Materials Today Bio
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2024
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IF 8.7
Jialu Weng,Shiyi Wu,Yating Pan,Yifan Lai,Jinrong Zhu,Wenzhang Jin,Deyu Lu,Yizhang Chen,Zhijie Yu,Xinjie Zan,Jinglin Xia
Chemotherapy is the primary palliative treatment for advanced hepatocellular carcinoma (HCC). However, the systemic delivery is associated with the drawbacks including a high risk of adverse effects and a low efficacy. Therefore, local injection therapy may be beneficial. Nevertheless, the existing local drug-carrying microspheres(DOBM)have the characteristics of low loading and abrupt release, can not simultaneously load two drugs, and may cause unnecessary toxicity. In this study, we created the dual-loaded bovine serum albumin (BSA) microspheres (also known as DOBM), which were hollow and contained both oxaliplatin (OXA) and Adriamycin hydrochloride (DOX). In addition, this pH-sensitive drug delivery method exhibited a high drug loading capacity and was promising in breaking through biological barriers, making it a viable option for the treatment of HCC through local implantation. Based on physiochemical evaluation of BSA microspheres, they had a porous structure which was close to the surface. Adriamycin and oxaliplatin were successfully added to the surface of BSA microspheres. According to in vitro experimental results, the growth of human HCC (HCC-LM3 and PLC/PRF/5) cell lines was significantly inhibited by DOBM. Furthermore, in the subcutaneous PLC/PRF/5 HCC model, DOBM played an essential role in tumor development and change in the tumor microenvironment.
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ACS Applied Polymer Materials
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2024
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IF 4.4
Zhicheng Liao,Cheng Zheng,Liyan Qiu
This study focuses on the development and evaluation of injectable drug delivery systems for the long-acting treatment of rheumatoid arthritis. Four types of poly(ortho ester)-polyesters (POC2, POC3, POL2, and POL3) were synthesized by the polycondensation reactions between an ortho ester diamine monomer and the active esters of oligocaprolactone diols (A-OCL) or oligolactide diols (A-OLA) with different molecular weights and exhibited discrepant zero-shearing viscosities and hydrophilic–hydrophobic properties. The degradation behaviors were collectively controlled by surface erosion and bulk degradation mechanisms, and the accelerated degradation at pH 5.0 was observed due to acid-responsive hydrolysis of ortho ester and ester groups. Consequently, the release of indomethacin (IND) was well sustained with the kinetics fitting of the Ritger–Peppas model. After being injected subcutaneously once into adjuvant-induced arthritis rats, the formulation IND-POC2 slowly released IND for up to 14 days and showed the best therapeutic effects on effectively alleviating the swelling of joints, bone erosion, and the expression of pro-inflammatory factors. To sum up, this research demonstrated the cheerful prospect of the obtained functional viscous poly(ortho ester)-polyester fluid for sustained drug release in rheumatoid arthritis disease.
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PACKAGING TECHNOLOGY AND SCIENCE
·
2024
·Vol. 37
·期 8
·793-807
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IF 2.8
Haiying Cui,Jie Gao,Myat Noe Khin,Tariq Aziz,Fahad Al-Asmari,Abdulhakeem S. Alamri,Majid Alhomrani,Lin Lin
A pH-sensitive protein fibre membrane was prepared using alizarin (ALI), curcumin (CUR), gelatin, zein and cinnamaldehyde as raw materials, by electrospinning technology. The membrane was developed to detect food deterioration and extend shelf life. It was observed that the addition of CUR significantly enhanced the antioxidant and barrier properties of the membrane. The fibre membrane was responsive to pH with minimal colour alteration in response to humidity (from 20% to 80% relative humidity) and demonstrated excellent reusability along with a low detection limit for ammonia gas. Moreover, it was capable of monitoring low concentrations of bacteria in the headspace. To assess the efficacy of the membrane, a freshness monitoring and preservation study was carried out on pork stored at 4°C for 5 days. The fibre membrane not only prolonged the shelf life of meat but also allowed real-time monitoring of its freshness. The results highlight the potential application of the prepared nanofibres in the simultaneous monitoring and preservation of meat freshness.
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ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Yueang Jin,Xueqian Zhang,Yongchun Zhu,Jiajia Ye,Yitai Qian,Zhiguo Hou
Vanadium oxide has been extensively studied as a host of zinc ion intercalation but still suffers from low conductivity, dissolution, and byproduct accumulation during cycling. Here, we hydrothermally synthesize the VO2@MXene Ti3C2 (MV) composite and find that in the MV//3 M Zn(CF3SO3)2//Zn system, the double hydroxide Zn12(CF3SO3)9(OH)15·nH2O (ZCOH) uniformly covers VO2 during the charging process and dissolves reversibly during the discharge process. In situ X-ray diffraction of the MV combined with in situ pH measurements reveals that ZCOH acts as a pH buffer during cycling, which is beneficial to the cycling stability of batteries. And the theoretical calculation indicates that the decomposition energy required by ZCOH on the MV surface is lower than that on pure VO2, which is more conducive to ZCOH dissolution. The coin battery exhibits high-rate performance of 65.1% capacity retention at a current density of 15 A g–1 (compared to 0.6 A g–1) and a long cycling life of 20,000 cycles with a capacity retention of 80.7%. For a 22.4 mA h soft-packaged battery, its capacity remains at 72.1% after 2000 cycles. This work demonstrates the active role of ZCOH in the electrochemical process of VO2 and provides a new perspective for exploiting this mechanism to develop high-performance aqueous zinc-ion battery vanadium oxide cathode materials.
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Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Guangxia Wang,Wenhui Wang,Yaozhong Yu,Tao Hu,Juan Ding,Yongming Sui
Active and durable catalysts are crucial for the hydrogen evolution reaction (HER). In the volcano plot, rhodium (Rh) and platinum (Pt) are positioned closely, while the activity and stability of Rh are much inferior to those of Pt. Here, we developed a Rh/TiO2/Ti electrocatalyst to mitigate Pt dependency. The in situ formed TiO2 with oxygen vacancies was prepared utilizing Ti foam as the Ti source. The TiO2 support can confine Rh nanoparticles and ensure charge accumulation at the Rh site, while Rh can enhance the conductivity of TiO2. DFT calculations demonstrate that the strong interaction between Rh and TiO2 could regulate the electronic structure of Rh, thereby accelerating water dissociation and optimizing the adsorption strength of *H. Consequently, compared to Rh/Ti, Rh/TiO2/Ti exhibits significantly enhanced HER activity, requiring overpotentials of only 37.3 and 34.3 mV to reach 10 mA cm−2 in the alkaline and acidic HER, respectively. Furthermore, the vertical nanoarray structure, surface roughness, and metal–support interaction endow Rh/TiO2/Ti with remarkable durability. It works in both alkaline and acidic media for 120 hours at 10 mA cm−2 with unnoticeable activity decline, outperforming commercial Pt/C. This work provides a strategy to overcome the activity and stability limitations of Rh-based catalysts, providing references for promising catalysts for water electrolysis.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Shaolong Han,Jinyu Wu,Shuaibo Shi,Sichen Li,Rui Zhu,Yu Li,Kun Zhang
It is a very challenging work to discriminate their isomers of aliphatic or aromatic carboxylic diacids for potential needs by the design and synthesis of conventional chemical receptors. Herein, we implement the efficient discrimination of selected carboxylic diacids based on the comprehensive analysis of sensing signals, associated with several fluorescent channels. A mononuclear terbium-macrocycle Tb - 2 a is synthesized by the template method, and it is used as a fluorescent probe to provide multi-channel responses for carboxylic diacids. Upon its narrow-range pH-responsive behaviors, complex Tb - 2 a exhibits differential fluorescence on three emission bands which are statistically analyzed. As a result, complex Tb - 2 a can efficiently distinguish carboxylic diacid isomers from each other by their visual fingerprints and determine p -PA contents by a linear equation. Further explorations also verify that this complex Tb - 2 a has good capability of identifying mixed carboxylic diacids and monitoring p -PA in the real sample. This multi-channel response strategy should be potentially referable for not only analogue discrimination of other isomers but also more multianalyte detection methods.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Mingzhu Ye,Roumei Ye,Yun Wang,Mengyu Guo,Maoshu Zhu,Fengyue Yin,Yubo Wang,Xiaoqin Lai,Yu Wang,Zhongqun Qi,Jinling Wang,Dengyue Chen
In recent years, the use of arsenic trioxide (ATO) in the context of ovarian cancer chemotherapy has attracted significant attention. However, ATO’s limited biocompatibility and the occurrence of severe toxic side effects hinder its clinical application. A nanoparticle (NP) drug delivery system using ATO as a therapeutic agent is reported in this study. Achieving a synergistic effect by combining starvation therapy, chemodynamic therapy, and chemotherapy for the treatment of ovarian cancer was the ultimate goal of this system. This nanotechnology-based drug delivery system (NDDS) introduced arsenic-manganese complexes into cancer cells, leading to the subsequent release of lethal arsenic ions (As 3+ ) and manganese ions (Mn 2+ ). The acidic microenvironment of the tumor facilitated this process, and MR imaging offered real-time monitoring of the ATO dose distribution. Simultaneously, to produce reactive oxygen species that induced cell death through a Fenton-like reaction, Mn 2+ exploited the surplus of hydrogen peroxide (H 2 O 2 ) within tumor cells. Glucose oxidase-based starvation therapy further supported this mechanism, which restored H 2 O 2 and lowered the cellular acidity. Consequently, this approach achieved self-enhanced chemodynamic therapy. Homologous targeting of the NPs was facilitated through the use of SKOV3 cell membranes that encapsulated the NPs. Hence, the use of a multimodal NDDS that integrated ATO delivery, therapy, and monitoring exhibited superior efficacy and biocompatibility compared with the nonspecific administration of ATO. This approach presents a novel concept for the diagnosis and treatment of ovarian cancer.
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JOURNAL OF MEMBRANE SCIENCE
·
2025
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IF 9
Chuan Yue,Shaopeng Gan,Zechen Yan,Baoting Su,Kang Liu,Fujun Xia,Hui Li,Lei Zhu,Qingzhong Xue,Jianqiang Zhang
Superhydrophilic oil-water separation membranes exhibit fixed interfacial properties, which limits their ability to withstand oil fouling. Enhancing the in-situ anti-fouling performance of membranes dynamically at the interface is challenging. Here, a structurally adjustable pH-responsive membrane for oil-water separation was prepared, combined with patterned silver gel to impart conductivity. Acting as a cathode, this membrane electrolyzes water to generate OH − ions that directly regulate the interfacial pH. The generated OH − ions trigger the responsive layers' contraction, which results in the expansion of the membrane's pore size. Such structural adjustments could shorten the oil-water-solid three-phase contact line of pinned oil droplets to reduce the adhension force, creating interfacial disturbances that enhance the anti-fouling capabilities of membrane. By this way, lubricants and crude oils adhered to the membrane could be de-wetted in 32 s without other assistance. Meanwhile, the expansion of the membrane's pore size increases the washing efficiency. The flux recovery rate after 300 min long-term cycling can reach up to 97.6 % without additional reagents. The fabricated anti-fouling membrane significantly improves separation efficiency and holds great potential for applications in oily wastewater treatment.
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ACS Biomaterials Science & Engineering
·
2025
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IF 5.5
Jun Liu,Xiangyun Lin,Junhui Ma,Lei Wang,Yan Tang,Nan Ma,Yuxia Zhao,Wei Zhang
Microbial colonization and infection of biomedical devices remain a persistent clinical challenge. Interfacial coatings with antifouling and antimicrobial functions simultaneously under physiological conditions are highly desired to mitigate the infection risks. Herein, we constructed a durable serine-derived zwitterionic antifouling and antimicrobial interfacial structure via amino-carboxylate coordination with Cu(II) ions in alkaline aqueous solutions. Comprehensive surface characterizations verified the successful incorporation of Cu(II) into serine-based zwitterionic polymeric brushes without changing the valence state. The engineered interfaces maintained favorable hydrophilicity with water contact angles ranging between 16° and 24°, which contributed to their remarkable antifouling activities against bacteria, red blood cells, and platelet adhesion. Crucially, the surface exhibited broad-spectrum antimicrobial efficacy against both Gram-positive and Gram-negative pathogens under physiological pH conditions without extra stimulation, achieving bactericidal rates exceeding 99%. Moreover, owing to the durable control release of Cu(II), the antibacterial rate against E. coli was still over 90% even after 28 days of exposure in PBS. Furthermore, the surface exhibited acceptable cytotoxicity while maintaining superior hemocompatibility, with the hemolysis rate below 1%. Overall, this physiological pH responsive integrated antifouling and antimicrobial interface presented a promising and convenient platform for next-generation biomedical devices requiring antifouling properties and long-term antimicrobial protection simultaneously.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 9
·1-13
·
IF 5.3
Li Zehao,Jing Weixuan,Yang Zhenwei,Gao Weizhuo,Zhou Fan,Han Feng,Mao Qi,Zhao Libo,Yang Zhaochu,Jiang Zhuangde
A low-hysteresis coaxial pH sensor was presented for continuous soil monitoring. The electrolyte was irradiated with ultraviolet (UV) light for different durations, and then used for the electrodeposition of the IrO x film onto the front end of a stainless-steel wire, forming the working electrode. The reference membrane/AgCl/Ag paste (reference electrode) was coaxially integrated onto the insulated middle section of the working electrode, creating the pH sensor. It is found that the UV irradiation treatment generates sufficient hydroxyl radicals in the electrolyte, which increases the proportion of IrO 2 on the surface of the formed IrO x film and further enhances its reversible surface reactions with H + . The reference electrode is reliably integrated with the working electrode, which effectively miniaturizes the pH sensor for soil monitoring. With the UV irradiation duration optimized to be 2 days, the sensitivity and hysteresis voltage of the pH sensor were determined to be -74.8 mV/pH and 3 mV, respectively. The pH sensor maintained a stable potentiometric response even when bent to a 180° angle or subjected to 50 bending cycles. Moreover, the pH values of six soil samples were reliably determined, and the pH variations in a soil sample were monitored over an 11-day testing period. These results benefit accurate and continuous pH monitoring in agricultural and livestock applications. Graphical
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ULTRASOUND IN MEDICINE AND BIOLOGY
·
2025
·
IF 2.6
Wendi Su,Hao Wang,Juhong Pan,Huan Pu,Bin Gui,Qianhui Liu,Sheng Cao,Qing Zhou
Objective Cerium oxide nanoparticles (CeO 2 NPs), as metal oxide nanomaterials with multi-enzyme activities, are gradually being applied in the biomedical field. However, we have limited knowledge about the factors influencing the enzymatic activity and biological functions of cerium oxide nanoparticles. This study aims to investigate whether ultrasonic irradiation has a significant impact on their enzymatic activity, reactive oxygen species scavenging ability, and antibacterial activity, and to discuss the underlying mechanisms of these effects. Methods We first synthesized cerium oxide nanoparticles using a chemical precipitation method and characterized them. We set up a control group and irradiation groups with different ultrasonic parameters, and tested the mimicking activities of catalase, superoxide dismutase, and peroxidase of the cerium oxide nanoparticles using enzymatic activity assay kits. Then, we assessed the biocompatibility of the cerium oxide nanoparticles in macrophages. Subsequently, we examined their reactive oxygen species scavenging ability in both tumor cells and macrophages. Finally, we tested their inhibitory effect on Staphylococcus aureus . Results We found that cerium oxide nanoparticles exhibited enhanced enzymatic activity after ultrasound irradiation. The direction of their catalysis was regulated by pH: in environments with lower pH values, the peroxidase activity of the cerium oxide nanoparticles was stronger than that of catalase and superoxide dismutase, whereas in environments with higher pH values, the opposite was true. This pH-regulated multienzymatic activity resulted in significantly different reactive oxygen species (ROS) scavenging abilities between acidic tumor cells and slightly alkaline normal tissue cells: it demonstrated excellent ROS scavenging ability in macrophages but showed no ROS scavenging ability in tumor cells. Lastly, we discovered that the nanoparticles exhibited stronger antibacterial capabilities after ultrasound irradiation. Conclusion Ultrasound can enhance the enzymatic activity, ROS scavenging ability, and antibacterial capability of cerium oxide nanoparticles.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Fansu Meng,Panpan Wang,Lina Yang,Junjie Yan,Anil K. Giri,Jaiwoo Lee,Kosuke Kusamori,Makiya Nishikawa,Shoko Itakura,Honghui Gu,Qi Li,Zhong Chen,Zhenjiang Yang,Detang Li,Yu Cai
Breast cancer (BC) stands as one of the primary malignancies threatening women's health. Baicalin (BA) exhibits anti - BC effects, yet it is plagued by issues such as low water solubility and poor bioavailability. To enhance the anti-BC efficacy of BA, this study developed a pH - responsive albumin nanoparticle loaded with BA (BA-AN-FA@mPEG). The optimized BA-AN-FA@mPEG features an average particle size of (185.8 ± 2.36) nm, a Zeta potential of (−32.70 ± 1.27) mV, an encapsulation efficiency of approximately 73.82 %, and a drug loading of about 5.68 %. The aqueous solution of BA-AN-FA@mPEG demonstrates excellent stability at 4 °C, with no significant drug leakage occurring within 12 weeks. BA-AN-FA@mPEG shows a certain sustained - release effect, and the drug release rate is faster under acidic conditions. The results of efficacy evaluation indicate that the half - maximal inhibitory concentration of BA-AN-FA@mPEG against MDA-MB-231 cells is 26.34 μg/mL. It can promote cellular uptake, effectively induce apoptosis, and cause cell cycle arrest. In summary, BA-AN-FA@mPEG is a promising tumor - targeted therapeutic formulation that can improve drug stability, tumor delivery efficiency, and therapeutic efficacy.
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