COLLOIDS AND SURFACES B-BIOINTERFACES
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2022
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IF 5.999
Jianbo Lin,Rujie Zheng,Liping Huang,Yuanrong Tu,Xu Li,Jianfeng Chen
Molecularly targeted drugs are flourishing in the clinical treatment of non-small cell lung cancer (NSCLC). However, the treatment of a single drug (such as Gefitinib (Geb)) had defects such as poor pharmacokinetics , insufficient drug delivery, and considerable toxic side effects, which greatly affect its therapeutic efficacy against NSCLC. To solve these issues, this study developed a new nanocomposite heterogeneous platform (MSNs@Ag@Geb-FA) that combined photothermal therapy and molecular targeted therapy. The high specific surface area empowered mesoporous silicon dioxide (SiO 2 ) heterostructure the ability to efficiently load Ag photothermal agents and anti-tumor drug Geb. Meanwhile, a favorable pH response (degradation of residual MnO 2 ) achieved the controlled release of Ag and Geb. Besides, the targeting and endocytosis properties of nano drugs were greatly improved through the modification of folic acid (FA). Both in vivo and in vitro experiments authenticated that this nanocomposite heterogeneous platform could effectively integrate the multiple tumor suppressor properties of Ag nanoparticles and cooperate with Geb to hasten A549 cell apoptosis, thereby achieving a favorable anti-tumor effect. This heterogeneous structure of the nanocomposite heterogeneous platform could provide an effective strategy for the treatment of NSCLC.
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SENSORS AND ACTUATORS B-CHEMICAL
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2022
·
IF 9.221
Xin Shang,Jiayang He,Chunli Yang,Siyu Zuo,Ruo Yuan,Wenju Xu
Development of logic AND-gated multivariate assay systems of DNA-scaffolded green- and red-fluorescent Ag nanoclusters ( g- AgNC and r- AgNC) is promising and remains challenging. By using two DNA segments ( T o and T r) as dual-targeting inputs, herein we report an innovative strategy that utilizes targets-recycled amplification to create a sensitive AND-gated light-up ratiometric sensor with reversely changed fluorescence of g- AgNC and r- AgNC. The design is based on that: two hairpins ( H o and H r) are individually recognizable to T o and T r, and two hybridized duplexes are resultantly implemented for transient dissipative base pairing, i.e. H o· H r, releasing T o and T r for repeated recycling. In an original stem-loop hairpin reporter (HR), one exposed overhang is to host g -AgNC. When HR is unfolded by the cooperative sticky toeholds in H o∙ H r, its liberated stem merging with the g -AgNC template is for r- AgNC clustering. Only when meeting simultaneously the overexpressed T o and T r in SARS-CoV-2, the AND-gated ratio fluorescence of r- AgNC over g- AgNC can be lighted-up in a typical assay, enabling highly specific-inputs binding and sensitive dose-dependence down to 0.29 pM. This enzyme-free and label-free AND-logic ratiometirc strategy illustrates the potential of using multicolor AgNCs emitters for more accurate multivariate assay.
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MICROCHEMICAL JOURNAL
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2022
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IF 5.304
Ziyu Xue,Dehong Bai,Yu Li,Qiankun Zhang,Tao shao,Peiqing Guo,Dongxia Zhang,Xibin Zhou
In this work, a simple strategy for the rapid detection of Ag + based on nitrogen, sulfur doped graphene quantum dots (N, S-GQDs) decorated platinum nanoclusters (PtNCs) was proposed for the first time. N, S-GQDs decorated PtNCs (N, S-GQDs@PtNCs) were prepared by a reduction method using ascorbic acid (AA) as reducing agent and N, S-GQDs as a stabilizer and morphology directing reagent, respectively. The N, S-GQDs@PtNCs have an excellent peroxidase activity, which could catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H 2 O 2 to lead to an obvious color change. However, Ag + could be reduced to Ag 0 by N,S-GQDs, and the Ag 0 covered the surface of N, S-GQDs@PtNCs causing its peroxidase activity to decrease. Ag + concentration could be quantified by measuring the maximum absorption signal at 652 nm for oxidized TMB with a wide linear range of 0.5–300.0 nM and a limit of detection (LOD) as low as 0.2 nM. In addition, satisfactory results were obtained for the detection of Ag + in actual water samples. The prepared colorimetric sensor had advantages such as simple operation, cost-effective, fast response, and visualization, and had great potential in detecting toxic Ag + in environmental.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2022
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IF 4.831
Xiaoyuan Ma,Shan Xu,Liangyu Li,Zhouping Wang
Here, an aptamer-based SERS method for the detection of Staphylococcus aureus ( S. aureus ) without immobilization using [email protected] NPs/slide as enhanced substrate was constructed. ROX-aptamer of S. aureus was modified on the surface of [email protected] NPs/slide through electrostatic interaction. Based on the specific binding effect of the aptamer to S. aureus , the ROX-aptamer fell off from the surface of the substrate, resulting in a decrease of the SERS signal intensity of the substrate. Under the optimal experimental conditions, a good linear relationship was found between SERS intensity at 1500 cm −1 and the logarithm of concentration of S. aureus in the range of 10 2 cfu/mL-10 7 cfu/mL (y = 6623-796lgx, R 2 = 0.994) with a detection limit of 6 cfu/mL. The selectivity analysis revealed that the method had higher selectivity toward the corresponding target. The results for milk sample using the developed SERS method for the detection of S. aureus were similar to those of the plate counting method. The recovery ratio was from 90.60% to 107.26%, indicating the accuracy and reliability of the developed method. This method eliminates the need for bacterial immobilization and improves the convenience and efficiency of detection.
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POLYMER TESTING
·
2022
·
IF 4.931
Qiao Li,Guangyi Lin,Su Zhang,Haitong Wang,Jyotishmoy Borah,Yuan Jing,Fumin Liu
In the present scenario of development in technology, the applications of stretchable conductive elastomers in modern electronic equipments have aroused great interest. Non-covalent bonding modification of carbon nanotubes (CNTs) using dopamine has improved the dispersion of CNT@PDA and interfacial interaction with the rubber matrix. The SiO 2 @Ag core-shell particles were prepared by coated with silver nanoparticles (AgNPs) on the surface of SiO 2 using dopamine oxidation self-polymerization and electroless plating process. ESBR composites were prepared by latex co-coagulation method, where CNT@PDA and SiO 2 @Ag were used to develop an 1D-3D synergistic conductive network in ESBR composites. One-dimensional (1D) CNT@PDA were incorporated in three-dimensional (3D) spherical SiO 2 @Ag core-shell particles, which effectively prevented the agglomeration of SiO 2 @Ag and CNT@PDA. Again, 1D CNT@PDA could also be used as bridges to interact with 3D SiO 2 @Ag to develop the charge transfer more effectively in ESBR composites. The optimum electrical conductivity of the ESBR/CNT@PDA/SiO 2 @Ag composites was 0.2 S/cm, which was found to be higher than that of single filler. Moreover, the high electrical conductivity can be controlled at low tensile strain. The mechanical property of ESBR/CNT@PDA/SiO 2 @Ag composite was also improved by 105.4% as compared by ESBR/CNTs. This work provides a new idea for the fabrication of stretchable conductive elastomer composites with high performance.
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BUILDING AND ENVIRONMENT
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2022
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IF 7.093
Fengping Wang,Wei Li,Wanming Zhang,Ranran Ye,Xiaohong Tan
Visible light photocatalysis represents a promising procedure for indoor air purification . Here we developed the Ag nanoparticles decorated graphitic carbon nitride photocatalyst film supported on glass substrate . This photocatalyst film can effectively use visible light to degrade various volatile organic compounds which contain formaldehyde, acetaldehyde, ethylene, benzene, toluene, and p -xylene and deactivate Escherichia coli , Staphylococcus aureus , and Candida albicans . The decoration of Ag nanoparticles enhanced the visible-light-driven activity of graphitic carbon nitride because Ag nanoparticles strongly absorb visible light through the localized surface plasmon resonance effect and facilitate the efficient separation of charge carriers by forming Schottky barrier with the semiconductor. Photo-generated holes and superoxide radical anions, rather than hydroxyl radicals , are the major active species in the photocatalytic degradation of volatile organic compounds and deactivation of microorganisms . The application potential of the developed photocatalyst film for indoor air purification was demonstrated by the efficient removal of HCHO and TVOC under a simulated indoor environment and the favorable recyclability of the photocatalyst.
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APPLIED SURFACE SCIENCE
·
2021
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IF 6.707
Yang Wu,Sheng Yang,Feiya Fu,Jingjing Zhang,Jianhua Li,Tingfang Ma,Xiangdong Liu,Juming Yao
In this paper, L-cysteine (Cys) is firstly bonded to the surface of cotton non-woven (CO) fabric as esterification. In this way, Ag + and tannic acid (TA) are adsorbed onto the modified fabric via complexation and hydrogen bond interaction. After a sustainable one-step redox reaction, a Cys modified CO fabric decorated with Ag NPs and TA (CO-Cys-Ag-TA) is prepared. Because of the stabilizing effect of Cys and TA, the synthesized Ag NPs with a mean size of 88.9 nm are uniformly distributed on the modified fabric surface. Through the comparative test, it has been revealed that the antibacterial activity of Ag NPs is improved after loading TA, and the loading of Ag NPs significantly reduces the cytotoxicity of TA. In this context, the bacteriostatic reduction rate of CO-Cys-Ag-TA against S. aureus and E. coli is close to 100%, and its antibacterial activities are greater than 98.5% after 50 washing cycles. Meanwhile, its cell viability value reaches up to 88.0% with the presence of 0.1 mg/mL to 0.8 mg/mL CO-Cys-Ag-TA.
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Applied Nanoscience
·
2021
·Vol. 13
·期 2
·1495-1506
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IF 3.674
Zhang Xian-bing,Hu Ya-ping,Yang Wei,Feng Ming-bao
For the efficient disposal of organic pollutants and Escherichia coli ( E. coli ) in water, Ag-loaded and Pd-loaded ZnO nanofibers (NFs) were prepared through electrospinning (e-spin), followed by the alcohol-thermal method. The NFs were prepared in membrane form to promote their separation, recovery, and reuse in practical applications. The complete decolorizations of three types of dyes (i.e., azo, triarylmethane, and heterocyclic dyes) were observed when the Ag-loaded or Pd-loaded ZnO nanofiber membrane (NFM) was first applied as photocatalyst under 30-min UV irradiation. The characterization of the catalysts and the decolorization performance of dyes both demonstrated that the optimal loading rates of Ag and Pd were 12% and 6%, respectively. Moreover, the 12%-Ag/ZnO NFM displayed excellent recyclability over five cycles than the 6%-Pd/ZnO NFM. The E. coli disinfection test demonstrated that the photocatalytic inactivation rates with the 12%-Pd/ZnO NFM and the 6%-Ag/ZnO NFM were significantly improved under solar or UV irradiation, and hydroxyl radicals (∙OH) was primarily responsible for the antibacterial performance. Therefore, the presented 12%-Ag/ZnO NFM and 6%-Pd/ZnO NFM can be used for the efficient photocatalytic treatment of dyes and E. coli in water.
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MACROMOLECULAR MATERIALS AND ENGINEERING
·
2021
·Vol. 307
·期 2
·2100654
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IF 4.367
Pengfei Yan,Mengya Li,Jie Liu,Yadi Hu,Keyong Tang
Hydrogel is an ideal wound dressing material because of its 3D network structure, which is similar to that of the extracellular matrix. However, it is a challenge to design antibiotic-free hydrogels with both antibacterial activity and enhanced mechanical strength. In this study, a polyvinyl alcohol (PVA) hybrid hydrogel incorporated with molybdenum disulfide@polydopamine@silver (MoS 2 @PDA@Ag) is prepared for rapid killing of bacteria under irradiation with near-infrared (NIR) light. The interpenetration of MoS 2 -based nanoparticles and PVA molecular chain significantly improves the mechanical property of the hydrogel. The hydrogels demonstrate an excellent photothermal effect and antibacterial activity, and the photocatalytic properties are considerably enhanced by Ag doping. The hydrogel exhibits favorable antibacterial activity after irradiation with 808 nm NIR light for 15 min due to the synergistic effect of reactive oxygen species and hyperthermia. Meanwhile, in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay further demonstrated that all hydrogels are nontoxic when their effects are examined against mouse fibroblasts ( L929 ) cells. In addition, the MoS 2 @PDA@Ag/PVA hydrogel can promote wound healing compared with the pure PVA hydrogel, demonstrating its significant potential in mitigating bacterial infection of wounds.
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Polymers
·
2021
·Vol. 13
·期 16
·2812
·
IF 4.329
Meng Zhang,Dong Wang,Nana Ji,Shaoxiang Lee,Guohui Wang,Yuqi Zheng,Xin Zhang,Lin Yang,Zhiwei Qin,Yang Yang
Due to the spread of drug-resistant bacteria in hospitals, the development of antibacterial dressings has become a strategy to control wound infections caused by bacteria. Here, we reported a green strategy for in situ biomimetic syntheses of silver nanoparticles@organic frameworks/graphene oxide (Ag@MOF–GO) in sericin/chitosan/polyvinyl alcohol hydrogel. Ag@MOF–GO was synthesized in situ from the redox properties of tyrosine residues in silk sericin without additional chemicals, similar to a biomineralization process. The sericin/chitosan/Ag@MOF–GO dressing possessed a high porosity, good water retention, and a swelling ratio. The hemolysis rate of the composite was 3.9% and the cell viability rate was 131.2%, which indicated the hydrogel possessed good biocompatibility. The composite also showed excellent lasting antibacterial properties against drug-sensitive and drug-resistant pathogenic bacteria. The composite possessed excellent hemostatic activity. The coagulation effect of the composite may be related to its effect on the red blood cells and platelets, but it has nothing to do with the activation of coagulation factors. An in vitro cell migration assay confirmed and an in vivo evaluation of mice indicated that the composite could accelerate wound healing and re-epithelialization. In summary, the composite material is an ideal dressing for accelerating hemostasis, preventing bacterial infection, and promoting wound healing.Keywords:biomimetic synthesis;hemostasis;antibacterial activity;wound healing
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
·
2021
·
IF 3.927
Chentao Hou,Huayang Liu,Mohammad Fahim Bakhtari
In order to solve the problem of tetracycline hydrochloride (TCH) wastewater pollution, a photocatalyst for the efficient utilization of sunlight was proposed. In this work, a new method for the synthesis of three-dimensional flower-like Ag/TiO 2 -{001}/HTiOF 3 photocatalyst was applied, where surface oxygen vacancies can induce Ag nanoparticles (NPs) to disperse on the surface of the photocatalyst, which avoids the aggregation of Ag NPs into large particles. The appropriate mesoporous structure of the photocatalyst makes TCH have a stronger affinity on its surface, which is more conducive to the subsequent photodegradation . Furthermore, the surface plasmon resonance (SPR) of Ag NPs extends the response region of photocatalyst to visible light, and the heterojunction formed with TiO 2 /HTiOF 3 further stimulates the electrons in the oxygen vacancy region and inhibits the recombination of carriers. 10-Ag/TiO 2 /HTiOF 3 showed the best degradation activity (96%) for TCH when the ratio of Ag and TiO 2 -{001}/HTiOF 3 was 10%. In addition, the Ag/TiO 2 -{001}/HTiOF 3 photocatalyst has excellent photocatalytic activity , structural stability and sedimentation performance. The prepared catalyst has practical application prospect.
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ADVANCED POWDER TECHNOLOGY
·
2021
·
IF 4.833
Hongji Li,Jinyue Zhang,Dandan Wang,Junfu Wang,Wei Jiang,Tianyu Zhou,Chunbo Liu,Guangbo Che
In this study, it presents a novel surface-enhanced Raman scattering (SERS) imprinted membrane to be applied into the detection of trace-level antibiotic in aqueous samples. Graphene oxide- argentum (GO/Ag) composites are chosen as the SERS substrates to fabricate on poly(vinylidene fluoride) (PVDF) membrane surface, increasing the hydrophilia and promoting the sensitivity. The amount of GO is investigated to confirm the optimal concentration. Whereafter, in order to effectively apply into practical sample detection, the technique of molecular imprinting is also introduced to improve the selectivity of SERS membrane. The SERS imprinted membrane (AGP-MIM) is synthesized by the process of two-step precipitation polymerization and applied into the detection of enrofloxacin hydrochloride. The characteristics are adequately investigated and proved that the AGP-MIM can be applied into practical samples detection.
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