JOURNAL OF NANOBIOTECHNOLOGY
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2020
·Vol. 18
·期 1
·1-19
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IF 6.518
Li Mingxin,Liu Guohao,Wang Kaixuan,Wang Lingfeng,Fu Xiang,Lim Lee Yong,Chen Wei,Mo Jingxin
Primary intracerebral hemorrhage (ICH) is a leading cause of long-term disability and death worldwide. Drug delivery vehicles to treat ICH are less than satisfactory because of their short circulation lives, lack of specific targeting to the hemorrhagic site, and poor control of drug release. To exploit the fact that metal ions such as Fe2+ are more abundant in peri-hematomal tissue than in healthy tissue because of red blood cell lysis, we developed a metal ion-responsive nanocarrier based on a phosphonated calix[4]arene derivative in order to deliver the neuroprotective agent dauricine (DRC) specifically to sites of primary and secondary brain injury. The potential of the dauricine-loaded nanocarriers for ICH therapy was systematically evaluated in vitro and in mouse models of autologous whole blood double infusion. The nanocarriers significantly reduced brain water content, restored blood-brain barrier integrity and attenuated neurological deficits by inhibiting the activation of glial cells, infiltration by neutrophils as well as production of pro-inflammatory factors (IL-1β, IL-6, TNF-α) and matrix-metalloprotease-9. These results suggest that our dauricine-loaded nanocarriers can improve neurological outcomes in an animal model of ICH by reducing inflammatory injury and inhibiting apoptosis and ferroptosis.
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TALANTA
·
2020
·
IF 5.339
Huadong Zhang,Huasheng Lai,Gongke Li,Yufei Hu
Halloysite nanotubes loaded with 4-aminothiophenol capped silver nanoparticles (mHNTs-AgNPs 4−ATP ) composite was synthesized as a sensitive surface-enhanced Raman scattering (SERS) probe for the determination of nitrite ions in sausage and pork luncheon meat . The as-prepared composite was characterized by transmission electron microscope, X-ray diffraction spectroscopy and Fourier transform infrared spectroscopy . The as-synthesized mHNTs-AgNPs 4−ATP composite with evenly distribution of AgNPs can provide in-situ derivatization site for sensitive and selective SERS detection of nitrite ions. Under acid condition, the 4-ATP capped on the AgNPs can be transformed into p , p ’-dimercaptoazobenzene (DMAB) through nitrite-triggered diazo reaction. This efficient nitrite-triggered reaction can be used to detect nitrite via the characteristic peaks of DMAB at 1143 cm −1 , 1392 cm −1 , and 1434 cm −1 . This SERS method has a wide logarithmic range of 0.0069–6.9 mg L −1 , with detection limit of 0.78, 3.4, 0.51 μg L −1 at the peak of 1143 cm −1 , 1392 cm −1 , and 1434 cm −1 , respectively. Besides, this method can be applied to detect nitrite ions in sausage and pork luncheon meat with relative standard deviation less than 10.3%, and the results were consistent with that analyzed by UV–Vis method. This method has good potential in efficient detection of meat product in food safety.
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SURFACE AND INTERFACE ANALYSIS
·
2016
·Vol. 48
·期 9
·990-994
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IF 1.018
Yuanjie Teng,Guocheng Ding,Wenhan Liu,Jiangmei Liu,Yonghui Nie,Pan Li
Column electrodes pretreated through oxidation–reduction cycles were traditionally used in electrochemical surface-enhanced Raman scattering (SERS). In this study, a disposable screen-printed carbon electrode was introduced into in situ electrochemical SERS through the electrodeposition of dendritic gold/silver nanoparticles (Au/AgNPs) onto the surface of the carbon working electrode to induce the SERS enhancement effect on the electrode. Scanning electron microscopy images showed that dendritic Au/AgNPs nanostructures could be fabricated under appropriate electrodeposition conditions and could present a minimum SERS factor of 4.25 × 10 5 . Furthermore, the absorbed behavior of 4-mercaptopyridine was investigated under different potentials. The adsorption configuration was inferred to transform from ‘vertical’ to ‘lying-flat’. The proposed new electrode combined with a portable Raman spectrometer could be useful in the identifying products or intermediates during electrochemical synthesis or electrochemical catalysis in in situ electrochemical SERS. Copyright © 2016 John Wiley & Sons, Ltd.
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ACTA CHIMICA SLOVENICA
·
2017
·Vol. 64
·期 4
·825-831
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IF 0.983
Ren YJ,Zhu JL,Zhang LX,Xu YX,Qian SS.
Three new complexes derived from 2-(4-(pyridin-2-yl)piperazin-1-yl)acetic acid (HL), [M(L)2(H2O)2] where M = CuII (1), ZnII (2) and CdII (3), have been synthesized and characterized by IR spectroscopy, elemental analysis and X-ray crystallography. The inhibitory activity of these three complexes against MAO-B was tested in vitro, and the molecular docking experiments were also carried out to rationalize their binding models. Both the experimental and docking simulation results indicated that complex 1 has the best inhibitory activity with IC50 value being 6.5 ± 0.31 μM.
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BMC Chemistry
·
2025
·Vol. 19
·期 1
·1-14
·
IF 4.6
Zhang Qiuyun,Li Xingxin,Wu Hanhong,Xu Nian,Chen Liangfu,Chen Lianlian,Deng Taoli,Ma Juan,Zhang Yutao
Metal-organic frameworks (MOFs) are promising heterogeneous catalysts or catalyst support materials for biodiesel production due to their high surface area, tunable porosity, and diverse morphology. However, developing bimetallic MOFs that combine easy scalability, high stability, and good catalytic activity that are beneficial for large-scale synthesis and applications is still highly desirable. Herein, a fascinating bimetallic Bi/Ce-MOFs (Bi/Ce-BTC) supported heteropolyacid (HPMo) was constructed by a simple hydrothermal synthesis strategy, and its catalytic performance was evaluated in the esterification of oleic acid. A comprehensive characterization of the composite material’s structure, composition, and properties was performed using various techniques (XRD, FTIR, N 2 physisorption, SEM-EDS, TG, NH 3 -TPD, Py-FTIR, and XPS). These characterization techniques thoroughly confirm the successful impregnation of HPMo on the Bi/Ce-BTC, and it possesses a relatively large specific surface area, meso-porosity, high acidity capacity, and synergistic catalytic effect between the substrates. Catalytic experiments demonstrated that HPMo@Bi/Ce-BTC exhibited the best catalytic performance, achieving 92.7% conversion of oleic acid under optimal reaction conditions. Remarkably, the catalyst could be easily reused six times with an acceptable oleic acid conversion (79.3%). In addition, the kinetic analysis of the esterification reaction by HPMo@Bi/Ce-BTC catalyst showed pseudo-first-order kinetics, with activation energies found to be 60.9 kJ/mol. Overall, the employment of bimetallic MOFs for impregnation of active species paves a potential way for broad applications in sustainable chemical processes. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 30
·1-13
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IF 2.8
Huang Yi-Rui,Li Wei,Wang Ze-Hong,Jian Xiao-Jian,Zhou Zi-Zhe,Jia Xiang-Xiang,Liu Hong-Yu,Lu Yi-Fan,Wang Jun-Chuan,Wu Xiang-Feng,Wang Hui,Zhou Er-Peng
Chiral optoelectronic sensors detect chirality by selectively binding with chiral substrates, causing changes in electrical signals, which have attracted wide attention for their chiral recognition ability. In this study, the Ti 3 C 2 /ZIF-67/D-His electrochemical sensors were successfully synthesized. Firstly, ZIF-67/D-His was obtained using hexahydrated cobalt nitrate, dimethylimidazole, and D-histidine (D-His). Then, the ZIF-67/D-His film was grown on the surface of the Ti 3 C 2 film using a spin-coating method. By changing the spin-coating cycles, the influence of the ZIF-67/D-His film thickness on the detection performance was studied. The results showed that when the spin-coating cycle was three, the electrochemical sensor (Ti 3 C 2 /ZIF-67/D-His-3) exhibited good detection performance for D-Ala with a detection limit of 1.1 μM, and additionally demonstrated an excellent selective detection ability for D-Ala, with a significant difference in the differential pulse voltammetry (DPV) current intensity between D-Ala and L-Ala solutions. Besides, the detection curve for D-Ala showed a linear relationship with the concentration of the D-Ala solution. Furthermore, the Ti 3 C 2 /ZIF-67/D-His-3 electrochemical sensor demonstrated good stability and could be reused multiple times after simple cleaning. The Ti 3 C 2 /ZIF-67/D-His prepared in this work shows promising application potential in the area of electrochemical sensors.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-24
·
IF 15.7
Zheng Liu-Ting,Yan Zeng-Shuai,Li Xin-Yue,Chang Jia-Jia,Tan Xiao-Qi,Wang Yu-Xing,Ding Hong-Ming,Liu Qin,Ma Yu-Qiang,Huo Da
Membraneless organelles form by phase separation and regulate cell behavior. We show that cholesterol-patterned AuNPs program nanomaterial-induced stress granules (NSGs) by lowering G3BP1 condensation barriers through a solid–liquid–liquid triphasic sequence: nanomaterials recruit hnRNPC, which then engages G3BP1 to nucleate gel-like condensates. We map NSG microenvironments (temperature, polarity, pH, and proteasome activity), uncover dual disassembly—a slow VCP/19S-dependent route and a rapid SUMO/20S-dependent backup—and show that NSGs remodel chemo-plasticity: they mitigate doxorubicin/cisplatin toxicity in normal tissues yet sensitize tumors to nocodazole in vivo. Local induction and selective dissolution of NSGs thus offers a strategy to decouple efficacy from toxicity. Our results establish design rules linking nanomaterial surface chemistry to condensate programming and provide actionable levers to steer therapeutic outcomes.
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Food and Bioprocess Technology
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2025
·
IF 5.8
Huang Jie,Li Yu,Hu Jielun,Liu Huan
This study aimed to evaluate the effects of microwave treatment on the physicochemical properties of konjac glucomannan (KGM) and the prebiotic potential of KGM fractions with varying molecular weights (Mw). After microwave treatment, KGM exhibited a significant reduction in Mw which resulted in dramatic structural alterations including a transition to rod-like chain conformation and amorphous crystallinity, and fragmented surface morphology. The in vitro fermentation assay revealed that microwave-treated KGM fractions can be more effectively metabolized by gut microbiota, and the lower the molecular weight, the superior the fermentability. Strikingly, both total short-chain fatty acids (SCFA) and valeric acid in lower-Mw KGM fractions showed significantly higher concentrations than those in inulin. Microbiota diversity and composition analysis revealed that consumption of microwave-treated KGM significantly increased the relative abundance of beneficial gut microbiota, especially Firmicutes , Actinobacteria , and Lactobacillus , indicating enhanced prebiotic activity. Graphical
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JOURNAL OF FLUORESCENCE
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2025
·
IF 3.1
Zhou Siqi,Ruan Chen,Hou Yuxian,Zou Lina,Wang Rong,Li Gaiping
Dopamine (DA), a crucial neurotransmitter, plays a pivotal role in various physiological and pathological processes, making the development of simple and novel detection methods highly significant. Herein, a facile ratiometric platform was constructed for ultrasensitive detection of DA based on the nanozyme facilitated in-situ fluorogenic reaction. Firstly, GMP-Ce 4+ CPs with enhanced oxidase-like activity were produced via an extremely simple one-step self-assembly method, which could efficiently initiate the fluorogenic reaction between DA and β-naphthol (β-NAP). Relying on the enhanced catalytic ability and the specificity of the fluorogenic reaction, a ratiometric platform was established by introducing rhodamine B (RhB) as a fluorescence reference. The proposed ratiometric method exhibited wide linear range (0.001-30 µM), ultra-high sensitivity (LOD 0.6 nM) and great selectivity. Finally, the designed method has been used for DA assay in practical health blood serum (HBS) samples with satisfactory results, demonstrating its potent analytical applicability in the biosensing field. Graphical
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CHINESE JOURNAL OF POLYMER SCIENCE
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2025
·
IF 4
Qian Yu-Ke,Feng Shao-Bo,Song Zi-Yuan
The preparation of polypeptide materials in continuous flow reactors shows great potential with improved reproducibility and scalability. However, conventional polypeptide synthesis from the polymerization of N -carboxyanhydride (NCA) is conducted at relatively slow rates, requiring long tubing or ending up with low-molecular-weight polymers. Inspired by recent advances in accelerated NCA polymerization, we report the crown-ether-catalyzed, rapid synthesis of polypeptide materials in cosolvents in flow reactors. The incorporation of low-polarity dichloromethane and the use of catalysts enabled fast conversion of monomers in 30 min, yielding well-defined polypeptides (up to 30 kDa) through a 20-cm tubing reactor. Additionally, random or block copolypeptides were efficiently prepared by incorporating a second NCA monomer. We believe that this work highlights the accelerated polymerization design in flow polymerization processes, offering the continuous production of polypeptide materials.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 4
Liu He-Chen,Li Xiang-Qing,Zhou Xin-Xin,Tian Huai-Qing
The introduction of dynamic covalent bonds into the structure of epoxy resins can improve the degradation performance of the materials. But to a certain extent, it will affect the insulating properties of the resin, and how to balance the insulating properties and degradation performance has become an urgent problem. In this paper, the effects of different catalysts on the thermal-force-electrical properties of sorbitol-based resins were systematically investigated based on the dynamic ester bonding to construct the resin crosslinking network, and the biobased sorbitol glycidyl ether was used as the resin matrix. The experiments show that the resin system catalyzed by triethanolamine (TEOA) exhibits excellent comprehensive performance, which combines good thermal stability and mechanical properties with excellent electrical properties (breakdown field strength of 44.21 kV/mm and dielectric loss factor of 0.29%). In addition, chemical degradation tests were conducted on the resin systems with different catalysts, and the experiments showed that the produced resins could be degraded in benzyl alcohol and exhibited good degradation performance. This study provides a theoretical basis and technical path for the development of new bio-based electrical insulating materials with both high insulation and degradation properties, which is conducive to the popularization and application of bio-based resins in the field of electrical equipment.
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Zhang Peng,Xu Faou,Li Wen,Chen Weiyin,Zhang Wenxin,Zhang Tong
Self-healable and antibacterial electronic skins with the appropriate mechanical performance have paid great attention to the smart devices, health information storage and signal sensing. However, conventional electronic skins are susceptible to bacterial colonization and microbial adhesion, which poses additional health risks. Therefore, developing antibacterial elastic substrates with tailored morphological features is crucial for practical applications. Herein, a bioinspired photopolymerized self-healing antibacterial architecture is reported. Multifunctional trimethylolpropane triacrylate (TMPTA) was integrated with acrylate-terminated polydimethylsiloxane (PDMS-IU-MA) to fabricate a coral-like dendritic structure with particular convex wrinkles through sandpaper-mold templating, thereby imparting the antibacterial properties. With the increase in TMPTA content, the elastomer presents the progressive antibacterial abilities of inhibiting Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. Aureus ) growth. Meanwhile, the introduction of multiple hydrogen bonds endows the elastomers with self-healing properties. Integrated with the flexible conductive circuit, a resistance-changed sensor with antibacterial and self-healing properties was developed for personalized motion monitoring, based on the PDMS-IU-MA elastomer. This work is expected to bring fresh horizons to the design of multifunctional sensing materials and establish the foundation for the development of antibacterial electronic skin. Graphical abstract
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