MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Biaobiao Ge,Jie Huang,Qianmin Dong,Fen Yang,Mengmeng Wang,Pei Liang
This work reveals a novel SERS enhancement mechanism of “satellite” structure. • Stable and uniform L-Au@ZIF-67@S-Au NPs were synthesized by self-assembly method. • L-Au@ZIF-67@S-Au NPs substrates was prepared with an enhancement factor of 3.4 × 10 6 . • Determination of fenpropathrin in citrus peel, and its LOD reached 0.995 μg/L. A new hybrid substrate of core-satellite plasma MOF, namely L-au @ ZIF-67 @ S au NPs, was developed in this study. The substrate aims to improve SERS performance by combining the molecular trapping layer of ZIF-67 with double electromagnetic hot spots distributed on the inner surface and the outer surface. The interface self-assembly strategy was adopted to combine MOF with plasma nanostructures, thus combining excellent molecular adsorption ability with strong local field enhancement effect. The results showed that the substrate had a low detection limit of 1.43 × 10 −10 M for rhodamine 6G, achieved rapid adsorption equilibrium within 10 min, and showed high signal reproducibility (relative standard deviation, RSD = 1.66%, n = 20). The substrate was applied to the detection of fenpropathrin residues in citrus peels, showing good sensitivity, and the detection limit was 0.995 μg·L −1 , with an enhancement factor of 3.4 × 10 6 and excellent reproducibility. This work builds a multifunctional and environment-friendly SERS platform, which effectively combines advanced nano-material design with practical applications of food safety monitoring Download: Download high-res image (146KB) Download: Download full-size image
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高影响因子
PHYTOMEDICINE
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2026
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IF 11.3
Kangjie Li,Runxin Ren,Qiongyi Qi,Min Wang,Qiao Zhang,Jing Sun,Jing Wang,Chongbo Zhao
This study reveals for the first time that madder can drive natural components to self assemble and form structurally superior nanoparticles (PRCL NPs) through charcoal frying, providing a scientific explanation of the "charcoal storage" theory at the nanoscale. • Compared with RCL NPs, PRCL NPs have smaller particle size (∼400 nm), higher stability, and exhibit excellent colitis targeting and macrophage uptake ability after processing. • PRCL NPs are significantly more effective than raw products in treating ulcerative colitis (UC) models, effectively alleviating colitis symptoms and promoting tissue repair. • Through multi omics integration analysis, it was first elucidated that PRCL NPs exert synergistic anti-inflammatory effects by activating the IL-17A/IL-22-C/EBP β - STAT3 signaling axis and inhibiting the expression of downstream key chemokines (CCL5, CXCL5, CXCL10). Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited treatment options. The carbonization of Rubia cordifolia L. traditionally enhances its therapeutic effects, but the mechanism remains unclear. Objective To investigate whether carbonization induces self‑assembled nanoparticles (PRCL NPs) from Rubia cordifolia and to elucidate their mechanism in UC. Study design Self‑assembled nanoparticles were extracted from raw (RCL NPs) and carbonized (PRCL NPs) Rubia cordifolia. A DSS‑induced acute UC mouse model was used to evaluate efficacy. Transcriptomics, proteomics, Western blot, and ELISA were performed to explore the mechanism. Methods Nanoparticles were characterized by DLS, SEM, FTIR, and stability assays. DSS‑induced colitis mice were orally treated with RCL NPs or PRCL NPs (1.3 and 5.2 g/kg). Inflammatory and pathway markers were assessed. Results PRCL NPs exhibited smaller particle size (337.2 nm vs. 947.2 nm) and enhanced stability (zeta potential –15.2 mV). Multi‑omics revealed convergent enrichment of the IL‑17 signaling pathway. PRCL NPs significantly upregulated IL‑17A, IL‑22, p‑STAT3, and p‑C/EBPβ (p < 0.001) and suppressed chemokines CCL5, CXCL5, and CXCL10. Conclusion Carbonization of Rubia cordifolia spontaneously forms structurally optimized self‑assembled nanoparticles (PRCL NPs) that alleviate UC by modulating the IL‑17A/IL‑22–C/EBPβ–STAT3 axis. This study provides a modern nanoscale interpretation of traditional processing theory. Download: Download high-res image (241KB) Download: Download full-size image
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高影响因子
Plants-Basel
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2026
·Vol. 15
·期 14
·2125
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IF 4.7
Wenjing Zhang,Yuting Li,Shuaibo Shao,Xingyuan Yao,Chengzhe Zhou,Zhong Wang,Yuqiong Guo
High-altitude environments provide a favorable basis for tea quality formation, but suitable processing parameters for high-altitude Oolong Tea (HAOT, Camellia sinensis (L.) O. Kuntze) remain unclear. This study optimized key processing parameters for HAOT using a three-factor, three-level orthogonal design involving withering method, shaking intensity and standing time. Sensory evaluation, quantitative descriptive analysis (QDA), macro-compositions determination, headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry (HS-SPME-GC-MS), multivariate statistics and correlation analysis were used to clarify quality differences and their chemical basis. Leaf anatomical observation showed that high-altitude fresh leaves had a thicker cuticle and more compact mesophyll structure, suggesting the need for targeted processing regulation. Range analysis indicated that shaking intensity had the largest R value for sensory scores, followed by withering method, whereas standing time showed a comparatively small R value. The favorable combination was combined withering, heavy shaking (6 rounds) and 60 min standing, hereafter referred to as FHM. FHM showed the highest floral and fruity aroma scores and produced a mellow, full-bodied taste with a sweet aftertaste. It also contained significantly higher flavonoid and soluble sugar levels than the other processing combinations. A total of 65 volatile organic compounds were detected, with terpenoids and esters as the dominant classes. ROAV analysis identified geraniol, linalool, β-ionone, ( E )-nerolidol and benzaldehyde as representative major aroma-active compounds, while geraniol and linalool were especially prominent in FHM. Correlation analysis further linked flavonoids and soluble sugars with positive taste attributes, and linalool and geraniol with floral–fruity aroma. These results provide a practical basis for optimizing HAOT processing and improving product quality.
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高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2026
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IF 6.4
Ru Zhao,Na Zhang,Meili Hu,Lei Yang,Chunte Feng,Xiaoli Li,Yulong Wu,Like Wang,Yaoyao Wang,Hongying Lin,Ailing Ben,Quanzhan Chen,Tingli Liu
A dual-stage strategy purified isoorientin from Thlaspi arvense L. leaves. • X-5 resin enabled efficient pre-enrichment of target flavonoids. • Fe 3 O 4 @SiO 2 @BA-Zn-MOFs selectively captured isoorientin via boronate affinity. • The magnetic adsorbent achieved rapid separation and good reusability. • Isoorientin purity reached 90.28% after integrated purification. Thlaspi arvense L. is a valuable industrial crop rich in bioactive flavonoids, specifically isoorientin and isovitexin. However, the efficient and selective separation of these isomers from complex plant matrices remains a significant challenge. In this study, a dual-stage purification strategy was developed by combining macroporous resin pre-enrichment with novel magnetic boronic acid-functionalized metal organic framework composites (Fe 3 O 4 @SiO 2 @BA Zn MOFs). The composite was synthesized via the coordinated assembly of 3,5-dicarboxyphenylboronic acid (BBDC) and zinc ions on magnetic silica cores. Systematic screening revealed X-5 resin as the optimal medium for preliminary enrichment, effectively removing major polar impurities. Subsequently, Fe 3 O 4 @SiO 2 @BA-Zn-MOFs were employed to selectively capture isoorientin via reversible boronate affinity. Under optimized conditions (pH 8.0, 120 min), the composite demonstrated high selectivity for isoorientin because of the formation of catechol-type ortho-dihydroxy moiety. The magnetic properties facilitated rapid solid liquid separation within 15 s. HPLC analysis revealed that the purity of isoorientin significantly improved from that of the crude extract to 90.28%. Furthermore, the magnetic adsorbent exhibited satisfactory stability and reusability, maintaining approximately 60% of its initial capacity after five consecutive cycles. This integrated approach provides an efficient and highly selective laboratory-scale strategy for the selective purification of high-value flavonoids from industrial crop byproducts and may provide a basis for future scale-up studies.
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高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2025
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IF 4.7
Shan Huang,Pingping Mu,Guixin Li,Wei Ni,Yi Fang,Fuxiang Wei,Qi Xiao
The detection of Cu 2+ ions and L-histidine (L-His), which are crucial trace elements and amino acids in biological systems, is of paramount importance for environmental health, food safety, and clinical diagnosis. However, conventional detection methods often suffer from drawbacks such as complexity, time-consuming procedures, and high costs. To address these challenges, we have developed an efficient, sensitive, and straightforward detection techniques. In this study, we successfully synthesized red-emitting carbon dots (R-CDs) with a remarkable quantum yield of 26.6 % and devised an R-CDs-based fluorescence sensor that operates via an “on-off-on” mode for the simultaneous detection of Cu 2+ ions and L-His. The sensor's working principle involves the static quenching of R-CDs fluorescence upon the addition of Cu 2+ ions, followed by the restoration of fluorescence through the competitive binding of L-His to Cu 2+ ions. This approach enables the ultrasensitive detection of Cu 2+ ions and L-His, with detection limits as low as 0.58 μM and 0.45 μM, respectively. The sensor has been effectively applied to detect Cu 2+ ions in environmental water samples and L-His in human blood, food additives, and health-care products. It demonstrates excellent selectivity, strong anti-interference ability, and high accuracy, with recovery rates ranging from 95.0 % to 105.0 %. Owing to its simplicity, rapidity, cost-effectiveness, and high sensitivity, the proposed R-CDs-based fluorescence sensor holds great promise as a valuable tool for environmental monitoring, food safety assessment, and clinical diagnosis. Future efforts will focus on further optimizing the sensor's performance and exploring its applications in a broader range of real-world samples, thereby providing substantial support for scientific research and technological advancements in related fields.
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高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2026
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IF 6.2
Qian Lin,Yupeng Fan,Yanliang Guo,Li Niu,Hanlin Guan,Wenhao Li,Huijun Zhang
Melon seed husk is an agricultural waste rich in lignocellulose, and its high-value utilization is of great significance for sustainable development. However, the recalcitrant structure of lignocellulose poses a major bottleneck to achieving efficient bioconversion. This study aims to elucidate the mechanism of efficient deconstruction of melon seed husk cellulose via synergistic pretreatment with electron beam irradiation (EBI) and a deep eutectic solvent (DES), and to develop a green biorefinery process. We applied synergistic pretreatment of melon seed husk using varying doses of EBI and choline chloride/urea DES. The structural evolution of the pretreated material was analyzed at multiple scales, and its saccharification efficiency was evaluated via enzymatic hydrolysis. The results revealed that EBI dose-dependently disrupted the hydrogen-bonding network and the crystalline structure of cellulose, reducing its crystallinity by 0.95 %–11.54 % and forming a porous network. The synergistic pretreatment exhibited a significant dose-threshold effect. At the optimized dose of 150 kGy, the cellulose-binding rate was significantly enhanced, resulting in a saccharification yield of 48.29 %. This study provides a theoretical foundation and a feasible strategy for the industrialization of green biomass refining.
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高影响因子
ACS Sustainable Chemistry & Engineering
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2014
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IF 0
Rui-Ying Bao,Wei Yang,Xin-Feng Wei,Bang-Hu Xie,Ming-Bo Yang
Melt processing of polymers is preferable in industry. Unfortunately, for high molecular weight (Mw) poly(l-lactide)/poly(d-lactide) (PLLA/PDLA) blends, exclusive formation of stereocomplex (sc) crystallites from the melt has never been achieved. We proposed a new and simple approach to enhance the melt crystallization of sc crystallites from high Mw PLLA/PDLA by using poly(ethylene glycol) (PEG). The crystallizability of the PLLA/PDLA blend is greatly enhanced by PEG during crystallization from the melt. The resulted crystalline structures depend on the Mw and content of PEG, and the crystallinity of sc crystallites increases with increasing content or decreasing Mw of PEG. More importantly, exclusive formation of sc crystallites is achieved in the blends with 10% PEG having Mw values of 1000 or 2000 g mol–1. Polarized optical microscopy (POM) observation shows that the spherulitic growth rates of sc crystallites are accelerated. The results demonstrate that segmental mobility of polylactides (PLA) chains plays a dominant role on the formation of sc crystallites from melt and provide a simple way to prepare sc crystallites from high Mw PLA by melt blending and enlarge the applications of PLA.
研究领域:
高分子科学
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材料工程
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聚合物结晶
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JOURNAL OF CHROMATOGRAPHY A
·
2026
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IF 4
Gege Zhu,Li Qi,Bing Niu,Qi Zhang,Qin Chen,Dan Zhong,Xiaodong Sun
Metal-organic frameworks (MOFs) are promising chiral separation materials owing to their well-defined pore structures and tunable functionality. In this work, mesoporous/microporous NU-1000 was functionalized with L-Cysteine (L-Cys) via solvent-assisted ligand exchange to produce L-Cys-NU-1000, which was applied as a stationary phase in capillary electrochromatography (CEC). The resulting L-Cys-NU-1000@capillary system achieved baseline separation of five chiral amino acid enantiomers with excellent intra-day, inter-day, and batch reproducibility (RSDs < 5%). Notably, the system retained high enantioselectivity even after 100 consecutive injections. This study represents the first application of NU-1000 in chiral separation, opening new avenues for its use and laying a foundation for broader future applications. The system demonstrates distinct advantages for quality control of amino acids, offering high efficiency, robustness, and reproducible enantiomeric separation crucial for food and pharmaceutical analysis.
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高影响因子
Food Biophysics
·
2026
·Vol. 21
·期 3
·83
·
IF 3.9
Zheng Hangrong,Liu Guosheng,Wang Litao,Zhou Wanmei,Zhang Xinlin,Fu Yujie
Lonicera caerulea L. anthocyanins (LA) exhibit notable bioactivities but suffer from poor stability, which severely limits their practical applications. To address this challenge, we fabricated double-layered nanoparticles using zein and gum arabic (GA) to encapsulate LA immediately after extraction. Gallic acid (GAc)was co-encapsulated as a copigment, which stabilized LA via noncovalent interactions (hydrogen bonds and π-π stacking), accompanied by obvious hyperchromic and bathochromic effects that enhanced LA stability. The nanoparticles were systematically characterized, and their stability, in vitro release behavior, and antioxidant activity were evaluated. The optimized nanoparticles were uniformly spherical with a particle size of 155.03 nm. The corresponding encapsulation efficiency was 85.53%. The retention rate of encapsulated LA reached 68.95% after thermal treatment for 5 h. After 25 days of storage, its retention rate was 74.81%. Both values were significantly higher than those of free LA. In vitro release profiles revealed intestinal targeting and sustained-release characteristics. The nanoparticles exhibited efficient DPPH and ABTS radical scavenging (IC₅₀ = 0.13 ± 0.01 mg/mL) and inhibited intracellular ROS production, indicating favorable biocompatibility and antioxidant activity. This nanoparticle system co-encapsulated with GAc significantly improved the stability, sustained release, and antioxidant performance of LA, extending its application potential in functional foods and nutraceuticals. Graphical
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高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Zheng-Kai Zhang,Meng-Chen Xie,Jun-Chao Zhang,Lu-Han Sun,Xiao-Shuang Cai,Run-Yang Zhang,Guo-Qiang Zhang,Hua-Min Liu
Profiled free polyphenols in tiger nut oil (TNO). • Quercetin/catechin/eriodictyol enhanced the oxidative stability of stripped TNO. • Quercetin/catechin/eriodictyol possessed excellent radical scavenging activity • The structure-activity relationship of key polyphenols in TNO was represented. • Hydroxyl number/position and C-ring structure regulate polyphenol activity. Tiger nut oil (TNO) is a promising edible oil with remarkable oxidative stability. This study aimed to elucidate the structure-activity features of endogenous free polyphenols in TNO associated with its oxidative stability. UPLC-ESI-Q TRAP-MS/MS analysis revealed 36 flavonoids, 14 phenolic acids, and 4 lignans in TNO. The major polyphenols covering the main skeletons were then added to stripped tiger nut oil (STNO) without any antioxidants. A combination of multi-method, including Rancimat assay and quantum chemical computations based on density functional theory was employed. Notably, quercetin, catechin, and eriodictyol showed the strongest antioxidant effect. The bond dissociation energy (75.69–100.89 kcal/mol) of the test polyphenol is significantly lower than its ionization potential and proton affinity. These differences were related to the structural characteristics of the polyphenols. This work improves our understanding of the key role of free polyphenols in the oxidative stability of TNO. Download: Download high-res image (216KB) Download: Download full-size image
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高影响因子
JOURNAL OF BIOTECHNOLOGY
·
2026
·
IF 4
Renmin Liu,Tiantian Jia,Hanbing Song,Zhenhui Yu,Chaoqi Lin,Qingchun Yang,Ziyuan Ye,Yaqi Wang,Yanwen Wang,Hongbo Suo
L -histidine ionic liquid modified magnetic COF was successfully fabricated. • Covalent modification of supports with IL optimized the enzyme microenvironment. • Introduction of IL enhanced the activity and stability of immobilized lipase. • IL boosted lipase-substrate affinity and catalytic efficiency. • Magnetic responsiveness improved the separation efficiency of immobilized lipase. This study proposes an innovative immobilized lipase construction strategy to address the low activity and poor stability limitations of current biocatalysts for flavor ester synthesis. L -histidine-based ionic liquid (IL) is covalently grafted onto the surface of magnetic covalent organic framework (COF) via Schiff base reaction, and porcine pancreatic lipase (PPL) is further covalently immobilized on the composite carrier through amide bond coupling. The resulting Fe₃O₄@COF-IL-PPL shows 1.6-fold higher catalytic activity and 2.3-fold better thermal stability than free PPL, and 32% higher activity retention after cycles than PPL immobilized on IL-free COF carrier. Its optimal reaction pH and temperature are 7.5 and 50 °C respectively, maintaining 86% of initial activity at 60 °C and 76% activity after 6 h incubation at 50 °C. Under n-hexane reaction system, the isoamyl acetate yield reaches 87.4% under optimal conditions, and the biocatalyst retains 71.4% activity after 10 consecutive isoamyl acetate synthesis cycles. Although the additional preparation steps and higher cost of the support need to be considered for industrial applications, the improved catalytic performance of Fe 3 O 4 @COF-IL-PPL verified the effectiveness of IL surface modification strategy, and the system can be further extended to solvent-free systems to verify its broader applicability.
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高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
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IF 5.8
Yue Huang,Chenguang Yang,Jianlin lv,Yu Zhang,Kun Wang,Lili Ma,Zhilin Liu,Haiyang Yu,Mingqiang Li,Zhaohui Tang
Poly(L-glutamic acid)- g -methoxy poly(ethylene glycol)/Combretastatin A4 (CA4)/BLZ945 nanoparticles (CB-NPs) have shown great potential in synergistic cancer therapy. However, it is still unclear how the nanoparticles’ formula, such as injection dose, active agent ratio, and drug loading content, affects the side effects and in vivo efficacy of CB-NPs. In this study, a series of CB-NPs with different BLZ945/CA4 (B/C) ratios and drug loading contents were synthesized and evaluated on a hepatoma (H22) tumor-bearing mice model. The injection dose and B/C ratio were found to have a significant influence on the in vivo anticancer efficacy. The CB-NPs 20 with B/C weight ratio of 0.45/1, and total drug loading content (B + C) of 20.7 wt%, showed the highest potential for clinical application. Systematic pharmacokinetics , biodistribution , and in vivo efficacy evaluation for CB-NPs 20 have been finished, which may provide significant instruction for medicine screening and clinical application.
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高影响因子
危险品化学品经营许可证（带存储）