JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-14
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IF 10.6
Sun Xiaodong,Li Yujie,Liu Xiaowan,Cui Dandan,Shi Yujiao,Huang Guojia
Background Properly designed second near-infrared (NIR-II) nanoplatform that is responsive tumor microenvironment can intelligently distinguish between normal and cancerous tissues to achieve better targeting efficiency. Conventional photoacoustic nanoprobes are always “on”, and tumor microenvironment-responsive nanoprobe can minimize the influence of endogenous chromophore background signals. Therefore, the development of nanoprobe that can respond to internal tumor microenvironment and external stimulus shows great application potential for the photoacoustic diagnosis of tumor. Results In this work, a low-pH-triggered thermal-responsive volume phase transition nanogel gold nanorod@poly(n-isopropylacrylamide)-vinyl acetic acid (AuNR@PNIPAM-VAA) was constructed for photoacoustic detection of tumor. Via an external near-infrared photothermal switch, the absorption of AuNR@PNIPAM-VAA nanogel in the tumor microenvironment can be dynamically regulated, so that AuNR@PNIPAM-VAA nanogel produces switchable photoacoustic signals in the NIR-II window for tumor-specific enhanced photoacoustic imaging. In vitro results show that at pH 5.8, the absorption and photoacoustic signal amplitude of AuNR@PNIPAM-VAA nanogel in NIR-II increases up obviously after photothermal modulating, while they remain slightly change at pH 7.4. Quantitative calculation presents that photoacoustic signal amplitude of AuNR@PNIPAM-VAA nanogel at 1064 nm has ~ 1.6 folds enhancement as temperature increases from 37.5 °C to 45 °C in simulative tumor microenvironment. In vivo results show that the prepared AuNR@PNIPAM-VAA nanogel can achieve enhanced NIR-II photoacoustic imaging for selective tumor detection through dynamically responding to thermal field, which can be precisely controlled by external light. Conclusions This work will offer a viable strategy for the tumor-specific photoacoustic imaging using NIR light to regulate the thermal field and target the low pH tumor microenvironment, which is expected to realize accurate and dynamic monitoring of tumor diagnosis and treatment.
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BIOMATERIALS
·
2025
·
IF 12.9
Yun Yuan,Zirong Li,Leilei Wu,Xinyi Cheng,Chao Deng,Yuanyuan Yu,Qiang Wang,Ping Wang
The treatment of chronic wounds remains a significant challenge in the clinical field, and optimizing the treatment plan through visual monitoring of wound healing is an effective way to solve such problem. Herein, we propose a feasible strategy to construct a smearable C–P-T/mCQDs hydrogel for real-time monitoring of wound infection and healing status, through the synergistic combination of modified carbon quantum dots (mCQD), cellulose nanofiber, tannic acid, and polyvinyl alcohol. The hydrogel can be readily applied on the skin and rapidly forms a gel dressing through high-density hydrogen bonding, demonstrating exceptional mechanical robustness (tensile elongation: 600 %) and autonomous self-healing capabilities. In particular, the carboxyl-rich mCQDs are more easily recognized by the sensitive pH-mediated polychromatic fluorescence response under ultraviolet excitation, exhibiting encouraging photodynamic therapy effect against bacterial infections. Under the irradiation of sunlight or near-infrared laser, the hydrogel achieves 99.99 % bactericidal efficacy against multiple types of bacteria ( S. aureus, E. coli, P. aeruginosa, A. baumannii ) within 20 min through reactive oxygen species generation. Furthermore, C–P-T/mCQDs demonstrates excellent antioxidant activity, biocompatibility, hemostatic efficiency and pro-healing properties. Notably, the mCQD-integrated hydrogel enables real-time, visual monitoring of wound status through its pH-responsive properties, providing substantial translational potential for personalized chronic wound management.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Liying Zhang,Yihan Sun,Shasha Huang,Hongze Xu,Zejun Zhang,Min Jiang,Boxiao Li,Lu Zong,Shuxue Wang,Jianming Zhang
Bio-based adhesives have drawn growing attention due to the environmental and ecological issues posed by petroleum-based adhesives. However, their practical applications remain constrained by the limited adhesion strength and insufficient humidity intolerance. Herein, we have developed a bio-based adhesive using poly(acrylic acid)-grafted cellulose nanocrystals (CNC-PAA) and poly(vinyl alcohol) (PVA) through the construction of highly dense non-covalent supramolecular networks. The abundance of active groups and improved cohesion endow the PVA/CNC-PAA adhesive excellent adhesion to diverse substrates, with a strength exceeding 7.52 MPa for ceramics. The rigid network structure and hydrophilicity of CNC-PAA markedly improve the adhesive's stability and humidity resistance, enabling it to retain 75 % of its maximum adhesion strength even at 100 % relative humidity. Furthermore, the high density of hydrogen bonding and structured water allow the adhesive to maintain excellent adhesion at −196 °C. By modulating the hydrogen bonding via pH adjustment, this adhesive also exhibits on-demand adhesion-dispergation and recyclability. In addition, its bio-mass framework renders the adhesive biodegradable character. This work provides a novel approach for developing bio-based adhesives with high adhesion strength, humidity-resistance, and on-demand debonding properties, paving the way for sustainable adhesives in packaging, labeling, cryogenic, and other applications.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2025
·
IF 4.6
Jiawei Tang,Muxi Wang,Hongming Li,Qingjian Liang,Zhongyan Zhang,Hong Liu,Jian Sun,Li-Jun Ma
The pyrene group is commonly used as a fluorophore in ratiometric fluorescence probes. However, these probes almost exclusively utilize the monomer/excimer of the pyrene group to achieve ratiometric fluorescence recognition for analytes. In the study, three structurally simple, mono-substituted pyrene derivatives, namely pyrene-1-ol ( Probe1 ), pyren-1-ylboronic acid ( Probe2 ), pyrene-1-carboxylic acid ( Probe3) utilize their protonation or deprotonation effects to influence the electronic excited state of the pyrene group, thereby achieving sensitive ratiometric fluorescence recognition of pH. Among them, Probe1 and Probe2 have been verified to function in alkaline environments with pH values ranging from 8.1 to 12.1 and 9.4 to 13.1, respectively, with p K a values of 8.9 and 11.1. Meanwhile, Probe3 performs optimally in weak acidic conditions with a pH range of 2.3–5.2, having a p K a value of 4.8. Additionally, three fluorescence probes exhibit excellent photo-stability, recyclability, and resistance to ionic interference. Furthermore, the three probes can also achieve ratiometric fluorescence detection of pH in environmental water sources such as tap water and Pearl River water, as well as fluorescence response to pH in living GS cells of epinephelus coioides.
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Laser & Photonics Reviews
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2025
·
IF 10
Yufeng Chang,Fuying Wang,Fuxing Li,Mingjun Chen,Jinxing Zhao,Fenghe Wang,Li Guan,Xu Li,Nian Fu
Phosphorescence (Phos) materials with tunable delay time can provide more modes of anti-counterfeiting and information encryption. Carbon dots (CDs), a novel nanomaterial, exhibit remarkable optical properties and potential. Matrix assistance is an effective method to realize CDs delayed emission. Here, a new CDs composite material (AB-CDs) is prepared using biuret and 2,4,6-Triphenylboroxin by hydrothermal treatment, which achieves fluorescence (FL) emission at 296 nm and Phos emission at 456 nm under 260 nm excitation. Under 365 nm excitation, delayed luminescence peaked at 456 nm can be observed with the naked eye for up to 5 s. By utilizing various spectra analysis, the origin of Phos is investigated, revealing luminescence mechanism of AB-CDs and the energy transfer (ET) process between the matrix and CDs. Simultaneously, tunable Phos delayed time from 2 to 7 s can be obtained at different pH. AB-CDs can also maintain a high stable Phos lifetime and intensity under the same pH over 300 h, demonstrating reversible cycling at pH value between 3 and 11. Based on the unique tunable Phos characteristic of AB-CDs, it shows potential applications in anti-counterfeiting, information encryption and recyclable pH test.
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Journal of Materials Chemistry A
·
2025
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IF 9.5
Guangxing Hu,Shuang Cui,Yan Shi,Hongda Wang,Zhuang Li
Flexible electronic devices with self-healing have garnered a wide attention, and the development of liquid metal-based electrode may extend their applications. The application of self-healing electronics is challenging and has not fully proven in a complex physiological environment. Herein, a one-step method prepared Ga-Sb and Ga-AgCl inks were employed to fabricate pH and reference electrodes for self-healing sweat pH devices. The Ga-Sb electrode exhibited a high pH sensitivity (62 mV/pH), small hysteresis (12 mV), excellent stability (1.5 mV/h) and selectivity. The Ga-AgCl electrode was insensitive to pH but demonstrated favorable selectivity and stability (2 mV/h), especially in solutions with halide ion. The wearable sweat pH sensor, incorporating both the two electrodes, offered real-time pH monitoring with excellent response performance. Additionally, these electrodes could be effectively repaired by simple heating treatment and maintained stable performance. This study provides a novel approach for the development of repairable and durable wearable sweat detecting devices.
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Carbohydrate Polymer Technologies and Applications
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2025
·
IF 6.5
Yao Fu,Shuwen Tan,Xiaojia Xu,Wenlong Xing,Qi He,Yi Lu,Jia Tang,Xiaoyan Liu,Yu Fang
Natural polysaccharides are widely used in biomedical and pharmaceutical applications due to their biocompatibility and biodegradability. In this study, alginate-based Poly( N -vinylcaprolactam)- co -sodium alginate (P(VCL- co -SA)) microgel particles with different mass ratios of VCL/SA were synthesized and employed as stabilizers for curcumin-loaded Pickering emulsions. The obtained P(VCL- co -SA) microgels display a uniform, spherical morphology with low polydispersity. Moreover, the microgels demonstrated high interfacial activity at the dodecane/water interface, enabling the stabilization of dodecane-in-water emulsions across a broad pH range (3–9) at 25°C. At an elevated temperature (55°C), the emulsions remained stable at pH 6 and 9 (above the p K a of alginate, ∼3.5), while phase separation was observed at pH 3 below the p K a . The emulsion stability was further enhanced by optimizing Ca 2+ ion concentration. Furthermore, high internal phase soybean oil-in-water emulsions stabilized by P(VCL 83 - co -SA 17 ) microgels were successfully developed for curcumin encapsulation. The emulsions provided excellent protection for curcumin at room temperature. When incubated at 37°C, curcumin retention was significantly enhanced after the addition of Ca 2+ ions. Compared to previously reported systems that encapsulate curcumin in emulsions, the present approach exhibits superior performance, such as, encapsulation efficiency and retention rate. These findings provide insights into the development of high-performance Pickering emulsions that are stabilized by natural products and highlight their potential applications in food technology and the pharmaceutical industry.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Yi Tian,Ping Yang,Xiao Zhang
The development of self-colorimetric probes for Fe 3+ detection without external reference remains a significant challenge, despite its critical importance in environmental monitoring and disease diagnosis. In this paper, bright red-emitting carbon dots (r-CDs) with photoluminescence (PL) quantum yield of 35.8 % were synthesized via a one-step solvothermal strategy. The abundant surface hydroxyl/carboxyl groups of r-CDs enabled specific Fe 3+ ion coordination resulted in a novel PL phenomenon, in which the red emitting (650 nm) of the r-CDs changed into green-emitting (500 nm) because of new fluorescent centers formation. pH stability test confirmed the robustness of r-CDs forFe 3+ sensing in a pH region of 2–13.This phenomenon is ascribed to a dual-mode self-colorimetric sensing platform, achieving a detection limit of 10.7 nM and a wide linear range of 0–700 μM in solution. Experimental result confirmed that Fe 3+ coordination triggered electron transfer and lead to new emitting center generation. This bright green emitting was also observed once r-CDs were added a SiO 2 gel with Fe ions, suggesting a significant application in solid-state moist environmental. This novel PL phenomenon is crucial for the preparation and application of CDs.
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ACS Sensors
·
2025
·
IF 9.1
Yuanyuan Lu,Tingting Ma,Menghuan Zhang,Qingwen Lan,Jiao Yang,Xinqiang Liang
Accurate detection of bioavailable phosphorus (BP) is critical to mitigate freshwater eutrophication from excess phosphorus, but quantifying trace soluble reactive phosphorus (SRP) under real-world pH remains challenging. We present a portable paper-based electrochemical sensor for simultaneous SRP and pH monitoring in agricultural water. The platform establishes dual linear correlations: peak current–SRP concentration (LOD < 2 μM) and peak potential–pH (1–7) via square wave voltammetry (SWV). This enables micromolar-level SRP quantification across an environmentally relevant pH range with minimal interference. Field validation in farmland solutions demonstrates direct differentiation of dissolved and colloidal phosphorus fractions without pH alteration, overcoming the limitations of conventional methods. This work provides a powerful tool for in situ environmental monitoring, offering new insights into P bioavailability and advancing sustainable nutrient management in diverse agricultural contexts.
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ACS Applied Nano Materials
·
2025
·
IF 5.5
Lingling Li,Zihao Lv,Hao Jiang,Xiaoxian Zhao,Lan Wu,Xiuming Cao,Helan Xu,Qufu Wei,Qingqing Wang
A pH-responsive bacterial cellulose (BC)-based composite nanofiber membrane functionalized with rose bengal (RB)-encapsulated ZIF-8 (BC/RB@ZIF-8) was developed via in situ growth for the targeted therapy of bacterial stomatitis. The BC film enhanced the photodynamic effect, addressing the challenges of photosensitizer aggregation-induced quenching and its reuse. The BC/RB@ZIF-8 nanofiber membrane demonstrated sustained photodynamic activity, maintaining a stable singlet oxygen (1O2) quantum yield under continuous 130 min irradiation. The nanofiber membrane exhibited robust mechanical properties, including a tensile strength greater than 33 MPa, high water absorption capacity (916.61 ± 4.7%), and optimal moisture vapor transmission rate (40.56 ± 1.37 g/m2·h), meeting the key requirements for oral wound dressings. In acidic infection microenvironments, ZIF-8 degradation facilitated the synchronized release of Zn2+ and RB, leading to dual-mode antibacterial action: (1) the continuous release of Zn2+ from ZIF-8 disrupts bacterial cell membranes through electrostatic interactions; and (2) ROS generation via Type I (•OH) and Type II (1O2) pathways, resulting in irreversible damage to bacterial cell membranes and components. This synergistic mechanism led to a 99.99% eradication of S. aureus and MRSA under acidic conditions, outperforming conventional therapies. Cytocompatibility and hemocompatibility were confirmed in accordance with ISO 10993 standards. The BC/RB@ZIF-8 nanofiber membrane represents a significant advancement in pH-responsive antibacterial materials, offering a promising alternative to antibiotic-based treatments for biofilm-infected oral wounds.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Tong Liu,Dawei Zhang,Rongjun Zhang,Jinke Wang,Lingwei Ma,Patrick Keil,Arjan Mol,Xiaogang Li
Organic coatings are one of the most used and versatile technologies to mitigate corrosion of metals. However, organic coatings are susceptible to defects and damages that may not be easily detected. If not repaired timely, these defects may develop into major coating failures due to corrosion occurring in the damaged region, thereby limiting the lifetime of the to be protected structure. Thus, the development of smart coatings that can accurately identify corrosion location and reliably recover the damage autonomously is of particular interest. Herein, we reported a robust, corrosion-sensing and self-healing coating which incorporated pH-sensitive ZIF-8-capped CaCO 3 microcontainers containing the healing agent tung oil (TO) and the corrosion indicator/inhibitor 1,10-phenanthrolin-5-amine (APhen). The spontaneous leakage of incorporated TO and APhen was restrained, and the release initiated when local pH variation occurred. The corrosion protection performance of the coatings implanted with different contents of smart microcontainers were evaluated. The intact epoxy coating containing 7.5 wt% of the microcontainers exhibited the best protection performance with low water absorption (0.65 wt%), low O 2 permeability (0.21 × 10 –15 cm 3 cm cm −2 s −1 Pa −1 ), and a high storage modulus (3.0 GPa). Electrochemical impedance spectroscopy (EIS) measurements in 3.5 wt% NaCl solution demonstrated superior durability of the composite coating after self-healing. The immersion test and neutral salt spray test confirmed the coating can accurately report corrosion sites via coloration.
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CARBOHYDRATE RESEARCH
·
2024
·
IF 2.4
Qianqian Zhang,Tong Wan,Guocheng Jin,Shiai Xu
The objective of this study is to develop a drug carrier to overcome the inherent drawbacks of 5-Fluorouracil (5-Fu), including low bioavailability, short half-life, and systemic toxicity. In the present work, mesoporous silica nanoparticles (MSNs) capped by chitosan (CS) to encapsulate 5-Fu (5-Fu MSNs/CS) were fabricated by the sol-gel process, ultrasonic impregnation, and emulsion cross-linking. The 5-Fu MSNs/CS microspheres exhibit pH-responsive drug release and remarkable drug encapsulation capacity, as well as perfect sphericity, high specific surface area (680.62 cm 2 /g), and uniform particle size (2.64 ± 0.05 μm). The drug-loading content and encapsulation efficiency are 14.12 ± 0.53 % and 82.21 ± 2.13 %, respectively. The cumulative release of 5-Fu from MSNs/CS microspheres is fast and sustained at pH 5.0 (89.56 ± 0.97 %) compared to that at pH 7.4 (57.88 ± 0.91 %) in 96 h, and it is Fickian diffusion controlled. In conclusion, the MSNs/CS microspheres prepared in this study could be potential carriers for 5-Fu delivery.
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