Small Methods
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2026
·Vol. 10
·期 4
·e01991
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IF 9.1
Huiling Liu,Xingkai Jia,Xuan Zhang,Lihua Feng,Hongge Pan,Mi Yan,Yinzhu Jiang
Metal-organic frameworks (MOFs) are promising hosts for quasi-solid electrolytes (QSEs) by integrating liquid electrolytes (MOF@LE QSEs), yet stabilizing lithium metal anodes (LMAs) to enhance electrochemical performance remains a challenge. Here, we introduce a strategy leveraging open metal sites (OMSs) in HKUST-1 (Cu 3 (BTC) 2 ) combined with LiNO 3 to tailor solid electrolyte interphase (SEI) chemistry and lithium deposition. OMSs in HKUST-1 anchor NO 3 − and promote LiNO 3 dissociation, enriching SEI with nitrogen-containing inorganic compounds and enabling uniform and spherical lithium morphology. Consequently, LMAs with LiNO 3 -incorporated HKUST-1 membrane QSE (HM-LN QSE) achieve a critical current density of 2.7 mA cm −2 , with stable lithium plating/stripping over 650 h at 0.2 mA cm −2 and more than 300 h at 0.5 mA cm −2 . Moreover, LiLiFePO 4 cells assembled with HM-LN QSEs delivere a discharge capacity of 81.2 mAh g −1 at 5 C and retain 81.2% capacity after 350 cycles at 2 C, demonstrating superior electrochemical stability and performance. This innovative MOF-based approach significantly enhances SEI stability and LMA performance, advancing lithium metal battery technology.
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FOOD CHEMISTRY
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2026
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IF 10.4
Yuzhuo Wei,WenJing Guo,Shiqi Hao,Xueying Sun,Lina Sun,Erke Sun,Xiaotong Li,Ye Jin,Lihua Zhao
2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) is a highly polar heterocyclic amine with elevated levels in high-temperature meat products and strong carcinogenicity. This study screened Pediococcus acidilactici X3-1B, achieving a PhIP adsorption rate of 74.30%. The stability of the complex formed between the strain and PhIP was highest at 0 h, 4 °C, and pH 7. Scanning electron microscopy (SEM) revealed significant morphological changes in the strain after PhIP adsorption. Fourier transform infrared spectroscopy (FTIR) results indicated that N H and C O groups on the bacterial surface played a primary role in adsorption. Zeta potential measurements revealed an increase in net negative charge on the bacterial surface following PhIP adsorption. Functional group chemical masking indicated that amino groups are one of the core functional groups influencing X3-1B's adsorption of PhIP. This study provides theoretical foundations and practical references for the application of lactic acid bacteria in food safety.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2026
·
IF 2.4
Jingli Sun,Yujie Zhen,Siyu Zheng,Lei Chen,Kebin Huang,Yingmin Yu
Abstract To investigate salt-type and salt-concentration effects on pyridine extraction performance, liquid–liquid equilibrium data for the aqueous pyridine +2-ethyl-1-hexanol system with KCl or CaCl2 were measured at 298.15 K and 101.3 kPa. Aqueous phases containing 5 and 10 wt % KCl and CaCl2 were systematically studied. Experimental results show that both inorganic salts expand the two-phase region, promote pyridine partitioning into the rich-organic phase, and enhance separation efficiency. The pyridine distribution coefficient and separation factor generally increase with the salt concentration. Relative to the salt-free system, the average separation factor rises by approximately 42.01% and 111.10% for 5 and 10 wt % KCl, respectively, and by 19.17% and 74.27% for the corresponding CaCl2 concentrations, respectively. Experimental LLE data were correlated using NRTL and UNIQUAC activity coefficient models, with RMSD below 1.02%. Thermodynamic consistency tests and Gibbs stability criteria further validate the reliability of the regressed model parameters. This work provides credible LLE data sets and thermodynamic model parameters for the design and optimization of pyridine extraction and separation processes in saline aqueous systems.
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FREE RADICAL BIOLOGY AND MEDICINE
·
2026
·
IF 8
Shenghui Zhang,Qin Liu,Bo Chen,Hui Chang,Ying Pan,Yanli Liu,Xin Zhao,Juntang Lin
MenSC-EVs alleviate STZ-induced ovarian dysfunction in diabetic mice. • MenSC-EVs suppress high-glucose-induced ferroptosis in granulosa cells. • EV-associated HSPA5 mediates protection via AKT/mTOR–BECN1/SLC7A11 signaling. Type 1 diabetes mellitus (T1DM) is associated with ovarian dysfunction, including menstrual irregularities, impaired ovarian reserve, and premature reproductive aging, yet effective therapeutic strategies to safeguard ovarian function against metabolic stress remain limited. Mesenchymal stem cells (MSCs) have emerged as pivotal regulators of tissue homeostasis, with their paracrine effects largely mediated by extracellular vesicles (EVs). Here, we demonstrate that menstrual blood-derived endometrial stem cell-EVs (MenSC-EVs) alleviate streptozotocin (STZ)-induced ovarian dysfunction and inhibit granulosa cells (GCs) ferroptosis by delivering HSPA5. Mechanistically, EV-associated HSPA5 restored AKT/mTOR signaling and was accompanied by reduced BECN1 phosphorylation, thereby preserving the SLC7A11/GPX4-associated antioxidant pathway. We further show that BECN1 directly interacts with SLC7A11, linking BECN1 signaling to regulation of the system Xc−/GPX4 antioxidant axis. MenSC-EVs preserved this antioxidant pathway and reduced lipid peroxidation in injured GCs. Collectively, these findings identify an HSPA5-dependent anti-ferroptotic mechanism through which MenSC-EVs ameliorate T1DM-associated ovarian dysfunction, supporting their potential as an ovarian-protective strategy under diabetic conditions. Download: Download high-res image (241KB) Download: Download full-size image
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ChemistrySelect
·
2026
·Vol. 11
·期 36
·e74557
·
IF 2.3
Xiaowei Zhou,Yuerong Wang,Youqing Sun,Dan Liu,Thabo T. I. Nkambule,Alex T. Kuvarega,Bhekie B. Mamba,Jianzhou Gui
In this study, a series of Ionic liquid-derived carbon dots (IL-CDs) were synthesized by microwave method from L-histidine and imidazolium-based ILs included 1-butyl-3-methylimidazolium chloride, 1-hexyl-3-methylimidazolium chloride and 1-decyl-3-methylimidazolium chloride. Their structures were elucidated using Fourier transform infrared spectroscopy (FTIR), Ultraviolet–visible spectrum (UV–vis), and nuclear magnetic resonance (NMR). The inhibition efficacy of IL-CDs on 45# steel within a 298 K, 1 M HCl solution system was investigated employing various techniques, including electrochemical analysis, weight loss measurement, scanning electron microscopy (SEM), atomic force microscopy (AFM), and molecular dynamics simulations. The microstructure and surface properties IL-CDs were obtained through a series of characterizations; and their corrosion inhibition performance for 45# steel was evaluated using weight loss and electrochemical methods in 1 M HCl solution. The electrochemical impedance spectroscopy (EIS) results showed that the corrosion inhibition efficiency of CDs in 1 M HCl solution could reach 98.2% at a concentration of 15 ppm, and 95% even at an increased temperature of 313 K. The strong adsorption of IL-CDs follows the Langmuir adsorption model, and the Gibbs free energy increases with the chain length of ionic liquids. The adsorption behavior of the IL-CDs on the carbon steel surface shows the chemisorption feature. Graphical The corrosion inhibition mechanism involves carbon dots that adsorb on the surface of carbon steel to form a hydrophobic film, which suppresses hydrogen evolution at the cathode and oxidation reactions at the anode.
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TOXICOLOGY AND APPLIED PHARMACOLOGY
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2026
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IF 3.6
Lina Li,Haotian Chen,Yang Zhu,Ren-shan Ge,Chao Chen,Shangqin Chen
Parabens are extensively employed as antimicrobial preservatives in cosmetics, personal care items, and pharmaceuticals. However, their potential metabolism regulating effects, particularly regarding the inhibition of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), remains unknown. This study assessed 4-hydroxybenzoic acid and 9 parabens for their ability to inhibit human and rat liver 11β-HSD1, investigating their mechanism of action, structure-activity relationship (SAR), molecular interactions (via in silico docking), and influence on cortisol metabolism in LX-2 cells. Nonylparaben emerged as the most potent inhibitor, demonstrating the lowest IC 50 values (human: 6.29 μM) and strongest binding affinity (ΔG: human: −6.84 kcal/mol). The inhibitor trend followed nonyl > heptyl (IC 50 = 11.37 μM) > hexyl (15.32 μM) > benzyl (29.99 μM) > phenyl (53.27 μM) > butyl (58.87 μM) paraben. Short-chain parabens (
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Materials Today Nano
·
2026
·
IF 7.6
Yue Zhao,Xin-Ya Zhou,Qing-Yin Li,Zheng-Hui Qiu,Zhi-Yong Sun,Guang-Long Zhang,Jin-Wei Zhang,Cun-Guo Lin
A carboxylic acid molecular bridging strategy for modifying M-HOFs is developed. • Synergistic “rigidity-flexibility” balance enhances structure and charge transport. • Charge recombination is significantly suppressed per time-resolved spectroscopy. • Improved photocatalytic degradation and antibacterial performance are achieved. • This work provides a design principle for HOF-based photocatalysts. High-performance photocatalysts are significant for overcoming contemporary energy and environmental challenges. Metal-complex hydrogen-bonded frameworks (M-HOFs) are promising materials, yet they often face the problem of poor charge separation. Herein we suggest a strategy of molecular design to enhance the photocatalytic activity of a standard M-HOF, which is MPM-1-TIFSIX that can be modified by trimesic acid. In this approach, trimesic acid acts as a molecular glue. It comprises both coordination bonds and hydrogen bonds, creating an equilibrium between rigidity and flexibility within the structure. This modification improves the structural ordering and arrangement, and also facilitates charge transport through the material. The experimental results indicate evident lower photoluminescence and longer carrier lifetime which confirms that charge recombination is highly curtailed. This work enhances the performance of M-HOFs in the areas of pollutants degradation, antibiofouling and antibacterial. It also offers the basic guidelines to the directed rationale approach in designing next generation HOF-based photocatalysts. Download: Download high-res image (284KB) Download: Download full-size image
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Frontiers in Immunology
·
2026
·
IF 7
Tianyi Xu,Qilei Yang,Yue Peng,Congcong Xie,Huimin Yu
Rheumatoid arthritis (RA) therapy demands agents that are both effective and safe, yet many natural products with promising bioactivity, such as curcumin, face major translational challenges due to poor solubility and bioavailability. To overcome these limitations, we designed and synthesized a series of dual-functional curcumin-borneol prodrugs via a succinate ester linkage, including the parent ester (CBS), its water-soluble sodium salt (CBS-Na), and a disubstituted analog (DCBS), to enhance delivery and synergize therapeutic action. These derivatives markedly improved cellular uptake and nuclear localization, potently scavenged reactive oxygen species, and effectively suppressed the MAPK/AP-1 signaling axis by inhibiting ERK and p38 phosphorylation and c-Fos expression, leading to downregulation of matrix metalloproteinase MMP9 and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β). In a collagen-induced arthritis rat model, the derivatives demonstrated superior efficacy over native curcumin in alleviating joint inflammation and destruction, while exhibiting an excellent safety profile, thus representing a novel and promising therapeutic strategy for RA.
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Dose-Response
·
2026
·
IF 2.8
AiJiao Sun,CuiYu Yu,FeiYan Zhu,Jing Chen,LiangChuan Chen,ZePing Hu,WeiBing Wang
BackgroundExtracellular matrix (ECM) deposition and excessive fibrosis are important factors in the deterioration of cardiac function after myocardial ischaemia‒reperfusion injury (I/RI). However, therapeutic strategies for inhibiting ECM deposition and excessive fibrosis have still not been elucidated.Methods and resultsSingle-nucleus RNA sequencing (snRNA-seq) revealed that the overexpression of type VI collagen-α 3 (Col6a3) in fibroblasts in the myocardial infarction area strongly promotes the process of myocardial fibrosis. Consistent results were not observed in the infarcted myocardial tissues of mice treated with 4,8-dicarboxyl-8,9-iridoid-1-glycoside (BIG). Echocardiography confirmed that BIG alleviated cardiac dysfunction in mice after myocardial I/RI, TTC and Evans blue double staining revealed that BIG reduced the myocardial infarction size and area at risk. BIG inhibited inflammatory responses, apoptosis, and matrix metalloproteinase (MMP) secretion both in vivo and in vitro. Immunofluorescence staining revealed that BIG downregulated the expressions of TGF‒β and Col6a3 in cardiac fibroblasts but not in cardiomyocytes. The PI3K-specific inhibitor LY294002 and AKT inhibitor were utilitzed to confirm that BIG suppressed myocardial fibrosis and alleviated cardiac dysfunction by activating the PI3K/AKT pathway.ConclusionsThe results provide valuable information for the treatment of myocardial fibrosis induced by myocardial I/RI and highlight the therapeutic potential of BIG in reducing collagen deposition.
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FUEL PROCESSING TECHNOLOGY
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2026
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IF 7.8
Zicong Wang,Jing Zhao,Weijiong Dai,Linquan Li,Yan Wang,Jiajun Zheng,Ruifeng Li
The fabrication of hierarchical zeolite structure and rational modulation of Ti active sites in TS-1 zeolite are both recognized as critical factors for improving catalytic performance in selective oxidation reactions. Herein, we propose a facile and cost-effective strategy combined a dry-gel conversion (DGC) method with a preliminary aging step for the direct synthesis of anatase-free hierarchical TS-1 zeolite containing highly active TiO 6 species. The coordination states of Ti species in TS-1 zeolites were thoroughly investigated via UV–vis, FTIR, XPS and UV-Raman spectroscopy. Additionally, systematic characterizations were performed to investigate the impacts of the synthetic strategy on the crystallization process, including the formation of hierarchical TS-1 zeolite structure and the modulation of Ti species coordination. The obtained TS-1 zeolite demonstrated exceptional catalytic activity and stability in olefin epoxidation and oxidative desulfurization reactions. This discovery not only advances the design and synthesis of titanosilicate zeolites but also expands their potential applications in various selective oxidation processes.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zhichao Sun,Songyin Yu,Yuhang Gong,Changhai Liang,Chuang Li
Different from the dehydration of ethanol, the catalytic dehydration of long-chain fatty alcohols to linear α-olefins with the low selectivity arises from a complex reaction network, particularly the secondary isomerization to internal olefins. This study aimed to elucidate the fundamental mechanisms governing selectivity in the catalytic dehydration of n-octanol to 1-octene over conventional γ-Al 2 O 3 catalysts. The combination of kinetic analysis, in situ infrared spectroscopy, and density functional theory (DFT) calculations, we demonstrated that the reaction primarily proceeded via a dioctyl ether intermediate, which rapidly decomposed into olefin and alcohol. In contrast, the isomerization of 1-octene followed a water-assisted re-adsorption and hydration pathway: 1-octene re-adsorbed onto surface acid sites, hydrated to form 2-octanol, and subsequently underwent secondary dehydration, preferentially yielding internal olefins in accordance with Saytzeff's rule. Based on these mechanistic insights, an integrated reaction-separation process was designed using Aspen Plus simulation. Employing a dual-column distillation scheme with heat integration, the process achieved a 1-octene product purity exceeding 98% with ~5.9% lower overall energy consumption. This work provided systematic insights and a feasible strategy, that bridges molecular-scale mechanisms with process engineering, facilitating the highly selective production of α-olefins from biomass-derived long-chain alcohols.
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Frontiers in Aging
·
2026
·
IF 4.9
Lipeng Xu,Jinze Li,Anran Li,Jixian Chen,Liping Wang,Yaming Shan,Xianbin Cheng
Introduction Ellagic acid (EA) is a naturally occurring polyphenolic antioxidant speculated to influence aging, but its precise biological mechanisms remain poorly understood. Methods Using Caenorhabditis elegans as a model system, we investigated the anti-aging properties of EA. Lifespan assays were performed at multiple concentrations, and healthspan parameters including locomotor activity, lipofuscin accumulation, and reactive oxygen species (ROS) levels were assessed under thermal and oxidative stress. Genetic requirement was examined using loss-of-function mutants of daf-16, hsf-1, hlh-30, and skn-1. Gene expression was analyzed by qRT-PCR and reporter strains, and global transcriptional changes were mapped by RNA-sequencing. Results EA extended lifespan and preserved key healthspan features, including improved locomotor activity, reduced intestinal lipofuscin accumulation, and decreased ROS levels under stress conditions. The lifespan-extending effects of EA required daf-16, hsf-1, hlh-30, and skn-1, as EA failed to extend lifespan in these mutants. EA also enhanced the expression of downstream cytoprotective genes. Complementary RNA-sequencing revealed broader transcriptional remodeling, including metabolic pathways. Discussion These findings position EA as a modulator of a coordinated transcriptional network—rather than a single pathway—involving the insulin/IGF-1 signaling pathway and interconnected stress-response networks to promote longevity and stress resistance.
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