NEUROREPORT
·
2020
·
IF 1.394
Liu Zhen,Hao Kai-Min,Wang Hao-Yu,Qi Wen-Xiu
The aim of this study was to investigate the effects of histone deacetyltase (HDAC) 6 on the functional and pathological changes of the amyloid beta (Aβ)-induced cognitive dysfunction rats by regulating protein tyrosine kinase 2 beta (PTK2B). Ninety Sprague-Dawley rats were randomly divided into nine groups, consisting of five experimental groups and four control groups. In five experimental groups, Aβ 1–42 was infused intracerebroventricularly and 3 days later, rats in each group were infused intracerebroventricularly with tubastatin A hydrochloride (TSA), the histone deacetyltase 6 (HDAC6)-specific inhibitor (Aβ + TSA group), theophylline, the HDACs agonist (Aβ + theophylline group), PF431396, the PTK2B inhibitor (Aβ + PF group), the combination of PF431396 and theophylline (Aβ + PF + theophylline group) and normal saline (Aβ + normal saline group), respectively. Rats in four control groups took normal saline that was equivalent to the volume of Aβ 1–42 , and 3 days later, TSA group, theophylline group, PF431396 (PF group), or normal saline group was given at a volume of 5 µL for rats in each group. Our results showed that HDAC6 may not only lead to the deterioration of learning and memory abilities but also elevate the levels of Aβo and Tau phosphorylation in Aβ-induced cognitive dysfunction rats via up-regulating PTK2B.
✓ 已验证
DOI
高影响因子
ACS Omega
·
2022
·
IF 4.132
Jialu Huang,Zhiming Ni,Xiaofan Song,Han Li,Xiaolei Chen,Aichuang Zhang,Hu Yang,Yuan Liu,Peng Zhu,Ping Hua,Xiaolei Yuan
PdPb nanocrystals have drawn considerable attention due to their excellent catalytic properties, while their practical applications have been impeded by the severe degradation of activity, which is caused by the adsorption of intermediates (especially CO) during the operation. Herein, we first present porous PdPb alloys with the incorporation of amorphous Pb(OH)2 species as highly active and stable electrocatalysts. Alloying Pd with Pb species is initially proposed to optimize the Pd–Pd interatomic distance and adjust the d-band center of Pd. Importantly, the amorphous Pb(OH)2 species are beneficial to promoting the formation of OHad and the removal of COad. Therefore, PdPb-Pb(OH)2 catalysts show a mass activity of 3.18 A mgPd–1 and keep excellent stability for the ethanol oxidation reaction (EOR). In addition, further CO stripping and a series of CO poisoning experiments indicate that PdPb-Pb(OH)2 composites possess much better CO tolerance benefiting from the tuned electronic structure of Pd and surface incorporation of Pb(OH)2 species.
✓ 已验证
DOI
高影响因子
ORGANOMETALLICS
·
2020
·
IF 3.804
Shuang Huang,Xi Hong,He-Zhen Cui,Bing Zhan,Zhi-Ming Li,Xiu-Feng Hou
Herein, an unprecedented bimetallic bis-NHC Cp*Ir complex 1 bearing 2-arylbenzo[d]oxazolyl and NHC ligands is reported. A significant increase in activity was observed for N-methylation of amines and reduction of aldehydes with MeOH catalyzed by 1 compared to the monometallic analogues (2–11). Under the optimal conditions, it showed to be highly effective in N-methylation of nitroarenes with MeOH as both C1 and H2 source. Substrates, including aromatic amines, ketones, and nitro compounds with various functional groups, can be well-tolerated. Mechanistic studies and DFT calculation highlight the significance of bimetallic centers cooperativity.
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 43
·15312-15321
·
IF 6.4
Rui Rui Yang,Fangrui Cheng,Bang Lan
Trivalent rare earth Eu3+-doped luminescent materials have been used successfully for illumination and displays due to their narrow emission lines and extreme stability. Extending the excitation band to the UV, near UV and blue region via doping lanthanide ions as a sensitizer is highly desired for white LED application. However, the complex redox reaction and forward/backward energy-transfer pathway between the sensitizer ion and Eu3+ ion in the same lattice of the phosphor host limits the potential of this strategy. Herein, we present the luminescence properties of hierarchical porous composite materials with the formula Tb(C12H8N2)2(NO3)3@Ca0.9Eu0.1MoO4 and report how interfacial energy-transfer enhanced the absorption range of the Eu3+-doped material in the UV region. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images illustrated that the obtained Ca0.9Eu0.1MoO4 had a hierarchical porous structure, and the Tb(C12H8N2)2(NO3)3 was evenly filled inside the holes or the surface. The photoluminescence and decay data indicated the existence of interfacial forward energy transfer from Tb3+ → Eu3+. Furthermore, the thermal stability of the composited Tb(C12H8N2)2(NO3)3 was improved, indicating the potential of the composite materials for application in UV light-emitting diodes.
✓ 已验证
DOI
高影响因子
OPTICAL MATERIALS
·
2022
·
IF 3.754
Dewei Ma,Xiaoyang Qin,Ning Dai,Xiuhua Cao
In contrast with three-dimensional perovskites , their two-dimensional (2D) analogues have been demonstrated to effectively improve the moisture tolerance due to the hydrophobicity of the long-chain organic layers. However, the insulating property of the long-chain organic layers will deteriorate the charge transport properties of the materials, limiting their applications in photovoltaics and optoelectronics . Short-chain organic cation with less carbon atoms may be a good substitution for the preparation of 2D perovskites with superior environmental stability and optoelectronic properties. In this research, quasi-2D (C 3 H 7 NH 3 ) 2 (MA) n-1 Pb n Br 3n+1 perovskite nanocrystals with an average size smaller than 10 nm were synthesized by a one-pot method, showing tunable emissions in the range of 406–524 nm for n = 1∼∞, with corresponding band-gaps of 3.63–2.30 eV. Time-resolved photoluminescence (PL) decays show that (C 3 H 7 NH 3 ) 2 PbBr 4 has the shortest average PL lifetime of 4.4 ns with the fast decay process occupying weighting proportion of 87.3%. When the nominal perovskite layers increases up to 2–4, the average PL lifetime raises up to 10.1–41.7 ns, with the slow decay process taking up most weighting percentage of >70%. MAPbBr 3 possesses the longest PL lifetime of 151.2 ns. The perovskite nanocrystals were then attempted to modify with oleic acid or to embed in PMMA matrix in order to improve their environmental stability. Results show that the stability of oleic acid and PMMA encapsulated nanocrystals improves greatly in comparison with bare nanocrystals.
✓ 已验证
DOI
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2019
·Vol. 33
·期 6
·e4815
·
IF 3.259
Qiancheng Zou,Yi Wei,Shuai Wang,Jinyan Xie,Aihua Xu,Xiaoxia Li
The development of green and efficient catalysts for peroxymonosulfate (PMS) activation and organic pollutants degradation has received widespread attention. In this study, the hybrid CaCO 3 /OMS-2 catalysts were prepared by a simple precipitation approach and characterized by X-ray powder diffraction, N 2 adsorption–desorption, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy and cyclic voltammetry. It was found that deposition of CaCO 3 on OMS-2 surface can weaken the Mn-O bond by formation of Ca-O-Mn bond. The interactions between CaCO 3 and OMS-2 significantly enhanced Acid Orange 7 degradation in the presence of PMS with a pseudo-first-order kinetic constant of 0.21 min −1 , which was much higher than those of OMS-2 (0.026 min −1 ) and CaCO 3 (0.021 min −1 ). The CaCO 3 /OMS catalysts were also much more efficient than other reported OMS-2 hybrid catalysts, and could be performed over a wide solution pH and for other organic dyes degradation. Sulfate and hydroxyl radicals were formed from the oxidation of low valent manganese species by PMS as the active species in the system. This study can provide a simple method for the design of efficient manganese-based hybrids for wastewater remediation via PMS activation.
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Mengdie Zhou,Pan Wang,Yulin Song,Hao Li,Jianquan Luo,Jianming Pan
Hydrogel microspheres encapsulating molecularly imprinted polymers (MIPs) are promising hybrid sorbents, due to several advantages of high selectivity, fast mass transfer efficiency, and simple collection. Thus, Janus single-hole hollow nanoparticles (J-HNPs) with the size of 550 ± 70 nm were firstly designed by anisotropic emulsion template, and then MIPs were grafted onto their inner surface through electron transfer atom transfer radical polymerization (ARGET ATRP). Then as-prepared J-HNPs-MIPs were loaded into hydrogel microspheres via polymerizable water-in-oil (W/O) emulsion droplets combining gelatin methacryloyl (GMA) as monomers, and then obtained J-HNPs-MIPs@Gel with the mean diameter of 2.0 µm was applied for effective and selective separation of 2′-deoxyadenosine (dA). Fast adsorption equilibrium of J-HNPs-MIPs@Gel for dA can be achieved within 40 min, thanks to the hydrogel matrix and single-hole hollow structure for enhancing diffusion. The maximum multi-layer adsorption capacity calculated according to the Freundlich model was 10.31 μmol g −1 at 298 K. The specific memory to the size, shape and functional groups of dA endowed excellent recognition ability, and 88% of the initial capacity after four consecutive adsorption-desorption cycles was maintained. In addition, J-HNPs-MIPs@Gel was expected to show great potential for the selective enrichment and analysis of target dA molecule in complex biological samples.
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Peng Ye,Qiancheng Zou,Luyang An,Yi Wei,Aihua Xu,Xiaoxia Li
Due to low cost and low toxicity, manganese oxides have been extensively explored to reduce organic pollutants in wastewater via peroxymonosulfate (PMS) activation; but the development of manganese-based catalysts with facile synthesis process at low temperatures and high efficiency is still of significant practical interest. In this paper, a simple room temperature method has been successfully developed to synthesize cryptomelane-type manganese octahedral molecular sieves (OMS-2) from KMnO 4 and MnSO 4 in the presence of carbon nanotubes (CNTs). The redox reaction between amorphous manganese oxide and CNTs results the decrease of manganese valences and the formation of OMS-2 phase at a low temperature of 25 °C. The changes of synthesis time, temperature and CNTs dosage altered the characteristics of the prepared materials. Compared with CNTs, OMS-2 and other manganese oxides hybrids, the synthesized catalysts demonstrated a remarkable efficiency for PMS activation to degrade organic dyes and a superior reusability during ten successive cycles. Sulfate radicals were formed as the active species in the system from the oxidation of low valent Mn species by PMS. This study not only provides a simple method to synthesize OMS-2 at room temperature, but also improves the understanding of PMS activation on manganese-based catalysts for pollutants degradation.
✓ 已验证
DOI
高影响因子
TALANTA
·
2021
·
IF 6.057
Huazheng Yu,Yanhong Li,Aisheng Huang
Sialic acid (SA) is a crucial component of glycoproteins and glycolipids on the cellular membrane, which is essential for maintaining the function of cell membranes, such as cell recognition and communication. Simultaneously, sialic acid plays a significant role in many physiological and pathological processes. Hence, it is urgent to develop a simple and sensitive strategy for determining sialic acid. In this work, a new metal-organic framework called UiO-66-NH 2 @B(OH) 2 has been designed and synthesized for the recognition and detection of sialic acid. The boronic acid functional group in UiO-66-NH 2 @B(OH) 2 can bind to a diol moiety of the glycerol side chain of sialic acid, which will attenuate or even quench the fluorescence of UiO-66-NH 2 @B(OH) 2 , thus opening a new road to detect sialic acid. Based on the measurement results, sialic acid can be quantitatively measured in a linear range of 0.05–2.5 mmoL/L with the UiO-66-NH 2 @B(OH) 2 probe. The detection limit of sialic acid is as low as 0.025 mmol/L. Furthermore, the boronic-acid functionalized probe UiO-66-NH 2 @B(OH) 2 displays high sensitivity and high selectivity to recognize the sialic acid in mouse serum samples. Therefore, the developed UiO-66-NH 2 @B(OH) 2 can be used as a promising probe to identify and detect sialic acid in the practical application.
✓ 已验证
DOI
高影响因子
Science China-Chemistry
·
2022
·Vol. 65
·期 4
·719-725
·
IF 10.138
Zhang Yanhui,Li Fuming,Yang Rong,Yang Yun,Zhang Fangfang,Yang Zhihua,Pan Shilie
The design and synthesis of new deep-ultraviolet (DUV) optical materials are important but challenging. It is well known that the polarizability anisotropy of linear [BO 2 ] − is larger than those of [BO 3 ] 3− and [BO 4 ] 5− , which is the better choice for exploring excellent optical materials. Here, we search for such crystals in borate systems based on the unusual fundamental structural unit [BO 2 ] − . By combining the linear [BO 2 ] − with the traditional triangular [BO 3 ] 3− and tetrahedral [BO 4 ] 5− units, a new mixed metal borate, Rb 5 Ba 2 (B 10 O 17 ) 2 (BO 2 ) was obtained via high-temperature solution method. It exhibits excellent optical properties including a DUV transmission window (188 nm) and suitable birefringence (0.06). It also has good thermal stability and its crystal plates can be prepared easily. Furthermore, the strategies of designing borates with [BO 2 ] − units have been proposed from the transformation of crystal framework and the preparation method.
✓ 已验证
DOI
高影响因子
Natural Product Communications
·
2025
·
IF 1.4
Longwei Fang,Zhen Ni,Yanglei Shen,Feng Gao,La Yang,Nanling Liu,Zhuoma Duoji,Dongzhi Zhuoma,Wangdui Suolang,Zhuoma Basang
ObjectiveTo study the chemical constituents of Synotis solidaginea (SS) from Tibet. In our previous research, it was found that the extract of Synotis solidaginea stems has potential inhibitory activity against the proliferation of melanoma cells. Therefore, we hope to separate, extract and structurally identify the extracts of Synotis solidaginea stems, and determine the main components that exert potential inhibitory activity on the proliferation of melanoma cells.MethodsThe compounds were separated and purified using silica gel, polyamide, reversed phase C18 column chromatography, and preparative high performance liquid chromatography. The structure of each compound was identified based on the spectral data and literature comparisons. To verify the inhibitory activity of each component against melanoma cells, cell and enzyme assay were conducted.ResultsA total of 7 compounds were isolated from the dichloromethane extract of Synotis solidaginea. The irimofen lactone structure compound SS-1 and SS-5 were isolated from Synotis solidaginea for the first time. Among these, irimofin sesquiterpenoid compound SS-2 exhibited strong inhibitory activity against B16F10 of melanoma cells. Meanwhile, the iremorphene sesquiterpenoid SS-2 exhibited significant tyrosinase inhibitory activity, and the docking results explained the mechanism of its action.DiscussionSolidaginea has laid the foundation for the prevention and treatment of melanoma with the active ingredients of Tibetan medicine.
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2019
·
IF 4.084
Hailiang Chu,Nianpu Li,Xueying Qiu,Yu Wang,Shujun Qiu,Ju-Lan Zeng,Yongjin Zou,Fen Xu,Lixian Sun
In this work, poly( N -vinyl-2-pyrrolidone) (PVP)-stabilized ruthenium nanoparticles (NPs) supported on bamboo leaf-derived porous carbon (Ru/BC) has been synthesized via a one-step procedure. The structure and morphology of the as-synthesized samples were characterized by means of X-ray diffraction (XRD), X-ray photoelectron spectrometry (XPS), scanning electron microscope (SEM) and transmission electron microscope (TEM). As a catalyst for hydrogen generation from the hydrolysis of ammonia-borane (AB, NH 3 BH 3 ) at room temperature, Ru/BC stabilized with 1 mg of PVP exhibited high activity (TOF = 718 mol H2 ·mol Ru −1 ·min −1 ) and low activation energy ( E a = 22.8 kJ mol −1 ). In addition, the catalyst could be easily recovered and showed fairly good recyclability with 55.6% of the initial catalytic activity retained after ten experimental cycles, which confirmed that PVP could stabilize the Ru NPs and prevent their agglomeration on BC surface. Our results suggest that PVP-stabilized Ru/BC is a highly efficient catalyst for the hydrolysis of AB.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）