JOURNAL OF SURFACTANTS AND DETERGENTS
·
2017
·Vol. 20
·期 5
·1121-1127
·
IF 1.45
Chen Xuewei,Xin Yujuan,Yu Fangcai,Lan Zhili
A series of carboxylic ester-containing imidazolium-based zwitterionic surfactants, namely, monoalkyl 2-(3-methylimidazolium-1-yl) succinate inner salts (C n MimSU, n = 8, 10, 12 and 14), have been synthesized. Their structures were confirmed by 1 H NMR, 13 C NMR and FTIR. The typical physicochemical properties parameters such as isoelectric point, critical micelle concentration (CMC), surface tension at CMC ( γ
CMC ), surface pressure at CMC (Π CMC ), adsorption efficiency (p C
20 ), the maximum surface excess ( Γ
m ), the minimum molecular cross-sectional area ( A
min ) and the value of CMC/ C
20 were determined. The effect of the long-chain length on the important physicochemical properties of C n MimSU was studied. It is found that the surface activity of C n MimSU is enhanced with the long-chain length increases.
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JOURNAL OF SEPARATION SCIENCE
·
2016
·Vol. 39
·期 23
·4585-4591
·
IF 2.741
Xinpei Li,Shigang Wei,Ying Sun,Qun Sun,Li Liang,Bo Zhang,Huilan Piao,Daqian Song,Xinghua Wang
A novel and simple supported ionic-liquid-based solid-phase extraction method for the determination of triazine herbicides in rice was developed. Glass slides were functionalized by an ionic liquid, 1-carboxyethyl-3-methylimidazolium chloride, and were used for the simultaneous extraction of seven triazine herbicides in rice samples. The effects of the type of extraction solvent, the extraction time, the type and volume of loading solvent, and the type of eluting solvent on the extraction efficiency were investigated and optimized. Under the optimum operation conditions, the limits of detection for seven triazine herbicides in rice samples obtained by high-performance liquid chromatography were 3.16–5.42 ng/g, which were lower than the maximum residue levels established by various organizations. The linear correlation coefficients were higher than 0.9975 in the concentration range of 0.015–1.08 μg/g for the seven triazine herbicides. The recoveries of the seven triazine herbicides at the two concentration levels of 0.15 and 0.45 μg/g are between 82.47 and 104.21%, with relative standard deviations of 0.69–9.19%. The intra- and inter-day ( n = 5) precisions for all triazine herbicides at the spiked level of 0.30 μg/g were 1.72–11.71%.
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JOURNAL OF MEMBRANE SCIENCE
·
2016
·
IF 5.557
Shu Xiong,Jian Zuo,Yuan Gui Ma,Lifen Liu,Hao Wu,Yan Wang
In this work, novel thin film composite (TFC) forward osmosis (FO) membranes are developed via interfacial polymerization on the polyacrylonitrile (PAN) substrate, using an organic-inorganic hybrid compound – N-[3-(trimethoxysilyl) propyl] ethylenediamine (NPED) as the amine monomer to mix with m-phenylenediamine (MPD). The PAN substrate was modified with sodium hydroxide and optimized by varying the hydrolyzation time. With the incorporation of NPED in the selective layer, the formed TFC membrane exhibits better hydrophilicity, improved water flux and fouling resistance, and therefore superior membrane performance. By varying the NPED content in the aqueous phase, the surface properties and performance of TFC membranes are investigated with various characterizations. In addition, the anti-fouling properties of the TFC membranes with different NPED content in the aqueous monomer are also studied.
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FOOD RESEARCH INTERNATIONAL
·
2024
·
IF 7
Fang Wu,Yaqiong Liu,Ming Zhang,Xinlei Yuan,Tengteng Ji,Yutong Jin,Yixuan Li,Ran Wang,Yanling Hao,Bing Fang
Recent studies have shown that 1-oleo-2-palmito-3-linoleyl glycerol (OPL) is the most abundant triacylglycerol in human breast milk in China. Epidemiologic studies have shown that sn -2 palmitate improves the absorption of fatty acids and calcium in infants. However, there have been few studies of the specific mechanism by which OPL affects intestinal function. In the present study, we have characterized the effects of various levels of OPL supplementation on the development of the intestinal epithelium and the intestinal microbiota of neonatal mice. OPL supplementation increased the body masses and intestinal lengths of weaned mice and promoted defecation. These positive effects were related to the effect of OPL to promote the development of intestinal villi and crypts. OPL increased the expression of the intestinal stem cell markers Olfm4 and Sox9 in the jejunum and ileum, which promoted their differentiation into goblet cells and Paneth cells. It also promoted the integrity of the epithelial barrier by increasing the secretion of mucin 2 and lysozyme 1 and the expression of the tight junction proteins occludin, ZO1, claudin 2, and claudin 3. More importantly, we found that low dose-OPL promotes the transformation of the intestinal microbiota of neonatal mice to the mature state in 3-month-old mice, increases the proportion of Firmicutes, and reduces the proportion of Bacteroidota. The proportions of anaerobic genera of bacteria, such as Lachnospiraceae_NK4A136_group, Lachnoclostridium, Ligilactobacillus, and Bifidobacterium were higher, as were the key producers of short-chain fatty acids, such as Bacteroides and Blautia . OPL also increased the butyric acid content of the feces, which significantly correlated with the abundance of Lactobacillus . High-dose OPL tended to be more effective at promoting defecation and the development of the villi and crypts, but these effects did not significantly differ from those achieved using the lower dose. A low dose of OPL was more effective at increasing the butyric acid content and causing the maturation of microbes. In summary, the OPL supplementation of newborn mice promotes the establishment of the intestinal epithelial layer structure and barrier function, and also promotes the transformation of the intestinal microbiota to a mature state. This study lays a theoretical foundation for the inclusion of OPL in infant formula and provides a scientific basis for the development of intestinal health products.
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Food Bioscience
·
2024
·
IF 4.8
Yuyue Qin,Hongda Yu,Kejun Chen,Rui Cui,Jianxin Cao,Zhengxuan Wang,Zhi-Hong Zhang,Thanapop Soteyome
The market value of strawberries is considerably impacted by quality deterioration and senescence during postharvest storage. In the study, the effect of isoreticular metal-organic skeleton (IRMOF-3) nanoparticles loaded with eugenol/chitosan-based active packaging film on the metabolism of reactive oxygen species (ROS) and the change rule of the structure of the microbial community in strawberries inoculated with strawberries spoilage bacteria ( Botrytis cinerea ) during the storage period was investigated. The results demonstrated that composite film contribute to the sustenance of reduced hydrogen peroxide and superoxide anion concentrations and the suppression of malondialdehyde accumulation, in contrast to the control group. This investigation revealed that the composite film significantly bolstered the antioxidant enzyme activities and disease resistance-related enzyme activities of strawberries, encompassing polyphenol oxidase, peroxidase, superoxide dismutase (SOD), and catalase (CAT). Moreover, the transcription levels of SOD and CAT genes were notably elevated in strawberries packed within the composite films. Besides, the composite film had an inhibitory effect on pathogenic bacterial genera ( Ralstonia , Sphingomonas , and Erwinia ) and fungal genera ( Botrytis cinerea ) that cause strawberries spoilage and a delayed decline in bacterial genera (unidentified_ Chloroplast and Chryseobacterium ) and fungal genera ( Rhodotorula ) that are biocontrols of strawberries postharvest diseases. Therefore, this study provides novel perspectives on the mechanisms underlying the preservation of fruits and vegetables, focusing on alterations in ROS metabolism and microbiota composition during storage.
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Chinese Medicine
·
2024
·Vol. 19
·期 1
·1-17
·
IF 5.3
Gao Jiaming,Guo Hao,Li Junmei,Zhan Min,You Yue,Xin Gaojie,Liu Zixin,Fan Xiaodi,Gao Qinghe,Liu Jianxun,Zhang Yehao,Fu Jianhua
Background Buyang Huanwu Decoction (BYHWD) is a traditional Chinese medicine to treat the syndrome of qi deficiency and blood stasis. Platelets play an important role in regulating thrombus and inflammation after ischemic injury, studies have shown that BYHWD regulate myocardial fibrosis and exert anti-inflammatory effects through IL-17 and TLR4 pathways, but the mechanism of platelet activation by BYHWD in stable coronary heart disease is still unknown. In the present study, model of left anterior descending coronary artery ligation was applied to investigate the mechanisms of BYHWD on modulating platelets hyperreactivity and heart function after fibrosis of ischemic myocardial infarction (MI). Methods Myocardial infarction model was constructed by ligation of the left anterior descending coronary artery. The rats were randomly divided into five groups: sham, model, MI with aspirin (positive), MI with a low dosage of BYHWD (BYHWD-ld) and MI with a high dosage of BYHWD (BYHWD-hd) for 28 days. Results Coronary artery ligation prominently induced left ventricle dysfunction, increased cardiomyocyte fibrosis, which was accompanied by platelets with hyperreactivity, and high levels of inflammatory factors. BYHWD obviously reversed cardiac dysfunction and fibrosis, increased the thickness of the left ventricular wall, and inhibited aggregation ratio and CD62p expression. BYHWD restored the mitochondrial respiration of platelets after MI, concomitant with an increased telomere expression and decreased inflammation. According to the result of transcriptome sequencing, we found that 106 differentially expressed genes compared model with BYHWD treatment. Enrichment analysis screened out the Ras-related protein Rap-1 (Rap1) signaling pathway and platelet activation biological function. Quantitative real-time PCR and Western blotting were applied to found that BYHWD reduced the expression of Rap1/PI3K-Akt/Src-CDC42 genes and attenuated the overactivity of PI3 kinase/Rap1/integrin α(IIb)β(3) pathway. Conclusion BYHWD reduced inflammation and platelet activation via the PI3 kinase/Rap1/integrin α(IIb)β(3) pathway and improved heart function after MI. Graphical Abstract
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CELLULAR SIGNALLING
·
2024
·
IF 4.4
Wentao Hu,Menghan Wang,Guifang Sun,Limin Zhang,Hong Lu
Parkinson's disease (PD) is a gradually debilitating neurodegenerative syndrome. Here, we analyzed GSE7621 chip data obtained from the Gene Expression Omnibus (GEO) database to explore the pathogenesis of PD. Early B Cell Factor 3 (EBF3), a member of the highly evolutionarily conserved EBF-transcription factor family, is involved in neuronal development. EBF3 expression is low in the substantia nigra of patients with PD. However, whether EBF3 is implicated in dopaminergic neuron death during PD has not yet been investigated. Therefore, we aimed to reveal the potential anti-apoptotic effect and molecular mechanism of EBF3 in PD. We established a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model in vivo and a 1-methyl-4-phenylpyridine (MPP + )-induced SH-SY5Y cell model in vitro . EBF3 was downregulated in the substantia nigra of PD mice and SH-SY5Y cells treated with MPP + , and the m6A methylation modification level was low. Fat mass and obesity-associated protein (FTO) siRNA upregulated m6A methylation modification of EBF3 and extended the EBF3 mRNA half-life. Functionally, as demonstrated by the results of the open-field test, pole test and gait analysis, EBF3 overexpression ameliorated MPTP-induced behavioral disorder. Further, EBF3 overexpression suppressed neuronal apoptosis in vivo , as evidenced by decreased TUNEL + cells, and the increased activation of caspase-3 and caspase-9. Similar results were obtained in vitro , as reflected by increased cell viability, decreased LDH activity and restored mitochondrial function, collectively protecting SH-SY5Y cells from MPP + -induced apoptosis. Mechanistically, the results of luciferase reporter, ch-IP and DNA pull-down assays confirmed that, as a transcription factor, EBF3 bound to the promoter of CNTNAP4 (a protein associated with neuronal differentiation) and directly regulated CNTNAP4 transcription. Strikingly, CNTNAP4 knockdown markedly abolished the effect of EBF3 on cell apoptosis, thus aggravating PD. In conclusion, the low level of m6A methylation modification may contribute to the low expression of EBF3 during PD. Additionally, EBF3 attenuates PD by activating CNTNAP4 transcription, suggesting that EBF3 may be a novel therapeutic target in PD.
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Food Bioscience
·
2025
·
IF 5.9
Mengli Wang,Xinjing Li,Foxin Zhang,Heping Cui,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
Extra-added l- cysteine effectively inhibited the browning of Maillard peptides (MPs) derived from Lentinus edodes . Meanwhile, an unsaturated fatty acid (UFA) was introduced to increase the content of 1-octen-3-ol (mushroom alcohol) to enhance the mushroom aroma of the MPs. Among the three UFAs tested, linoleic acid (LA) exhibited the strongest promoting effect on 1-octen-3-ol, resulting in a 1-octen-3-ol content of 74.57 ± 1.48 μg/L in MPs. When LA was co-heated with l- cysteine and/or xylose, a synergistic effect was observed between LA and l- cysteine, leading to the highest 1-octen-3-ol content of 211.29 ± 3.62 μg/L in LA- l- cysteine-xylose system. The enzymatic hydrolysate of commercial safflower seed oil was further used as an alternative source of LA to fortify the typical mushroom flavor. The incorporation of 25 % safflower seed oil hydrolysate was recommended to enhance the 1-octen-3-ol production (133.09 ± 8.74 μg/L) in MPs. These findings provide new ideas for enhancing the mushroom aroma, offering potential applications in flavor design and food processing.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Zhenfeng Xie,Yi Wu
Emulsion-based carriers have been widely studied for the co-encapsulation of active ingredients with different partition coefficient (Log P). However, it is challenging to encapsulate active ingredients with low Log P values in emulsified oil droplets. In this study, (-)-epigallocatechin gallate (EGCG, 160 µg/g*emulsion, Log P 2.38) and resveratrol (Res, 320 µg/g*emulsion, Log P 2.57), as models with low Log P, were co-encapsulated in emulsified oil droplets for the first time by peppermint essential oil (PEO) mediation. During storage process, EGCG and Res consistently remain co-located inside the emulsified oil droplets. However, both EGCG and Res migrated towards the inner layer of the interface of emulsified oil droplets along with PEO. Res exhibited better stability compared to EGCG, while the degradation of EGCG occurred within the emulsified oil droplets. Furthermore, when co-localized with Res, the degradation rate of EGCG slowed down. PEO did not degrade during storage, and over 98 % of PEO was encapsulated within the emulsified oil droplets. This is the crucial reason for maintaining the stability of SC-stabilized emulsion and achieving high encapsulation efficiency of active ingredients. This provides a green and simple strategy for co-encapsulation of active ingredients with Log P lower than 3.0 within emulsified oil droplets.
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JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Yang Chen,Jianda Niu,Siheng Zhang,Zhixian Dong,Jinbao Xu,Caihong Lei
The quest for next-generation energy storage systems has led to the development of high-voltage all-solid-state lithium metal batteries (ASSLMBs), which promise unprecedented energy density and safety. However, the challenge lies in creating of a robust electrolyte that can meet high room temperature ionic conductivity, Li-ion transference number and a wide electrochemical stability window (ESW) while maintaining flexibility and compatibility with lithium metal anodes. Here, novel polyurethane-based composite polymer electrolytes (CPEs) have been successfully fabricated by the cross-linking reaction of poly(1,5-dioxepan-2-one) diols (poly(ether-ester) soft segment) and hexamethylene diisocyanate trimer (hard segment) (PDH) blending with inorganic NASICON-type ceramic fillers Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (PDH@LATP). The resulting CPE exhibits an impressive ionic conductivity of 1.65 × 10 −4 S cm −1 at room temperature and a Li-ion transference number of 0.63, which is attributed to the amorphous structure of PDH and the formation of an interconnected ionic pathway by the inorganic filler. The incorporation of LATP also improve the ESW of CPE to 5.3 V while maintaining good mechanical properties. Therefore, the assembled LiFePO 4 /PDH@LATP/Li batteries displayed low interfacial resistance, Li dendrite suppression, high specific capacity and excellent cyclic performance. The high-voltage LiNi 0.5 Co 0.2 Mn 0.3 O 2 /PDH@LATP/Li batteries also exhibits good cycling performance and durability. The design principles and materials presented herein provide a blueprint for the next wave of ASSLMBs.
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Biomaterials Advances
·
2024
·
IF 5.5
Wuming Wu,Xiaolian Jiang,Qin Zeng,Huiyu Zou,Chunyan Deng
In this study, epigallocatechin-3-gallate nanospheres (EGCG NSs) are employed as an innovative alternative to traditional reducing agents for the in-situ growth of AuNPs on the EGCG NS surface to produce the Au nanoparticles decorated EGCG nanospheres (EGCG NS@AuNPs). This eco-friendly approach avoids toxic chemicals and simplifies the synthesis process, enhancing biocompatibility and functional properties of the resulting EGCG NS@AuNPs nanocomposite. The nanocomposite exhibits remarkable stability, photothermal properties, and peroxidase-like enzymatic activity. Taking advantage of the enhanced photothermal properties, the application of EGCG NS@AuNPs in the antibacterial field was investigated, and the antibacterial activity was greatly improved against both Gram-negative and Gram-positive bacteria comparing to bare AuNPs or EGCG Ns. Additionally, based on the excellent enzymatic activity, the sensing application of EGCG NS@AuNPs was explored by developing a colorimetric method for detecting ascorbic acid (AA). A remarkably low detection limit of 0.076 μM was achieved. This method has been successfully applied to measure the AA content in vitamin C tablets, demonstrating the practicality and accuracy of this approach. Therefore, the synthesis for EGCG NS@AuNPs is not only rapid, and cost-effective, but also eco-friendly and not harmful to biological systems, which is potential in biosensing, clinical diagnosis, and therapeutics. Future research could explore further applications of EGCG NS@AuNPs in biomedicine field, revealing even more of its remarkable potential.
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ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Sen Yang,Li Wu,Yujian He,Xiangjun Li
Background 3-Hydroxyaspartate(3-HA) is a non-proteinaceous amino acid whose four stereoisomers have different biological functions, making it meaningful to separate and analyze them. A combination of capillary zone electrophoresis-mass spectrometry (CZE-MS) and electron circular dichroism enables the separation and analysis of the four stereoisomers of 3-HA, but relies on enantiomeric standards. In contrast, the new method based on vibrational circular dichroism (VCD) can successfully confirm the peak order of the four enantiomers simultaneously without a single enantiomeric standard. This method is suitable for molecules without UV absorption, as well as for molecules with polychiral centers, and does not require enantiomeric standards. Results We present a new analytical method based on CZE-MS coupled with VCD for the simultaneous determination of four stereoisomers of 3-HA with two chiral centers (D- threo -3-hydroxyaspartate, D-THA; L- threo -3-hydroxyaspartate, L-THA; D- erythro -3-hydroxyaspartate, D-EHA; L- erythro -3-hydroxyaspartate, L-EHA) in the absence of an optically pure single enantiomeric standard. The semipreparations of the non-racemic mixtures of DL-THA and DL-EHA were performed using high performance liquid chromatography (HPLC), with enantiomeric excess values reaching 90%. By comparing the experimental VCD spectra of the DL-THA/DL-EHA mixture with the theoretical VCD spectra of the single L-THA/L-EHA enantiomer, the configuration of the dominant enantiomer in the nonracemic mixture was determined, where the two characteristic peaks in the 1250-1750 cm -1 spectral range fitted well. Finally, combined with the comparison of CE peak areas, the four stereoisomers were identified successfully. Significance This is the first combined CZE-MS and VCD method for the simultaneous separation and analysis of four stereoisomers of 3-HA without relying on enantiomeric standards. This method is simple and reliable, and provides a new idea for the separation and analysis of chiral compounds with polychiral centers, which are difficult to obtain from enantiomeric standards.
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