Journal of Energy Storage
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2024
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IF 8.9
Mengna Qin,Guibao Wu,Kai Zheng,Xiaofei Yu,Juan Xu,Jianyu Cao
The pH-neutral aqueous redox flow battery (ARFB) is one of the most attractive flow batteries due to its non-corrosiveness, low-cost, and wider electrochemical stability window compared to those with acidic or alkaline electrolytes. However, there are few families of organic redox-active molecules available as catholyte materials for pH-neutral ARFBs. Herein, through incorporation of quaternary ammonium moiety into the redox-active phenoxazine nucleus, an organic catholyte material, N , N , N -trimethyl-2-(10H-phenoxazin-10-yl) ethan-1-aminium chloride (NEt-POZ) is achieved for pH-neutral ARFBs. The NEt-POZ has a high redox potential of 0.79 V versus SHE and rapid redox kinetics (0.23 cm s −1 ) as well as high water-solubility (∼2.6 M in H 2 O). Paired with a methyl viologen (MV) anolyte in the pH-neutral aqueous electrolyte, a viologen-phenoxazine ARFB full cell is assembled, which shows an open circuit voltage of ∼1.23 V. However, the results of long-term cycling experiments indicate low Coulomb efficiency and rapid declining capacity of the NEt-POZ catholyte. The mechanism analysis unveils that the unstable doubly oxidized tri-cations (NEt-POZ 3+ ) formed via the disproportionation of radical di-cations (NEt-POZ 2+ ) in solution readily react with chloride anions to form poly-chlorinated derivatives, which precipitate from the catholyte due to their poor water solubility, leading to a rapid decrease in capacity. When there is no chloride present in the electrolyte solution, highly reactive NEt-POZ 3+ cations can interact with other counter-anions (such as sulfate and carbonate ions) and even water to form complex adducts.
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International Journal of Nanomedicine
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2024
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IF 6.6
Xiaomei Jiang,Xiaohong Jiang,Dongjie Wu,Wanzhu Xie,Xiong Liu,Jintao Zheng
Background Radiotherapy is a widely used clinical tool for tumor treatment but can cause systemic toxicity if excessive radiation is administered. Although numerous nanoparticles have been developed as radiosensitizers to reduce the required dose of X-ray irradiation, they often have limitations, such as passive reliance on radiation-induced apoptosis in tumors, and little consider the unique tumor microenvironment that contributes radiotherapy resistance.Methods In this study, we developed and characterized a novel self-assembled nanoparticle containing dysprosium ion and manganese ion (Dy/Mn-P). We systematically investigated the potential of Dy/Mn-P nanoparticles (NPs) as a reactive oxygen species (ROS) amplifier and radiosensitizer to enhance radiation therapy and modulate the tumor microenvironment at the cellular level. Additionally, we evaluated the effect of Dy/Mn-P on the stimulator of interferon genes (STING), an innate immune signaling pathway.Results Physicochemical analysis demonstrated the prepared Dy/Mn-P NPs exhibited excellent dispersibility and stability, and degraded rapidly at lower pH values. Furthermore, Dy/Mn-P was internalized by cells and exhibited selective toxicity towards tumor cells compared to normal cells. Our findings also revealed that Dy/Mn-P NPs improved the tumor microenvironment and significantly increased ROS generation under ionizing radiation, resulting in a ~70% increase in ROS levels compared to radiation therapy alone. This enhanced ROS generation inhibited ~92% of cell clone formation and greatly contributed to cytoplasmic DNA exposure. Subsequently, the activation of the STING pathway was observed, leading to the secretion of pro-inflammatory immune factors and maturation of dendritic cells (DCs).Conclusion Our study demonstrates that Dy/Mn-P NPs can potentiate tumor radiotherapy by improving the tumor microenvironment and increasing endogenous ROS levels within the tumor. Furthermore, Dy/Mn-P can amplify the activation of the STING pathway during radiotherapy, thereby triggering an anti-tumor immune response. This novel approach has the potential to expand the application of radiotherapy in tumor treatment.
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PROGRESS IN ORGANIC COATINGS
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2025
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IF 7.3
Yufei Xiong,Yi Guo,Zixiang Zeng,Lijie Dong
Inhibitor-loading nanocontainers are considered as promising materials for smart anticorrosion coatings due to their potential to realize stimuli-responsive self-diagnose and self-healing. However, unsatisfying inhibitor-loading capacity and robustness as well as elaborated design restrict their up-scaling and application in long-term corrosion protection. In this work, cobalt ferrite (CoFe 2 O 4 , CFO) nanospheres with nanoporous structure and robustness are utilized as smart nanocontainers, which are successively coated with polyethyleneimine (PEI), polyacrylic acid sodium (PAAS) and imidazoline quaternary amination salt (IQAS) via electrostatic layer-by-layer assembly (CFO@PEI/PAAS/IQAS). Subsequently, the CFO@PEI/PAAS/IQAS is incorporated with styrene-ethylene-butylene-styrene thermoplastic elastomer (SEBS), forming a smart anticorrosion coating (CFO@PEI/PAAS/IQAS composite coating). The porous structure together with the robustness of CFO facilitate the high inhibitor-loading capacity and the mechanical durability of the coating. Moreover, the CFO@PEI/PAAS/IQAS composite coating exhibits outstanding corrosion resistance and pH-responsive self-healing performance for scratches. This kind of pH-responsive nanocontainers with facile preparation method provides a broad application potential for the next generation of smart anticorrosion coatings.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2011
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IF 2.733
Ying Hua Xu,Hong Zhang,Cheng Pu Chu,Chun An Ma
Chloroacetic acids (CAAs, including trichloroacetic acid, dichloroacetic acid and monochloroacetic acid) are byproducts formed upon the addition of chlorine to water for disinfection purpose and they pose a potential human health risk. To catalyze the dechlorination of CAAs, an activated silver electrode was prepared by an oxidation–reduction cycle process. Surface structure and roughness factor of the activated silver electrode and its catalytic activity (including stability) towards the dechlorination of CAAs in aqueous solutions of different pH were studied by SEM, underpotential deposition (UPD) method, cyclic voltammetry (CV) and controlled-current electrolysis, respectively. Experimental evidence is presented that the activated silver electrode, having a porous surface with a roughness factor of approx. 63.9, is an excellent electrocatalytic material for direct dechlorination of CAAs and the complete dechlorination of trichloroacetic acid to safe acetic acid with excellent current efficiency (near 95%) can be successfully achieved by using this peculiar electrode in alkaline aqueous solutions. The reduction of trichloroacetic acid in a stepwise dechlorination fashion was suggested and trichloroacetic acid (TCAA) → dichloroacetic acid (DCAA) → monochloroacetic acid (MCAA) → acetic acid (AA) probably is the main reductive reaction route independent of pH.
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WATER RESEARCH
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2017
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IF 6.942
Jing Zhao,Yang Liu,Bo Pan,Guoqian Gao,Ying Liu,Siqian Liu,Ni Liang,Dandan Zhou,Martina G. Vijver,Willie J.G.M. Peijnenburg
The increasing number of applications in which copper oxide nanoparticles (CuO NPs) are used, may lead to potential release of CuO NPs into the environment. However, the impact of natural organic matters on the behavior and fate of CuO NPs in aquatic media is still largely unknown. In this study, the dissolution and aggregation of CuO NPs under the exposure of tannic acid (TA) were monitored over a period of 72 h, with a focus on assessing the contributions of solution pH changes and complexation reactions. Results showed that the total amount of Cu 2+ released from CuO NPs increased in the presence of TA especially at the highest TA concentration of 73.5 μmol/L. Although TA was observed to wrap around the CuO NPs, the aggregation of CuO NPs was not strongly influenced by TA and by the solution pH as investigated in this study. The kinetics of Cu 2+ release were fitted using the modified pseudo second-order model and the rate of dissolution was assessed to be highest at TA = 14.7 μmol/L. At pH = 4, the increased H + concentration was responsible for increased Cu 2+ release, whereas the complexation reaction between Cu 2+ and TA dominated at pH = 7. These findings suggested that the effects of TA on the dissolution of CuO NPs were a combination of solution pH change and complexation reaction, the relative fractions of which also depended on the solution pH. Additionally, the percentage of Cu 2+ released from the CuO NPs was found to increase upon decreasing concentrations of CuO NPs. Our work helps to further understand how and to which extent natural organic matters affect the behavior and fate of CuO NPs.
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INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
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2017
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IF 1.208
Yongli Liu,Qingxiang Zhou
In present work, fluorescent carbon dots (CDs) with an average diameter of 2.5 nm were firstly synthesised by a simple, convenient and low-cost hydrothermal method from chocolate. The obtained CDs possessed fine monodispersity and bright blue fluorescence that was strongest at an excitation wavelength of 360 nm and had a comparable quantum yield of 12% (in case of dots prepared in presence of nitric acid). The emission peak depended on the excitation wavelength in the range from 320 to 440 nm. Ionic strength had a weak effect up to 1.0 M and then no significant change was found in the range of 1.0–4.5 M. The fluorescence intensity of CDs displayed good pH adaptability and a linear dependence on the pH change in the range of pH 1.0–3.0 and pH 9.0–12.5, which have promising potentials for pH sensor.
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RSC Advances
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2017
·Vol. 7
·期 42
·25978-25986
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IF 3.108
Ce Cheng,Shengfeng Peng,Ziling Li,Liqiang Zou,Wei Liu,Chengmei Liu
The poor water solubility and bioavailability of curcumin can be improved by encapsulating it into liposomes. However, the existing encapsulation technologies, such as the thin film method and the ethanol injection method, are complex and require the use of organic solvents. In this study, an organic solvent-free and easily scalable encapsulation technique was studied by utilizing the pH-dependent solubility properties of curcumin. Phospholipid was dissolved in water to form liposomes. Curcumin was deprotonated and dissolved under alkaline conditions and then encapsulated into the liposomes after acidification. Morphological observation and X-ray diffraction analysis confirmed that curcumin liposomes had been successfully prepared. Curcumin liposomes prepared by the pH-driven method were stable during storage. During in vitro digestion, curcumin liposomes prepared by the pH-driven method showed similar bioaccessibility to those prepared by the thin film method and higher bioaccessibility than those prepared by the ethanol injection method. The pH-driven method, which is organic solvent-free and easily scalable for industrial production, is thus a promising method for the preparation of curcumin liposomes.
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Food Bioscience
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2025
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IF 5.9
Jiaying Ren,Jiarui Jin,Yuze Wang,Yu Liu,Hang Qi
Fucoxanthin (FX), a natural carotenoid sourced from algae, is renowned for its strong antioxidant, anti-inflammatory, and anticancer effects, positioning it as a promising candidate for applications in functional foods and pharmaceuticals. Despite its potential, FX suffers from low oral bioavailability and is prone to degradation during digestion, hindering its effective absorption in the colon. In this study, κ-carrageenan-sodium alginate (Car-SAA) hydrogel beads were employed as an encapsulation system to investigate their pH-responsive drug release behavior and their influence on FX's oral bioavailability. The results showed that the hydrogel beads exhibited excellent mechanical properties in simulated colonic fluid (SCF), intestinal fluid (SIF), and gastric fluid (SGF). FX was gradually released in SGF and SIF, while a rapid release was observed in SCF, with a cumulative release of 74.38 ± 2.00% after 72 h for Car-SAA2.0-FX. This behavior was likely due to the swelling properties of the hydrogel, and the release kinetics were consistent with the Korsmeyer-Peppas model. Moreover, in vitro cytotoxicity assays showed that FX-loaded Car-SAA2.0 hydrogel beads had no significant impact on HaCaT cells but exhibited significant inhibitory effects on cancer cells. These findings indicated that the formulation holds promise as a colon-targeted delivery system, paving the way for future innovations in functional foods and pharmaceutical formulations.
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MATERIALS CHEMISTRY AND PHYSICS
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2025
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IF 4.7
Handa Liu,Kexin An,Ning Qiao,Lihua Liu,Xiaoran Sun,Xuepeng Zhang,Hongzhou Shang
In this study, a multifunctional nanoplatform was developed. Mesoporous carbon nanospheres were prepared using silica microspheres as hard templates through a hard-template method. Low molecular weight polyethyleneimine and succinic anhydride were grafted onto the spheres through amidation reactions to obtain near-infrared and pH dual-responsive mesoporous carbon nanospheres for targeted controlled drug release and photothermal therapy. The successful preparation of the nanocomposites with a particle size of approximately 120 nm was confirmed by SEM and TEM. The in-vitro cytotoxicity and photothermal performance were evaluated, and the results showed that the carrier exhibited low toxicity, with a survival rate of 91.94 % for mouse macrophages (RAW264.7). Additionally, the carrier demonstrated excellent photothermal stability with a photothermal conversion efficiency of 39.05 % and a maximum temperature increase of 39.6 °C. Drug adsorption tests revealed that the carrier's maximum equilibrium adsorption capacity for curcumin was 133.3 mg L −1 . In-vitro drug release experiments showed that the release performance could be controlled by pH and near-infrared laser irradiation. Under conditions of pH = 6 and near-infrared light, the cumulative drug release rate was 15.1 %. The excellent targeting, curcumin loading, and release performance of the carrier offer new possibilities for integrating photothermal therapy with chemotherapy for synergistic tumor treatment.
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ENVIRONMENTAL RESEARCH
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2025
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IF 7.7
Jie Song,Zhiwen Yuan,Lijun Chen,Yuhua Niu,Zhiqiang Wei
For the effective removal of phenol from the environment, photocatalytic synergistic adsorption is currently one of the key methods. By leveraging the polysaccharide backbone structure of sodium alginate (SA), Zinc hydroxystannate (ZHS) was introduced into the gel structure using a co-precipitation technique. Additionally, gangue waste was repurposed through a polymerization reaction. This approach not only enhanced the specific surface area of the gel material but also compensated for its limited absorption in the visible light spectrum. As a result, the PKSPGM@ZHS was successfully synthesized. The adsorption of Ph by PKSPGM@ZHS in the dark reaction phase aligns with the quasi-second-order kinetic model and the Langmuir model, it shows that this is a spontaneous exothermic process, and its photocatalytic process conforms to the Langmuir-Hinshelwood first-order reaction kinetics model, where ZHS undergoes a series of reactions to generate ·OH radicals from ·O 2 − in the presence of photocatalysis. Ph can be degraded to CO 2 and H 2 O through a series of reactions, thereby achieving complete removal of Ph from wastewater solutions, with a removal rate reaching up to 70 %. After 5 cycles of adsorption/photocatalysis tests, KSPGM@ZHS still h exhibits a high removal efficiency, with the removal rate remaining at 54.26%. This demonstrates its excellent recyclability.
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JOURNAL OF HAZARDOUS MATERIALS
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2024
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IF 12.2
Peng Zhang,Minglu Sun,Juan Liang,Zhaokun Xiong,Yang Liu,Jiali Peng,Yue Yuan,Heng Zhang,Peng Zhou,Bo Lai
Solution pH is one of the primary factors affecting the efficiency of water decontamination . Although the influence of pH on oxidants activation, catalyst activity, and reactive oxygen species have been widely explored, there is still a scarcity of systemic studies on the changes in the oxidation behavior of organic pollutants at different pH levels. Herein, we report the influence laws of pH on the forms, reactivities, active sites, degradation pathways, and products toxicities of organic pollutants. Changes in pH cause the protonation or deprotonation of organic pollutants and further affect their forms and chemistry (e.g., electrostatic force , hydrophobicity , and oxidation potential). The oxidation potential of organic pollutants follows the order: protonated form > pristine form > deprotonated form. Moreover, protonation or deprotonation can modify the active sites and degradation pathways of organic pollutants, wherein deprotonation renders them more susceptible to electrophilic attack, while protonation reduces their activity against electrophilic and nucleophilic attacks. Additionally, pH adjustments can modify the degradation pathway and the toxicity of transformation products. Overall, pH changes can affect the oxidation fate of organic pollutants by altering their structure, which distinguishes it from the effect of pH on oxidants or oxidant activation processes.
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Carbohydrate Polymer Technologies and Applications
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2024
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IF 6.2
Yingqi Mi,Yuan Chen,Qing Li,Wenqiang Tan,Zhanyong Guo
Development of secure and efficient drug delivery systems to overcome physicochemical challenges in cancer clinical treatment is one of the most active fields, and novel drug carriers are actively sought. In this work, the successful synthesis of amphiphilic chitosan derivatives containing pyridine cations and folic acid (TMACMCF) was confirmed by FTIR and 1 H NMR spectroscopy. The critical micelle concentration (CMC) of TMACMCF was studied, and the results indicated that it possessed a relatively low CMC (0.186 mg/mL). Self-assembled nanoparticles (TMACMCF-ADM NPs) for the entrapment and delivery of adriamycin (ADM) were synthesized based on TMACMCF, and the morphology, particle size, zeta potential, sustained release performance, antioxidant and antitumor activities, and cytotoxicity were investigated. The particle size of TMACMCF-ADM NPs was 163.79 ± 7.31 nm, and the morphology observed by SEM and TEM showed spherical or oval particles. TMACMCF-ADM NPs showed excellent entrapment of ADM with entrapment efficiency and drug loading efficiency of 65.04 ± 1.20 % and 22.73 ± 0.40 %, respectively. The release performance results showed that in vitro release profiles of ADM from NPs exhibited pH-sensitive controlled and sustained release properties. The assay of antioxidant activity exhibited that TMACMCF-ADM NPs possessed significantly improved scavenging ability against three kinds of radicals (Superoxide-radical, DPPH radical, and ABTS radical). Moreover, the assay of antitumor activity by CCK-8 test exhibited that nanoparticles led to statistically significant enhancement in inhibition index for four kinds of cancer cells (BGC-823, MCF-7, HEPG-2, and A549). This work provides a promising carrier for secure and effective entrapment and delivery of ADM.
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