International Journal of Nanomedicine
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2026
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IF 6.5
Xijie Qu,Tong Liu,Yu Wang,Xinyuan Wei,Ye Yang,Liya Gu,Kun Yang,Jing Zhang,Yan Liu,Yiqian Liang,Yanzhen Zheng,Aimin Yang
Introduction Radioactive iodine (RAI) therapy is a highly specific targeted treatment for thyroid cancer. However, the intrinsic low energy of 131I limits its efficacy in tumor eradication. Additionally, certain thyroid cancers exhibit a loss of sodium/iodine symporter (NIS) function due to severe dedifferentiation, compromising the therapeutic effectiveness of RAI.Methods Our work was based on two distinct RAI-sensitizing strategies: (1) the generation of secondary electrons by irradiated metallic nanomaterials to promote hydrolysis and enhance reactive oxygen species (ROS) production, and (2) drug-induced reversal of the dedifferentiated phenotype of tumor cells to restore iodine uptake. Accordingly, we developed a multifunctional nanoplatform, termed Bi@Digoxin, by loading digoxin onto bismuth nanoparticles (BiNPs). The physicochemical properties of Bi@Digoxin were systematically characterized. Furthermore, its therapeutic efficacy was rigorously evaluated through in vitro and in vivo experiments, demonstrating significant treatment outcomes.Results The experiments demonstrate that Bi@Digoxin enhances the efficacy of RAI in Anaplastic thyroid cancer (ATC) through a triple synergistic mechanism: utilizing nanocarriers for efficient delivery of Digoxin to restore NIS function in tumor cells, reversing RAI resistance in ATC; leveraging the high atomic number property of bismuth (Bi) to enhance radiation energy deposition, promoting ROS bursts and DNA double-strand breaks; and combining near-infrared (NIR) laser-triggered controlled drug release with photothermal ablation to significantly inhibit tumor growth.Conclusion Bi@Digoxin significantly enhances the therapeutic efficacy of RAI, offering a novel synergistic treatment strategy for ATC that combines biosafety and scalable production, with significant potential for clinical translation.
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DIAMOND AND RELATED MATERIALS
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2026
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IF 5.1
Shan Huang,Guixin Li,Wei Ni,Yutong Zhao,Shiqin Zhang,Yi Fang,Fuxiang Wei,Qi Xiao
Cancer remains a leading cause of global mortality, with nearly 10 million annual deaths. High intracellular glutathione (GSH) levels and tumor hypoxia critically limit chemotherapy efficacy and photodynamic therapy (PDT) effectiveness. Conventional nanocatalytic materials, particularly blue/green-emitting nanomaterials, face limited deep-tissue penetration, hindering their utility in bioimaging and targeted therapy. Herein, we report a microwave-assisted one-pot synthesis of copper-doped red-emissive carbon dots (Cu-CDs) using dicyandiamide, 4′-aminoacetanilide, and anhydrous copper sulfate as precursors. The synthesized Cu-CDs exhibit excellent optical properties ( λ ex / λ em = 525/595 nm) with a quantum yield of 12.7%, enabling nuclear fluorescent imaging for precise tumor localization. Notably, Cu-CDs demonstrate triple-enzyme (peroxidase, catalase, oxidase) mimetic activities, which synergistically deplete GSH, alleviate tumor hypoxia, and enhance reactive oxygen species (ROS) generation. In vitro studies revealed that Cu-CDs-mediated chemodynamic therapy (CDT) alone achieved 60.4% tumor cell apoptosis, while combination with PDT elevated the rate to 92.96%. Mechanistically, Cu-CDs exploit endogenous H 2 O 2 overexpression in tumors to produce cytotoxic ‧OH radicals via peroxidase activity, while catalase activity mitigates hypoxia by decomposing H 2 O 2 into O 2 . This multi-enzyme synergy reduces ROS scavenging by GSH, amplifying PDT efficacy. Biocompatibility assessments confirmed low cytotoxicity and efficient cellular uptake of Cu-CDs. The red-emissive feature enables deep-tissue penetration and nuclear targeting, minimizing off-target damage. This work establishes a paradigm for metal-doped CDs in cancer theranostics, overcoming single-enzyme limitations and advancing synergistic enzyme-mimetic therapy. The strategy holds significant promise for biomedical applications, offering a novel platform for precision tumor treatment.
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Journal of Materials Chemistry B
·
2026
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IF 5.7
Shuai He,Denver P. Linklater,Zheyu Li,Suyao Yin,Zechang Li,Shuai Xiang,Zenglian Zong,Liping Wen,Saulius Juodkazis,Elena P. Ivanova,Lei Jiang,Kai Sun
The widespread use of antibiotics to combat bacterial infections has now introduced significant new risks, particularly the continuous evolution of antibiotic-resistant strains. Consequently, the development of non-antibiotic antibacterial materials with high efficacy has become a major focus of research. Inspired by the morphology of sea urchins, we developed novel spiky microparticles (SMPs) fabricated using a natural fatty acid mixture (lauric acid and stearic acid) loaded with hemin chloride and silver nanoparticles (Ag NPs). The SMPs exhibited excellent photothermal and photodynamic properties. Under mild photothermal conditions (<45 °C), the SMPs achieved bactericidal rates exceeding 99.999% against Escherichia coli (E. coli) and over 99.9% against tetracycline-resistant enteroinvasive Escherichia coli (E. coli EIEC) within 10 min. Under near-infrared (NIR) light irradiation, there was a significant increase in the production of reactive oxygen species (ROS), ultimately achieving rapid and highly efficient bacterial eradication. Thus, we propose that SMPs synergistically disrupt bacterial cell membranes due to their urchin-inspired spiky structure and photothermal effects. Moreover, in a mouse model of bacterial wound infection, the SMPs demonstrated outstanding antibacterial efficacy. SMPs promoted wound tissue healing and suppressed the production of inflammatory cytokines, without inducing significant cytotoxicity. Therefore, this study presents a novel non-antibiotic tool for antibacterial therapy that offers a promising alternative approach for future clinical applications in treating bacterial infections.
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FOOD CHEMISTRY
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2026
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IF 9.8
Donglin Xiang,Xiao Wang,Chun Ji,Laping He,Yuangen Wu,Han Tao
This study presents a novel electrochemical strategy for detecting organophosphorus pesticides based on the synergistic catalytic of red kidney bean esterase (RKBE) and iron–cobalt dual-atom catalyst embedded in N-doped carbon carrier (FeCo–NC). RKBE was extracted from the widely cultivated British red kidney beans ( Phaseolus vulgaris L.) . FeCo–NC exhibited excellent electrocatalytic and peroxidase-like activity, catalyzing o -phenylenediamine oxidation to produce electroactive 2,3-diaminophenazine, which served as signal probe generating a sensitive cathodic current. Notably, RKBE product 1-naphthol inhibited FeCo–NC activity, while organophosphorus pesticides counteracted this inhibition by suppressing RKBE activity, restoring the electrochemical signal of 2,3-diaminophenazine. Leveraging this signal-regulation mechanism, a dichlorvos sensor was developed, with wide linear range (50–50,000 pM), low detection limit (14 pM), and excellent real-sample recovery (93.33%–107.08%), demonstrating practical application potential. This study provides an affordable and easy-to-operate approach for large-scale on-site monitoring of organophosphorus pesticide residues in foods.
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Desalination and Water Treatment
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2026
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IF 1
Dezhi Zhao,Haiping Chen,Yuyang Tian,Yuan Liu
The COVID-19 pandemic has brought about increasing demand of face masks, however, due to the inadequate disposal, it has caused great environmental problems. In this study, we try to recycle these wastes to fabricate chelating materials for the potential application in heavy metal removal from wastewater. Surface characteristics of the prepared amine-modified polypropylene (AMP) adsorbent were identified by advanced methods. The introduced amino groups endowed AMP a more basic and hydrophilic surface, which facilitated electrostatic attraction with cations in acidic to neutral conditions. Moreover, batch experiments showed the adsorption of heavy metals onto the AMP was pH dependent and followed pseudo-second-order kinetic model and Langmuir adsorption isotherm model, and the theoretical adsorption capacities were 58.275, 62.500 and 58.207 mg/g for Pb 2 + , Cu 2+ and Zn 2+ , respectively. In particular, the prepared AMP can be regenerated for 10 cycles with relatively stable heavy metal absorption capacity. Chemical adsorption was proposed as the main adsorption mechanism, as N worked as electron donor to form complex with metal ions, and metal salt crystal growth was also observed on AMP surface. The favorable adsorption capacity and reusability of AMP demonstrated the potential of upcycling the waste masks in wastewater treatment.
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ACS Omega
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2026
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IF 4.3
Ying Liu,Linlin Yu,Le Wang,Xiaowei Fang,Tenggao Zhu,Huanwen Chen,Wenliu Zhang,Dong Wu
To explore the changes in quality formation during the honey-processing of Glycyrrhiza uralensis from six geographical origins, including Inner Mongolia, Xinjiang, Anhui, Gansu, Guangdong, and Jiangxi. In this study, raw G. uralensis was mixed with honey and smoldered, then heated and stir-fried, and finally cooled. The water-soluble components (WSCs) and methanol-soluble components (MSCs) in G. uralensis were simultaneously analyzed by sequential electrospray ionization mass spectrometry (SESI-MS) without the need for complex sample pretreatment. Fifteen WSCs (e.g., proline, arginine, serine, glabrol, monosaccharides, disaccharides, and trisaccharides) and twenty-eight MSCs (e.g., liquiritigenin, naringenin, glycyrrhizic acid, glycyrrhetinic acid, and formononetin) were identified within 2 min. Both principal component analysis and partial least-squares discrimination analysis showed that samples of honey-processed G. uralensis (HPGU) from six different geographical origins were effectively distinguished; liquiritin, daidzein, sinapic acid, and ferulic acid were identified as potential differential metabolites by variable importance for the projection; and the contents of saccharides, glabridin, formononetin, glabrol, and glycyrrhetinic acid were high in HPGU. Meanwhile, Inner Mongolia showed the highest contents of glycyrrhetinic acid and daidzein, suggesting these samples may possess superior quality based on these specific markers. SESI-MS could enhance our understanding of the changes in quality formation during the honey-processing of G. uralensis.
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ACS Sustainable Chemistry & Engineering
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2026
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IF 7.3
Dapeng Zhang,Huijian Guo,Sirui Xu,Xueqing Chen,Sihui Pang,Yun Li,Jilin Cao
The depletion of fossil fuels and environmental pollution over petroleum-based plastics have driven the demand for sustainable biopolymers such as polylactic acid (PLA). Lactide (LD) is the key monomer for synthesis of high-molecular-weight PLA. Herein, we propose amphiphilic zeolite beta-stabilized Pickering emulsion as a high-efficiency interfacial catalytic platform for LD synthesis. Amphiphilic zeolite beta is fabricated by the surface modification of dimethyldiethoxysilane, enabling the formation of stable water-in-oil Pickering emulsions. The microstructure of the emulsion, catalytic performances, and process intensification mechanism are systematically investigated. Under optimized conditions (100 mg zeolite beta, 3 mL of p-xylene, 0.05 mL of H2O, and 140 °C, 2 h), lactic acid (LA) conversion and LD yield reaches 98.3% and 95.78%, respectively. The superior performance arises from three synergistic effects in Pickering emulsion: (1) Enhanced mass transfer via a large oil–water interface; (2) By precisely matching Brønsted acidic sites with the reaction microenvironment, the coupling of LA esterification to LD and hydrolysis of lactate oligomers to regenerate LA is achieved, contributing to effective conversion of LA; (3) Rapid spatial isolation of oil-soluble LD in the oil phase to inhibit hydrolysis. This work offers a low-energy and high-efficiency synthesis route for LD, advancing sustainable PLA production.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.7
Ziwei Xiang,Xinyi Liu,Yuzhu Long,Ketao Yan,Hongmei Deng,Yuzhu Yuan,Huayu Xiong,Xiuhua Zhang,Heng Liu
Diabetic wound management remains a major clinical challenge due to the difficulty in achieving precise therapeutic modulation and the lack of reliable approaches for real-time identification of wound pathological stages. To address this, we report the development of a novel covalent organic frameworks@metal-organic frameworks theranostic nanoreactor, namely glucose oxidase (GOx)-encapsulated zeolitic imidazolate framework-8 (ZIF-8) assembled on the surface of fluorescent hollow covalent organic frameworks (denoted as HCOF@FZG) through a one-pot coordination strategy. The nanoreactor is designed to concurrently monitor wound pH fluctuations and provide synergistic treatment for diabetic wounds. Leveraging pH-triggered fluorescence changes, HCOF@FZG enables non-invasive, dynamic assessment of wound conditions, allowing for precise discrimination between the healing and infection stages. Upon detecting signs of infection, HCOF@FZG initiates a cascade reaction in which GOx-mediated oxidation depletes local glucose for starvation therapy, while the generated H 2 O 2 is subsequently converted into bactericidal hydroxyl radicals via a Fenton-like reaction for chemodynamic therapy. Moreover, HCOF@FZG demonstrates remarkable pro-healing properties by significantly promoting endothelial cell proliferation and migration. This acceleration of granulation tissue formation and re-epithelialization critically improves overall wound recovery, offering an intelligent and precise solution for managing diabetic chronic wounds.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.7
Fengqin Wang,Xinyue Ren,Yang Wang,Muhammad Tayyab,Zhongliao Wang,Sugang Meng
The photocatalytic coupling of selective phenylcarbinol oxidation with hydrogen evolution has attracted considerable attention as a promising dual-functional reaction system. Herein, a lattice-matched 2D/3D NiS/CdIn 2 S 4 (NiS/CIS) Schottky heterojunction is rationally designed for efficient dual-functional photocatalysis under visible light. Structural analyses confirm the uniform deposition of NiS nanosheets on octahedral CIS with a lattice mismatch below 5%, ensuring coherent interfacial contact. The optimal 3% NiS/CIS composite exhibits exceptional hydrogen and benzaldehyde production rates of 2636.4 and 2717.6 μmol g −1 h −1 , respectively—representing enhancements of 39.7 and 38.0 times over pristine CIS. The catalyst also demonstrates remarkable stability, retaining over >99.0% activity after six cycles. Mechanistic studies reveal that the Schottky junction facilitates spatial separation of photogenerated carriers: electrons migrate to NiS, prolonging charge carrier lifetimes and lowering the hydrogen evolution overpotential, while holes accumulate on CIS that facilitated phenylcarbinol adsorption to drive selective phenylcarbinol oxidation via a carbon-radical pathway. This work provides a viable approach for designing efficient bifunctional photocatalysts through lattice-matched interface engineering.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2026
·Vol. 27
·期 2
·569
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IF 4.9
Xue Li,Xinduo Huang,Xiaoyong Wei
Diabetic cataract (DC) is a major complication of diabetes, with human lens epithelial cells (HLECs) playing a central role in its pathogenesis. Gigantol, a natural compound, has demonstrated protective effects against HLEC damage, yet its underlying mechanisms, particularly concerning cellular biophysical properties, remain poorly understood. This study investigated the protective role of gigantol against high-glucose-induced damage in HLECs, with a specific focus on alterations in cellular biophysical properties. Using a multi-technique approach including transmission electron microscopy (TEM), atomic force microscopy, laser scanning confocal microscopy, and Raman spectroscopy, we analyzed changes in ultrastructure, morphology, stiffness, roughness, membrane fluidity, and cytoskeletal organization. Treatment with gigantol effectively restored cellular ultrastructure, mitigated cytoskeletal disruption, and normalized key biomechanical properties: it reduced cell stiffness and roughness by approximately one-fourth, increased cell height by nearly onefold, and enhanced membrane fluidity by one-fifth. Raman spectroscopy indicated that gigantol improved membrane fluidity by modulating lipid bilayer structure, specifically through alterations in –CH2– bending and –C=C– stretching modes. These findings demonstrate that gigantol protects HLECs from high-glucose-induced damage not only by biochemical means but also by restoring cellular biophysical homeostasis. This study provides novel biophysical–pathological insights into the anti-cataract mechanism of gigantol, highlighting its potential as a therapeutic agent that targets both biochemical and biophysical aspects of DC.
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Applied Materials Today
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2026
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IF 6.9
Ruiwen Zhou,Yuchen Li,Yi Jiang,Miqi Hu,Zhaohui Li,Yu-E Lian,Hui Gao,Lanmei Chen,Dongdong Sun
The rapid emergence of antibiotic resistance and resilient bacterial biofilms poses a critical threat to global public health. To address this challenge, we developed SA-GDL-Ru—a novel sodium alginate hydrogel integrated with a synthesized ruthenium(II) complex ( Ru , RuCl(η⁶-C₆H₆)(TolBig)). This hydrogel overcomes the poor aqueous solubility and toxicity limitations of traditional metal complexes while enhancing antibacterial efficacy. In vitro studies demonstrated potent activity against Staphylococcus aureus (MIC = 13.90 μM) and Escherichia coli (MIC = 20.85 μM), with the SA-GDL-Ru hydrogel (SGR-2) exhibiting 6–8-fold greater reactive oxygen species (ROS) induction than Ru alone. Transcriptomic analysis revealed that SA-GDL-Ru downregulates fabH (fatty acid synthase) and sigB (biofilm synthesis) genes while upregulating quorum-sensing regulators (agrA/agrC), disrupting biofilm integrity. Molecular docking confirmed Ru ’s binding affinity with biofilm-associated proteins, inhibiting key enzymatic functions. Crucially, SA-GDL-Ru accelerated wound closure in S. aureus -infected mice by 4 days through EGFR/Akt pathway activation, increasing VEGF-A/HIF-1α and reducing Caspase-3 expression. In acute pneumonia models, it achieved near-complete bacterial eradication with suppressed inflammation. Safety assessments confirmed minimal cytotoxicity (< 25 μM in zebrafish) and no hemolysis or organ damage. This work establishes SA-GDL-Ru as a translatable therapeutic platform combating biofilm-mediated infections while promoting tissue regeneration.
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Journal of Water Process Engineering
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2026
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IF 6.7
Junchi Wei,Haoran Chen,Daotong Zhao,Jinlong Wang,Miao Zhang,Lei Miao
Bioaugmentation can effectively improve biodegradation of recalcitrant compounds through adding specific substances or microbial consortia. In this study, a small quantity of co-metabolic sludge was introduced to conventional anaerobic sludge system (with a ratio of 1:4 between co-metabolic sludge to conventional anaerobic sludge), and enhancement effect on ceftriaxone sodium (CTX) biodegradation was investigated. The addition of co-metabolic sludge significantly improved CTX removal efficiency in anaerobic sludge system (with an average increase of 20.6 %), and the maximum removal of CTX reached 60.8 %. Co -metabolic sludge also elevated extracellular polymeric substance (EPS) secretion, increasing protein and polysaccharide contents by 34.66 % and 40.64 %, respectively, which mitigated CTX toxicity. Compared to conventional sludge, the system after bioaugmentation exhibited 4.3 % and 2.5 % increases in enzyme diversity and microbial population, respectively. Relative abundances of resistance genes evgS, NmcR, and Burkholderia pseudomallei Omp38 increased by 2.8 %, 7.6 %, and 2.5 %, respectively, which benefited improving CTX degradation. Furthermore, the abundances of pathways Two-component system (TCS) and Quorum sensing (QS) increased by 20.0 % and 21.7 %, respectively, indicating their involvement in bioaugmentation-mediated CTX degradation. Overall, this study strengthens CTX degradation in conventional sludge system with addition of some co-metabolic sludge, which provided a novel strategy for CTX wastewater treatment.
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