Frontiers in Aging
·
2026
·
IF 4.9
Lipeng Xu,Jinze Li,Anran Li,Jixian Chen,Liping Wang,Yaming Shan,Xianbin Cheng
Introduction Ellagic acid (EA) is a naturally occurring polyphenolic antioxidant speculated to influence aging, but its precise biological mechanisms remain poorly understood. Methods Using Caenorhabditis elegans as a model system, we investigated the anti-aging properties of EA. Lifespan assays were performed at multiple concentrations, and healthspan parameters including locomotor activity, lipofuscin accumulation, and reactive oxygen species (ROS) levels were assessed under thermal and oxidative stress. Genetic requirement was examined using loss-of-function mutants of daf-16, hsf-1, hlh-30, and skn-1. Gene expression was analyzed by qRT-PCR and reporter strains, and global transcriptional changes were mapped by RNA-sequencing. Results EA extended lifespan and preserved key healthspan features, including improved locomotor activity, reduced intestinal lipofuscin accumulation, and decreased ROS levels under stress conditions. The lifespan-extending effects of EA required daf-16, hsf-1, hlh-30, and skn-1, as EA failed to extend lifespan in these mutants. EA also enhanced the expression of downstream cytoprotective genes. Complementary RNA-sequencing revealed broader transcriptional remodeling, including metabolic pathways. Discussion These findings position EA as a modulator of a coordinated transcriptional network—rather than a single pathway—involving the insulin/IGF-1 signaling pathway and interconnected stress-response networks to promote longevity and stress resistance.
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MOLECULAR THERAPY
·
2026
·
IF 11.4
Peng Gu,Yunfei Zhao,Jiajia Hu,Yuguang Tian,Lingyan Zhao,Jingjing Ren,Qin Yang,Jiaxin Li,Wenhao He,Jiayin Guo,Peng Chen
Hereditary tyrosinemia type 1 (HT1) is a life-threatening metabolic disorder caused by the toxic accumulation of tyrosine and its metabolites. While treatment with nitisinone (NTBC) combined with a strict dietary regimen has improved outcomes, it imposes a significant lifelong burden and is associated with debilitating side effects and incomplete protection. Here, we developed an engineered probiotic with an optimized design, e-EcN-HT, and demonstrated its comprehensive efficacy and safety in HT1 across multiple animal models, including FAH -/- mice, FAH -/- rabbits, and Bama minipigs. Our findings indicate that e-EcN-HT not only mitigates multifaceted acute manifestations of FAH -/- mice, including neonatal death, acute liver injury, but also improves chronic liver lesions when combined with NTBC. The therapeutic effect translated successfully to the FAH -/- rabbit model. Moreover, e-EcN-HT administration led to the rapid metabolism of orally administered 13 C-tyrosine, confirming robust and active tyrosine consumption in pigs. Comprehensive safety assessments across murine and porcine models showed that e-EcN-HT was well-tolerated, with no significant adverse effects, systemic dissemination, or detrimental disruption to the resident gut microbiota. Collectively, our multi-species preclinical data underscore the potential of engineered bacteria as a viable therapeutic strategy for HT1 and possibly other metabolic disorders.
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WATER RESEARCH
·
2026
·
IF 12.8
Xuan Qu,Qian Xu,Zhiqiang Chen,Ang Li
Reactive oxygen species (ROS) generated on or near the oil droplet surface have remarkable potential in altering the structure of 1-adamantanecaboxylic acid (ACA) at the oil-water interface, facilitating separation of oil and water. To stimulate confined multi-phase ROS, a thermodynamic control strategy for ozone catalysis by Fe clusters anchored on nanoscale supports was developed. This strategy explored interfacial pollutant redistribution within film of microdroplets (10-20 μm in size) prepared with a high-speed shear emulsifier. Experimental results indicated that 1 O 2 selectively attacked carboxylic groups confined at the oil-water interface and two-electron migration pathway from ACA to adsorbed O 3 at interfacial oxygen vacancies (O v ) led to spatial redistribution with hydrophilic dihydroxylated intermediates via synchronous electrophilic substitution. ACA attached to interface of microdroplet is fueled by •OH and 1 O 2 , achieving degradation at 89.84% within 30 min, and pseudo-first-order kinetics rate constants ( k obs ) of 0.0793 min –1 . Thermodynamic analysis revealed that 1 O 2 reduced the Gibbs free energy (Δ G ) by 23.98 kJ mol −1 relative to that of •OH. This phenomenon is attributed to the narrow site distribution of Fe clusters, which enhances the overall electron utilization efficiency. These findings demonstrate the feasibility of manipulating ROS to regulate the distribution of interfacial species, representing a promising strategy for promoting the coalescence of oil microdroplets.
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NEW JOURNAL OF CHEMISTRY
·
2026
·
IF 2.6
Xingbo Qi,Lei Ni,Ziyan He,Xu Sun,Hejie Lu,Haiqiang Li,Ruixi Meng,Maosen Fu,Xiao Ma
Cobalt-free, nickel-rich layered oxide cathode material LiNixMn1-xO2 (NM) has attracted much attention due to its high specific capacity and low cost. However, cobalt-free cathode materials have more serious problems such as Li/Ni disorder and structural degradation compared to ternary LiNixCOyMn1-x-yO2 (x ≥0.5, NCM) cathodes. To address these challenges, LiNi0.6Mn0.4O2 (NM64) and a series of Mo-doped Li(Ni0.6Mn0.4)(1-x)MoxO2 (x = 0, 0.01, 0.02, 0.03, 0.04, 0.05) cathode materials were designed and prepared by high-temperature solid-phase method, and the effect of Mo doping on the structure and electrochemical performance of NM64 cathodes was systematically investigated. Mo doping not only suppresses Li/Ni mixing and enlarges interlayer spacing but also effectively inhibits primary particle overgrowth, resulting in refined particle morphology that enhances structural stability and Li+ transport kinetics. Consequently, the Mo-doped NMM cathodes exhibit more stable interface with significantly suppressed side reactions. Li(Ni0.6Mn0.4)0.98Mo0.02O2 cathode exhibited superior capacity retention of 86.83% after 100 cycles at 1.0 C (at 25℃ and 2.8-4.3 V), surpassing the NM matrix by 8.98% and demonstrating the remarkable cycling stability improvement. This work elucidates the structural and interfacial stabilization mechanisms induced by high-valent Mo doping, providing an effective approach to developing high-performance Co-free layered oxide cathodes.
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Small Methods
·
2026
·Vol. 10
·期 4
·e01991
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IF 9.1
Huiling Liu,Xingkai Jia,Xuan Zhang,Lihua Feng,Hongge Pan,Mi Yan,Yinzhu Jiang
Metal-organic frameworks (MOFs) are promising hosts for quasi-solid electrolytes (QSEs) by integrating liquid electrolytes (MOF@LE QSEs), yet stabilizing lithium metal anodes (LMAs) to enhance electrochemical performance remains a challenge. Here, we introduce a strategy leveraging open metal sites (OMSs) in HKUST-1 (Cu 3 (BTC) 2 ) combined with LiNO 3 to tailor solid electrolyte interphase (SEI) chemistry and lithium deposition. OMSs in HKUST-1 anchor NO 3 − and promote LiNO 3 dissociation, enriching SEI with nitrogen-containing inorganic compounds and enabling uniform and spherical lithium morphology. Consequently, LMAs with LiNO 3 -incorporated HKUST-1 membrane QSE (HM-LN QSE) achieve a critical current density of 2.7 mA cm −2 , with stable lithium plating/stripping over 650 h at 0.2 mA cm −2 and more than 300 h at 0.5 mA cm −2 . Moreover, LiLiFePO 4 cells assembled with HM-LN QSEs delivere a discharge capacity of 81.2 mAh g −1 at 5 C and retain 81.2% capacity after 350 cycles at 2 C, demonstrating superior electrochemical stability and performance. This innovative MOF-based approach significantly enhances SEI stability and LMA performance, advancing lithium metal battery technology.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Yuzhuo Wei,WenJing Guo,Shiqi Hao,Xueying Sun,Lina Sun,Erke Sun,Xiaotong Li,Ye Jin,Lihua Zhao
2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) is a highly polar heterocyclic amine with elevated levels in high-temperature meat products and strong carcinogenicity. This study screened Pediococcus acidilactici X3-1B, achieving a PhIP adsorption rate of 74.30%. The stability of the complex formed between the strain and PhIP was highest at 0 h, 4 °C, and pH 7. Scanning electron microscopy (SEM) revealed significant morphological changes in the strain after PhIP adsorption. Fourier transform infrared spectroscopy (FTIR) results indicated that N H and C O groups on the bacterial surface played a primary role in adsorption. Zeta potential measurements revealed an increase in net negative charge on the bacterial surface following PhIP adsorption. Functional group chemical masking indicated that amino groups are one of the core functional groups influencing X3-1B's adsorption of PhIP. This study provides theoretical foundations and practical references for the application of lactic acid bacteria in food safety.
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ENVIRONMENTAL POLLUTION
·
2026
·
IF 7.2
Zixu Li,Muge Xu,Yahan Zhang,Yao Chen,Weiwei Feng,Ting Zhao,Liuqing Yang,Guanghua Mao,Xiangyang Wu
The widespread presence of plastic pollutants, particularly phthalate esters such as dibutyl phthalate (DBP), poses a significant threat to both ecosystems and human health. Despite the accumulating evidence of DBP toxicity, the mechanisms driving DBP-induced hepatotoxicity remain poorly understood. In this study, an integrated approach combining network toxicology, molecular docking, and multidimensional experimental validation was applied to elucidate the molecular pathways through which DBP causes liver damage. Ferroptosis was identified as a central player in DBP-induced hepatotoxicity. The results showed that DBP activates the aryl hydrocarbon receptor (AhR), regulating the NRF2/HO-1 signaling axis, which in turn induces iron overload and lipid peroxidation. Furthermore, ferroptotic hepatocytes release high-mobility group box 1 (HMGB1), activating the TLR4/NF-κB pathway in macrophages and amplifying inflammatory responses that exacerbate liver injury. Crucially, inhibition of either AhR expression or ferroptosis significantly attenuated these changes, highlighting the potential of AhR and ferroptosis as therapeutic targets. Together, these findings establish a novel mechanistic framework for DBP-induced hepatotoxicity: the AhR–NRF2/HO-1–ferroptosis–HMGB1/TLR4 axis. This study advances our understanding of plasticizer toxicity and offers insights for risk assessment and intervention strategies for combating environmental hepatotoxins.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Zhao Haiting,Meng Li,Du Peng,Chen Yun,Gong Mengqi,Zan Bo,Chen Jiaxin,Zeng Mengting,Liao Yiwei
Glioblastoma (GBM) is a highly lethal brain tumor with limited treatment efficacy due to therapy resistance and the blood-brain barrier (BBB). Here, we developed tLyP-1-modified polyethylene glycol (PEG)-coated hollow catalase-mimicking MnO₂-based nanocarriers (HM@si-SLC16A1/TMZ-tLyP-1, tLyP-NPs) for the targeted co-delivery of temozolomide (TMZ) and SLC16A1 siRNA (si-SLC16A1). These nanoparticles generate oxygen through H₂O₂ decomposition, alleviating tumor hypoxia and enhancing MRI imaging via Mn²⁺ release. In vitro, tLyP-NPs exhibited high siRNA loading efficiency, pH-responsive drug release, and effective SLC16A1 silencing, leading to reduced glioma cell viability and enhanced apoptosis under both normoxic and hypoxic conditions. tLyP-1 modification facilitated BBB penetration and glioma targeting, as evidenced by increased cellular uptake in a BMEC–C6 glioma co-culture model. In an orthotopic GBM rat model, the nanoparticles demonstrated superior tumor accumulation, prolonged T1-weighted MRI contrast, and enhanced therapeutic efficacy compared to non-modified formulations. Mechanistically, SLC16A1 silencing induced intracellular lactate accumulation, suppressed lactate-stimulated HCAR1/PI3K/AKT signaling, and promoted apoptosis in both in vitro and in vivo models. Histological analysis showed extensive tumor necrosis, increased apoptosis (Caspase-3, TUNEL), reduced proliferation (Ki67), and alleviated hypoxia (HIF-1α). Survival analysis revealed significantly prolonged survival without systemic toxicity. Collectively, tLyP-NPs represent a promising multifunctional nanoplatform that integrates BBB penetration, TME-responsive drug release, and synergistic chemo-gene therapy for GBM treatment. Graphical abstract
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Journal of Inorganic and Organometallic Polymers and Materials
·
2026
·
IF 6
Li Qiaomei,Hong Wei,Wei Tianyu,Fan Yupeng,Luo Yuhui,Li Jinlou,Qiao Zhihua,Jia Xuemeng,Zhang Dong-En
Metal-organic frameworks (MOFs) have shown great promise for water treatment owing to their tunable porous structures and abundant active sites. However, the practical application of conventional MOFs, such as HKUST-1, is still limited by insufficient structural stability in aqueous environments and poor recoverability in powder form. Herein, a coordination-induced in situ self-assembly strategy was developed to fabricate structurally stable carboxymethyl chitosan (CMCS)@HKUST-1/polyvinylidene fluoride (PVDF) electrospun fibers. In detail, Cu 2+ was first incorporated into PVDF matrix by electrospinning to obtain Cu 2+ /PVDF fibers, which were subsequently immersed in a mixed ligand solution containing 1,3,5-benzenetricarboxylic acid (H 3 BTC) and CMCS, enabling the in situ growth of CMCS-modified HKUST-1 on the fiber matrix. CMCS participated in the coordination-induced assembly process mainly through -COOH/-COO⁻, thereby strengthening the Cu-O coordination environment and improving the resistance of HKUST-1 to water-induced structural degradation. Meanwhile, the flexible CMCS chains and their hydrophilic functional groups enhanced the interfacial interaction, wettability, and accessibility of adsorption sites within the composite fibrous network. The practical potential of CMCS@HKUST-1/PVDF electrospun fibers was evaluated through the treatment of simulated dyeing wastewater, in which it exhibited a high Congo red adsorption capacity of 173.08 mg/g and maintained robust structural stability under elevated temperature treatment at 70 ℃, as well as in aqueous environments over a pH range of 6–10. This work provides a facile and effective strategy for constructing recoverable, structurally stable, and high-performance MOF-based fibrous adsorbents for water treatment applications.
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ACS Food Science & Technology
·
2026
·Vol. 6
·期 8
·2570-2583
·
IF 3
He Wanjun,Lv Danyu,Wu Qingxiao,Xu Huanyu,Guan Yongguang,Zeng Xin-An
Litchi
( L. chinensis Sonn.) is a
perishable fruit that is vulnerable to oxidative browning and fungal
infection. Herein, ferulic acid and natamycin were chosen as the antioxidant
and antimycotic agents, respectively. To improve their water solubility,
we used CD-MOF-1 to encapsulate ferulic acid. Meanwhile, natamycin
was encapsulated with gum arabic and pullulan. The most homogeneous
and stable natamycin nanocapsules were fabricated through stirring
0.5 mg/mL natamycin using 2.5% (w/v) gum arabic-pullulan (1:1, w/w,
1.25% each) in water. The main encapsulation mechanisms of ferulic
acid and natamycin were electrostatic interactions between the carboxyl
groups of ferulic acid and K + ions from CD-MOF-1 and hydrophobic
interactions between the macrocyclic lactone ring of natamycin and
the protein part of gum arabic, respectively. In addition, pullulan
was indispensable for stabilizing natamycin. The antioxidant and antifungal
composite sol presented 99.85% oxidation inhibition and 79.06% mycelial
growth inhibition and effectively delayed the oxidative browning and
fungal decay on litchi pericarps.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Jiaqi Chen,Jiayue Zhao,Yibin Xu,Xianglin Fei,Shujie Xu,Binke Chen,Wenzi Wu,Jiachen Zhuang,Xiuan Zhan,Aikun Fu
Enteric Lactobacillus plays a crucial role in maintaining the intestinal barrier integrity. Lactobacillus reuteri , one of the most described probiotic species of Lactobacillus , has been shown to alleviate enteritis-associated intestinal mucosal damage by stimulating the expansion of intestinal stem cells (ISCs). However, the underlying ligand-protein interactions remain unexplored. Therefore, this study aimed to elucidate the specific molecular mechanisms by which L. reuteri and its metabolites govern ISC stemness. We employed broiler enteritis model and organoid culture to compare the probiotic effect of a wild-type (WT) L. reuteri strain and a reuterin-deficient isogenic mutant. Compared to the WT strain, the deficient strain exhibited an impaired ability to alleviate inflammation, restore the intestinal barrier, and stimulate ISC proliferation both in vivo and ex vivo, indicating that reuterin is the essential effector. Furthermore, bioorthogonal click chemistry combined with in silico molecular docking were utilized to map the direct host protein targets. We identified protein disulfide-isomerase 1 (PDIA1), an endoplasmic reticulum (ER)-resident redox-active protein, as the direct binding partner of reuterin, characterized by a strong binding affinity. The inactivation of PDIA1 by reuterin binding increased ER-derived reactive oxygen species (ROS) level, leading to the upregulation of Wnt/β-catenin pathway and the maintenance of ISCs. In conclusion, by inactivating the ER-resident PDIA1, L. reuteri -derived reuterin promoted ISC proliferation and ameliorated intestinal mucosal damage.
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ACS Nano
·
2026
·
IF 17.3
Gang Zhao,Xiaodong Liu,Xiaodong Wen,Xujun Zhao,Chenchen Hang,Lei Wang,Yuchen Ding,Liming Zhang,Liang Zhang,Yude Su
The tandem strategy for electrochemical CO2 reduction (ECO2R), which utilizes CO gas as the essential intermediate, offers a promising route for converting CO2 into multicarbon (C2+) products. However, inefficient retention and utilization of the CO intermediate remain fundamental issues limiting the practical viability of these tandem systems. Here, we introduce a proof-of-concept “CO reservoir” strategy to directly address this bottleneck. With a well-defined bilayer tandem ECO2R system, we show that incorporating N-doped carbon nanotube (NCNT) as a CO reservoir into the downstream Cu catalyst layer simultaneously enhances the retention time, local concentration, and utilization efficiency of the CO intermediate, a discovery validated by COMSOL simulations, potential-step chronoamperometry, theoretical calculations, and in situ Raman spectroscopy. Enabled by this reservoir effect, the tandem electrocatalyst demonstrates exceptional CO2-to-C2+ performance, achieving a peak C2+ Faradaic efficiency (FEC2+) of 87.1 ± 2.7% and, notably, an optimal C2+ partial current density (jC2+) exceeding 1 A cm–2. The CO reservoir strategy constitutes a promising approach for effective intermediate management in tandem ECO2R systems, establishing a viable tandem route toward industrial-level C2+ production from CO2.
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