ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2025
·
IF 3.8
Zou Ying,Zhang Manli,Zhou Dongdong,Chi Chaoxian,Wu Fangling,Ding Chuan-Fan
Vitamin C (L-( +)-ascorbic acid, L-AA) is an essential micronutrient. Its diastereoisomer, D-(-)-isoascorbic acid (D-IAA), is only 5% as active as L-AA. Therefore, it is crucial to identify and characterize the diastereoisomers of ascorbic acid. In this work, a straightforward and direct method using ion mobility-mass spectrometry (IM-MS) was proposed to identify ascorbic acid isomers. Ternary complexes [L-AA + γ-CD + 2Cs-H] + and [D-IAA + γ-CD + 2Cs-H] + , formed by non-covalent interaction of the isomer with the selective agent γ-CD and the metal ion Cs + , were separated in ion drift tubes with a resolution of R p-p as high as 1.398. Meanwhile, comparisons with different CDs and metal ions revealed varying separation efficiencies. Theoretical calculations were conducted to determine the optimal conformations of [L-AA + γ-CD + 2Cs-H] + and [D-IAA + γ-CD + 2Cs-H] + . Conformational analysis highlighted distinct structural differences at the molecular level, providing insight into the mobility separation mechanism of AA via the formation of ternary complexes with γ-CD and metal ions. Additionally, a quantitative analysis for the determination of chiral isomers was established with effective linearity and acceptable sensitivity. The method was successfully applied to assess L-AA/D-IAA content in pharmaceuticals and fruit samples. Graphical
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CELLULAR AND MOLECULAR LIFE SCIENCES
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2025
·Vol. 82
·期 1
·1-15
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IF 6.2
Guan Yiting,Deng Shuyue,Zou Xiaopeng,Wei Wenlu,Li Zechen,Zhong Jiajing,Zhu Yanmei,Zhang Donghui,Ju Yanmin,Sun Qing-Yuan,Zhang Hongyong
Low-quality oocytes directly affect fertilization and embryonic development, contributing to infertility in women, while germ cell senescence leads to reduced germ cell numbers and decreased egg quality. Dasatinib and quercetin (D and Q), as senolytic drugs, have been extensively explored in different age-related diseases. However, their effects on in vitro cultured senescent oocytes and the molecular mechanisms underpinning ovarian aging remain elusive. Here, we report that a nano-encapsulated senolytic D + Q cocktail efficiently improves the quality of post-ovulatory aging oocyte in vitro and follicle quantity in ovaries in a cyclophosphamide (Cy)-induced premature ovarian failure (POF) mouse model. Cocktail supplementation to cultured oocytes potently reduces reactive oxygen species (ROS) levels, maintains spindle integrity, decreases fragmented oocyte frequencies, rescues mislocalized cortical granules (CGs) and mitochondrial membrane potential (MMP), and alleviates DNA damage and apoptosis. Importantly, the cocktail effectively ameliorates fertility deficits in the model. Transcriptome analysis shows cocktail administration to fertility-deficient mice not only up-regulates developmental gene expression but also reduces senescence-associated secretory phenotype (SASP) accumulation. Therefore, our nano-encapsulated D + Q cocktail is a promising reagent for assisted reproductive technology and improving reproductive outcomes in POF. Graphical
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JOURNAL OF POLYMER RESEARCH
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2025
·Vol. 32
·期 5
·1-11
·
IF 2.8
Sang Zhuo,He Liangyong,Yang Bin,Lu Tianyu,Kang Shijun,Sang Jiaojiao,Zheng Zhengzhi,Hu Weiqiang,Qian Jiasheng,Jia Ning,Ke Yuchao
In this work, free radical solution polymerization was used to prepare polymeric nanocomposite films by copolymerization of flexible butyl acrylate (BA) monomer and modified nano−silica with methyl acrylate (MMA) monomer. Our findings showed that the addition of BA monomer and nano−silica had limited effect on the transmittance of PMMA films, and the transmittance could achieve as high as 93%. Perfect overall properties of the as−prepared films (with a tensile strength of 36 MPa and an elongation at break of 42%) could be achieved when the monomer MMA:BA was set as 6:2 at a nano−silica content of 20 wt%. The PMMA−based nanocomposite films prepared in this work possessed excellent transparency, desired toughness and good hydrophobicity, which made them potentially promising for the applications as protective films for polarizing films.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2024
·Vol. 149
·期 10
·4655-4670
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IF 3
Qu Haowen,Bai Mingqi,Dang Jing,Shu Chi-Min,Yu Yanan,Li Kai,Deng Zijian,Li Bing,Liu Yi
Methylene diphenyl diisocyanate (MDI) serves as a primary component of polyurethane in various applications, including household appliances, architectural structures, automobiles, and adhesives. A recent MDI plant explosion in China highlighted the importance of studying MDI’s thermal stability and parameters to prevent accidental thermal decomposition. In this study, an extensive array of analytical techniques, including differential scanning calorimetry, thermogravimetric analysis, and adiabatic accelerating calorimeter, was employed to determine the thermokinetic constants of MDI, providing a solid foundation for further in-depth investigations. The findings revealed that MDI containing water reacts at substantially lower temperatures, while pure MDI can release heat and gases in an adiabatic environment, posing a considerable explosion risk. The kinetic constant of MDI was calculated using the Flynn–Wall–Ozawa method, yielding apparent activation energy values ranging from 51.78 to 96.70 kJ mol −1 across a conversion degree range of 0.05–0.70. The Coats–Redfern model pinpointed the kinetic reaction mechanism as a two-stage chemical process based on the apparent activation energy. Molecular optimization, following the energy minimisation principle, was conducted using Gaussian 09 software, which led to the identification of the optimal pathway for generating carbodiimide and carbon dioxide. This investigation offers valuable insights for the effective management of MDI during production, transportation, and storage, contributing to improve loss prevention practices in the industry.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Dai Zechuan,Chen Yanxu,Zhang Huaikun,Cheng Mingyu,Zhang Bocheng,Feng Pingyi,Feng Yafei,Zhang Genqiang
Electrochemical urea synthesis has recently emerged as a fascinating energy-efficient alternative route, while it remains challenging to achieve simultaneously high production rate and Faradaic efficiency. Herein, we realize an energy-favorable electrochemical C-N coupling path through CO 2 and NO 3 − co-reduction at the heterointerfaces of Cu/Cu 2 O microparticles, generated by in-situ electrochemical engineering on bulk Cu 2 O. We achieve urea production rate of 632.1 μg h −1 mg cat. −1 with a corresponding Faradaic efficiency of 42.3% at −0.3 V (versus RHE) under ambient conditions. Operando synchrotron radiation-Fourier transform infrared spectroscopy, along with theoretical calculations, reveals the coupling of intermediates NOH* and CO* at the heterointerfaces, benefiting from the modified electronic structure. This work provides a practical route for catalyst design and insights into urea electrosynthesis systems.
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METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
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2025
·
IF 3.1
Chen Shi-Liang,Lu Chang,Yan Yu-Chi,Guo Zhi-Peng,Fan You-Qi,Zhao Wei-Cheng,Wang Xin,Guan Xiu-Tao,He Shi-Wei,Zheng Jia-Le
Silver is the most difficult non-copper impurity element to be purified and removed during the preparation of high-purity copper products by electrolysis. This is primarily due to the unpredictable behavior of trace amounts of silver during electrolysis. As a result, current methods for reducing silver content in cathode copper are limited and often ineffective, with silver levels remaining above 8 ppm. This work examines the cathodic behavior of Ag + during copper electrolysis using thermodynamic and kinetic theoretical calculations, variable experiments, and a detailed analysis of the trace Ag phase in copper cathode. Experimental findings indicate that the concentration of Ag + in the electrolyte is the primary determinant of silver content in cathode copper, specifically, the silver content in copper cathode rises dramatically with increasing the concentration of Ag + in the electrolyte. Under the condition of current density 300 A/m 2 , T = 63 °C, Ag + concentration of 0.01 mg L −1 , the silver content in copper cathode diminishes by 81.43 pct from 8.51 to 1.41 ppm. Combining electrochemical tests (cyclic voltammetry and square wave voltammetry) with scanning electron microscopy, an intriguing revelation has emerged. Following electromigration, diffusion, desolvation, and electroreduction, the silver most likely embeds into the copper deposition layer with the occurrence state of Cu 9 Ag solid solution alloy, rather than the traditional belief that silver exists as an independent silver element. This study contributes to a fundamental understanding of the underlying causes of the difficulty in removing silver from copper cathode, and provides inspiration for the development of new methods to improve the purity of electrolytic copper and to reduce the silver lost therein. Graphical
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Nature Chemical Biology
·
2025
·
IF 13.7
Yao Shunyu,Xie Shengling,Liu Run-Zhou,Huang Zilei,Zhang Lihan
Modular polyketide synthases biosynthesize structurally diverse natural products by a set of catalytic domains that operate in an assembly line fashion. Although extensive research has focused on the rational reprogramming of modular polyketide synthases, little has been attempted to introduce noncanonical catalytic reactions on the assembly line. Here, we demonstrate the insertion of a thioester reductase domain, which can generate a terminal alcohol group instead of the canonical carboxylic acid, onto the assembly line polyketide synthases. We show that the didomain insertion of the acyl carrier protein and thioester reductase pair is generally effective for engineering of various polyketide synthase pathways. As a proof of concept, stereoselective and stereodivergent bioproduction of non-natural diols, namely, 1,3-butanediols and 2-methyl-1,3-butanediols, is achieved by harnessing the modularity of polyketide synthases. Our study expands the catalytic versatility of modular polyketide synthases and paves the way toward biosynthesis of designer alcohols.
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JOURNAL OF ELECTRONIC MATERIALS
·
2025
·
IF 2.5
Xiao Linfeng,Wang Xinyue,Fu Lichun,Deng Wenqiang,Liang Boyu,Li Runrun,Hong Yan,Du Jie,Zhou Zhenyuan,Liao Runhua
Due to the low cost and abundant reserves of transition metals, there is an urgent imperative for the design and fabrication of transition metal electrocatalysts to expedite hydrogen production through the hydrogen evolution reaction (HER). We present a self-supported needle-grass-shaped Zn-Co (ZC) composition on porous nickel foam (NF) via conventional hydrothermal synthesis. The Zn-Co/NF electrodes demonstrate remarkably efficient HER performance in 1.0M KOH alkaline solution. Specifically, the ZC (1:4)/NF catalyst exhibits an overpotential of 171.9 mV at a current density of 10 mA cm −2 owing to the synergistic effect arising from the combination of Zn-Co composition and Ni layers. Furthermore, stability tests demonstrate that the linear sweep voltammetry (LSV) curves of the ZC (1:4)/NF catalyst exhibits only marginal changes even after undergoing 1000 consecutive cycles at a scan rate of 20 mV s −1 . This study presents an innovative approach for the design and fabrication of highly efficient electrocatalysts for HER. Graphical
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2015
·Vol. 407
·期 16
·4607-4613
·
IF 3.436
Deng Xiang,Huang Xiaomei,Wu Di
Nitroaromatic compounds, for example trinitrotoluene and 2,4,6-trinitrophenol (TNP), are well-known primary constituents of many unexploded landmines worldwide. These compounds are recognized as environmental contaminants and as toxic to living organisms. Therefore, Förster resonance energy transfer (FRET) for TNP detection was developed on the basis of spectral overlap between the fluorescence spectrum of copper nanoclusters (CuNCs) and absorption spectrum of TNP (the calculated Förster distance R
0 of the donor CuNCs and the acceptor TNP is 2.8 nm). Water-soluble fluorescent CuNCs capped with bovine serum albumin have fluorescence emission from 350 nm to 500 nm with maximum fluorescence emission at 400 nm, which overlaps with the absorption spectra of TNP from 350 nm to 450 nm. Inspired by FRET structures, an unprecedented energy-donor-and-acceptor pair of fluorescent CuNCs and TNP is developed in this work. Fluorescence of CuNCs is quenched in the presence of TNP as a result of FRET from fluorescent CuNCs to TNP. Therefore a fluorescence quenching method for the determination of TNP is developed. It achieves TNP detection from 0.8 μmol L −1 to 100 μmol L −1 , with response within 1 min and with good selectivity compared with that for other nitroaromatic compounds, including 2,4-dinitrotoluene, p -nitrotoluene, and nitrobenzene, and phenol.
Förster resonance-energy-transfer detection of 2,4,6-trinitrophenol using copper nanoclusters was first developed. It achieves TNP detection from 0.8 mmol L −1 to 100 mmol L −1 within 1 min with good selectivity compared with other nitroaromatic compounds
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2025
·
IF 3.1
Zhang Han,Li Ping-feng,Shu Chi-Min,Wu Hong-bo
To improve the storage stability and delay accuracy of boron series delayed composition, in this study, the reaction thermokinetic characteristics and microscopic reaction mechanism of B-Pb 3 O 4 delay composition were systematically analysed. Synchronous thermal analysis and differential scanning calorimetry were used to evaluate the thermodynamic properties of the delay composition. The kinetic parameters were calculated based upon Ozawa method. The macroscopic and microscopic reaction characteristics of Pb 3 O 4 -B were studied via X-ray photoelectron spectroscopy and density functional theory calculation. The reaction path and reaction site were determined by analysing the HOMO–LUMO orbit of reactants. The results showed that there are two reaction sites in the reaction process of lead tetraoxide and boron, which are Pb6 (Pb5) and Pb7 (Pb4) sites, respectively. The poor storage stability was mainly due to the reaction energy barrier of Pb 3 O 4 cluster and B being low, which are prone to chemical reactions in storage. The microscopic reaction mechanism of lead trioxide and boron mainly consists of five steps: Pb 3 O 4 + B → BO + 3PbO, (2) BO + Pb 3 O 4 → BO 2 + 3PbO, (3) B + PbO → BO + Pb, (4) BO + BO → B 2 O 2 , and (5) BO + BO 2 → B 2 O 3 , respectively.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2025
·
IF 3.5
Huhe Dule,Ma Zhengxiang,Zheng Jiali,Wang Yanji
2,5-Furandicarboxamide (FDA) is a promising bio-based platform compound for synthesizing high-value chemicals. Conventional synthesis methods, including strong acid/base-catalyzed reactions and ammonia oxidation, present significant environmental concerns and safety risks. In this paper, we investigated the performance of various oxide catalysts and the kinetics of the hydration reaction of 2,5-dicyanofuran (DCF) to produce FDA. The nanorod manganese oxide (NR-MnO 2 ) catalyst demonstrated remarkable efficacy, achieving an FDA yield of 97.5% at a reaction temperature of 110 °C over 2.5 h. Additionally, integrating cerium oxide (CeO 2 ) with NR-MnO 2 enhanced the selectivity for the single cyano hydration reaction. Specifically, the Mn 1 -Ce 0.25 oxide catalyst yielded 76.1% for 5-cyano- 2-furancarboxamide (DFFA) with an impressive selectivity of 89.2%. A kinetic model for the DCF hydration reaction was successfully developed using NR-MnO 2 as the catalyst. The model revealed that the initial stages involve the hydration of monocyano to form DFFA, followed by further hydration to form the FDA. Based on the Arrhenius model, the apparent activation energies were 48.5 kJ/mol and 35.4 kJ/mol, respectively. The results of this study provide a scientific foundation for the hydration of DCF in the production of DFFA or FDA, offering a more selective and environmentally friendly approach to the synthesis of bio-based amides.
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Journal of the Australian Ceramic Society
·
2020
·Vol. 56
·期 4
·1413-1419
·
IF 1.307
Yuan Qiuhua,Wan Lei,Wu Jianbo,Xu Anping
In this paper, experimental method and first-principles calculations were combined to study the properties of pure hydroxyapatite and Zn-doped hydroxyapatite. Pure and Zn-doped hydroxyapatite (HA) powders were synthesized using the hydrothermal method. The FTIR spectra show that the adding of Zn atoms makes the intensity of PO 4 3− stretching peaks become weaken and obscure. In addition, the O-H bending peaks at 3570 and 632 cm −1 become weaker and broader. The XRD patterns show that the replacement of Zn ion in the HA structure leads to the distortion in HA lattice, which is shown and proved by the TEM analysis. First-principles calculations based on density functional theory (DFT) method were applied to investigate the Zn-doped hydroxyapatite. The elastic properties of HA, HA with Ca 2+ (II) vacancy, and Zn doped HA systems were calculated. Through the calculation, we found that the doping of Zn atoms made the elastic modulus of HA crystal becoming soft. The elastic properties dropped dramatically when there is a vacancy in the Ca 2+ (II) position. Compared with the HA-VCa 2+ structure, the Zn-doped HA has better elastic properties and stability. The local structure of the substitution position was presented and analyzed. In the Zn-doped HA structure, the OH − group adjacent to Zn 2+ is significantly displaced from the c axis toward to the Zn 2+ , making the lattice distorted. The distortion of the crystal lattice is responsible for the weakness of the P-O stretching peaks and O-H bending peaks in the FTIR spectra of the Zn doped HA crystal. The softness of the elastic modulus is also caused by the distortion of the lattice and the weak bonding force between Zn atom and O atom.
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