JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2026
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IF 2.4
Jingli Sun,Yujie Zhen,Siyu Zheng,Lei Chen,Kebin Huang,Yingmin Yu
Abstract To investigate salt-type and salt-concentration effects on pyridine extraction performance, liquid–liquid equilibrium data for the aqueous pyridine +2-ethyl-1-hexanol system with KCl or CaCl2 were measured at 298.15 K and 101.3 kPa. Aqueous phases containing 5 and 10 wt % KCl and CaCl2 were systematically studied. Experimental results show that both inorganic salts expand the two-phase region, promote pyridine partitioning into the rich-organic phase, and enhance separation efficiency. The pyridine distribution coefficient and separation factor generally increase with the salt concentration. Relative to the salt-free system, the average separation factor rises by approximately 42.01% and 111.10% for 5 and 10 wt % KCl, respectively, and by 19.17% and 74.27% for the corresponding CaCl2 concentrations, respectively. Experimental LLE data were correlated using NRTL and UNIQUAC activity coefficient models, with RMSD below 1.02%. Thermodynamic consistency tests and Gibbs stability criteria further validate the reliability of the regressed model parameters. This work provides credible LLE data sets and thermodynamic model parameters for the design and optimization of pyridine extraction and separation processes in saline aqueous systems.
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FREE RADICAL BIOLOGY AND MEDICINE
·
2026
·
IF 8
Shenghui Zhang,Qin Liu,Bo Chen,Hui Chang,Ying Pan,Yanli Liu,Xin Zhao,Juntang Lin
MenSC-EVs alleviate STZ-induced ovarian dysfunction in diabetic mice. • MenSC-EVs suppress high-glucose-induced ferroptosis in granulosa cells. • EV-associated HSPA5 mediates protection via AKT/mTOR–BECN1/SLC7A11 signaling. Type 1 diabetes mellitus (T1DM) is associated with ovarian dysfunction, including menstrual irregularities, impaired ovarian reserve, and premature reproductive aging, yet effective therapeutic strategies to safeguard ovarian function against metabolic stress remain limited. Mesenchymal stem cells (MSCs) have emerged as pivotal regulators of tissue homeostasis, with their paracrine effects largely mediated by extracellular vesicles (EVs). Here, we demonstrate that menstrual blood-derived endometrial stem cell-EVs (MenSC-EVs) alleviate streptozotocin (STZ)-induced ovarian dysfunction and inhibit granulosa cells (GCs) ferroptosis by delivering HSPA5. Mechanistically, EV-associated HSPA5 restored AKT/mTOR signaling and was accompanied by reduced BECN1 phosphorylation, thereby preserving the SLC7A11/GPX4-associated antioxidant pathway. We further show that BECN1 directly interacts with SLC7A11, linking BECN1 signaling to regulation of the system Xc−/GPX4 antioxidant axis. MenSC-EVs preserved this antioxidant pathway and reduced lipid peroxidation in injured GCs. Collectively, these findings identify an HSPA5-dependent anti-ferroptotic mechanism through which MenSC-EVs ameliorate T1DM-associated ovarian dysfunction, supporting their potential as an ovarian-protective strategy under diabetic conditions. Download: Download high-res image (241KB) Download: Download full-size image
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ChemistrySelect
·
2026
·Vol. 11
·期 36
·e74557
·
IF 2.3
Xiaowei Zhou,Yuerong Wang,Youqing Sun,Dan Liu,Thabo T. I. Nkambule,Alex T. Kuvarega,Bhekie B. Mamba,Jianzhou Gui
In this study, a series of Ionic liquid-derived carbon dots (IL-CDs) were synthesized by microwave method from L-histidine and imidazolium-based ILs included 1-butyl-3-methylimidazolium chloride, 1-hexyl-3-methylimidazolium chloride and 1-decyl-3-methylimidazolium chloride. Their structures were elucidated using Fourier transform infrared spectroscopy (FTIR), Ultraviolet–visible spectrum (UV–vis), and nuclear magnetic resonance (NMR). The inhibition efficacy of IL-CDs on 45# steel within a 298 K, 1 M HCl solution system was investigated employing various techniques, including electrochemical analysis, weight loss measurement, scanning electron microscopy (SEM), atomic force microscopy (AFM), and molecular dynamics simulations. The microstructure and surface properties IL-CDs were obtained through a series of characterizations; and their corrosion inhibition performance for 45# steel was evaluated using weight loss and electrochemical methods in 1 M HCl solution. The electrochemical impedance spectroscopy (EIS) results showed that the corrosion inhibition efficiency of CDs in 1 M HCl solution could reach 98.2% at a concentration of 15 ppm, and 95% even at an increased temperature of 313 K. The strong adsorption of IL-CDs follows the Langmuir adsorption model, and the Gibbs free energy increases with the chain length of ionic liquids. The adsorption behavior of the IL-CDs on the carbon steel surface shows the chemisorption feature. Graphical The corrosion inhibition mechanism involves carbon dots that adsorb on the surface of carbon steel to form a hydrophobic film, which suppresses hydrogen evolution at the cathode and oxidation reactions at the anode.
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Journal of Extracellular Vesicles
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2025
·Vol. 14
·期 6
·e70105
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IF 14.5
Wenxin Zhang,Weichen Dong,Chen Cheng,Hongting Zhao,Yutong Liu,Kristina Zaydel,Liora Frech,Zhiyao Xing,Wusheng Zhu,Bing Zhou,Yi Li,Esther G Meyron‐Holtz,Kuanyu Li
The incidence of inflammatory bowel disease (IBD) is on the rise, yet current clinical treatments are limited. Previous studies have identified impairments in both systemic and local iron metabolism in IBD patients. However, the impact of iron dyshomeostasis on the development and pathogenesis of IBD remains elusive. In this study, we confirmed iron deposition in inflamed intestinal lesions of IBD patients and mice with DSS‐induced colitis, accompanied by distinct distribution patterns of the iron storage protein ferritin. To reveal the role of ferritin in the involvement of pathology of IBD, we constructed intestinal epithelial cell‐ or myeloid‐specific ferritin H ( FtH ) knockout mice and demonstrated that intestinal epithelial cells (IECs) release extracellular vesicles (EVs) that contain iron‐loaded ferritin. These EVs are internalized by macrophages via the macrophage scavenger receptor 1 (Msr1), leading to the activation of inflammatory responses and oxidative stress, thereby exacerbating colitis severity. Genetic deletion of FtH in IECs or blockage of macrophage ferritin uptake, either through Msr1 inhibitor fucoidan or through Msr1 knockdown (KD), suppressed inflammatory symptoms. Thus, EVs containing iron‐loaded ferritin released from IECs activate macrophages and contribute to IBD development, supporting that IBD patients with iron deficiency anaemia are often prescribed iron supplementation in a remission phase, other than in an active phase of the disease. Pharmacological inhibition of this ferritin secretion and engulfing process provides a therapeutic target for the disease. This study explores the interaction between intestinal epithelial cells (IECs) and macrophages through extracellular vesicles (EVs) in the context of inflammatory bowel disease (IBD). IECs release iron‐loaded ferritin via EVs as the donor, while macrophage scavenger receptor 1 on the surface of macrophages serves as the receptor for the internalization of the iron‐loaded ferritin‐containing EVs. This process activates macrophages and contributes to the development of IBD. These findings highlight the pathophysiological significance of iron metabolism disorders and suggest potential targets for future clinical applications in patients with IBD.
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Foods
·
2025
·Vol. 14
·期 20
·3474
·
IF 5.1
Shaodan Peng,Lian Yang,Wei Zhou,Yuan Yuan,Liangkun Liao,Xiaobing Huang,Chenghui Zhang,Xiao Gong,Jihua Li
Lactic acid bacteria (LAB) are widely utilized in the production of various fermented foods.Lacticaseibacillus casei(Ls. casei) fermentation has been demonstrated to enhance antioxidant activity, flavor, and nutritional value. This study aimed to evaluate the physicochemical properties, proximate chemical compositions, antioxidant activities, and volatile profiles of pineapple juice fermented byLs. caseiLK-1. Strain growth, physicochemical parameters, phenolics and flavonoids, carbohydrates, organic acids (by HPLC), free amino acids (FAAs), antioxidant activities (DPPH and FRAP methods), and volatile profiles (by GC-MS) of fermented pineapple juice were characterized. After 30 h of fermentation, the cell count reached 9.07 log CFU/mL. The fermentation process led to a significant decrease in pH, total soluble solids (TSS), and thea* value (p< 0.05), with an increase in theL* andb* values (p< 0.05). Lactic acid and total umami amino acids were elevated, whereas sucrose and total sweet amino acid levels remained unchanged. The fermented juice exhibited enhanced DPPH scavenging activity and FRAP values. In terms of volatile profiles, esters and terpenes were the dominant volatiles in the fermented pineapple juice. The fermentation resulted in the production of 2-heptanone, 2-undecanone, and a significant reduction in 2-furaldehyde (p< 0.05). These findings demonstrate the feasibility of usingLs. caseiLK-1 for fermentation to develop novel fermented pineapple juice with improved antioxidant properties and a modified volatile profile.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
·
IF 9
Liwen Zhang,Shaohua Chen,Shanyi Tan,Huizi Wen,Shuyu He,Fen Zhang,Xiangru Zuo,Ling Xiong
The inherent limitations of nano zero-valent iron (nZVI) severely limit its widespread application in heavy metal pollution remediation. To address this, Shewanella oneidenis MR-1 (MR-1) was utilized to counteract the iron oxide passivation layer on nZVI surface, however, this approach suffered from low electron transfer rate between MR-1 and the passivation layer. In this research, a novel PDA-modified nZVI composite (PDA-nZVI) was synthesized. Compared to unmodified nZVI, the proportions of Fe 0 and Fe(II) on the PDA-nZVI surface increased 2.06 % and 21.63 %, respectively. The electrochemical tests (e.g., a more negative corrosion potential, a lower charge-transfer resistance, a higher current density, and a 3.4-times larger electrochemical active surface area for PDA-nZVI compared to nZVI) confirm that PDA enhances electron transfer from iron core to the outside, thereby promoting Fe 0 availability and Fe(II) generation on the PDA-nZVI surface. Meanwhile, PDA modification successfully enhanced the material's dispersibility and hydrophilicity in aqueous solutions. Results demonstrate that the Cr(VI) elimination capacity of the PDA-nZVI and MR-1 combined system (PDA-nZVI/MR-1) was markedly superior to that of the nZVI/MR-1 system. Mechanism analyses demonstrate that PDA can act as an electron shuttle to accelerate electron transfer between MR-1 and the passivation layer, thereby promoting more Fe(III) transformation to Fe(II). This process enables more Cr(VI) to be reduced to Cr(III), which is subsequently adsorbed or complexed on the material surface as Cr 2 O 3 /FeCr 2 O 4 and Cr x Fe 1-x (OH) 3 , ultimately being removed from the solution via co-precipitation. The PDA-nZVI/MR-1 system successfully overcomes the inherent limitations and exhibits an exceptional Cr(VI) elimination capability
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Chengxun Li,Fei Chen,Jianing Wu,Jun Ren,Yingzhu Li,Shengjie Li,Zuguang Xia
Antibody drug conjugates (ADCs) offer targeted cancer therapy but face limitations in drug loading, stability, and immune modulation. Here, antibody DNA nanostructure conjugates (ADNCs) is reported as a next-generation platform that overcomes these challenges. By leveraging the programmable architecture of DNA nanostructures, ADNCs achieve high, tunable drug payloads without inducing antibody aggregation—a major drawback of conventional ADCs. In CT26 cells, gemcitabine-loaded ADNCs trigger dual cell death pathways—caspase-3-mediated apoptosis and RIP3-mediated necroptosis—enhancing tumor cell killing. In the CT26 syngeneic model, ADNCs suppress tumor growth with no observable toxicity and, notably, activate anti-tumor immunity without upregulating PD-1, suggesting avoidance of T-cell exhaustion. Critically, ADNCs maintain efficacy in patient-derived xenograft (PDX) models despite tumor heterogeneity. The study presents a novel, stable, and scalable antibody-drug conjugate (ADC)-inspired platform that integrates high payload delivery capacity with enhanced and adjustable drug-loading capabilities—characteristics that are seldom achieved in existing ADC technologies—thereby demonstrating translational potential for applications in precision oncology.
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Cell Death & Disease
·
2025
·Vol. 16
·期 1
·1-16
·
IF 9.6
Jing Yukai,Zhang Yunfei,Wang Xiaocui,Wang Yufen,Hu Ying,Wen Bin,Dai Xin,Duan Xuemei,Li Haonan,Dong Shumin,Yan Ze,Fan Yufeng,Wang Cong-yi,Liu Xiansheng,Zhang Ruiping
Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by the overproduction of autoantibodies and type I interferon, which damages its own tissues, causing multiple organ damage. B cells are thought to play a major role in the pathogenesis of SLE. As a DNA methylation reader, Methyl-CpG-binding domain protein 2 (MBD2) has been extensively studied in the contexts of innate immunity, adaptive immunity, and autoimmune diseases. However, its specific role in B cells and SLE remains unexamined. Herein, we found that MBD2 was highly expressed in B cells of SLE patients and positively correlated with disease activity. Knockout of MBD2 in B cells disturbed B-cell differentiation, dampened B-cell activation, B-cell receptor (BCR) signaling, and T-cell-dependent humoral immune responses in mice. What’s more, MBD2 deficiency effectively attenuated lupus-like symptoms, reduced the germinal center responses, and decreased anti-dsDNA antibodies in lupus model mice. Mechanistically, MBD2 selectively bound to the methylated CpG of Lef-1 induced by IFN-α, inhibiting the transcription and expression of Lef-1 , which repressed Pten transcription and expression, thereby promoting PI3K-Akt-mTOR signaling. This study first demonstrated the role of MBD2 in the pathogenesis of SLE and provided a new target for SLE.
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ACS Catalysis
·
2026
·
IF 13.6
Qiliang Liu,Wenxing Yang
Recently, an intense Raman peak at approximately 520–544 cm–1 (briefly named as *530 in this study) has been widely observed and discussed during in situ spectroscopic studies of electrochemical CO2 or CO reduction reaction (CO(2)RR). Several mechanisms were proposed to explain the nature of this peak, most notably attributing it to Cu–OHad or CuOx(OH)y, which was then utilized as a key spectroscopic indicator in various mechanistic discussions. Herein, by systematic isotopic-labeled spectroscopic studies, we show that the nature of the *530 peak may not be the previously proposed species, but more likely a surface species containing (C, O) in equilibrium with inert bridging-type adsorbed CO (*CObridge). Both the formation of *530 and *CObridge is shown to be associated with the spontaneous reconstruction of Cu. The *CObridge and *530 Raman modes share the same adsorption sites and can interconvert into each other via the variation of electrochemical potentials. Finally, the appearance of both peaks is shown to signalize a deteriorated C2+ products performance of CO2RR and CORR. These results update the current understandings of the role of *530 for CO(2)RR. It also highlights that the emerging-recognized electrocatalyst reconstruction phenomenon can be accompanied by the formation of diverse surface adsorbates, casting challenges, and necessitating rigorous spectroscopic studies for better mechanistic understanding.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Zhi Hu,Jiapeng Chen,Hengyong Xu,Xuyang Ji,Jiajun Zhu,Longge Guo,Xinqi Wang,Yiping Liu,Chaowu Yang,Chunlin Yu,Zengrong Zhang,Mohan Qiu,Yan Wang
Understanding the biochemical basis of chicken meat flavor is important for improving meat quality. An integrated metabolomic, lipidomic, and transcriptomic approach was applied to compare breast (BM) and leg meat (LM) of 120-day-old Tianfu broilers. Compared with BM, LM showed higher pH values, a 43.05% lower drip loss, and markedly higher intramuscular fat (IMF) content (6.217% vs. 1.954%), whereas BM contained more inosine monophosphate and exhibited greater shear force. GC–MS and lipidomics identified 147 volatile compounds and 1972 lipid species, respectively, with glycerophospholipids, particularly phosphatidylethanolamine and phosphatidylcholine, closely associated with flavor differences between muscles. Multi-omics factor analysis indicated circ_015424 as a key molecular feature correlated with lipid metabolism and flavor-related pathways. Functional assays further showed that circ_015424 enhanced lipid droplet accumulation in intramuscular adipocytes via the miR-196-1-3p/MOGAT1 axis. These results clarify lipid-related mechanisms underlying muscle-specific flavor formation in chicken.
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Dose-Response
·
2026
·
IF 2.8
AiJiao Sun,CuiYu Yu,FeiYan Zhu,Jing Chen,LiangChuan Chen,ZePing Hu,WeiBing Wang
BackgroundExtracellular matrix (ECM) deposition and excessive fibrosis are important factors in the deterioration of cardiac function after myocardial ischaemia‒reperfusion injury (I/RI). However, therapeutic strategies for inhibiting ECM deposition and excessive fibrosis have still not been elucidated.Methods and resultsSingle-nucleus RNA sequencing (snRNA-seq) revealed that the overexpression of type VI collagen-α 3 (Col6a3) in fibroblasts in the myocardial infarction area strongly promotes the process of myocardial fibrosis. Consistent results were not observed in the infarcted myocardial tissues of mice treated with 4,8-dicarboxyl-8,9-iridoid-1-glycoside (BIG). Echocardiography confirmed that BIG alleviated cardiac dysfunction in mice after myocardial I/RI, TTC and Evans blue double staining revealed that BIG reduced the myocardial infarction size and area at risk. BIG inhibited inflammatory responses, apoptosis, and matrix metalloproteinase (MMP) secretion both in vivo and in vitro. Immunofluorescence staining revealed that BIG downregulated the expressions of TGF‒β and Col6a3 in cardiac fibroblasts but not in cardiomyocytes. The PI3K-specific inhibitor LY294002 and AKT inhibitor were utilitzed to confirm that BIG suppressed myocardial fibrosis and alleviated cardiac dysfunction by activating the PI3K/AKT pathway.ConclusionsThe results provide valuable information for the treatment of myocardial fibrosis induced by myocardial I/RI and highlight the therapeutic potential of BIG in reducing collagen deposition.
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FUEL PROCESSING TECHNOLOGY
·
2026
·
IF 7.8
Zicong Wang,Jing Zhao,Weijiong Dai,Linquan Li,Yan Wang,Jiajun Zheng,Ruifeng Li
The fabrication of hierarchical zeolite structure and rational modulation of Ti active sites in TS-1 zeolite are both recognized as critical factors for improving catalytic performance in selective oxidation reactions. Herein, we propose a facile and cost-effective strategy combined a dry-gel conversion (DGC) method with a preliminary aging step for the direct synthesis of anatase-free hierarchical TS-1 zeolite containing highly active TiO 6 species. The coordination states of Ti species in TS-1 zeolites were thoroughly investigated via UV–vis, FTIR, XPS and UV-Raman spectroscopy. Additionally, systematic characterizations were performed to investigate the impacts of the synthetic strategy on the crystallization process, including the formation of hierarchical TS-1 zeolite structure and the modulation of Ti species coordination. The obtained TS-1 zeolite demonstrated exceptional catalytic activity and stability in olefin epoxidation and oxidative desulfurization reactions. This discovery not only advances the design and synthesis of titanosilicate zeolites but also expands their potential applications in various selective oxidation processes.
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危险品化学品经营许可证（带存储）