MEDICINAL CHEMISTRY RESEARCH
·
2021
·Vol. 30
·期 12
·2228-2239
·
IF 1.965
Shang Fan-Fan,Wang Mei-Yuan,Ai Jiang-Ping,Shen Qing-Kun,Guo Hong-Yan,Jin Chun-Mei,Chen Fen-Er,Quan Zhe-Shan,Jin Lili,Zhang Changhao
Nineteen mycophenolic acid (MPA) derivatives were designed and synthesized, and their anti- Toxoplasma activity evaluated for the first time. Among them, N -propylimidazole-modified compound E5 demonstrated the strongest activity, and the IC 50 against HFF-1 (Human Foreskin Fibroblasts-1) cells following infection with T. gondii is 80.9 μM (MPA-211.5 μM) and its selectivity index is 2.2 (MPA-1.2). In vivo experiments, E5 can significantly inhibit the proliferation of tachyzoites in the abdominal cavity of mice acutely infected with T. gondii (inhibition rates 46.7%), and this inhibitory effect was greater than that of spiramycin (inhibition rates 31.3%) and MPA (inhibition rates 15.9%), this indicated that E5 had significant protective effects on the host during acute Toxoplasma infection. In addition, E5 can reduce the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the serum of infected mice, significantly increase the level of glutathione (GSH) in the liver, and significantly reduce the level of malondialdehyde (MDA), indicating that it has a hepatoprotective effect against T. gondii infection. Similarly, E5 can relieve hepatomegaly and splenomegaly induced by acute Toxoplasma infection. Spiramycin aggravated appetite loss in infected mice, while E5 did not. In summary, the results indicated that E5 has potential as a candidate anti- T. gondii drug.
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Nano-Micro Letters
·
2021
·Vol. 13
·期 1
·1-15
·
IF 16.419
Wu Xinyu,Tu Tingxiang,Dai Yang,Tang Pingping,Zhang Yu,Deng Zhiming,Li Lulu,Zhang Hao-Bin,Yu Zhong-Zhen
Highlights
3D printing of MXene frames with tunable electromagnetic interference shielding efficiency is demonstrated.
Highly conductive MXene frames are reinforced by cross-linking with aluminum ions.
Electromagnetic wave is visualized by electromagnetic-thermochromic MXene patterns.
Abstract The highly integrated and miniaturized next-generation electronic products call for high-performance electromagnetic interference (EMI) shielding materials to assure the normal operation of their closely assembled components. However, the most current techniques are not adequate for the fabrication of shielding materials with programmable structure and controllable shielding efficiency. Herein, we demonstrate the direct ink writing of robust and highly conductive Ti 3 C 2 T x MXene frames with customizable structures by using MXene/AlOOH inks for tunable EMI shielding and electromagnetic wave-induced thermochromism applications. The as-printed frames are reinforced by immersing in AlCl 3 /HCl solution to remove the electrically insulating AlOOH nanoparticles, as well as cross-link the MXene sheets and fuse the filament interfaces with aluminum ions. After freeze-drying, the resultant robust and porous MXene frames exhibit tunable EMI shielding efficiencies in the range of 25–80 dB with the highest electrical conductivity of 5323 S m −1 . Furthermore, an electromagnetic wave-induced thermochromic MXene pattern is assembled by coating and curing with thermochromic polydimethylsiloxane on a printed MXene pattern, and its color can be changed from blue to red under the high-intensity electromagnetic irradiation. This work demonstrates a direct ink printing of customizable EMI frames and patterns for tuning EMI shielding efficiency and visualizing electromagnetic waves.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2018
·Vol. 410
·期 25
·6489-6495
·
IF 3.307
Wen Aoli,Peng Xiaoxiao,Zhang Pingping,Long Yunfei,Gong Huiming,Xie Qingru,Yue Ming,Chen Shu
Berberine hydrochloride (BHC), a natural isoquinoline alkaloid, is widely applied as a an agent in traditional Chinese medicine. Almost all the traditional methods for BHC detection require complicated preprocessing steps or expensive instruments. In this article, we report a simple, rapid, sensitive, and selective method for BHC detection using fluorescent gold nanoclusters (F-AuNCs) as the fluorescent probe with a large Stokes shift of 237 nm. The F-AuNCs prepared with citrate-stabilized stannous chloride and hydrogen tetrachloroaurate(III) as raw materials in an aqueous medium display strong and stable fluorescence at 566 nm. When F-AuNCs are mixed with BHC, the fluorescence of F-AuNCs is effectively quenched. Under optimized conditions, this method allows sensitive and selective measurements of BHC in a concentration ranging from 1.0 × 10 -6 to 1.0 × 10 -4 mol L -1 with a detection limit of 7.5 × 10 -8 mol L -1 , which is relatively low among reported spectral methods. This method provides excellent selectivity for the detection of BHC against inorganic anions and natural amino acids. In addition, the BHC content in two different types of berberine tablets was successfully determined by this method and the results showed high accuracy.
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Frontiers of Chemical Science and Engineering
·
2023
·Vol. 17
·期 8
·1096-1108
·
IF 4.5
Hou De-Fa,Yuan Pan-Pan,Feng Zi-Wei,An Meng,Li Pei-Yao,Liu Can,Yang Ming-Bo
Derivatization has great potential for the high-value utilization of cellulose by enhancing its processability and functionality. However, due to the low reactivity of natural cellulose, it remains challenging to rapidly prepare cellulose derivatives with high degrees of substitution. The “cavitation effect” of ultrasound can reduce the particle size and crystalline index of cellulose, which provides a possible method for preparing cellulose derivatives. Herein, a feasible method was proposed for efficiently converting regenerated cellulose to cellulose oleate with the assistance of ultrasonic treatment. By adjusting the reaction conditions including ultrasonic intensity, feeding ratios of oleic acid, reaction time, and reaction solvent, a series of cellulose oleates with degrees of substitution ranging from 0.37 to 1.71 were synthesized. Additionally, the effects of different reaction conditions on the chemical structures, crystalline structures, and thermal behaviors were investigated thoroughly. Cellulose oleates with degrees of substitution exceeding 1.23 exhibited amorphous structures and thermoplasticity with glass transition temperatures at 159.8 to 172.6 °C. This study presented a sustainable and practicable method for effectively derivatizing cellulose.
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Cancer Cell International
·
2019
·Vol. 19
·期 1
·1-10
·
IF 3.439
Han Jingli,Zhang Junhua,Zhang Wei,Zhang Dalei,Li Ying,Zhang Jinsong,Zhang Yaqun,Diao Tongxiang,Cui Luwei,Li Wenqing,Xiao Fei,Liu Ming,Zou Lihui
Background Abiraterone and MDV3100 are two effective anticancer agents for prostate cancer, however, the mechanism of their downstream action remains undefined.Methods A dual fluorescent biosensor plasmid was transfected in LNCaP cells to measure mitophagy. The DNA of LNCaP cells was extracted and performed with quantitative real-time PCR to detect mitochondrial DNA copy number. JC-1 staining was utilized to detect the mitochondrial membrane potential and electron microscope was performed to analyze mitochondrial morphology. Moreover, the protein levels of mitochondrial markers and apoptotic markers were detected by western blot. At last, the proliferation and apoptosis of LNCaP cells were analyzed with CCK-8 assay and flow cytometry after abiraterone or MDV3100 treatment.Results Mitophagy was induced by abiraterone and MDV3100 in LNCaP cells. The low expression level of mitochondrial DNA copy number and mitochondrial depolarization were further identified in the abiraterone or MDV3100 treatment groups compared with the control group. Besides, severe mitochondria swelling and substantial autophagy-lysosomes were observed in abiraterone- and MDV3100-treated LNCaP cells. The expression of mitochondria-related proteins, frataxin, ACO2 and Tom20 were significantly downregulated in abiraterone and MDV3100 treated LNCaP cells, whereas the expression level of inner membrane protein of mitochondria (Tim23) was significantly upregulated in the same condition. Moreover, the proliferation of LNCaP cells were drastically inhibited, and the apoptosis of LNCaP cells was increased in abiraterone or MDV3100 treatment groups. Meanwhile, the addition of mitophagy inhibitor Mdivi-1 (mitochondrial division inhibitor 1) could conversely elevate proliferation and constrain apoptosis of LNCaP cells.Conclusion sOur results prove that both abiraterone and MDV3100 inhibit the proliferation, promote the apoptosis of prostate cancer cells through regulating mitophagy. The promotion of mitophagy might enhance the efficacy of abiraterone and MDV3100, which could be a potential strategy to improve chemotherapy with these two reagents.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2019
·Vol. 38
·期 4
·342-348
·
IF 2.804
Yang Ying,Shan Tong,Cao Jian,Wang Hua-Chun,Wang Ji-Kang,Zhong Hong-Liang,Xu Yun-Xiang
Two conjugated polymers (PuIDTBD and PuIDTQ) with unsymmetric side chains have been prepared for polymer solar cells using two other polymers (PIDTBD and PIDTQ) with symmetric side chains as control compounds. The combination of methyl and 4-hexylphenyl side chains on the same bridged carbon can ensure good solubility, decrease π - π stacking distances, and bring proper miscibility with PC 71 BM simultaneously. Therefore, the corresponding polymer solar cells (PSCs) based on donor polymers with unsymmetric side chains exhibited enhanced short-circuit current density ( J SC ) and power conversion efficiency (PCE) compared with those of control polymers. The PIDTBD and PIDTQ based devices possessed low PCE of 2.13% and 1.48%, while PCEs of devices based on PuIDTBD and PuIDTQ were improved to 3.93% and 4.12%, respectively. The results demonstrate that unsymmetric side chain engineering of conjugated polymers is an effective approach to achieve high performance PSCs.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 414
·期 26
·7675-7681
·
IF 4.478
Sheng Yilun,Huang Zhongnan,Chen Yaling,Guo Xiaoyun,Chen Lan,Peng Huaping,Chen Wei
Monitoring of dihydropyridine drugs, such as nifedipine (NIF), has attracted considerable attention owing to the side effects arising from the consumption of such drugs. Herein, a highly sensitive and facile fluorescence-sensing platform based on a high-quantum-yield sulfur quantum dot (SQDs) probe for NIF detection is proposed. Based on the principle of the inner filter effect, the rapid detection of NIF with high sensitivity is successfully realized on the basis of the change in the fluorescence signal due to the quenching effect of NIF on SQDs. The results show a good linear relationship between the NIF concentration and fluorescence intensity within the range of 5–150 μmol/L, with a low detection limit of 1.63 μmol/L (S/N = 3). Moreover, because no surface modification or establishment of any coupling between the receptor and the fluorophore is necessary, this approach provides considerable flexibility and simplicity for the construction of a fluorescence sensor and substantially reduces the detection time. A systematic investigation was conducted to verify the applicability of this method for the analysis of pharmaceutical components in NIF tablets. This study not only promotes the design and development of a fluorescence analysis platform for NIF detection, but also facilitates the fabrication of novel SQD-based fluorescence-sensing systems for the molecular detection of drugs. Graphical abstract
Proposal for a facile nifedipine assay method based on the inner filter effect of nifedipine to high-quantum-yield sulfur quantum dots, and realizing nifedipine detection in tablets and human urine samples.
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高影响因子
Frontiers of Chemical Science and Engineering
·
2023
·Vol. 17
·期 7
·906-917
·
IF 4.5
Zou Min,Tan Chao,Yuan Zhengqiu,Wu Ming,Jian Jian,Zhang Lei,Zhang Yan,Ma Zhou,Zhou Hu
The industrial application of nano-photocatalysts in wastewater treatment has been severely restricted for a long time due to their difficult separation, poor reusability, and low efficiency. In this work, a facile strategy was proposed to enhance the photocatalytic activity and recovery performance of Ag@AgCl nanocatalysts. Biological veins (Bio-veins) with a unique 3D porous construction were used as carriers for the in-situ growth of Ag@AgCl nanoparticles. Scanning electron microscopy results showed that the Ag@AgCl nanoparticles were uniformly loaded on the surface and interior of the Bio-veins, and the size of the Ag@AgCl nanoparticles immobilized on the Bio-veins (50–300 nm) was significantly smaller than Ag@AgCl obtained by the co-precipitation method (1–3 µm). The Bio-veins played a vital role in the photocatalysis reaction system. The degradation efficiency of the Ag@AgCl/Bio-veins(CI4) was up to 3.50 times as high as pure Ag@AgCl. Furthermore, the composites also exhibited excellent recyclability and stability under both visible and solar light. This work provided a suitable strategy for nanophotocatalysts for practical application and may also offer new possibilities for the high-value utilization of biomass materials.
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JOURNAL OF POROUS MATERIALS
·
2019
·Vol. 27
·期 1
·11-19
·
IF 1.947
Fu Hong Yi,Lu Cheng,Huang Yu Hui,Li Juan,Wu Yong Jun
Porous texture of graphene-hydrogel electrode material is critical for the performance of supercapacitors. In this work, the pore channels are controlled by two aspects, including the graphene oxide concentration and the pressure for fabricating hydrogel electrodes. It is found that the sample starting from 3 mg ml −1 graphene oxide shows the largest specific capacitance of 297 F g −1 at a current density of 0.5 A g −1 in 2 M KOH solution after the hydrothermal process. By increasing the pressure to 10 MPa, the electrochemical performance can be further improved to 330 F g −1 . This good performance is mainly attributed to the preferable specific surface area (2110 m 2 g −1 ) and the dense laminated structure under the optimizing preparation conditions. Besides, the cycle measurement demonstrates the excellent cycling stability of the samples, while 88% of its initial capacitance can be retained after 10,000 cycles.
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Nature Communications
·
2020
·Vol. 11
·期 1
·1-9
·
IF 12.121
Wang Lingxiang,Guan Erjia,Wang Yeqing,Wang Liang,Gong Zhongmiao,Cui Yi,Meng Xiangju,Gates Bruce C.,Xiao Feng-Shou
The reaction pathways on supported catalysts can be tuned by optimizing the catalyst structures, which helps the development of efficient catalysts. Such design is particularly desired for CO 2 hydrogenation, which is characterized by complex pathways and multiple products. Here, we report an investigation of supported cobalt, which is known for its hydrocarbon production and ability to turn into a selective catalyst for methanol synthesis in CO 2 hydrogenation which exhibits good activity and stability. The crucial technique is to use the silica, acting as a support and ligand, to modify the cobalt species via Co‒O‒SiO n linkages, which favor the reactivity of spectroscopically identified *CH 3 O intermediates, that more readily undergo hydrogenation to methanol than the C‒O dissociation associated with hydrocarbon formation. Cobalt catalysts in this class offer appealing opportunities for optimizing selectivity in CO 2 hydrogenation and producing high-grade methanol. By identifying this function of silica, we provide support for rationally controlling these reaction pathways.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2017
·Vol. 53
·期 3
·1623-1633
·
IF 2.599
Qiao Yujie,Liu Xuelong,Fu Gongbu,He Zhongyuan,Hou Chengyi,Li Yaogang,Zhang Qinghong,Yan Hexin,Wang Hongzhi
Nanofiber scaffolds are widely used as the platform for three-dimensional culture of hepatocytes in vitro. The pore size of scaffolds plays an important role in promoting the infiltration and proliferation of hepatocyte. We show that the average pore size of electrospun scaffold increases from ~ 7.6 to 13.2 μm, while the average fiber diameter decreases from ~ 2.0 to 1.5 μm when collected by probe array collectors. Though increase in pore size decreases the tensile stress of scaffolds, it leads to enhance the proliferation and attachment of hepatocytes. Specifically, a 6 × 6 array scaffold which was prepared by probe collector was orderly arrayed. Compared with the conventional scaffold, the pore size of the arrayed scaffold doubled and the hydrophilicity was improved. When HepG 2 cells were seeded on the arrayed scaffold, cells showed superior adhesion ability, better cell morphology and three-dimensional growth. These results indicated that the ordered 6 × 6 array scaffold has the potential as a suitable substratum for in vitro culture of hepatocytes.
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CHINESE SCIENCE BULLETIN
·
2013
·Vol. 58
·期 26
·3266-3273
·
IF 1.319
Wu Qiong,Bai LinQuan,Liu WeiCheng,Li YingYing,Lu CaiGe,Li YaQian,Lin ZhenYa,Wang Meng,Xue ChunSheng,Chen Jie
Streptomyces lydicus A01 resists many plant pathogens (including Fusarium spp.) by producing the antifungal agent natamycin, which binds to the ergosterol of fungal cell membranes and inhibits the growth of pathogens. Trichoderma harzianum CECT2413 is a widely-distributed soil fungus that antagonizes several plant fungal pathogens (including Fusarium spp.) by producing chitinase and degrading chitin, a major component of the fungal cell wall. This study attempted to enhance the biocontrol effect of S. lydicus A01 on Fusarium spp. by transforming the chitinase gene of Trichoderma . Chitinase and natamycin could act synergistically on both the cell walls and cell membranes of pathogens. The 33-kD chitinase-encoding gene ( chit33 ) was cloned and conjugal-transformed from T. harzianum CECT2413 to S. lydicus A01, and then confirmed via polymerase chain reaction (PCR) assays. Subsequent analyses using the 3,5-dinitrosalicylic acid (DNS) method and ultraviolet spectrophotometry showed that compared with its wild type strain (WT), the S. lydicus A01 conjugal transformant (CT) with chit33 gene exhibited substantially higher chitinase activity and natamycin production. The resistance of S. lydicus A01- chit33 CT and WT to four Fusaria in crops and vegetables was tested via the cup-plate method. Compared with the WT, the conjugal transformant of S. lydicus A01 with chit33 gene from T. harzianum CECT2413 showed greatly increased biocontrol effect on fusarium disease. This study would be beneficial to the development of high-quality antifungal bio-agents for agricultural applications via the synergy between the previously non-existent and pre-existing functions achieved through heterogeneous gene transformation.
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危险品化学品经营许可证（带存储）