CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2025
·
IF 3.7
Haoran Yin,Lili Mu,Yifeng Chen,Licheng Li,Kang Sun,Xiaoyan Ji
Confinement effect is an effective method to enhance carbon dioxide (CO 2 ) solubility. In this study, a hybrid sorbent of 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Hmim][NTf 2 ])/mesoporous titanium dioxide (M-TiO 2 )/water (H 2 O) was developed, and its confinement effect was regulated by changing the pore structure of M-TiO 2 . CO 2 solubility in the hybrid sorbent was measured experimentally, and the thermodynamic properties including Henry’s constant and desorption enthalpy were calculated. Furthermore, the confinement effect in the hybrid sorbent was quantified. Additionally, the hybrid sorbent was recycled with a multi-cycle experiment. The results showed that M-TiO 2 calcined at 773.2 K (MT500) could lead to an efficient confinement effect. CO 2 solubility in the hybrid sorbent increased by 49.8% compared to that of H 2 O when the mass fraction of [Hmim][NTf 2 ]/MT500 was 5.0% (mass), where the contribution of confinement effect on Gibbs free energy occupied 5.2%.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Lulu Wu,Yu Zhang,Shuyue Fan,Mario Prejanò,Tiziana Marino,Nino Russo,Yongsheng Tao,Yunkui Li
The copigmentation effect between malvidin-3- O -glucoside and caffeic acid was comprehensive inquiry on the model wine solution, theoretical simulation and real wine. Thermodynamic parameters were determined by UV/Visible spectroscopy and Isothermal titration calorimetry (ITC). Theoretical data were obtained employing a dispersion-corrected density functional approach. The effects in real wines were investigated by adding the caffeic acid during different fermentation periods. Results shown that the copigmentation reaction between caffeic acid and malvidin-3- O -glucoside is a spontaneous exothermic reaction driven by hydrogen bonding and dispersions forces. Computations show that the polyhydroxyl sugar moiety and phenolic hydroxyl groups are the key active sites. The addition of caffeic acid in post-alcohol fermentation samples evidences an improving color characteristics in the wine.
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高影响因子
BMC MUSCULOSKELETAL DISORDERS
·
2024
·Vol. 25
·期 1
·1-10
·
IF 2.2
Lai Zhen,Li Mingming,Yang Xiaodong,Xian Zhenjie
Osteoporosis is caused by the imbalance of osteoblasts and osteoclasts. The regulatory mechanisms of differentially expressed genes (DEGs) in pathogenesis of osteoporosis are of significant and needed to be further investigated. GSE100609 dataset downloaded from Gene Expression Omnibus (GEO) database was used to identified DEGs in osteoporosis patients. KEGG analysis was conducted to demonstrate signaling pathways related to enriched genes. Osteoporosis patients and the human mesenchymal stem cells (hMSCs) were obtained for in vivo and in vitro resaerch. Lentivirus construction and viral infection was used to knockdown genes. mRNA expression and protein expression were detected via qRT-PCR and western blot assay separately. Alkaline phosphatase (ALP) activity detection, alizarin Red S (ARS) staining, and expression of bone morphogenetic protein 2 (BMP2), osteocalcin (OCN) and Osterix were evaluated to determine osteoblast differentiation capacity. UL-16 binding protein 1 (ULBP1) gene was upregulated in osteoporosis and downregulated in differentiated hMSCs. Knockdown of ULBP1 increased ALP activity, mineralization ability evaluated by ARS staining, expression of BMP2, OCN and Osterix in differentiated hMSCs. Furthermore, rescue experiment demonstrated that suppressed ULBP1 boosted osteoblast differentiation by activating TNF-β signaling pathway. Knockdown of ULBP1 gene could promoted osteoblast differentiation by activating TNF-β signaling pathway in differentiated hMSCs. ULBP1 may be a the Achilles’ heel of osteoporosis, and suppression of ULBP1 could be a promising treatment for osteoporosis.
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Tao Huanga,Lifeng Guan,Shuai Jin,Dehui Zhang,Wangwen Liao,Xiangyang Zhou,Xingxing Liu,Chen Wu,Wei Zeng
The low electrical conductivity of Li 3 V 2 (PO 4 ) 3 (LVP) impedes its practical application. To address this issue, this study enhances its conductivity by introducing nitrogen-doped carbon nanoframes into LVP. Using phytic acid as a carbon and phosphorus source, and polyvinylpyrrolidone (PVP) as a nitrogen source, nitrogen-doped nanoframe-modified LVP material (LVP@NC) was successfully synthesized. Importantly, the carbon nanoframes of LVP@NC are entirely derived from the precursor’s thermal decomposition, simplifying the synthesis process and reducing production costs. By optimizing the process parameters, significant improvements were achieved in key performance indicators, including the initial discharge capacity at 1C (132.85 mAh·g −1 ), long cycling life at 10C (98.98 % capacity retention after 1000 cycles), and rate capability at 50C (99.65 mAh·g −1 ). These improvements are attributed to the introduction of nitrogen-doped nanoframes, where the high-temperature decomposition of PVP leads to the formation of porous honeycomb-like structures, and nitrogen doping in the nanocarbon framework introduces defects and active sites, thereby promoting lithium-ion migration and facilitating electrolyte penetration. This simple, novel, and energy-efficient method demonstrates significant potential for the large-scale preparation of high-performance cathode materials.
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高影响因子
JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Lu Sai,Zhongsheng Dai,Zhenbo Wang,Huiling Zhao,Ying Bai
Li-rich layered oxides with high energy densities have become one kind of promising cathode for advanced lithium-ion batteries, however some issues are severely hindering their practical applications. To address these challenges, fast ion conductive LiTi 2 (PO 4 ) 3 (LTPO) is employed to modify the typical Li-rich cathode Li 1 · 2 Mn 0 · 56 Ni 0 · 17 Co 0 · 07 O 2 (LMNCO) via a sol-gel process combined with a two-step annealing treatment in this work. Serving as a physical separator, LTPO coating effectively depresses the side reactions at cathode-electrolyte interface and the transition-metal dissolution from LMNCO active material under harsh electrochemical environment. Meanwhile, LTPO layer with high ion conductivity could facilitate the interfacial Li + diffusion during charge/discharge process. In addition, partial Ti 4+ ions doped into LMNCO effectively elevate the oxygen electronegativity and restrain the excessive oxidization of lattice oxygen, thus stabilizing the crystal structure and alleviating the stress-strain propagation upon cycling. Electrochemical characterization results demonstrate that the LTPO-modified LMNCO cathode exhibits a superior capacity retention of 86.5 % after 400 cycles at room temperature and that of 73.7 % even under an elevated temperature of 45 °C after 250 cycles under 1C. This study provides a facile strategy for the surface modification of Li-rich layered-structure oxides, which also sheds light in enhancing electrochemical performances for various cathode materials .
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2018
·
IF 2.297
Yunzhi Yin,Yiyue Wang,Jun Zhang,Jing Li,Jingjing Chen,Qi Shen
Docetaxel (DTX) is one kind of well-known anticancer drugs against tumors. GDC0941 was used to inhibit PI3K/Akt signal pathway and improve anti-tumor activity. PLGA-PEG-R7 (poly lactic-co-glycolic acid polyethylene glycol bending with cell penetrating peptide R7)/poly sulfadimethoxine-Folate nanoparticles (R7/PSD-Fol NPs) were made to load DTX and GDC0941 simultaneously. In vitro, the release capacity of DTX and GDC0941 inside nanoparticles was determined and both drugs could release from nanoparticles to 70% within 48h. The result of flow cytometry showed that GDC0941 had no interference on cell uptake and R7/PSD-Fol NPs could enhance MCF-7 cells uptake the most significantly. In cell colony study, GDC0941 could further improve the anti-tumor effect of DTX and inhibit the formation of cell clones on the basis of enhancing the uptake of R7/PSD-Fol NPs. The capability of cell colony formation was as follows: DTX > DTX + GDC0941 > R7 NPs > R7/PSD-Fol NPs. The expression of cell apoptosis proteins treated with R7/PSD-Fol NPs was the lowest. The addition of GDC0941 could decrease the full-length content of apoptotic proteins caspase-3 and caspase-9. In vivo, pharmacokinetic parameters results showed us that GDC0941 had no interference on pharmacokinetic study. Main pharmacokinetic parameters of DTX suspension and R7/PSD-Folate NPs suspension showed significant differences.
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MOLECULES
·
2018
·Vol. 23
·期 3
·582
·
IF 3.098
Lunqiang Jin,Feng Liang
Increasing interests have been invested in the development of synthetic strategies toward the construction of spiro[pyrrolidine-2,3′-oxindole], which is the core structural skeleton in some compounds with diverse biological activities. In this work, an efficient diastereoselective 1,3-dipolar cycloaddition reaction of azomethine ylides generated in situ from 3-amino oxindoles and aldehydes with maleimides has been described. The protocol provides a facile and efficient access to structurally diverse succinimide-fused spiro[pyrrolidine-2,3′-oxindole] compounds in good to high yields (up to 93%) with moderate to excellent diastereoselectivities (up to >95:5). The relative stereochemistry of cycloaddition products has been assigned by X-ray diffraction analysis.Keywords:1,3-dipolar cycloaddition;azomethine ylide;one pot synthesis;maleimide;succinimide-fused spiro[pyrrolidine-2,3′-oxindole]
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高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2018
·Vol. 41
·期 10
·2197-2206
·
IF 2.415
Xiafei Guo,Faqiong Zhao,Baizhao Zeng
We report the electrochemical fabrication of a poly(2,2-bithiophene-co-3-methylthiophene)-graphene composite coating and its application in the headspace solid-phase microextraction and gas chromatography determination of benzenes (i.e., bromobenzene, 4-bromotoluene, 2-nitrotoluene, 3-nitrotoluene and 1,2,4-trichlorobenzene). The coating was uniform and showed cauliflower-like microstructure. It had high thermal stability (up to 375°C) and could be used for at least 180 times of solid-phase microextraction without a decrease in extraction performance. Furthermore, it presented high extraction capacity for the benzenes due to the hydrophobic effect and π–π interaction between the analytes and the coating. Under optimized extraction conditions, good linearity (correlation coefficients higher than 0.9946), wide linear range (0.01–50 μg/L), and low limits of detection (5.25–12.5 ng/L) were achieved for these analytes. The relative standard deviation was lower than 5.7% for five successive measurements with one fiber, and the relative standard deviation for fiber-to-fiber was 4.9–6.8% ( n = 5). The solid-phase microextraction and gas chromatography method was successfully applied for the determination of three real samples, and the recoveries for standards added were 89.6–106% for nail polish, 85.8–110% for hair dye, and 90–106.2% for correction fluid, respectively.
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2024
·
IF 2.5
He Liu,Qian Gao,Kaiyue Zhang,Meng Xu,Hualei Wang,Dongzhi Wei
( R )-selective transaminases have the potential to act as efficient biocatalysts for the synthesis of important pharmaceutical intermediates. However, their low catalytic efficiency and unfavorable equilibrium limit their industrial application. Seven ( R )-selective transaminases were identified using homologous sequence mining. Beginning with the optimal candidate from Mycolicibacterium hippocampi , virtual mutagenesis and substrate tunnel engineering were performed to improve catalytic efficiency. The obtained variant, T282S/Q137E, exhibited 3.68-fold greater catalytic efficiency ( k cat / K m ) than the wild-type enzyme . Using substrate fed-batch and air sweeping processes, effective conversion of 100 mM 4-hydroxy-2-butanone was achieved with a conversion rate of 93 % and an ee value > 99.9 %. This study provides a basis for mutation of ( R )-selective transaminases and offers an efficient biocatalytic process for the asymmetric synthesis of ( R )-3-aminobutanol.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Danyang Liu,Yiming Song,Bing Zheng,Jianhua Xie,Yi Chen,Jiayan Xie,Xinyi Chen,Qiang Yu
This study aimed to investigate the mitigation effect of epigallocatechin gallate (EGCG) on aging induced by 3-monochloropropane-1,2-diol (3-MCPD) in Caenorhabditis elegans, evaluate health indicators during the process, and reveal the underlying mechanism through transcriptomics and identification of mutants. The results showed that EGCG alleviated the declined fertility, shortened lifespan, reduced body size, weakened movement, increased reactive oxygen species and lipofuscin, and damaged antioxidative stress response and excessive heat shock proteins caused by 3-MCPD. Transcriptomics study indicated that treatment with 3-MCPD and EGCG altered gene expression, and gene mutants confirmed the involvement of insulin/IGF-1 signaling pathway in mediating the process that EGCG alleviated the aging toxicity induced by 3-MCPD. The study showed that EGCG alleviated the aging toxicity induced by 3-MCPD.
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ACTA PHARMACOLOGICA SINICA
·
2026
·
IF 10.4
Li Jing-shu,Jiang Xiao-wen,Chen Pei-bin,Li Xuan,Yang Xiao,Fan Shi-cheng,Gao Yue,Fang Jian-hong,Qiu Feng,Bi Hui-chang
There is a lack of effective therapies for cholestatic liver injury. Recent studies have shown that pan-inhibitors of histone deacetylases (HDACs) play a protective role in cholestasis and fibrosis, but the dynamic changes and role of histone deacetylase 3 (HDAC3) under these conditions remain unclear. In the current study, the expression of acetylation-modifying enzymes, including HDAC3, in livers from lithocholic acid (LCA)-induced intrahepatic and bile duct ligation (BDL)-induced extrahepatic cholestatic mice, as well as in cholestatic patients, was examined. HDAC3 was aberrantly upregulated in the livers of cholestatic mice and patients. Functional studies in LCA- and BDL-induced cholestatic mouse models using RGFP966, a specific HDAC3 inhibitor, were then performed. Pharmacological inhibition of HDAC3 significantly alleviated liver injury in LCA-induced cholestasis but had no protective effect on BDL-induced cholestasis, as assessed by survival tests, gross examination, H&E staining, serum biochemical assays, cytokine expression, and immunohistochemical staining of immune cell biomarkers. Mechanistically, HDAC3 inhibition upregulated genes involved in bile acid and lipid homeostasis in LCA-induced cholestatic mice, as determined by RNA-Seq and validated by RT‒qPCR and Western blotting. The upregulation of these genes, together with increased levels of acetylation of histone H3 at lysine 9 (H3K9Ac) and lysine 27 (H3K27Ac), was validated in transformed human liver epithelial-2 (THLE-2) cells treated with RGFP966. In summary, this study demonstrated that HDAC3 is a potential therapeutic target for LCA-induced intrahepatic cholestasis, with inhibition exerting protective effects through genes involved in bile acid and lipid homeostasis, possibly via epigenetic regulation.
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ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Chaoqiang Wu,Xin Zhang,Wei Liu,Chengyong Wang,Qianqian Jiang,Feifei Chen,Quanzhen Liu,Fei Cao,Gaowei Zheng,Alei Zhang,Kequan Chen
Chitin, as the second most abundant biomass in nature, possesses 7 wt % biologically fixed nitrogen, and its direct valorization into valuable nitrogen (N)-containing chemicals is optimal. Herein, we report the biosynthesis of two specific furan-based amine compounds, 2-acetyl-4-aminofuran (2A4AF) and 3-acetylamino-5-(α-aminoethyl)-furan (3A5AEF), from chitin-derived 3-acetamido-5-acetylfuran (3A5AF) via biocatalytic deacetylation and reduction amination, respectively. An amidase (MmH) from Starkeya sp. and an R-selective aminotransferase (ATA117) from Arthrobacter sp. were obtained, which can, respectively, convert 3A5AF to 2A4AF with a yield of 79.3% (47.58 mM) and (R)-3A5AEF (enantiomeric excess (ee) value of >99%) with a yield of 84.0% (126 mM), respectively, under the optimal conditions. The biosynthesis efficiency of the two amines was high in comparison with chemical approaches. This work paves the way for green and efficient production of furan-based amino chemicals from inexpensive renewable chitin resources.
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