Scientific Reports
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2025
·Vol. 15
·期 1
·1-17
·
IF 3.9
Zhao Yuliang,Sun Tingting,Zhang Huawei,Lian Chao,Zhao Zhongpeng,Jiang Yongqiang,Duan Huiqi,Ren Yuhao,Sun Xuyang,Zhan Zhikun,Qu Mingyue,Chen Shaolong
Staphylococcal enterotoxin B (SEB) holds critical importance in disease diagnosis, food safety, and public health due to its high toxicity and potent pathogenicity. Traditional immunoassay methods for detecting SEB often exhibit insufficient accuracy and robustness. This study leverages machine learning technology to integrate the quantitative measurement advantages of electrochemical methods with the strong specificity of immunoassays, achieving high-precision coupled electrochemical immunodetection of SEB. Firstly, an electrochemical immunosensing system was developed to capture the target analyte SEB by immobilizing specific antibodies on the electrode surface. Cyclic voltammetry (CV) was utilized to accurately characterize the immune response process. Secondly, feature selection methodologies within machine learning are utilized to identify eight key parameters from CV curves that are highly related to SEB concentration. This enhancement significantly improves both the accuracy and interpretability of SEB measurement data. Lastly, a multivariate linear regression algorithm is employed to effectively train and fit the extracted feature data. This approach successfully mitigates noise introduced by variations in electrode batches, experimental conditions, and operational techniques-thereby enabling robust quantitative measurements of SEB concentration with high precision. The entire detection process requires only 20 μL sample and is accomplished in just two minutes. This method can detect antigen concentrations at both ng/mL and μg/mL levels, with a detection limit of 1 ng/mL. The \(R^2\) score for predicting SEB antigen concentration is approximately 0.999, accompanied by a mean absolute percentage error (MAPE) of 6.09% This approach achieves high precision, robustness, and specificity in SEB detection, offering extensive detection range, rapid response time, and cost-effectiveness, presenting new opportunities for identifying various pathogenic toxins.
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Journal of Inorganic and Organometallic Polymers and Materials
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2025
·
IF 4.9
Bai Yizhuo,Zhang Shiyu,Zhang Kaifan,Li Jiali,Zhang Jiehe,Hao Mingxu,Tao Haisheng
Nitro-functionalized NO 2 -MIL-53(Fe) was synthesized by modifying MIL-53(Fe) to enhance persulfate activation for the degradation of tetracycline (TCN). Comparative studies with NH 2 -MIL-53(Fe) and pristine MIL-53(Fe), it was found that NO 2 -MIL-53(Fe) is categorized as an ideal type I isotherm, without observable hysteresis loop. The introduction of nitro-group incorporation significantly increased specific surface area clocking in at 298.3 m 2 /g and an average pore diameter of 3.3 nm, created uniform micropores, and improved adsorption capacity. Structural characterization confirmed Fe(II) generation and electron transfer in NO 2 -MIL-53(Fe), enabling 82.1% TCN removal within 30 min. Radical (SO 4 ·− , ·OH, O 2 ·⁻ ) and non-radical ( 1 O 2 , charge transfer) pathways synergistically drove degradation, as evidenced by quenching experiments and EPR analysis. ESI-Q-TOF MS identified key intermediates, proposing plausible TCN degradation pathways. This study highlights the potential of nitro-functionalized metal-organic frameworks (MOFs) in advanced oxidation processes, emphasizing their enhanced catalytic activity and performance mechanisms, and provides new ideas for the remediation of pollutants in water bodies. Graphical abstract
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JOURNAL OF POROUS MATERIALS
·
2025
·
IF 3.2
Yan Xuemei,Gou Zenian,Chang Weichun,Liu Ruixiang,Su Jikai,Su Dong,Li Xiaolei
The inherent brittleness of pure SiO 2 aerogels due to the fragile Si–O–Si bonding connection at the neck greatly limits their applications. The limitations in mechanical properties of SiO 2 aerogels can be effectively overcome through the recent advancements in organic–inorganic hybrid systems. In this paper, resorcinol- formaldehyde (RF) reinforced silica aerogels (RSA) were synthesized using tetraethyl orthosilicate (TEOS) as the silicon precursor through a two-step sol–gel approach coupled with an ethanol supercritical drying process. The structural evolution and properties of aerogels during RSA's preparation were studied in relation to RF sol properties, gelation catalysts, and the doping content of RF sol. In particular, the aerogels crosslinked with γ-aminopropyltriethoxysilane (APTES), exhibit multifunctional properties including a high specific surface area of 802 m 2 /g, a low density of 0.208 g/cm 3 , a low thermal conductivity of 0.0230 W/(m·K), good hydrophobicity (a water contact angle of 141.5°) and compressive strength (0.58 MPa at 10% strain). The thermally insulating, hydrophobic and robust resorcinol–formaldehyde modified silica aerogel materials have positive significance in expanding the applications of silica aerogels.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2025
·Vol. 36
·期 1
·1-12
·
IF 4.5
Chi Menghui,Zhang Leyuan,Deng Bing,Lin Jing,Wang Qian,Zhang Lina,Yin Min,Gu Lingwen,Li Daohao,Zhao Guiqiu,Li Cui
The blindness rate of fungal keratitis is high, however, traditional therapy, like eye drops, has poor bioavailability. To make the traditional treatment more effective, new drug-loading system was explored, which can attach to the ocular surface to prolong the release time of natamycin (NATA). Sodium alginate (SA) has attractive properties of biocompatibility, biodegradability, which have been exploited to be natural-origin polymer of drug release. Because of special egg box structure of SA, the sodium ions in the structure can be exchanged with divalent cations through crosslinking, which could control the pore size inside the material and release rate of the loaded drug. Here, we utilized the composite of sodium alginate and polyethylene oxide (PEO) with natamycin loaded through crosslinking with calcium ion ethanol aqueous solution to delay drug release and treat fungal keratitis. The results from experiments proved that the membrane with the slowest rate of drug release was the group with the ratio of ethanol to water 2:1, and the 1% natamycin-loaded films could effectively inhibit the growth of Aspergillus fumigatus . SA-PEO membranes could reduce the inflammatory response. Conclusively, NATA-SA-PEO films could be considered a useful approach to prolong ocular natamycin maintenance and improve the outcome of fungal keratitis. Graphical
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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
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2025
·
IF 3.3
Wang Xiang,Zhang Di,Li Charlie,Zhang Junwei,Tong Cailing,Sun Yilan,Pang Jie
Pure konjac glucomannan (KGM) film has certain limitations in mechanical properties, antioxidant activity, and preservation ability. To solve these limitations, osmanthus powder (OP) was innovatively added to KGM film-forming solution to prepare KGM-based film by casting method.The effect of varying amounts of OP on the rheological properties of film-forming solution, the structure, physicochemical, functional properties of KGM edible film were evaluated. The results showed that the addition of different amounts of OP variously affects the performance of the KGM film. The addition of OP enhanced the mechanical properties, antioxidant, antibacterial, UV blocking, and degradation ability of the film. Furthermore, when the addition amount of OP was 0.25%, the KGM edible film containing osmanthus aroma exhibited optimal overall performance. The film showed good mechanical properties, antioxidant, UV blocking, and had preservation effects for fresh-cut apples. Additionally, the addition of OP improved the sensory evaluation of edible films, imparting them with a unique osmanthus aroma, thus providing a new method to improve edible film packaging.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
·
IF 4.6
Yin Hao-Ting,Ye Dong-Yuan,Zhao Wei,Wei Xue-Wei,Meng Xiao-Yu,Ye Hai-Mu
Poly(ethylene succinate) (PES), a promising biodegradable polyester with cost advantages, suffers from inherently slow crystallization kinetics, which severely limits its processability and practical applications. To address this challenge, this study explored the use of commercially available, low-cost, and food-safe sugar alcohols, including Xylitol (Xy), D-sorbitol (DS), and D-mannitol (DM), as effective nucleating agents for PES. Remarkably, all three polyols significantly enhanced the nucleation and crystallization ability of PES, with DM exhibiting the most pronounced effect. DM increased the crystallization temperature by up to 23.9 °C and accelerated the overall crystallization rate by more than 13-fold at only 0.5 wt% loading level. Through a combination of differential scanning calorimetry (DSC), polarized optical microscopy (POM), and wide-angle X-ray diffraction (WAXD) analyses, we revealed that DM promotes PES crystallization via a dual mechanism: epitaxial templating facilitated by excellent lattice matching, and enhanced chain adjustment through intermolecular hydrogen-bonding interactions. In contrast, Xy and DS primarily function through hydrogen-bonding interactions. This work not only identifies DM as a highly efficient, economical, and industrially viable nucleating agent for PES, but also provides fundamental insights into the role of the molecular structure and crystallization ability of nucleating agents in regulating polymer crystallization.
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Food and Bioprocess Technology
·
2026
·Vol. 19
·期 3
·155
·
IF 5.6
Fan Zhihao,Shen Yu,Usman Muhammad,Su Kerui,Shahid Ayesha,Zhao Anqi,Li Xinyu,Zhang Beixiao,Xu Jingliang
Spirulina platensis is a nutrient-rich cyanobacterium with immune-enhancing, anti-aging, and cholesterol-lowering properties. However, fresh Spirulina is highly susceptible to spoilage during storage. This study developed a preservation strategy based on curcumin encapsulated in hydroxypropyl- β -cyclodextrin (HBC-Cur) to improve the storage stability of fresh Spirulina . During storage, treatment of fresh Spirulina with 2 mg/mL HBC-Cur exhibited protective effects by synergistically inhibiting microbial growth and mitigating oxidative reactions. Chlorophyll content was retained at 74.39% of the initial level. In terms of lipid and protein oxidation, malondialdehyde (MDA) content decreased by 45.73%, and protein carbonyl formation was reduced by 19.69%, indicating effective alleviation of oxidative deterioration. In addition, biogenic amines remained at consistently low levels, with putrescine content reduced by 76.53% relative to the control after 8 days. During the late storage phase, oxidative rancidity and spoilage-related VOCs, including hexanal, heptanal, nonenal, propionic acid, and nitrogen- and sulfur-containing volatiles, significantly increased in the control, whereas the VOCs of HBC-Cur-treated Spirulina remained relatively stable. This approach may offer a potential strategy for preserving bioactive components and suppressing the formation of spoilage-related compounds in Spirulina with implications for the development of sustainable food storage technologies. Graphical
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IONICS
·
2026
·
IF 3.4
Yang Shan,Qin Liming,Chen Yehong,Wu Chaojun
The rational and effective combination of different electrochemical substances to prepare high ionic conductivity supercapacitor gel polymer electrolytes (GPEs) has been widely studied by researchers. Currently, most work focuses on adding many crosslinker or initiator agents into polymers to prepare the GPE of supercapacitor. This method is efficient, but the steps are tedious. In this study, a GPE exhibiting high ionic conductivity across a wide temperature range is developed by integrating TEMPO-oxidized cellulose nanofiber (TOCNF) through a facile freeze-thaw method. The findings revealed that the gel polymer electrolyte of PTC-7 showed a high ionic conductivity of 6.0 S m −1 at a temperature of 25 °C, a tensile strength of 403.81 kPa, and a compressive strength of 624.17 kPa. The fabricated symmetric supercapacitor demonstrates stable charge-discharge characteristics under harsh environmental conditions ranging from − 25 °C to 75 °C. Even after bending 90° or 180° at room temperature, it retains its original electrochemical properties, thereby demonstrating exceptional practical applicability. This work offers an effective strategy to design gel electrolytes for the supercapacitors, solid-state batteries, and other fields.
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Nature Photonics
·
2026
·
IF 38.1
Yin Hang,Wu Haodi,Zhang Yang,Liu Fei,Bai Qi,Yan Shuwen,Jin Tong,Pang Jincong,Gao Yuting,Ling Qinghao,Xue Kan-Hao,Zhu Chongqin,Li Luying,Zhou Ziling,Li Zhen,Zheng Zhiping,Xu Ling,Chu Qian,Tang Jiang,Niu Guangda
Ultrahigh-energy radiations, including X-rays, electrons and protons exceeding 1 MeV, are prevalent in various field, including radiation therapy, astronomy, high-energy physics and nuclear power plants. However, their detection remains challenging owing to low interaction cross-sections, and even when interactions occur, radiation-induced atomic displacements lead to severe material damage, compromising both the sensitivity and stability of current detectors. Here we report a design principle of lattice-anchoring-enhanced dynamic repair in organic–inorganic hybrid perovskites for simultaneous boosting the sensitivity and stability. Leveraging this approach, the FA 0.9 Cs 0.1 PbBr 3 single-crystal detector achieves high sensitivity of 165.6 μC mGy −1 cm −3 and high radiation stability against high-fluence 6-MeV X-rays (6.4 × 10 11 photons cm −2 ) and 1.2-MeV electrons (6 × 10 16 electrons cm −2 ). The assembled miniature, implantable detector enables precise, real-time dose monitoring, significantly improving the safety and efficacy of cancer treatments. This work advances the development of high-end semiconductors for diverse high-energy applications, from medical therapy to aerospace electronics, wearable electronics, space photovoltaics and nuclear technology.
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ARCHIVES OF TOXICOLOGY
·
2026
·
IF 10.9
Zhang Mingyu,Guan Chunjing,Sheng Gaofan,Ding Zifang,Zhao Yanjia,Zhao Guode,Li Weiwei,Hu Zixia,Peng Ying,Zheng Jiang
Pyrazinamide (PZA) has been approved for the treatment of tuberculosis in clinical practice. However, its adverse effects, particularly hepatotoxicity, have raised concerns. The present study aimed at exploring the potential relationship between PZA-induced hepatotoxicity and its metabolites resulting from metabolic activation. Glutathione (GSH) conjugates with confirmed structures were detected in mouse cytosol incubations containing PZA or pyrazinoic acid (POA, a major metabolite of PZA) supplemented with glutathione (GSH). Such GSH metabolites were also observed in both liver homogenates from mice administered with PZA and mouse primary hepatocytes exposed to PZA. Aldehyde oxidase (AO) and xanthine oxidase (XOD) were identified as key enzymes in the metabolic activation of PZA and POA. Both vitamin C (VC) and N -acetylcysteine (NAC) were found to reduce the generation of GSH conjugates derived from PZA and POA in incubation systems. Additionally, VC alleviated the susceptibility of hepatocytes to PZA-induced cytotoxicity. Consecutive administration of PZA for 7 days resulted in a marked elevation of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in mice, and PZA-derived hepatic protein adduction was detected. Allopurinol administration attenuated the elevated serum ALT and AST in company with a reduction in the formation of GSH conjugates. This work provides solid evidence for the correlation between the metabolic activation of PZA and PZA-induced hepatotoxicity, enhancing the understanding of the underlying mechanisms of PZA toxicity in terms of molecular chemical structure.
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Applied Biological Chemistry
·
2026
·Vol. 69
·期 1
·8
·
IF 4.2
Jia Xuewei,Xue Huijie,Yang Xiao,Yan Qingdan,Gao Yuan,Qin Yanchong,Li Tianxiao,Hu Jun,Xu Chunping
This study examined the structural features and anti-aging mechanisms of a pectic polysaccharide (AAP) extracted from Actinidia arguta leaves. AAP was extracted via three-phase partitioning coupled with ammonium sulfate precipitation and subsequently purified on a DEAE-52 cellulose column. Structural characterization via FT-IR, GC‒MS, NMR, and SEC-MALLS-RI revealed that AAP is a rhamnogalacturonan I (RG-I)-type pectin, consisting of rhamnose, arabinose, galactose, and galacturonic acid with a molar ratio of 20.1:28.4:14.8:36.7, with a weight-average molecular weight (Mw) of 4.14 × 10 5 g/mol and a random coil conformation in aqueous solution; the Congo red assay confirmed that it does not possess a stable triple-helical structure. In Caenorhabditis elegans models, AAP significantly prolonged lifespan and improved exercise capacity, accompanied by reduced accumulation of lipofuscin and reactive oxygen species. Transcriptome profiling revealed 334 differentially expressed genes (DEGs) in response to AAP treatment, with bioinformatics analysis indicating enrichment in metabolic pathways (e.g., lipid metabolism, amino acid metabolism, one-carbon metabolism), extracellular matrix homeostasis, and innate immunity. The key regulated genes included upregulated fat-7 (lipid desaturase), alh-2 (aldehyde dehydrogenase), and collagen-encoding genes ( col-138 , lon-3 ) and immune-related dod-17 , as well as downregulated fmo-2 (involved in one-carbon metabolism). Protein‒protein interaction (PPI) network analysis revealed that collagen-encoding genes and other genes served as core regulatory nodes; qRT‒PCR validated the expression trends of key DEGs, such as fat-7, lon-3, and dod-17, which were consistent with the transcriptomic data. These findings demonstrate that AAP exerts antioxidant and anti-aging effects in C. elegans by coordinating multiple pathways, emphasizing its potential as a natural anti-aging ingredient for functional foods or pharmaceuticals.
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Nature Communications
·
2026
·
IF 18.1
Xi Yamin,Zhang Chaoqi,Bao Tong,Liu Suzhao,Wang Tianxiang,Tu Wenjing,Guo Yuntian,Zou Yingying,Yu Chengzhong,Liu Chao
Photocatalytic nitrate reduction reaction coupled carbon dioxide reduction reaction holds great promise for sustainable urea synthesis, the design of photocatalysts with efficient C-N coupling and charge separation is crucial yet challenging. Herein, we report the synthesis of a novel MOF-on-MOF S-scheme heterojunction photocatalyst with interfacial dual active sites for efficient urea production via nitrate reduction reaction coupled carbon dioxide reduction reaction. The integration of semiconducting Zr-MOF and Co-MOF produces interfacial Co and Zr dual sites for NO 3 - activation and CO 2 adsorption, synergistically promoting C-N coupling with reduced energy barriers. Besides, the S-scheme heterojunction enables the strong redox capability and facilitates the charge transfer. Consequently, the rationally designed MOF-on-MOF heterojunction achieves a high urea yield of 3523.4 μg g⁻¹ h⁻¹ and an apparent quantum yield of 1.16% at 365 nm in the absence of sacrificial agents. This work paves the way for the development of high-performance photocatalysts for urea production.
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