CHEMISTRY-A EUROPEAN JOURNAL
·
2026
·
IF 3.6
Jiyong Wu,Jing Nie,Huina Wu,Dongbo Wang,Yamei Li,Minyan Liang,Huimei Qian,Yong Wang
Platinum-based chemotherapeutics remain clinically indispensable for treating various malignancies despite causing severe side effects, with ototoxicity being particularly limiting. This study reports the synthesis and evaluation of platinum(IV) prodrugs incorporating the hearing-protective ligand RG108. Among the synthesized mono- and di-substituted cisplatin and oxaliplatin derivatives, compound 4 exhibited exceptional antitumor activity with an IC 50 value of 0.07 ± 0.08 µM in FaDu cells. Mechanistic investigations revealed that the enhanced anti-tumor effect was primarily mediated via the EZH2/SLC47A2 regulatory axis. These prodrugs significantly mitigated ototoxicity, preserving cochlear hair cell viability, stabilizing auditory brainstem response thresholds, and maintaining cochlear basement membrane morphology. Our findings establish a framework for designing dual-functional platinum agents that synergize antitumor efficacy with organoprotective properties, addressing critical hearing loss limitations of conventional platinum chemotherapy while maintaining robust therapeutic outcomes. Graphical
✓ 已验证
产品关联
DOI
高影响因子
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
·
2026
·
IF 4.2
Pengrui Zhang,Haiyang Zhang,Xinyu Yang,Yuanli Wu,Shanshan Dai,Yanqin Ding,Shanshan Sun
Bacteria play an important role in the biodegradation of polycyclic aromatic hydrocarbons (PAHs), especially the more recalcitrant high-molecular-weight compounds like pyrene. In this study, we isolated and characterized a novel pyrene-degrading bacterium, Glutamicibacter soli ENR6, from petroleum-contaminated soil. Strain ENR6 was able to utilize various PAHs as sole carbon sources and degrade 88.8% of 50 mg L−1 pyrene and 76.8% of 100 mg L−1 pyrene within 15 days. During pyrene degradation, eight metabolites were detected, with 2,2′-diphenic acid emerging as the predominant intermediate. By day 7, 40.6% of the degraded pyrene had accumulated in the form of 2,2′-diphenic acid, which was subsequently metabolized via the phthalate pathway. To our knowledge, this is the first report identifying 2,2′-diphenic acid as an intermediate in pyrene degradation. Integrated genomic and transcriptomic analyses revealed four gene clusters (clusters I–IV) involved in pyrene degradation in strain ENR6. Reverse transcription-quantitative PCR (RT-qPCR) analysis demonstrated that these clusters were specifically induced by pyrene and its intermediates, with genes chr_3400-chr_3404 in cluster I strongly associated with 2,2′-diphenic acid degradation. Based on these findings, we propose a distinct 2,2′-diphenic acid-centered pathway for pyrene degradation in strain ENR6. This study not only broadens the bacterial repertoire available for PAH bioremediation but also provides new insights into the metabolic diversity of PAH-degrading microorganisms.
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2026
·
IF 11.8
Min Mu,Bo Chen,Hui Li,Chenqian Feng,Susu Xiao,Rangrang Fan,Aiping Tong,Nianyong Chen,Gang Guo
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with limited efficacy of conventional therapies due to immunosuppressive tumor microenvironments and high recurrence. While bispecific T-cell engagers (BiTEs) show promise by engaging T cells against tumors, their clinical translation is hindered by poor stability, on-target off-tumor effect, and systemic toxicity. Herein, we develop a tumor-targeted nanozyme (MnO 2 -dsDNA@BiTE/APT) that co-delivers hydrolytically stable double-strand DNA (dsDNA: a STING agonist) and PD-L1/CD3 BiTE to overcome these limitations. The nanozyme leverages MnO 2 as a carrier for dsDNA, surface-loaded with BiTE via polyphenol-protein coordination, and functionalized with an aptamer (APT) for active targeting. Upon systemic administration, the nanozyme accumulates in tumors, releasing dsDNA, Mn 2+ , and BiTE. The synergistically activates the STING pathway to remodel the immunosuppressive microenvironment and enhances T cell-mediated cytotoxicity. This strategy represents a promising approach for potentiating immunotherapy in CRC by integrating innate immune activation with adaptive T cell engagement.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2026
·
IF 3.6
Hafiza Aroosa Aslam Khan,Naveed Ramzan,Asif Jamil,Ghulam Rasool,Muneerah Alomar,Muhammad Sarfraz
Decarbonization is essential to address climatic variations caused by greenhouse effects. Membrane-based separation processes present an energy-efficient and scalable pathway for flue gas purification. Permeability-selectivity trade-off of polymeric membranes can be mitigated through combined impregnation of bi-fillers within polymer matrix coupled with applying ultrathin secondary polymer coating to fabricate efficacious dual-layer composite membrane. Microporous activated MOF-5 nanocrystals with high surface area and CO 2 affinity, combined with graphene nanoplatelets possessing exceptional CO 2 uptake, were synergistically embedded into flexible polysulfone matrix. Biodegradable poly(vinyl alcohol) coating layer was uniformly deposited onto doped polysulfone substrate, yielding novel class of anisotropic dual-layer mixed matrix composite membranes, rendering drastically improved CO 2 /N 2 selectivity of 70 and upgraded CO 2 permeability of 92 Barrer as compared to bare polysulfone membrane. Advanced characterizations verified uniform nanofiller dispersion, strong interfacial bonding, and enhanced thermal stability. Five percent PVA coating boosted thermal stability and improved mechanical robustness by 84%, markedly strengthening membrane structural and thermal resilience. An effective strategy is introduced to produce dual-layer membranes with remarkable CO 2 capture performance via optimized bi-filler loading and PVA based surface modification. Highlights Solvothermal synthesis of highly microporous activated MOF-5 nanocrystals. Preparation of Zn-BDC MOF- and graphene nanoplates-embedded composite membranes. Enhanced nanofiller-polymer interfacial compatibility furnishing uniform filler dispersal. Constructing a dual-layer composite membrane by depositing an ultrathin poly(vinyl alcohol) layer. Marked improvement in decarbonization performance of prepared multilayered membranes.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2026
·
IF 2.6
Xiaoqiang Zhang,Quanlei Wang,Junli Ren,Huixiang Li,Da-Ming Gao
The selective ring-opening of biomass-derived furanic molecules offers an attractive route for the synthesis of industrially relevant linear ketones. Herein, the ring-opening reaction of 2,5-dimethylfuran (2,5-DMF) was systematically investigated over a series of oxide catalysts. Anatase TiO2 (TiO2-A) exhibits superior catalytic performance for the conversion of 2,5-DMF to 2,5-hexanedione (2,5-HD), delivering high selectivity under mild reaction conditions. Structure-activity correlation studies reveal that surface hydroxyl groups on TiO2-A play a decisive role in promoting the ring-opening reaction through strong interfacial interactions with the furan ring. Spectroscopic analyses indicate that these hydroxyls serve as the primary surface sites involved in the activation and subsequent cleavage of the furan C-O bond. Nevertheless, catalyst deactivation occurs during prolonged operation, which is mainly attributed to the strong and irreversible adsorption of 2,5-HD on surface hydroxyl groups, leading to progressive site blockage and loss of activity.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Science
·
2026
·
IF 14.1
Wenqing Zhang,Jinhui Xu,Bo Li,Yao Li,Yue Zhang,Zhishu Tang,Huaxu Zhu,Jingwei Hou
Janus membranes (JMs) promise advanced liquid separations, but fabrication speed, substrate universality, and precise configurational control remain challenging. Here, we report an ultrafast and universal interfacial engineering strategy to construct JMs with desirable micro-nano structures. Founded on a rapidly formed tannic acid/polyethyleneimine (TA/PEI) platform, the approach utilizes highly reactive stearoyl chloride (SC) for minute-scale hydrophobic modification. Crucially, a novel physicochemical control principle is revealed. Specifically, interfacial wettability and tension are modulated at the molecular level by phytic acid (PA). Through this modulation, the membrane's physical immersion depth is governed to provide unprecedented, quantifiable control over hydrophilic layer thickness during liquid-liquid interface modification. This enables tailored JMs exhibiting pronounced asymmetric super-wettability (water contact angle (WCA) difference >157°) and tunable unidirectional liquid transport. Demonstrated across diverse metallic and polymeric substrates, the resulting JMs show remarkable separation performance for challenging mixtures, alongside exceptional stability. This facile and controllable strategy overcomes previous limitations in speed, universality, and regulation of asymmetric configurations, offering a versatile platform for designing nano-engineered functional materials for sophisticated liquid separation applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2026
·
IF 11
Yongheng Zhou,Qinggang Liu,Linna Wang,Haoyu Sun,Yixi Liu,Tianyu Xiang,Meikai Zhu,Xin Liu,Tao Liu,Huiling Cong,Limin Liao
Overactive bladder (OAB) is a symptomatic disease that is difficult to treat. This study developed APTES-functionalized spiky titanium dioxide nanoparticles (ASNPs) loaded with botulinum toxin A (ASNP@BA), which is coated with P407/HA (HP) thermosensitive gel to treat OAB. Spiky nanoparticles exhibited a spiky nanostructure and were APTES-functionalized to exhibit enhanced drug-loading capacity. The optimal HP gel changed from liquid to gel near body temperature. In vitro, ASNPs enter cells via MYH9-mediated endocytosis. The expression of ZO-1 and E-cadherin proteins, along with changes in TEER, indicates that ASNPs entering cells do not compromise the integrity of the bladder barrier. In vivo, ASNP@HP showed excellent biocompatibility. Following bladder instillation of ASNP@HP, no significant toxicity was observed in major organs. The bladder barrier integrity was not significantly compromised. In a rat model, pretreatment of the bladder with ASNP@HPBA significantly reduced the excessive contraction induced by acetic acid, markedly reducing the intercontraction interval decline to 41.83% ± 17.78% compared to controls (∼75%) and free BTX-A (71.72%). The downregulation of SNAP-25 and SNAP-23 in the ASNP@HPBA group demonstrated successful targeted delivery and bioactivity. This platform combines macromolecular drug delivery with effective therapeutic efficacy and safety profile, representing a promising strategy for the treatment of OAB.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
HUMAN REPRODUCTION
·
2026
·
IF 6.8
Wang Xinlei,Jia Yan,Wang Chao,Li Danyang,Guo Xiaoping,Jiang Shengyu,Zhou Zhengjie,Gao Chencheng,Wang Fang
STUDY QUESTIONHow can the potential mechanisms and targets of endometriosis be explored through multi-omics and multi-location approaches?SUMMARY ANSWERThis exploration of the gut–reproductive axis in patients with endometriosis found that serotonin is elevated in endometriosis and promotes disease progression through enhanced cell proliferation and inflammation.WHAT IS KNOWN ALREADYEndometriosis is a common inflammatory disease. Recent studies indicate that peripheral serotonin, which is regulated by the gut microbiota, can promote the progression of irritable bowel syndrome and various cancers.STUDY DESIGN, SIZE, DURATIONThis cross-sectional study enrolled 22 endometriosis patients and 22 control patients with uterine fibroids (surgical cases, October 2022–June 2023). Samples of vaginal secretions, endometrial tissue, peritoneal lavage fluid, feces, and ectopic lesions were collected from both groups. For validation, serum samples were added from 20 additional endometriosis patients and 20 healthy reproductive-age volunteers.PARTICIPANTS/MATERIALS, SETTING, METHODSThis study employed 16S rRNA gene sequencing to analyze the microbiota in the vagina, endometrial tissue, peritoneal fluid, and feces of patients with endometriosis and control groups, complemented by untargeted metabolomic analysis of peritoneal fluid. The results identified serotonin as a key metabolite and revealed specific bacterial species, shared between the reproductive and gastrointestinal tracts of endometriosis patients, which were significantly correlated with serotonin levels. Mendelian randomization analysis was conducted to explore the relationship between serotonin, these bacterial species, and endometriosis. Serum serotonin levels in endometriosis patients, BALB/C mouse models, and their respective controls were measured using ELISA. Immunohistochemistry and fluorescence staining were used to detect the expression of serotonin and its receptors in both ectopic and normal endometrium. The effects of serotonin on the biological behavior of various endometriosis cell models, including proliferation, migration, invasion, and apoptosis, were investigated using CCK8 assay, wound healing test, Transwell assay, apoptosis detection, ELISA, transcriptomics, and qPCR. The impact of serotonin on BALB/C mouse models was evaluated using H&E staining, flow cytometry, and ELISA.MAIN RESULTS AND THE ROLE OF CHANCEWe identified a significant enrichment of Akkermansia muciniphila (a bacterium shared by the gut and reproductive tract) in endometriosis patients, which positively correlated with peritoneal serotonin levels; Mendelian randomization analysis linked both to elevated endometriosis risk. Serotonin levels were elevated in patients’ serum (using mouse models) and in ectopic endometrium, in comparison to those of controls. In vitro, serotonin boosted endometriosis cell proliferation, migration, invasion, and inflammation, with upregulated IL-17/NF-κB pathways. In mice, serotonin treatment increased lesion growth, cell proliferation, and inflammation.LARGE SCALE DATAN/A.LIMITATIONS, REASONS FOR CAUTION(a) The relatively limited sample size, together with potential imbalance in endometriosis ASRM stage distribution and cesarean section rates, may restrict the generalizability of our findings. In addition, due to the requirement for peritoneal lavage fluid collection, the control group could not consist of entirely healthy women, which may have resulted in a more conservative estimation of group differences. Serum sex hormone levels were not assessed; however, strict inclusion criteria and uniform surgical timing were applied to minimize hormonal confounding. Future studies incorporating cycle-phase–standardized hormone measurements may provide additional insights. (b) Dietary information was not collected in this study, despite the known influence of diet on gut microbiota composition and serotonin metabolism. (c) The direct causal relationship between Akkermansia muciniphila and elevated serotonin levels remains to be established and warrants further validation using germ-free mouse models or fecal microbiota transplantation approaches. (d) The precise mechanisms by which the gut–reproductive tract microbiota axis regulates local and systemic serotonin synthesis remain unclear and require further investigation.WIDER IMPLICATIONS OF THE FINDINGSOur study is the first to utilize a multi-omics approach combined with a joint analysis of the female gut–reproductive tract axis across multiple loci, revealing and validating a significant increase in serotonin levels in patients with endometriosis. This change may be regulated by the gut–reproductive microbiota axis. These findings provide new insights into the pathogenesis of endometriosis and identify potential targets for prevention and treatment.STUDY FUNDING/COMPETING INTEREST(S)This study was funded by the Jilin Provincial Key Laboratory of Precision Infectious Diseases (Grant No. 20200601011JC), Key Laboratory of Health and Family Planning Commission of Jilin Province (Grant No. 3D5200117426). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.TRIAL REGISTRATION NUMBERChiCTR2300077490.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PINEAL RESEARCH
·
2026
·Vol. 78
·期 2
·e70139
·
IF 7.5
Yi Zheng,Qing-qing Chen,Hai-xiang Guo,Yu-xin Zhang,Ling-ling Qiu,Bing-bing Wang,Song Yu,Jia-rui Gao,Zhe Zhang,Jia-bao Zhang,Guo-shi Liu,Bao Yuan
Melatonin, a signaling molecule secreted by the pineal gland, is closely associated with physiological activities, such as animal growth, development, and reproduction. Multiple studies have indicated that melatonin acts on the adenohypophysis to promote the synthesis and secretion of growth hormone (GH), but the specific mechanism of melatonin remains unclear. We have previously reported that melatonin levels in bovine serum are closely correlated with GH levels. In the present study, transcriptome sequencing was performed on primary bovine adenohypophyseal cells treated with melatonin, which identified FOXO1 as a key transcription factor that is responsive to melatonin and regulates GH synthesis and secretion. Cellular experiments revealed that melatonin binds to the MTNR1A in bovine adenohypophyseal cells, activates the cAMP/PKA signaling pathway, and promotes the expression of FOXO1 protein. Dual-luciferase reporter assays verified the binding of FOXO1 to the GH1 promoter. Treatment with Luzindole, 4P-PDOT, 2′,5′-Dideoxyadenosine or H-89 elucidated the molecular mechanism through which melatonin promotes GH synthesis and secretion in adenohypophyseal cells through the cAMP/PKA/CREB/FOXO1 pathway. The present study provides critical evidence for the direct action of melatonin on adenohypophyseal cells and its targeted regulatory sites, and it offers new insights into the conserved and species-specific modes of action of melatonin across different species, providing data and theoretical support for the application of melatonin in promoting animal growth and development.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Composites and Hybrid Materials
·
2026
·
IF 15.5
Bai Tian,Qin Xionghai,Wu Zhenguo,Su Junjie,Li Lin,Yao Hang,Niu Zhaoxuan,Yue Chengbin,Wang Dong,Yue Yiying,Cheng Wanli,Zeng Chengjun,Zhao Wei,Han Guangping
Commercial airway stents often slip and deform, leading to severe complications such as mucosal injury, granulation tissue formation, and stent migration, which can cause recurrent airway obstruction and necessitate repeated interventions. Here, we introduce a 3D-printed tracheal stent composed of continuous bamboo fiber reinforced shape memory polylactic acid (BF/SMP). These naturally derived fibers (tensile strength ~ 1.90 GPa, modulus ~ 91.30 GPa) exhibit excellent mechanical resilience. Following an instantaneous thermal treatment, their interfacial compatibility with SMP is notably improved. The 30% BF/SMP stent can undergo over 1,000 three-point bending cycles under a 20 N load, with a bending deflection of 30.85%. In vitro, it promotes bronchial epithelial cell proliferation. Preliminary animal studies suggest that the biomass-based stent provides airway support without causing significant inflammation or organ abnormalities. Overall, this work demonstrates a biomass-reinforced, thermally deployable airway stent concept and provides a foundation for future studies on catheter-compatible delivery and long-term in vivo performance.
✓ 已验证
产品关联
DOI
高影响因子
WOOD SCIENCE AND TECHNOLOGY
·
2026
·Vol. 60
·期 3
·48
·
IF 3.2
Li Jing,Zha Yu-Ning,Wang Han-Min,Hou Qing-Xi
The pulp and paper industry faces growing challenges arising from fiber shortages and environmental concerns. High yield pulping technology has emerged as a key solution, but the high lignin content in high yield pulp (HYP) restricts its brightness, posing a significant challenge for the bleaching process. Although traditional strong alkaline hydrogen peroxide (H 2 O 2 ) bleaching of HYP is effective, it results in fiber yield loss and the generation of anionic impurities, thereby bringing about additional environmental burdens. In contrast, weakly alkaline H 2 O 2 bleaching is more environmentally friendly and preserves a high pulp yield, but it struggles to achieve the desired brightness due to the reduced reactivity of lignin. This work addresses these challenges by investigating the effect of xylanase-pectinase (XP) pretreatment combined with weakly alkaline H 2 O 2 bleaching to improve both bleaching efficiency and environmental benefits in the bleaching of poplar chemi-thermomechanical pulp (CTMP). The kinetic analysis reveals that the XP pretreatment significantly enhanced the efficiency of weakly alkaline H 2 O 2 bleaching, accelerating lignin removal and increasing pulp brightness. The XP pretreatment effectively reduced the electrical conductivity, cationic demand, and chemical oxygen demand of the bleaching effluent. The mechanism studies demonstrate that the XP pretreatment effectively cleaved lignin-carbohydrate complex linkages and degraded hemicelluloses side chains, significantly increasing the accessibility and reactivity of the residual lignin. The integration of XP pretreatment with weakly alkaline H 2 O 2 bleaching can offer a sustainable and efficient process for poplar CTMP upgrading, simultaneously enhancing the bleaching efficiency and mitigating the environmental footprint.
✓ 已验证
产品关联
DOI
高影响因子
ARCHIVES OF MICROBIOLOGY
·
2026
·Vol. 208
·期 6
·286
·
IF 3.4
Bi Yinli,Wang Kun,Ma Shaopeng,Zhou Yang,He Yong
Agricultural crop yields are limited by soil nutrient status and crop nutrient utilization efficiency. Both intercropping and arbuscular mycorrhizal fungal colonization can increase plant nutrient utilization and crop yields. However, although common mycorrhizal networks have been widely studied, the role of arbuscular mycorrhizal fungi in mediating nutrient transfer within networks formed between intercropped plants, and the consequences for the component crops, remain insufficiently resolved. We hypothesized that CMN-mediated P redistribution between intercropped maize ( Zea mays L.) and soybean ( Glycine max (L.) Merr.) is governed by plant P demand (sink strength), and that the direction and magnitude of P transfer shift under contrasting soil P supply. Here, we combined a five-chamber root device with multi-wavelength quantum-dot P labeling to directly trace CMN-mediated P transfer in a maize–soybean intercropping system. A maize–soybean intercropping system was established in a greenhouse under two phosphorus supply levels (low P, 20 mg kg⁻¹ Olsen-P; high P, 100 mg kg⁻¹ Olsen-P) to investigate P allocation within plant–mycorrhiza associations and mycorrhizal networks. Plant physiological traits (photosynthetic parameters and biomass), root traits, and rhizosphere enzyme activities were simultaneously quantified to link CMN-mediated P transfer with plant performance and soil P cycling. In low-phosphorus conditions, inoculation with Diversispora epigaea significantly improved maize physiological in-dices but had no significant effect on soybean, and facilitated net phosphorus (P) transfer from soybean to maize through the common mycorrhizal network (CMN). Under high-phosphorus conditions, inoculation markedly enhanced soybean physiological indices, inhibited maize growth, and redirected P transfer from maize to soybean via the CMN. Overall, mycorrhizal inoculation increased the total P flux within the maize–soybean intercropping system, and the direction of inter-plant P exchange was regulated by the fungal mycelial network in response to contrasting soil P supply, which altered host P demand.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）