CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Yuhan Yang,Yangyi Chen,Dianpeng Li,Shiyuan Lin,Hui Chen,Wei Wu,Wei Zhang
A novel delivery system based on linolenic acid (LA) conjugated chitosan (CS) polymeric micelles were proposed for improving the oral absorption of doxorubicin (DOX) through targeting intestinal fatty acid transporter. LA, as a ligand of the transporter, was grafted into CS to construct CS-LA micelles, and DOX was encapsulated into the micelles. The synthesized micelle material was identified by 1 H NMR and FT-IR. The micelles showed regular spherical shapes with a particle size of 117.1 ± 1.6 nm, drug loading of 8.77 ± 0.02 %, and critical micelle concentration (CMC) of 23.6 μg/ml. The pharmacokinetics studies showed the relative bioavailability of 166 % versus DOX·HCl. The fatty acid transport protein 4-mediated intestinal uptake process of micelles was confirmed by the intracellular uptake, immunofluorescent imaging and permeation test. These findings confirmed the potential of CS-LA micelles as an effective oral delivery vehicle, and fatty acid transporter as a target spot for enhancing intestinal drug absorption.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
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IF 9.965
Yaru Xi,Zuoyi Xiao,Hui Lv,Haodong Sun,Shangru Zhai,Qingda An
Copper oxide (CuO) and copper (Cu) have been viewed as the prospective pseudocapacitive electrode materials for supercapacitors. Nevertheless, the poor electron transfer capacity, loading amount, and cycling stability limit their wide applications, which can be addressed by developing the CuO based heterojunction on conductive carbons. Here, a CuO/Cu@C comprising CuO/Cu nanoflowers and chitosan-derived N -doped porous carbon was compounded by simple mechanical mixing, freeze-drying, and carbonization. The composite heated at 700 °C exhibited a high specific capacitance of 2479F/g at 0.5 A/g and excellent cycling stability with capacitance retention of 82.43 % after 10 000 charge–discharge cycles. In addition, the asymmetric supercapacitor (ASC), i.e., CuO/Cu@C-700//AC assembled by CuO/Cu@C (as a positive electrode) and activated carbon (AC, as a negative electrode) displayed a great energy density of 76.87 W h kg −1 at 374.5 W kg −1 and kept as high as 25.83 W h kg −1 even at 14998 W kg −1 . Our work provides a new pathway to preparing transition metal oxide-based electrode materials with distinguished electrochemical performances.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2023
·Vol. 103
·期 7
·3306-3314
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IF 4.1
Hongxu Yan,Yayuan Xu,Zhuqing Dai,Zhongyuan Zhang,Yihong Bao,Da-jing Li
BACKGROUND Numerous positive effects have been attributed to lutein, a lipophilic nutrient, including resisting ultraviolet radiation and protecting retinal pigment epithelial (RPE) cells against blue light damage. It also has preventive effects against cardiovascular disease and cancer. However, its use could be limited by its poor stability and low bioaccessibility in the human digestive system. An encapsulation delivery system was therefore developed to resolve these limitations. In this study, chitosan-modified lutein nanoliposomes (CS-LNLs), chitosan-EGCG covalently modified lutein nanoliposomes (C-CS-EGCG-LNLs), and chitosan-EGCG noncovalently modified lutein nanoliposomes (non-C-CS-EGCG-LNLs) were designed. The average particle size, ζ -potential, and retention of lutein during storage were measured to indicate the physicochemical stability of the modified lutein nanoliposomes. The bioaccessibility of modified lutein nanoliposomes was also investigated to demonstrate the availability of lutein in the human digestive system. RESULTS First, Fourier-transform infrared spectroscopy (FTIR) verified that covalent bonds between chitosan and EGCG were formed. Subsequently, ζ -potential results revealed that C-CS-EGCG-LNLs had a relatively stable structure in comparison with lutein nanoliposomes (LNLs). The retention rate of lutein in CS-LNLs, C-CS-EGCG-LNLs, and non-C-CS-EGCG-LNLs was improved, especially in C-CS-EGCG-LNLs (at around 70% of lutein in initial system). An in vitro digestion experiment illustrated that CS-LNLs, C-CS-EGCG-LNLs, and non-C-CS-EGCG-LNLs presented relatively higher bioaccessibility, especially in C-CS-EGCG-LNLs (at around 33% of luein in initial system), which increased 2.5 and 1.65 times in comparison with free lutein and LNLs, respectively. CONCLUSION Overall, the results showed that C-CS-EGCG-LNLs presented greater physicochemical stability and bioaccessibility than LNLs, CS-LNLs, and non-C-CS-EGCG-LNLs. © 2023 Society of Chemical Industry.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Jinxin Lan,Jiazhen Chen,Ruiqi Zhu,Changmei Lin,Xiaojuan Ma,Shilin Cao
The worldwide outbreak of SARS-CoV-2 has attracted extensive attention to antibacterial and antivirus materials. Cellulose is the most potential candidate for the preparation of green, environmentally friendly antibacterial and antiviral materials. Herein, modified cellulosic fibers with sustained antibacterial and antiviral performance was prepared by introducing chitosan oligosaccharide onto the fibers. The two-step method is proved to be more effective than the one-step method for enhanced chitosan oligosaccharide loadings and antibacterial and antiviral activity. In this instance, the modified fibers with 61.77 mg/g chitosan oligosaccharide loadings can inhibit Staphylococcus aureus and Escherichia coli by 100 % after contacting with bacteria for 12 h and reduce the bacteriophage MS2 by 99.19 % after 1 h of contact. More importantly, the modified fibers have washing durable antibacterial and antiviral activity; the modified fibers have 100 % antibacterial and 98.38 % antiviral activity after 20 washing cycles. Benefiting from the excellent performance of the individual fibers, the paper prepared from the modified fibers show great antibacterial (100 %) and antiviral performance (99.01 %) and comparable mechanical strength. The modified fibers have potential applications in the manufacture of protective clothing and protective hygiene products.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Longquan Xiao,Shuai Kang,Molazi Lapu,Peng Jiang,Xinhui Wang,Dayu Liu,Jing Li,Mingxue Liu
In this research, the common microorganisms in chilled meat were used as the targeted antibacterial objects. Chitosan, pullulan, and carvacrol were chosen to prepare the edible antibacterial film. The effects of different concentrations of carvacrol on the microstructure, physical properties and antibacterial properties of the films were investigated. The results showed that the antibacterial activity of chitosan/pullulan film (CS/PU) was unsatisfactory, when carvacrol was added, the antibacterial activity of the chitosan/pullulan/carvacrol film (CS/PU/CAR) improved significantly ( p < 0.05 ), and the water vapor permeability (WVP) of the CS/PU/CAR decreased significantly ( p < 0.05 ). When the carvacrol concentration was higher than 1.25% (w/v), the tensile strength and percentage elongation at break of the CS/PU/CAR increased significantly ( p < 0.05 ), and the CS/PU/CAR exhibited satisfying antibacterial activity against the common bacteria in chilled meat such as Pseudomonas fluorescens , Listeria monocytogenes , Escherichia coli , Pseudomonas putida , Enterobacter cloacae , and Staphylococcus aureus . Finally, the CS/PU/CAR film was applied to the preservation of chilled goat meat and extended the shelf life of goat meat to more than 15 days. These results suggested that the targeted CS/PU/CAR film can be used as biodegradable films for the active packaging of chilled meat.
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JOURNAL OF SOILS AND SEDIMENTS
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2022
·Vol. 22
·期 8
·2129-2145
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IF 3.536
Nkoh Jackson Nkoh,He Xian,Lu Hai-long,Li Ke-wei,Shi Ren-yong,Li Jiu-yu,Xu Ren-kou
Purpose This study aims to evaluate the effects of chitosan and D-fructose 1,6-bisphosphate (F16BP) trisodium salt on the acidity of selected Ultisols (Ultisol-QY1, Ultisol-QY2, Ultisol-LX, and Ultisol-YT) and their resistance to soil acidification. Materials and methods The effect of adsorbed chitosan and F16BP on soil acidity was evaluated by interacting different concentrations of the organic substrates with 4.0 g soil under different agitation times (2 to 264 h, 200 rpm, 25 °C). Also, the soils were amended with the organic substrate and incubated for 14 days to determine their effects on soil physicochemical properties. Afterwards, the soil solid phases from the adsorption studies and incubated soil were acidified with different concentrations of nitric acid to simulate soil acidification and activate soil aluminum (Al). Results and discussion The adsorption interactions of chitosan and F16BP with Ultisols demonstrated different potentials in their ability to displace mineral-bound hydroxyl groups and ameliorate soil acidity. The R-PO 4 3− group of F16BP was more effective in displacing the hydroxyl groups through a ligand exchange mechanism and thus showed greater ameliorating effect on soil acidity than chitosan. Compared to lime and F16BP, chitosan-treated soils exhibited the least decrease in pH during soil acidification due to the significant improvement in soil pH buffering capacity (pHBC). Specifically, when amended with chitosan, the pHBC of Ultisol-QY1, Ultisol-QY2, Ultisol-LX, and Ultisol-YT was increased by 262.2%, 88.9%, 337.7%, and 320.6% as opposed to 22.1%, 18.4%, 27.4%, and 83.0% for these Ultisols by F16BP, respectively. Thus, F16BP is a better material to improve soil pH, while chitosan is a better option to improve soil pHBC, inhibit soil acidification, and retard the activation of phytotoxic Al 3+ . By the nature of their functional groups, we deduced that F16BP ameliorated soil acidity by displacing the hydroxyl groups on soils due to adsorption of R-PO 4 3− group through ligand exchange mechanism, while chitosan directly improved pHBC by providing abundant R-NH 2 groups to accommodate excess exogenous H + . Conclusions Chitosan is a promising soil amendment material for use in the management of acidic soils due to its high N content and potential to inhibit soil acidification. Given the readily available raw materials and ease of producing chitosan, long-term incubation studies should be carried out to assess the effect of chitosan on soil pH variations, carbon, and N mineralization.
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CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Miao Miao,Lan Mu,Shaomei Cao,Yuhuan Yang,Xin Feng
Tetracycline (TC) residues have been noted as an important class of emerging contaminants in the environment, thus fast, straightforward, highly sensitive detection method is becoming an issue that must be addressed. Herein, a novel CDs@ZIF-8 sensing material was fabricated by encapsulating luminescent carbon dots (CDs) into the metal-organic framework (ZIF-8) to achieve highly luminescent porous composites. Furthermore, to avoid the secondary contamination caused by powders, a shapable CDs@ZIF-8/CS film sensor as a portable disposable test strip with dual-function of TC detection and adsorption was designed by crosslinking CDs@ZIF-8 with chitosan (CS). The as-prepared CDs@ZIF-8/CS hybrid film exhibited the high sensitivity and selectivity for TC fluorescence detection and rapid decontaminate capability, as well as high optical transmittance and robust mechanical property, which were essential for the practical sensing application. This paper-based dual-functional luminescent sensor exhibits promising practicability for TC detection and contaminant removal in pharmaceutical analysis, food safety and water treatment.
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FOOD CHEMISTRY
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2022
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IF 9.231
Huanhuan Cui,Cuie Tang,Shan Wu,David Julian McClements,Shilin Liu,Bin Li,Yan Li
In this study, chitosan-based bigels were fabricated, where glycerol monolaurate was added in MCT oil to produce a gelled lipid phase and cinnamaldehyde was included in the lipid phase in order to act as a crosslinking agent. The synergistic effect of pH on chemical crosslinking effects was investigated. The potential of using these bigels as an alternative to cream was also investigated. The pH of the aqueous phase played an important role in controlling the extent of the Schiff-base reaction promoted by cinnamaldehyde. At pH 3.8, the bigels formed were homogenous but at pH 5.0 and 5.5 they exhibited phase separation, which highlighted the importance of chemical crosslinking. To better mimic the properties of real cream, span 80 was added to create a more homogeneous and smoother structure of the bigels. These bigels might provide a healthy and more sustainable alterative to food products that contain plastic fats, like cream.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Xin-Hao Yu,Fu-Zhen Zhou,Yong-Kang Xi,Xiao-Nan Huang,Shou-Wei Yin,Xiao-Quan Yang
Water-in-oil (W/O) emulsions have numerous applications in many industries like foods, pharmaceuticals, in particular biphasic bio-catalysis. However, most of them are stabilized by surfactants or synthetic particles, which lead to limited uses in foods. Here, a W/O type Pickering emulsion was successfully prepared firstly by ordered ethyl cellulose-chitosan complex particles (ECCPs) and used for a recyclable biocatalytic micro-reactor. The performances of emulsions with different ethyl cellulose-chitosan ratios, water phase fraction and particle concentration were discussed. The type of emulsions could be shifted from W/O to W/O/W and O/W as water fraction increased. Interestingly, a recyclable bio-catalytic microreactor platform was constructed using such novel W/O emulsions, and the activity of lipase was significantly increased by encapsulating it into Pickering emulsions, and was 6.3-times higher than that of free lipase in biphasic system. In particular, the encapsulated lipase remained stable and could be recycled over 15 times without the loss of activity.
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Marine Drugs
·
2022
·Vol. 20
·期 2
·86
·
IF 6.085
Jingmin Cui,Xia Ji,Yingqi Mi,Qin Miao,Fang Dong,Wenqiang Tan,Zhanyong Guo
N-2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC), a cationic quaternary ammonium salt polymer exhibiting good solubility in water, is widely used because of its low toxicity and good biocompatibility. Herein, through ion exchange reaction, we preparedN-2-hydroxypropyltrimethyl ammonium chitosan derivatives bearing amino acid Schiff bases with good biological activities. The accuracy of the structures was verified by FT-IR and1H NMR. The antibacterial activity, antifungal activity, and scavenging ability of DPPH radical and superoxide radical of HACC derivatives were significantly improved compared with that of HACC. In particular, HACGM (HACC-potassium 2-((2-hydroxy-3-methoxybenzylidene)amino)acetate) and HACGB (HACC-potassium 2-((5-bromo-2-hydroxybenzylidene)amino)acetate) showed good inhibitory effect on bacteria and fungi, includingStaphylococcus aureus,Escherichia coli,Botrytis cinerea,andFusarium oxysporumf. sp.cubense. The inhibition rate of HACGB onStaphylococcus aureusandEscherichia colicould reach 100% at the concentration of 0.1 mg/mL, and the inhibition rate of HACGM and HACGB onBotrytis cinereaandFusarium oxysporumf. sp.cubensecould also reach 100% at the concentration of 0.5 mg/mL. Improving antimicrobial and antioxidant activities of HACC could provide ideas and experiences for the development and utilization of chitosan derivatives.Keywords:N-2-hydroxypropyltrimethyl ammonium chloride chitosan;amino acid Schiff bases;antimicrobial activity;antioxidant activity
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CELLULOSE
·
2022
·Vol. 29
·期 4
·2731-2742
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IF 6.123
Liu Zihan,Luo Yapei,Zhao Xiaomin,Zheng Keying,Wu Minghua,Wang Lili
Natural antibacterial agents have attracted increasing attention due to safety, ecological, and environmental protection concerns. In this study, hinokitiol-grafted-chitosan (HTCS) was prepared via the Mannich reaction and used as an antibacterial agent for the treatment of cotton fabric. The results showed that, compared with chitosan (CS) and hinokitiol (HT) alone, HTCS exhibited a lower value of minimum inhibitory concentration (MIC). Compared with the fabrics treated by CS and HT, the antibacterial rate of the treated fabric against Escherichia coli using HTCS as antibacterial agent increased by approximately 90% and 27%, the bacterial reduction rate against Staphylococcus aureus increased by about 58% and 39%. The HTCS-treated cotton fabric possessed good antibacterial properties even after 25 washing cycles. Moreover, the antibacterial cotton fabric retained original hydrophilicity, handle, and strength. Consequently, HTCS has great potential as a natural antibacterial agent for textiles.
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ACS Applied Materials & Interfaces
·
2022
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IF 10.383
Yingqi Chen,Weibei Sheng,Jianjing Lin,Chongzhou Fang,Jiapeng Deng,Peng Zhang,Meng Zhou,Peng Liu,Jian Weng,Fei Yu,Deli Wang,Bin Kang,Hui Zeng
Natural polysaccharide (NPH)-based injectable hydrogels have shown great potential for critical-sized bone defect repair. However, their osteogenic, angiogenic, and mechanical properties are insufficient. Here, MgO nanoparticles (NPs) were incorporated into a newly synthesized water-soluble phosphocreatine-functionalized chitosan (CSMP) water solution to form an injectable hydrogel (CSMP-MgO) via supramolecular combination between phosphate groups in CSMP and magnesium in MgO NPs to circumvent these drawbacks of chitosan-based injectable hydrogels. Water-soluble chitosan deviate CSMP was first synthesized by grafting methacrylic anhydride and phosphocreatine into a chitosan chain in a one-step lyophilization process. The phosphocreatine in this hydrogel not only provides sites to combine with MgO NPs to form supramolecular binding but also serves as the reservoir to control Mg2+ release. As a result, the lyophilized CSMP-MgO hydrogels presented a porous structure with some small holes in the pore wall, and the pore diameters ranged from 50 to 100 μm. The CSMP-MgO injectable hydrogels were restricted from swelling in DI water (lowest swelling ratio was 16.0 ± 1.1 g/g) and presented no brittle failure during compression even at a strain above 85% (maximum compressive strength was 195.0 kPa) versus the control groups (28.0 and 41.3 kPa for CSMP and CSMP-MgO (0.5) hydrogels), with regulated Mg2+ release in a stable and sustained manner. The CSMP-MgO injectable hydrogels promoted in vitro calcium phosphate (hydroxyapatite (HA) and tetracalcium phosphate (TTCP)) deposition in supersaturated calcium phosphate solution and presented no cytotoxicity to MC3T3-E1 cells; the CSMP-MgO hydrogel promoted MC3T3-E1 cell osteogenic differentiation with upregulation of BSP, OPN, and Osterix osteogenic gene expression and mineralization and HUVEC tube formation. Among them, CSMP-MgO (5) presented most of these properties. Moreover, this hydrogel (CSMP-MgO (5)) showed an excellent ability to promote new bone formation in critical-sized calvarial defects in rats. Thus, the CSMP-MgO injectable hydrogel shows great promise for bone regeneration.
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