicated that PBA-IL formed stronger interactions with OVA compared to traditional monomer. Based on these characteristics, the WCS@UiO-66@MIPs achieved rapid adsorption equilibrium within 40 min, exhibiting surprisingly high adsorption capacity (up to 571 mg g −1 ) and recognition ability (imprinting factor of 5.09) for OVA. The competitive adsorption experiments also demonstrated the efficient extraction of OVA from biological samples by WCS@UiO-66@MIPs, confirming its exceptional specificity. Additionally, the osmotic separation experiments revealed that WCS@UiO-66@MIPs achieved a selective permeation factor of up to 7.68 for OVA in a binary protein mixture, further demonstrating their potential for large-scale continuous separation processes. Therefore, this work provides a promising strategy for the efficient and specific recognition of glycoproteins, advancing their application in biotechnology and analytical chemistry.
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