IONICS
·
2024
·
IF 2.4
Gao Liang,Li Wenxin,Jiang Jiahao,Wang Mengjie,Yao Changyu,Li Li,Gao Hanyang
Reducing silicon particle size in lithium-ion battery anodes not only mitigates surface stress, prevents pulverization, and reduces SEI film cracking but also significantly enhances surface area, thereby amplifying the impact of particle surface chemistry on performance. In this study, the surface of silicon particles with 80-nm diameter were oxidized in air to prepare Si@SiO x with a core–shell structure. We investigated the effect of different oxidation levels of the shell on the cycling performance of the nanosized silicon particles. The results showed that longer heating times decreased initial coulombic efficiency (ICE) but improved cycling performance. An interesting phenomenon was observed that, when the oxidation level was high, fast charging reduced battery capacity; while at lower oxidation levels, fast charging maintained or even slightly increased battery capacity. Based on electrochemical analysis, we proposed an explanation for this phenomenon: for small-sized nanoparticles with a large specific surface area, the effect of potential is particularly significant. The oxidation level of the particle surface affects the impedance of the SEI film, and high charge/discharge rates will also produce bias voltage, both of the two factors will limit the formation of crystallized Li 15 Si 4 (c-Li 15 Si 4 ). Reducing the amount of c-Li 15 Si 4 can effectively improve the cycling performance of the electrode, but excessive bias voltage will sacrifice the lithium storage capacity of the electrode. For the designing of small size silicon particles, both factors should be considered.
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BMC MICROBIOLOGY
·
2024
·Vol. 24
·期 1
·1-14
·
IF 4
Liu Ting,Wang Yin,Hou Zhuoer,Shi Zhenyu,Wang Rongyun,Shi Yanan,Hua Lijiangshan,Wu Lingyun,Xu Min,Ding Xinghong,Sun Qiuhua
Background The guts of mammals are home to trillions of microbes, forming a complex and dynamic ecosystem. Gut microbiota is an important biological barrier for maintaining immune homeostasis. Recently, the use of antibiotics to clear gut microbiota has gained popularity as a low cost and easy-to-use alternative to germ-free animals. However, the effect of the duration of the antibiotic cocktail on the gut microbiome is unclear, and more importantly, the effect of dramatic changes in the gut microbiota on intestinal tissue morphology and local immune response is rarely reported.Results We observed a significant reduction in fecal microbiota species and abundance after 1 week of exposure to an antibiotic cocktail, gavage twice daily by intragastric administration. In terms of composition, Bacteroidetes and Firmicutes were replaced by Proteobacteria. Extending antibiotic exposure to 2–3 weeks did not significantly improve the overall efficiency of microbiotal consumption. No significant histomorphological changes were observed in the first 2 weeks of antibiotic cocktail exposure, but the expression of inflammatory mediators in intestinal tissue was increased after 3 weeks of antibiotic cocktail exposure. Mendelian randomization analysis showed that Actinobacteria had a significant causal association with the increase of IL-1β (OR = 1.65, 95% CI = 1.23 to 2.21, P = 0.007) and TNF-α (OR = 1.81, 95% CI = 1.26 to 2.61, P = 0.001).Conclusion sOur data suggest that treatment with an antibiotic cocktail lasting 1 week is sufficient to induce a significant reduction in gut microbes. 3 weeks of antibiotic exposure can lead to the colonization of persistant microbiota and cause changes in intestinal tissue and local immune responses,
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AAPS PHARMSCITECH
·
2024
·Vol. 25
·期 6
·1-15
·
IF 3.4
Chen Jiasheng,Chen Zhenzhen,Wang Wentao,Wang Liyang,Zheng Jiaqi,Wu Shiqiong,Pan Yuru,Li Sai,Zhao Jie,Cai Zheng
Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The surfactants used in oral drug preparations can affect the function of transporter proteins. This study aimed to investigate the effect of commonly used surfactants, Poloxamer 188 and Tween 80, on the drug transport capacity of IGTs. Previous studies have shown that gastrodin is the optimal drug substrate for IGTs. Gastrodin was used as a probe drug to evaluate the effect of these two surfactants on intestinal absorption in SD rats through pharmacokinetic and in situ single-pass intestinal perfusion. Then, the effects of the two surfactants on the expression of glucose transporters and tight-junction proteins were examined using RT-PCR and western blotting. Additionally, the effect of surfactants on intestinal permeability was evaluated through hematoxylin-eosin staining. The results found that all experimental for Poloxamer 188 (0.5%, 2.0% and 8.0%) and Tween 80 (0.1% and 2.0%) were not significantly different from those of the blank group. However, the AUC (0-∞) of gastrodin increased by approximately 32% when 0.5% Tween 80 was used. The changes in IGT expression correlated with the intestinal absorption of gastrodin. A significant increase in the expression of IGTs was observed at 0.5% Tween 80. In conclusion, Poloxamer 188 had minimal effect on the drug transport capacity of IGTs within the recommended limits of use. However, the expression of IGTs increased in response to 0.5% Tween 80, which significantly enhanced the drug transport capacity of IGTs. However, 0.1% and 2.0% Tween 80 had no significant effect. Graphical Abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 17
·1-11
·
IF 2.8
Huang Jie-Ping,Pan Qiu-Ren,Jiang Hui-Huan,Zhou Xiao-Feng,Li Nan
Efficient and cost-effective non-precious metal catalysts play a crucial role in the evolution of energy storage and conversion technologies. This work introduces a novel cobalt–nickel bimetallic catalyst (Co x /Ni y –N–C), synthesized via SiO 2 spheres as templates and ZIF-8 as precursors, aiming to address this critical need. The Co 1 Ni 1 –N–C catalyst, synthesized with a 1:1 Co to Ni doping ratio, displayed exceptional electrocatalytic activity for oxygen reduction. Its impressive half-wave potential of 0.81 V and limiting current density of 4.89 mA cm −2 nearly approached those of Pt/C catalysts (0.82 V and 5.09 mA cm −2 ), showcasing its competitive edge. Integration of the Co 1 Ni 1 –N–C catalyst into a zinc-air battery demonstrated substantial promise, yielding a commendable power density of 185.17 mW cm −2 , marginally trailing behind the commercial Pt/C catalyst (198.33 mW cm −2 ). By offering a cost-effective alternative without compromising efficiency, this research significantly contributes to the wider adoption of sustainable energy technologies.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-17
·
IF 10.6
Lu Wei,Li Yang,Zhang Xiaojun,Wang Ning,Chen Dong,Zhao Yatong,Li Guang,Shi Xuzhi,Ma Xiaobo,Su Xiaodan,Wang Feng,Shu Chuqiang,Chen Kun
Amidst the burgeoning field of cancer nanomedicine, dense extracellular matrices and anomalous vascular structures in the tumor microenvironment (TME) present substantial physical barriers to effective therapeutic delivery. These physical barriers hinder the optimal bioavailability of nanomedicine. Here, we propose a pioneering dual-modal strategy for overcoming physical barriers via soft organosilica nanocapsules (SMONs). Hyaluronidase-modified flexible spheres work by degrading the extracellular matrix and utilizing their flexible characteristics to enhance penetration into deeper layers. Compared with their stiff counterparts, the SMONs show diminished Young’s modulus, then the inherent softness of the SMONs confers distinct advantages, and significantly augmented cellular internalization within 4T1 cells, leading to an amplified in vitro photodynamic therapeutic effect. Furthermore, hyaluronidase-functionalized SMONs (SMONs-HAase) exhibit enhanced tumor penetration in 3D spheroids. Post incorporation of the photosensitizer chlorin e6, when administered intravenously, these soft organosilica nanocapsules amplify the efficacy of photodynamic therapy. In addition, RNA-seq analysis of SMONs-HAase-Ce6 shows it alters gene expression, degrading the extracellular matrix and impairing mitochondrial function. To sum up, this work elucidates the potential of a dual-modal strategy, highlighting the promise of SMONs in overcoming TME physical barriers and optimizing therapeutic outcomes. Graphical abstract
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2024
·
IF 2.6
Chen Wang,Li Wenxin,Jiang Jiahao,Yao Changyu,Li Li,Gao Hanyang
Silicon nanomaterials have received much attention due to their ability to adapt to large volume changes and thus avoid fragmentation. Studies have shown that two-dimensional flaky silicon particles (F–Si) have better mechanical stability than spherical silicon particles (S–Si), but the larger specific surface area of flaky silicon highlights the problem of chemical stability. A suitable binder can stabilize the surface of the silicon particles through interaction with the silicon particles. This work is a comparative study of various binder systems for S–Si and F–Si: sodium carboxymethyl cellulose (CMC), polyacrylic acid (PAA), and sodium alginate (SA). The relationships between the rheological properties of the electrode slurry, the functional group states of the silicon particles and electrode coatings, the state of the dried electrode surface, and the type of binder were investigated. The experimental analysis shows that CMC and SA as rigid binders exhibit better cycling performance in S–Si/F–Si electrodes due to their better dispersion states. The dispersion of S–Si electrodes with higher silanol (Si–OH) content is dominantly influenced by electrostatic repulsion, and that of F–Si electrodes with lower Si–OH content is dominantly influenced by bridging. The experimental analysis demonstrates that CMC and SA as rigid binders exhibit better cycling performance in S–Si/F–Si electrodes, respectively, due to their better dispersion states. The dispersion of S–Si electrodes with higher silanol Si–OH content is dominantly influenced by electrostatic repulsion, and that of F–Si electrodes with lower Si–OH content is dominantly influenced by bridging.
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CELLULOSE
·
2024
·Vol. 31
·期 10
·6373-6385
·
IF 4.9
Du Wenfang,Li Hong,Luo Jie,Wang Yuxiao,Xi Qiang,Liu Jie,Yang Shengyuan,Li Junjie,Xiao Fubing
The development of wound dressing materials with both self-healing and antibacterial properties for promoting wound closure is highly desirable in health care. Herein, a smart double-network hydrogel (GS/DPPDH) with promising traits was developed by combining a dynamic Schiff base reaction between dialdehyde carboxymethyl cellulose (DCMC) and poly(ethylene imine) (PEI) with free radical polymerization. Because of its abundant amino groups, the common antibacterial drug gentamycin sulfate (GS) can be loaded into hydrogels by the formation of Schiff base bonds with DCMC. The slightly acidic wound microenvironment caused hydrolysis of the Schiff base bonds, thus releasing the drug GS on-demand. The prepared hydrogel not only showed good self-healing and injectable properties but also displayed excellent blood compatibility and cytocompatibility. The in vitro antibacterial experimental data proved that the GS/DPPDH had high antibacterial ratios of nearly 90% against both gram-positive ( S. aureus ) and gram-negative ( E. coli ) bacteria. In addition, in vivo assessment in a mouse model of S. aureus -infected full-thickness skin wounds revealed a wound closure ratio of 83.22 ± 2.90% after 7 days of healing, which was significantly greater than that in the gauze (59.78 ± 2.60%) and DPPDH (66.08 ± 0.21%) groups. Taken together, the results showed that the prepared antibacterial double-network hydrogel with injectable, self-healing, and pH-responsive properties exhibits great potential as a dressing material for infected wound healing.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2024
·
IF 2.8
Tong Jiale,Huang Yeyin,Tang Wanjun,You Qingliang,Xie Guangyong
This work aims at developing a customized ammoxidation catalyst through optimizing the metal oxide content in CrVO 4 /SiO 2 catalysts. Various amounts of Cr–V–O with 1:1 molar ratio of Cr/V were successfully loaded on SiO 2 via spray-drying method with colloidal silica as the binder. Polarized light microscope illustrated that the CrVO 4 /SiO 2 particles presented as well dispersed microspheres in the microsize (20–80 μm). X-ray diffraction spectra confirmed the formation of monoclinic CrVO 4 phase wherein the metal oxide content was ranged from 30 to 70 weight percent. FT-IR spectra indicated that the introduction of metal oxide had no obvious effects on the skeletal structure of SiO 2 . X-ray photoelectron spectroscopy analysis revealed that the valence state of V and Cr was hardly affected with increasing the metal oxide content. Performances of the obtained CrVO 4 /SiO 2 catalysts with different metal oxide contents were investigated via the ammoxidation of a model compound, namely para-chlorotoluene (PCT) to para-chlorobenzonitrile (PCBN). A maximum conversion of 99.6% of PCT and 86.5% yield and 86.8% selectivity to PCBN have been obtained over the CrVO 4 /SiO 2 catalyst with 60% weight of metal oxides at a temperature of 410 °C, n( PCT): n (NH 3 ): n (air) = 1:3:15 and reaction load = 0.13 g/gCat·h. In addition, this catalyst was efficient and selective toward ammoxidation reactions of toluene, ortho- and meta-chlorotoluenes. Graphical abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Xing Kun,Hao Yanan,Wang Xin-Jie,Huang Lei,Gao Yi,Liang Tong,Meng Yan,Bi Ke,Zhong Shao-Long,Dang Zhi-Min
Maintaining high charge/discharge efficiency while enhancing discharged energy density is crucial for energy storage dielectric films applied in electrostatic capacitors. Here, a nano-submicron structural film comprising ferroelectric material P(VDF-HFP) and linear dielectric material PMMA has been flexibly designed via the electrospinning process. Nano-submicron structure enables the film to maximize the ferroelectric material component and obtain improved dielectric performance without sacrificing breakdown strength and charge/discharge efficiency. As a result, the 40%-420 nm PMMA-P(VDF-HFP)@PMMA sample achieved an discharged energy density of 13.72 J/cm³ at a field of 740 kV/mm, with an impressive charge/discharge efficiency of 80%. This work presents a composite dielectric film that excels in breakdown strength, discharged energy density, and charge/discharge efficiency, offering a strategy for designing reliable, industrial-grade energy storage dielectrics.
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IONICS
·
2024
·
IF 2.4
Wang Lei,Tian Yanting,Li Zhanfeng,Zhu Jiping,Bian Tianlong
La 0.6 Sr 0.4 Co 0.2 Fe 0.8 O 3−δ (LSCF) perovskite with good stability and high oxygen diffusion coefficient has been extensively studied as oxygen electrode in reversible solid oxide cells (RSOCs). Significant promotion of oxygen reaction kinetics of the LSCF oxygen electrode was achieved by the addition of Ca x Co 4 O 9+δ (CCOx, x = 3, 1.5) nano-catalysts in the present study. The La 0.6 Sr 0.4 Co 0.2 Fe 0.8 O 3−δ -Ca 1.5 Co 4 O 9+δ (LSCF-CCO1.5) electrode exhibited the optimal electrochemical property among the LSCF-based electrodes and the lowest polarization resistance ( R p ) of 0.039 Ω·cm 2 was attained at 800 °C, which was ~ 97% lower than that of the LSFM electrode. Furthermore, the LSCF-CCO1.5 oxygen electrode also manifested excellent thermal cycling stability and alternating polarization durability. The hydrogen production rate of the LSCF-CCO1.5 electrolytic cell was 946 mL·cm −2 ·h −1 at 1.5 V at 800 °C, which was 2.6 times higher than that of the LSCF cell (362 mL·cm −2 ·h −1 ). The results certified the enhancement of electrochemical properties for LSCF oxygen electrode by the addition of CCOx nano-catalysts.
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Heritage Science
·
2024
·Vol. 12
·期 1
·1-9
·
IF 2.6
Liu Jiaojiao,Dong Wenqiang,Yang Junchang,Chen Zhongwei,Cao Jing,Chen Ran
Owing to the instability of gelatine in hygrothermal environments, gelatine-based cultural heritage undergo various deterioration processes, such as cracking, peeling, warping, curling and fracture, posing significant threats to its long-term preservation. Building on previous research, this study investigates the stability of polyol glycidyl ether–gelatine composite films under high-humidity and high-temperature conditions using ethylene glycol diglycidyl ether (EGDE) as a model compound. The hygrothermal ageing properties of EGDE–gelatine composite films are evaluated in terms of macrosize, mesoscopic structure, surface properties and mechanical properties. Results indicate that EGDE enhances the dimensional stability and swelling ratios of the composite films, stabilizes the pore structure and distribution and maintains the hydrophilicity and molecular structural stability under hygrothermal ageing conditions. Furthermore, the incorporation of EGDE leads to superior stress–strain properties of the composite films in such challenging environments. This study provides valuable experimental data for the preparation and conservation applications of gelatine-based cultural heritage materials.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-14
·
IF 12.6
Yang Lu-Yao,Liang Guo-Wu,Cai Bing-Jie,Xu Ke-Min,Zhao Yu-Jie,Xie Xiao-Ting,Zhang Yu-Lin,Li Chao-Qing,Zhang Guo-Jun
Plant-derived nanovesicles (PDVs) as nanodrug delivery carriers have gained recognition due to their satisfactory biosafety. However, there remains a challenge to target tumor sites accurately due to the uncertain membrane protein components on the surface of vesicles. Herein, a composite nanodrug delivery system by encapsulating the chemotherapy drug DOX is establish to efficiently target breast cancer. The novel nanoplatform (LEVBD) is formed by embedding the membrane fragments from breast cancer cell with the lemon-derived nanovesicles (LEVs) as the foundational skeleton. LEVBD reveal wonderful homologous tumor targeting due to fusion of cancer cell membrane components with LEVs, and the encapsulation of hybrid vesicles facilitates the transcellular transport of drugs. After intravenous injection, LEVBD could efficiently and selectively home to homologous tumor sites even under competition from heterologous tumors and significantly inhibit tumor growth without any observable toxic side effects. The doping of homologous cancer cell membranes provides a paradigm for the precise delivery of drug delivery vehicles using plant-derived vesicles as the backbone. Graphical abstract
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危险品化学品经营许可证（带存储）