Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Xuan Liu,Chen Wang,Xueyan Wang,Chen Tian,Yuhua Shen,Manzhou Zhu
Designing a proper intelligent platform to target cancer cells accurately and reducing its toxic side effects on normal tissues remain a challenge in medicine application. Herein, a novel dual-targeted and tumor microenvironment-triggered Fe 3 O 4 @carbon(C)/ZnO-doxorubicin (DOX) -folic acid (FA) drug delivery system with porous structure was designed and fabricated for the first time. The co-presence of Fe 3 O 4 core and FA molecules functioned successfully could successfully realize the magnetic targeting and cancer cell-specific targeting. In addition, pH-responsive ZnO and porous carbon both derived directly from zinc-2-methylimidazolate complex (Zn-ZIF) could play the roles of “gatekeeper” and photothermal agent, respectively. The former could efficiently block the drug within mesoporous in blood environment for decreasing the damage to the normal tissues and achieving the controlled DOX release in the simulated and real acidic tumor microenvironment. And the latter could exhibit the intrinsic photothermal conversion efficiency upon 638 nm laser irradiation. Therefore, the Fe 3 O 4 @C/ZnO-DOX-FA nanoplatform integrated dual targeting, controlled chemotherapy with photothermal therapy (PTT) for cancer, displaying a significantly superior synergistic anticancer efficiency both in vitro and in vivo experiments to either monotherapy. Above results suggested the prepared nanoplatforms might be a promising candidate for effectively synergetic therapeutics to cancers.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yong Xu,Gang Wang,Lijing Zhu,Wanshun Deng,Chunting Wang,Tianhui Ren,Baikang Zhu,Zhixiang Zeng
Owing to its high selective adsorption and excellent cyclability, superwetting materials have attracted considerable attention in environmental governance, especially oily wastewater treatment. However, the inferior separation efficiency and high recovery energy consumption seriously limit the actual application of superwetting particles in oil–water emulsion separation. Herein, inspired reversely by the water collection and water retention of the hydrophilic/superhydrophobic structure on the Stenocara beetle’s back, we fabricated magnetic graphene oxide composite with beetle-like microstructure by one-step solvothermal and environmentally friendly ball milling method. Magnetic composite with superhydrophobic/superoleophilic bumps–hydrophilic underlayer exhibits high hydrophobicity/oleophilicity in air and high oleophobicity underwater. In the process of particle assembly, the Fe 3 O 4 grains with abundant oxygen vacancies peeled off from the in-situ deposited magnetic Fe 3 O 4 microspheres play a bridging role to immobilize the superhydrophobic carbon black particles on the graphene oxide (GO) surface. On the unique surface of magnetic composite, attributed to strong π–π/n–π interface adsorption and hydrophobic interaction, the oil–water separation can be rapidly demulsified and the superoleophilic bumps (superhydrophobic carbon black nanoparticles) can capture and aggregate tiny oil droplets. The hydration layer formed in the hydrophilic region effectively prevents the captured oil droplets from spreading on the composite structure, thus enhancing the emulsion separation ability of magnetic GO. More importantly, the prepared composites exhibit efficient recycling and regeneration under solar irradiation, which is superior to the recovery efficiency of traditional GO sheets lacking high self-heating components. These inverse beetle-like magnetic GO-based particles open up a new opportunity for the design and fabrication of advanced demulsifiers in the field of oil–water emulsion separation.
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Journal of Materials Chemistry B
·
2019
·Vol. 8
·期 6
·1202-1211
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IF 5.047
Kecan Lin,Yanbing Cao,Dongye Zheng,Qin Li,Hui Liu,Peiwen Yu,Jiong Li,Yanan Xue,Ming Wu
The development of nanotheranostic agents integrating diagnosis and therapy has gained tremendous attention in the past few decades, but many of them are inherently hydrophobic and need complicated phase-transfer and tedious surface modifications. This work proposed a facile method of transferring hydrophobic Fe3O4@Cu2−xS nanoparticles from oil to water by using red blood cell membrane to create theranostic nanobeads for T2-weighted MRI and second near-infrared photothermal ablation. The obtained nanoplatform, namely SCS@RBCM, showed a core–shell structure with the inner core densely packed with Fe3O4@Cu2−xS nanoclusters and the surface coated with a layer of RBCM. SCS@RBCM displayed a stable nanostructure, high NIR II light absorption and photothermal conversion ability, T2-weighted MR imaging and magnetic field targeting ability. Meanwhile, the RBCM cloaking endowed SCS with reduced elimination by macrophages. With the navigation of an external magnetic field (MF), the tumor accumulation of SCS@RBCM was dramatically increased, thus achieving good performance of MR imaging and antitumor efficacy through the PTT effect under NIR II irradiation. Therefore, our strategy presents a new and desirable paradigm in the phase-transfer of hydrophobic nanotheranostics for optimizing their biomedical performance.
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CHEMICAL ENGINEERING JOURNAL
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2019
·
IF 8.355
Lu Huang,Tao Zeng,Xuyang Xu,Zhiqiao He,Jianmeng Chen,Shuang Song
Immobilized activators of persulfate (PS) with high activity and stability are highly desirable from an industrial and environmental point of view. In this work, nitrogen-doped carbon (CNx) was successfully hybridized with stainless steel (SS) derived Fe 3 O 4 to construct a SS supported CNx/Fe 3 O 4 heterogeneous catalyst (CNx/Fe 3 O 4 /SS). When used in a sulfate radical (SO 4 − )-based advanced oxidation process (SR-AOP), CNx/Fe 3 O 4 /SS displayed significantly higher activity towards the degradation of aqueous carbamazepine (CBZ) when compared to the single Fe 3 O 4 and CNx activators. The removal of CBZ had the most rapid progression, with an initial pH of 3.5, a temperature of 35 °C, an initially added PS concentration of 250 mg L −1 and an added amount of CNx/Fe 3 O 4 /SS of 0.30 g. The removal efficiency of CBZ was ∼100% after 35 min of SR-AOPs. In addition, the CNx/Fe 3 O 4 /SS catalyst was stable, as demonstrated by six successive cycling experiments. The results obtained from the electron paramagnetic resonance (EPR) spectra and radical quenching experiments indicated that both SO 4 − and HO contributed to the CBZ oxidation process. On the basis of X-ray photoelectron spectroscopy (XPS) and Fermi level analyses, it can be concluded that SO 4 − and HO originated from the Fe 3 O 4 catalyzed decomposition of aqueous PS. CNx facilitated the redox cycle of Fe(III)/Fe(II) in Fe 3 O 4 . This study demonstrated the potential application of SR-AOPs to efficiently degrade organic contaminants.
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TALANTA
·
2019
·
IF 4.916
Qing Lu,Hao Guo,Yuanyuan Zhang,Xiaodong Tang,Weibin Lei,Ruijuan Qi,Junhao Chu,Dezeng Li,Qingbiao Zhao
Graphene oxide–Fe 3 O 4 (GO–Fe 3 O 4 ) nanocomposite was synthesized by a facile chemical co-precipitation method. The GO–Fe 3 O 4 was used as magnetic sorbent to extract the eight psychoactive drugs from urine samples. The analytes are morphine (MOR), 6-monoacetylmorphine (6-MAM), amphetamine (AMP), methamphetamine (MAMP), codeine, cocaine, dolantin and benzoylecgonine (BZE), which were determined by ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). This method has high selectivity for the target analytes. The limit of detection (LOD) and limit of quantification (LOQ) were 0.02–0.2 μg L −1 and 0.05–0.5 μg L −1 , respectively. The Mandel's fitting test revealed good linearity within all linear ranges. The linear ranges were calculated as 0.05–1000 μg L −1 for AMP, MAMP, cocaine and dolantin; 0.1–1000 μg L −1 for 6-MAM and codein; and 0.5–1000 μg L −1 for MOR and BZE. The recoveries ranged in 80.4–105.5%. The intra-day and inter-day RSDs are in the range of 2.7–13.1% and 3.9–13.7%, respectively. Magnetic solid phase extraction (MSPE) with GO–Fe 3 O 4 provides a convenient, rapid and green sample pretreatment method for extracting the target psychoactive drugs from urine. This methodology can be used for simultaneous or individual detection of eight major psychoactive drugs with high sensitivity. This method has high potential in clinical and forensic areas for psychoactive drugs analysis.
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RENEWABLE ENERGY
·
2019
·
IF 5.439
Zengshuai Zhang,Liang Guo,Yi Wang,Yangguo Zhao,Zonglian She,Mengchun Gao,Yiding Guo
Fe 3 O 4 nanoparticles (FNP) were implemented in two-stage anaerobic digestion to enhance the biogas production and waste sludge reduction in this study. The degradation and transformation of extracellular polymeric substances (EPS) and dissolved organic matters (DOM) under optimal FNP concentration during two-stage anaerobic process with heat pretreated waste sludge was investigated by analyzing the changes of soluble chemical oxygen demand (SCOD), carbohydrate and protein in EPS and DOM. FNP addition significantly enhanced volatile fatty acids (VFAs) production. The optimal dosage of FNP was 100 mg/L yielded 11.9 ml H 2 /g VS hydrogen and 109.8 ml CH 4 /g VS methane, which increased by 15.1% of hydrogen yield and 58.7% of methane yield compared with that of control. The maximum volatile suspended solids (VS) reduction was 46.9% with the addition of 100 mg/L FNP compared with that of control (34.3%). NH 4 + -N production was inhibited with 20, 50, and 100 mg/L FNP addition comparing with control.
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Arabian Journal of Chemistry
·
2018
·
IF 2.969
Umair Azhar,Chenxi Huyan,Xiaozheng Wan,Chuanyong Zong,Anhou Xu,Jitao Liu,Jiachen Ma,Shuxiang Zhang,Bing Geng
Fluoropolymers are very important owing to their excellent application performances, especially in extreme conditions. On the other hand, the preparation of porous fluoropolymers is a difficult task due to unavailability of suitable surfactants as well as tedious synthesis steps. Here we prepared multifunctional porous fluoropolymer composite foams with a simple process of “high internal phase emulsion (HIPE)” by using humic acid modified iron oxide nanoparticles (HA-Fe 3 O 4 NPs) and cationic fluorosurfactant (CFS) (PDMAEMA- b -PHFBA) as co-stabilizer. The inclusion of HA-Fe 3 O 4 NPs in the system made fluoro-HIPE more stable than the emulsion prepared using only CFS or other conventional stabilizers. Morphology of the prepared polyHIPE was easily controlled by altering the concentration of HA-Fe 3 O 4 and/or CFS in the original formulation. Adjustment of the porous structure with open/close cells was performed and the average diameter of the pores tuned between 4.9 and 23 μm. With the increase in specific surface area by using nanoparticles (NPs) and CFS as co-surfactants, Pickering HIPE monoliths adsorbed double amount of oil compared to foams based solely on HIPE template. Multiple functional groups were bound onto Fe 3 O 4 NPs through HA modification that made the fluoro-monolith capable of adsorbing dye, i.e. methylene blue, from water. A simple centrifugation enabled regeneration of the oil soaked foams and adsorption capacity was not decreased after 10 adsorption/regeneration cycles.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2018
·
IF 3.235
Ning Kang,Lifei Ji,Jun Zhao,Xian Zhou,Xianjun Weng,Hui Li,Xin Zhang,Fengchun Yang
The electrochemical methods with the advantages of sensitivity, accuracy, low-cost, simplicity and real-time online determination are expected to detect organic dyes, Methyl Orange (MO) and Rhodamine B (RhB), which are harmful to human beings extensively. In this work, Fe 3 O 4 and single-walled carbon nanotubes (SWNTs) hybrid, as a non-noble metal electrocatalyst , was synthesized by hydrothermal method and modified on the electrode to prepare an electro-sensor for monitoring MO and RhB. Due to the synergistic effects between Fe 3 O 4 and SWNTs, the magnified surface area and good dispersion of SWNTs, the Fe 3 O 4 /SWNTs hybrid, has the outstanding superiority of higher-conductivity and catalytical activity with a wide linear concentration range of 0.025–4000 μM, 0.1–250 μM and a calculated low detection limit (LOD) of 4 nM, 25 nM for MO and RhB respectively. Furthermore, it's the first time that the proposed electrode achieves the simultaneous determination of both dyes. Then, from the investigation of kinetics and pH value, it's found that both oxidation reactions involve two electrons and one proton participating. The modified electrode also exhibited good selectivity, high reproducibility and promising feasibility in practical sample analysis.
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TALANTA
·
2013
·
IF 3.498
Xiaofei Liu,Xin Lu,Yong Huang,Chengwei Liu,Shulin Zhao
A novel nano-adsorbent, Fe 3 O 4 @ionic liquid@methyl orange nanoparticles (Fe 3 O 4 @IL@MO NPs), was prepared for magnetic solid-phase extraction (MSPE) of polycyclic aromatic hydrocarbons (PAHs) in environmental water samples. The Fe 3 O 4 @IL@MO NPs were synthesized by self-assembly of the ionic liquid 1-octadecyl-3-methylimidazolium bromide (C18mimBr) and methyl orange (MO) onto the surface of Fe 3 O 4 silica magnetic nanoparticles , as confirmed by infrared spectroscopy, ultraviolet–visible spectroscopy and superconducting quantum interface device magnetometer. The extraction performance of Fe 3 O 4 @IL@MO NPs as a nano-adsorbent was evaluated by using five PAHs, fluorene (FLu), anthracene (AnT), pyrene (Pyr), benzo(a)anthracene (BaA) and benzo(a)pyrene (BaP) as model analytes. Under the optimum conditions, detection limits in the range of 0.1–2 ng/L were obtained by high performance liquid chromatography–fluorescence detection (HPLC–FLD). This method has been successfully applied for the determination of PAHs in environmental water samples by using the MSPE–HPLC–FLD. The recoveries for the five PAHs tested in spiked real water samples were in the range of 80.4–104.0% with relative standard deviations ranging from 2.3 to 4.9%.
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高影响因子
DALTON TRANSACTIONS
·
2015
·Vol. 44
·期 46
·19836-19843
·
IF 4.197
Jinbin Pan,Shao-Kai Sun,Yaqiong Wang,Yan-Yan Fu,Xuejun Zhang,Yi Zhang,Chunshui Yu
Clinical diagnosis of malignant tumors using nanoprobes needs severe improvements in the aspects of sensitivity and biocompatibility. Integrating a dual-targeting strategy with the selection of human-inherent elements and molecules as raw materials shows great potential in the development of a biosafe and sensitive nanoplatform. To carry out the proposed design, we constructed a biocompatible, dual-targeting MR imaging nanoprobe, based on Fe3O4 nanoparticles (NPs) co-modified with inherently innoxious hyaluronic acid (HA) and transferrin (Tf). HA was used as both a template and a targeting molecule to form Fe3O4@HA NPs through a one-step co-precipitation method, which were then further modified with Tf to obtain the dual-targeting Fe3O4@HA@Tf NPs at room temperature. The excellent biocompatibility of the nanoprobe was demonstrated via toxicity assays in vitro and in vivo. The desirable dual-targeting ability towards tumor cells was confirmed by a cellular uptake test (Hela cells, overexpressing both CD44 and transferrin receptors), and the developed nanoprobe was successfully applied in tumor-targeted MR imaging in vivo. In summation, we developed a dual-targeting Fe3O4 nanoprobe, following a facile procedure at room temperature. The nanoprobe showed a high targeting ability towards tumor cells and excellent biocompatibility, which showed its great potential to be applied in the clinical diagnosis of tumors.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2013
·Vol. 37
·期 8
·2509-2514
·
IF 2.966
Kun Shang,Bing Sun,Jianchao Sun,Jun Li,Shiyun Ai
A novel poly-(3-thiopheneacetic acid) coated Fe3O4@LDHs photocatalyst was prepared and used for the photocatalytic disinfection of bacteria under solar light irradiation. The influencing parameters of the photocatalytic antibacterial activity of the Fe3O4@PTAA-LDHs photocatalyst were optimized against E. coli and S. aureus. Results showed that the Fe3O4@PTAA-LDHs photocatalyst could effectively absorb ultraviolet and visible light. The antibacterial rate could achieve 99.99% when irradiated by solar light with 0.8 mg mL−1 Fe3O4@PTAA-LDHs during 140 min. Moreover, it was confirmed that the ˙OH were generated during the photocatalytic process, which was the major reason for the photocatalytic disinfection. The structural destruction of the bacteria cells that occurred during the bactericidal procedure was observed by TEM images. The novel photocatalyst could have potential applications in the related bactericidal fields.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Yuezhen He,Jian Sun,Xiaoxun Wang,Lun Wang
A sandwich chemiluminescence (CL) immunosensor for sensitive detection of human leptin was developed with a multiple signal amplification strategy from catalytic hemin/G-quadruplex DNAzymes and functional superparamagnetic nanocomposites. To construct this sensing platform, core–shell structural Fe 3 O 4 /polydopamine (PD)/Au superparamagnetic nanocomposites were synthesized by an in situ method with PD as a substrate adhesive. These nanocomposites were further characterized by scanning electron microscopy, transmission electronic microscopy, energy-dispersive spectroscopy, Fourier transform infrared spectrum and a vibrating sample magnetometer at room temperature. In this immunosensor, the monoclonal anti-human leptin antibody (capture antibody) was bound to the Fe 3 O 4 /PD/Au nanocomposites. Human leptin, biotinylated detection antibodies and streptavidin-DNAzymes were successively combined the above-mentioned nanocomposites to form sandwich-type immunocomplex through specific interactions. The magnetic particles loaded with the immunocomplex were separated by an external magnet, and the DNAzymes in the immunocomplex greatly enhanced the CL emission of the luminol–H 2 O 2 system. The immunosensor exhibited a high sensitivity, a good specificity, and a wide linear range for human leptin detection from 1.0 pg mL −1 to 8.0 × 10 2 pg mL −1 with a low detection limit of 0.3 pg mL −1 . This sensor is one of the most sensitive methods for leptin detection due to the highly efficient catalysis of the DNAzymes and analyte enrichment on magnetic capture.
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