JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2026
·Vol. 46
·期 10
·118296
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IF 6.3
Bing Wang,Liyan Wang,Yunchuan Zhang,Jiangyuan Ma,Yang Yu,Furui Sun,Jianjun Shi,Lei Kong,Liuchun Zheng
The organic-inorganic hybridization has emerged as a promising strategy in advanced materials research. Herein, chitosan, a bio-polymer, was successfully introduced to fabricate monolithic mullite aerogel with excellent performance under ambient pressure drying (APD). The structures and properties of the aerogels were carefully regulated by varying the chitosan concentrations and acid concentrations, and the aerogels were characterized by SEM, FTIR, XPS, NMR, TG/DTG, BET, XRD, and so on. The results confirmed the formation of organic-inorganic hybrid network through coordination bond and hydrogen bonding, conducive to APD. The aerogels possess low density (0.225–0.292 g/cm 3 ), low thermal conductivity coefficient (0.03037–0.04101 W·m −1 ·K −1 ), low mass loss (25.90–34.32%), and high specific area (442.39–748.26 m 2 /g). Furthermore, an excellent high-temperature stability was granted owing to the superior dimensional stability and pore structural preservation of the aerogel under thermal cycling experiments. After heat treatment at 800–1400 °C, the aerogel reached high compressive strength of 0.29–4.82 MPa. This paper provides a facile preparation of high-performance aerogels, offering possibilities to confront harsh operating environments.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Haihua Wang,Jianxia Yao,Ying Hou,Zhuoya Liu,Dong Yang
The development of eco-friendly and multifunctional edible coatings is crucial for mitigating postharvest losses of perishable fruits. Hence, a novel composite coating was engineered based on chitosan (CS) and pullulan (PUL) matrix, enhanced by a gallic acid-grafted chitosan (GS) conjugate synthesized through free radical grafting. The GS conjugate served as a multifunctional crosslinker, establishing a dense intermolecular network within the CS-PUL matrix primarily (CP) through hydrogen bonding, as confirmed by structural characterization. This molecular-level interaction significantly improved the mechanical strength (Tensile stress = 4.95 MPa, Elongation at break =121.21%) and barrier properties of the resulting coating. The chitosan/pullulan-gallic acid grafted chitosan (CP-GS) coating, applicable by spraying or dipping, exhibited remarkable antioxidant activity, achieving 97.8% DPPH radical scavenging (25 °C, 50% RH), the CP-GS coating significantly reduced weight loss, delayed the decline in titratable acidity, and effectively suppressed microbial growth, thereby extending the shelf life by 7 to 9 days compared to the uncoated samples. This study highlights the effectiveness of molecular grafting in designing advanced bio-based coatings and presents a promising strategy for fruit preservation using biological macromolecules.
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Wenjuan Tan,Chengnuo Zhang,Huiling Guo,Yunpeng Yang,Qingyun Guo,Hao Huang,Shuguang Yang
Alginate/chitosan (ALG/CHI) polyelectrolyte complex films are widely used across multiple disciplines. However, they typically exhibit weak mechanical behavior in hydrated form or salty environment due to water affinity and ion sensitivity. In this work, we modulated interpolymer interactions through salt and fabricated a ALG/CHI complex film with an equimolar ratio and then systematically investigated the mechanical behaviors of the film with temperature, water content, and ionic strength changes. The initial modulus of the dry ALG/CHI film at room temperature is 600 MPa and remains largely stable across 25–120 °C. When water uptake reaches equilibrium in aqueous solution, the initial modulus decreases to 25 MPa, exhibiting ductile behavior. In a 1 M salt solution, it maintains a modulus of 14 MPa, showing excellent salt-resistance behavior. The prepared ALG/CHI film is demonstrated to have a robust mechanical performance in salt solution at 37 °C and remains stable in artificial sweat and simulated body fluid for 1 week, implying its applications in physiological environments.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Huiqiu Quan,Zhiye Dong,Long Mao,Kun Wu,Weijun Li,Siyong Gu
A mussel-inspired polysaccharide bilayer film is developed for active packaging. • Functionalized chitosan and layered clay exhibit effective synergistic enhancement. • The bilayer film exhibits superior antibacterial activity and UV barrier properties. • This bilayer system is well-suited as a food preservation coating. Food spoilage during post-harvest storage underscores the critical need for sustainable active packaging, yet single-layer polysaccharide films suffer from limited functionality and conventional bilayer strategies lack molecular-level integration. Herein, we proposed a mussel-inspired bilayer composite system fabricated by layer-by-layer casting, which addresses these limitations through synergistic interfacial design. This design integrated the molecular-level functionalization of chitosan (CS) layer with polyphenols to impart enhanced adhesion and biological activity, combined with nano-reinforcement of alginate (ALG) layer using a metal-phenolic network (MPN) functionalized layered clay to achieve superior barrier function. The resultant bilayer composite system demonstrated outstanding antibacterial activities against E. coli (up to 98.8%) and S. aureus (up to 98.0%), excellent UV barrier capacity in the UVB (up to 99.99%) and UVA (up to 99.91%) regions, alongside improved hydrophobicity, antioxidant activity, and acceptable opacity. In addition, the tensile strength reached as high as 14.40 MPa, representing an improvement of 221.43% compared with pure ALG film. In the strawberry preservation experiment, the bilayer composite system effectively extended the shelf life of strawberries to seven days, owing to the structural complementarity and the high bioactivity of polyphenols. These results reveal that utilizing natural polysaccharides, polyphenols, and layered clay to construct a mussel-inspired bilayer composite system is a feasible strategy, providing a sustainable and promising approach for designing multifunctional packaging materials to mitigate food waste. Download: Download high-res image (272KB) Download: Download full-size image
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International Journal of Electrochemical Science
·
2023
·Vol. 6
·期 10
·4700-4713
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IF 1.5
Lingli Wan,Yonghai Song,Haozhi Zhu,Yu Wang,Li Wang
Cytochrome c (Cyt c ) and horseradish peroxidase (HRP) were co-immobilized on graphene oxide (GO)-chitosan (CHIT) modified Au electrode and the electron-transfer between the two proteins was investigated. The GO-CHIT nanocomposite was assembled on an Au electrode which covered by a mixed self-assembled monolayer of mecraptoundecanoic acid (MUA) and 6-mercapto-1-hexanol (MCH) and coated with Cyt c . The GO-CHIT nanocomposite as a novel electrochemical platform designed by combining the biocompatibility of CHIT and the conductivity of GO was used for the immobilization of the redox enzymes. Based on electrostatic interactions, the Cyt c -HRP/GO-CHIT/Cyt c /MUA-MCH/Au electrode was constructed by a layer-by-layer technique. Electron transfer and electrocatalytic performances of the modified electrode were investigated. Results showed that direct electron transfer has been established for the bi-protein system and the average rate constant of electron transfer k s , (Cyt c - HRP) =2.63 s -1 was larger than those values at the electrodes modified with single protein (k s , (Cyt c ) =1.44 s -1 , ks, (HRP) =1.53 s-1). The bi-protein modified electrode exhibited good electrocatalytic response to reduction of oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ), suggesting that a third-generation biosensor could be obtained for the detection of O 2 and H 2 O 2 .
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yanfei Liu,Juan Li,Shaowen Huang,Dingbo Shu,Yanru Shan,Zhuohao Qiao,Xiaogang Yin
To address the heavy metal water pollution caused by industrial wastewater discharge, a novel hydrogel adsorbent was prepared using organic matter derived from distiller's grains (DGS), a by-product of the brewing industry, as the main raw material and carboxymethyl chitosan (CMCS) as the modifier. Characterization results revealed that CMCS converted the adsorbent into a three-dimensional macroporous structure while enhancing its highly selective adsorption performance for Pb(II) and Cd(II), with adsorption capacities reaching as high as 825.3 mg·g −1 and 644.3 mg·g −1 , respectively, and removal efficiencies up to 99.4% and 95.2% within 10 min. The adsorption process fitted well with the pseudo-second-order adsorption kinetic model (R 2 > 0.996) and the Langmuir isotherm model, indicating that the adsorption was dominated by chemical adsorption. Mechanistic analysis revealed that the hydrogel formed complexation and coordination with Pb(II) and Cd(II) via the lone pair electrons of O and N atoms, and combined with hydrogen bonding and electrostatic attraction to achieve synergistic adsorption. Furthermore, adsorption experiments on industrial wastewater using this adsorbent demonstrated that it maintained excellent adsorption performance even after six adsorption-desorption cycles, and achieved a degradation rate of 51.3% after 28 days. The synthesis of this highly efficient adsorbent not only realizes the functional modification and high-value utilization of DGS but also provides a green solution for wastewater remediation, exhibiting great application potential.
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Sustainable Materials and Technologies
·
2026
·
IF 9.7
Yanen Wang,Pei Wang,Qi Cai,Xinyuan Zhang,Jiaxuan Guo,Shige Wang,Zhen Tang,Tielou Chen
Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease marked by oxidative stress, cartilage loss, and inflammation. Current therapies are largely palliative and fail to restore joint structure or function. Here, we developed an injectable multifunctional hydroxybutyl-chitosan hydrogel (HBC@ZIrK) with thermo-responsive sol-gel transition property that integrates iridium nanozymes (Ir NPs), zeolitic imidazolate framework-8 (ZIF-8), and the chondrogenic molecule kartogenin (KGN) for synergistic therapy. ZIF-8 stabilized ultra-small Ir NPs, preserved their multi-enzyme activity, and enabled efficient KGN loading with sustained release in the inflamed microenvironment. The hydroxybutyl-chitosan matrix ensured injectability in sol state at room temperature, and underwent rapid gelation at body temperature to form a localized depot, achieving prolonged intra-articular retention of therapeutic components. In vitro studies proved that HBC@ZIrK showed excellent cytocompatibility, potent reactive oxygen species scavenging, apoptosis inhibition, and sustained KGN release. In a rat TMJ-OA model, micro-CT and histological analyses confirmed that the HBC@ZIrK hydrogel preserved subchondral bone, reduced osteophytes, suppressed inflammatory cytokines, and enhanced cartilage matrix synthesis. Remarkably, the joint morphology in the HBC@ZIrK group was statistically indistinguishable from that of healthy controls, which highlights the synergy between KGN and nanozyme-mediated antioxidation. Collectively, these results demonstrate that HBC@ZIrK is a minimally invasive and effective therapeutic platform, offering a dual-action strategy for microenvironmental modulation and structural regeneration in TMJ-OA.
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Materials Today Bio
·
2026
·
IF 11
Fangying Zheng,Yanyun Su,Xianbin Sun,Ding Tan,Ya Wang,Xiumei Li,Yu Gao
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are primary treatments for EGFR-mutated non-small cell lung cancer (NSCLC), but acquired resistance limits efficacy. To address this challenge, we developed CsO/IGA, a multifunctional nanoplatform combining osimertinib (AZD9291) with an indocyanine green-gadolinium (ICG-Gd) probe via oleanolic acid (OA)-modified chitosan encapsulation, integrating fluorescence/magnetic resonance imaging (FLI/MRI) with chemo-phototherapy and tumor microenvironment (TME) modulation. CsO/IGA (∼100 nm) demonstrated excellent stability and generated both singlet oxygen and hyperthermia under 808 nm irradiation. The nanoplatform exerted efficient anti-cancer effects to overcome resistance through reactive oxygen species induction, mitochondrial membrane potential reduction, and EGFR/phosphorylated EGFR downregulation in sensitive and resistant NSCLC cells. Notably, the OA component suppressed cancer-associated fibroblasts and α-smooth muscle actin expression, remodeling the TME to enhance tumor penetration. In vivo studies confirmed tumor-specific accumulation and deep penetration, FLI/MRI capability, and superior antitumor efficacy through chemo-phototherapy synergy. This work presents a promising OA-integrated theranostic strategy integrating targeted therapy, phototherapy, TME modulation, and diagnostic imaging for overcoming EGFR-TKI resistance in NSCLC.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Yanchen Fan,Mengyu Yin,Hongbo Chen
Chitosan is widely used as a dewatering flocculant , but whether it affects hydrogen production from sludge anaerobic fermentation is unclear. This study aimed to elucidate the role of chitosan in the dark fermentation of waste activated sludge for hydrogen production. The results showed that chitosan had a negative effect on hydrogen production from sludge. Chitosan at 30 g/kg total suspended solids reduced hydrogen accumulation by 56.70 ± 1.22 % from 3.94 ± 0.12 to 1.71 ± 0.10 mL/g volatile suspended solids. Chitosan hindered the solubilization of sludge by flocculation , which reduced the available substrate for anaerobic fermentation. In addition, chitosan interfered with the electron transport system by reducing cytochrome C and caused lipid peroxidation by inducing reactive oxygen species , thereby inhibiting the activity of enzymes involved in anaerobic fermentation. Hydrogen production was reduced because hydrogen-producing processes (i.e., hydrolysis, acidification, and acetification) were inhibited more strongly than hydrogen-consuming processes (i.e., methanogenesis , sulfate reduction, and homoacetogenesis). Furthermore, chitosan enriched the abundance of Spirochaetaceae sp. and Holophagaceae sp., which occupied the survival space of hydrogen-producing microorganisms . This study reveals the potential impact of chitosan on hydrogen production in dark fermentation of sludge and provide direct evidence that chitosan triggers oxidative stress in anaerobic fermentation.
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FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Fenghui Wang,Cancan Xie,Hongjie Tang,Wenhui Hao,Jinyao Wu,Yue Sun,Jiapeng Sun,Yingzhu Liu,Longwei Jiang
The aim of this study was to develop intelligent/active packaging by using chitosan/esterified chitin nanofibers (CN) film matrix and anthocyanins from eggplant peel extract (EE) to monitor the freshness of pork. Fourier transform infrared spectroscopy , X-ray diffraction and zeta potential results showed that the CN filled into the film network and precisely bonded to the chitosan via electrostatic interactions and hydrogen bonding. Moreover, the incorporation of EE formed hydrogen bonds with chitosan and CN. Thermogravimetric analysis and scanning electron microscopy showed that the films became more compact and that thermal stability was improved. Hydrogen bonding, electrostatic interaction and nanofilling effects synergistically improved the mechanical and barrier properties (water vapor, oxygen and optical barrier properties) of the films with the addition of CN. When the content of CN was 5 wt%, the tensile strength, elongation at break, the water vapor and oxygen barrier properties of chitosan film were significantly increased by about 1.44, 1.52, 1.23 and 5.21 times (p < 0.05), respectively. When EE was added to the films, the antibacterial and antioxidant capacities of the film were significantly (p < 0.05) improved. All the films containing eggplant anthocyanins were sensitive to pH 3–11 buffer solutions, and the films had good ammonia-sensitivity and acid-sensitivity. Chitosan-CN-EE films effectively indicated the freshness of pork during storage. Hence, these results suggested that the chitosan-CN-EE films are promising candidates for intelligent and active food packaging applications.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Yuting Shi,Wenwen Yu,Xiaoqin Liang,Ju Cheng,Yufei Cao,Mingsheng Liu,Yu Fang,Zheng Yang,Hongbin Liu,Hua Wei,Guanghui Zhao
Preventing arterial hemorrhage by intervening within the first few minutes is critical to the patient's life. Hemostatic materials have been developed over the last decades to address this issue, nevertheless these materials alone do not contribute to improve the survival effects in many extreme conditions, which is usually caused by penetrating arterial bleeding wounds that are incompressible and deep arterial bleeding with irregularly shapes. It is well known that, after calcium ion stimulation, many intriguing changes occurred in the major components of plasma, including the activation of several coagulation factors , such as the conversion of fibrinogen to fibrin, prothrombin to thrombin, and so on. Therefore, we constructed an expansion sponge with interpenetrating network based on chitosan and plasma, while various activated coagulation factors in plasma were also loaded into the pore structure of chitosan sponges. The prepared CS-PG sponge is capable of providing a simpler and more efficient method for treating high-pressure arterial bleeding wounds, which includes three steps: Rapid sealing and adhension, Thrombin catalysis and Activated autocoagulation. As the next generation bioactive materials , compared to conventional hemostatic materials, CS-PG sponge demonstrated superior hemostatic characteristics in both rabbit femoral artery damage and rat liver injury models.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Zhenan Rao,Xiaojuan Lei,Yuanyuan Chen,Jiang Ling,Jichun Zhao,Jian Ming
The utilization of microcarriers is an effective technique to protect and slow down the release of active ingredients, while the combination of microcarriers and film materials is an important way to expand the application scenario of active ingredients. The aim of this study was to develop a simple and facile strategy for designing a multifunctional bilayer bioactive film that combines stable mechanical properties, sustained-release characteristics for active ingredients with good antioxidant and antibacterial properties . The EGCG-loaded chitosan active microspheres were prepared by sol-gel method, and then the carboxymethyl cellulose solution containing the active microspheres was assembled onto the carboxymethyl chitosan gel substrate based on intermolecular hydrogen bonding to construct a film with a stable bilayer structure. The results indicated that the bilayer film had dense microstructure and excellent mechanical strength (37.05 MPa), and exhibited UV-blocking properties and excellent gas barrier performance. Meanwhile, the loading of active ingredients (EGCG) in the microspheres enabled the bilayer film to exhibit excellent antioxidant and antibacterial properties, and the controlled release of EGCG by the film was sustainable and showed pH responsiveness. The results of this work provide a new perspective for the design and development of bio-based active packaging film with tunable functional characteristics.
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