Cell Death & Disease
·
2026
·Vol. 17
·期 1
·198
·
IF 12.2
Guo Chipeng,Luo Siweier,Luo Jigang,Lu Siyao,You Xiaomei,Cao Junlin,Du Yufei,Lv Haoran,Liang Hanzhi,Wang Le,Wang Liangchun,Liu Tao,Zhou Yiming
Ultraviolet B (UVB) is a well-recognized trigger of cutaneous lupus erythematosus (CLE), yet its molecular basis remains largely undefined. Here, using single-cell transcriptomics and a lupus-prone mouse model, we identify keratinocyte-derived macrophage migration inhibitory factor (MIF) as a key amplifier of cutaneous inflammation through a self-sustaining feedback loop. Single-cell RNA sequencing reveals elevated MIF expression specifically within pathogenic, interferon-high keratinocyte subclusters associated with CLE, which is further validated across major CLE subtypes in clinical skin samples. In vitro, UVB irradiation dose-dependently induces the release of MIF from keratinocytes, which in turn promotes inflammatory signaling and matrix remodeling in both keratinocytes and fibroblasts. Mechanistically, we demonstrate that UVB irradiation activates the ribotoxic stress response (RSR), leading to the p38-C/EBPβ-mediated transcriptional upregulation of NLRP3 and GSDMD cleavage in keratinocytes. The ensuing GSDMD-dependent pyroptosis facilitates the release of MIF, primarily through GSDMD pores rather than vesicular secretion, which in turn amplifies the p38-C/EBPβ signaling pathway. Therapeutic disruption of this loop either by gene silencing via AAVs or pharmacological inhibition via microneedles, markedly attenuates epidermal hyperplasia and cytokine imbalance in lupus-prone mice. These findings uncover a previously unrecognized MIF-p38-GSDMD inflammatory loop contributes to the UVB-induced cutaneous lupus, offering both mechanistic insights and translational opportunities for CLE.
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CHEMICAL PAPERS
·
2026
·
IF 2.7
Wu Yanlin,Qin Pixian,Li Yuan,Dong Wenbo,Monfort Olivier,Zeng Yilan
In this study, trace chlorogenic acid (CGA) was introduced as a natural reductant and ligand to facilitate the activation of Fe(III) in a sulfate radical-based advanced oxidation process (SR-AOP), enabling effective Fenton-like degradation of ofloxacin (OFL) under mild conditions. The CGA/Fe(III)/PMS system exhibited excellent performance in the degradation of ofloxacin (OFL) at near-neutral pH. The presence of CGA effectively promoted Fe(III)/Fe(II) cycling via dual redox and chelation effects, thereby enhancing PMS activation. Reactive oxygen species (ROS) analysis suggested that sulfate radicals (SO 4 ·− ) were the dominant contributors to OFL degrdation, while other reactive species played minor roles. The system maintained high activity in the presence of common coexisting anions in water (e.g., Cl − , and SO 4 2− ), whereas HCO 3 − and HPO 4 2− significantly suppressed degradation. These findings demonstrated the promising potential of CGA as an environmentally compatible additive for Fe(III)-based AOPs, providing useful mechanistic insight for mitigating antibiotic contamination in aquatic environments. Graphical abstract
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JOURNAL OF POLYMER RESEARCH
·
2026
·Vol. 33
·期 8
·333
·
IF 3.5
Zhang Xinxing,Ma Luxiang
A novel Schiff Base as a flame-retardant monomer (FSB, 5-((3,5-bis(trifluoromethyl) benzylidene) amino) isophthalic acid) with -CF 3 was designed and used to synthesize FSB n PETs (PET copolyester) by copolymerization, which shows good flame retardancy and anti-dripping. The introduction of the –CF₃ group increases the cyclization temperature of the FSB Schiff base unit by suppressing the cyclization reaction through its strong electron-withdrawing effect, which is 350–398 °C, higher than 250–348 °C from the PET copolyesters modified by Schiff Base without -CF 3 , indicating that FSB n PETs exhibits a broadened processing temperature window. And FSB also increased the glass transition temperature (Tg), reduced the melting temperature (Tm) and the crystallizability of FSB n PETs. FSB n PETs possessed good flame retardancy and anti-dripping properties, FSB 10 PET (7.4 mol% of FSB) owned V-0 level of UL-94 and 31% value of LOI without dripping phenomenon. The bond of -C-F had not broken into the air phase to make an obvious influence on the flame retardancy property of FSB n PETs, whose flame retardancy mechanism is still type of the condense flame retardancy. Additionally, in the new preparation process for FSB n PETs, the dicarboxylic acid structure of FSB could speed up the condensation polymerization between the BHET precursors, which could save 50% of the preparation time, showing an exciting economic advantage. The -CF₃ modified Schiff base (FSB) is an effective modifier for PET copolyesters, offering improved processing performance and good flame-retardant properties.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 19
·1512
·
IF 3.2
Jiang Chaojin,Zhang Yuanyuan,Guan Erbu,Jiang Yuqin,Li Shuaishuai,Xin Yanmei
The development of efficient and economical photocatalysts is the focus of achieving sustainable remediation of water pollution. However, slow photogenerated carrier transfer and insufficient catalytic sites are the main reasons affecting photocatalytic applications. Herein, we developed flake-octahedral BiOBr/MIL-101(Fe) heterojunction catalysts through a facile solvothermal strategy for the degradation of pollutants under visible light irradiation. Scanning electron microscope, X-ray photoelectron spectrometer, Fourier infrared spectrometer, and X-ray diffraction analysis characterizations proved the successful synthesis of flake-octahedral BiOBr/MIL-101(Fe) heterojunction. Absorption spectra and Brunauer–Emmett–Teller analyses showed that the BiOBr/MIL-101(Fe) composites with an atomic percentage of Fe of 9.1 (denoted as BiOBr/MIL III ) had the optimal light absorption and the largest specific surface area. The BiOBr/MIL III achieved a remarkable Rhodamine B (Rh B) degradation efficiency of 94.5% within 60 min, with an apparent rate constant ( k ) of 0.03540 min −1 , demonstrating excellent visible light-driven photocatalytic activity. Photocatalytic mechanistic studies showed that the solvothermal-induced flake-octahedral BiOBr/MIL-101(Fe) III heterojunction promotes the formation of Z-scheme, which significantly enhances the carrier separation efficiency and accelerates the rapid generation of reactive radicals · O 2 − and h + . This work provides a feasible strategy for the construction of flake-octahedral inorganic-MIL photocatalysts with excellent photocatalytic performance.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Zhou Xinyue,Duan Sufei,Lou Yuye,Deng Yue,Feng Shuang,Liu Jiale,Zhang Jiarui,Xi Yalin,Shi Meiyun,Yin Lei
A sensitive UPLC-MS/MS method was developed and validated for quantifying polyethylene glycol 1000 (PEG1000) in zebrafish tissues, featuring a systematic comparison of two MS acquisition strategies. Through comprehensive optimization, the ammonium adduct [M+NH 4 ] + of the representative 18-EO oligomer ( m/z 828.5) was selected as the precursor ion, achieving approximately fourfold higher signal intensity than [M+H] + . Critically, the conventional high declustering potential in-source CID approach monitoring fragment ions was outperformed by the optimized MRM method monitoring the intact ammoniated precursor, which demonstrated 2.7-fold signal enhancement and superior selectivity. The integration of micro-solid-phase extraction (μ-SPE) further improved method performance, yielding 1.5-fold signal gain and markedly reduced matrix effects compared to conventional protein precipitation. The fully validated method exhibited excellent linearity (0.5–50 μg/mL, r > 0.995), accuracy, precision, and stability. Application to zebrafish tissue distribution studies revealed pronounced organ-specific accumulation following aqueous exposure to 200 μg/mL PEG1000, with highest concentrations in intestine tissue exhibiting a time-dependent increase, followed by muscle, while muscle maintained consistently low levels. This analytical platform, synergistically combining μ-SPE cleanup and ammoniated adduct-based MRM, offers superior sensitivity over in-source CID approaches and provides a practical framework for polymer bioanalysis, yielding critical insights into the in vivo fate of PEG-based compounds. The key novelties of this work are the following: (i) the first systematic comparison between ammoniated adduct MRM and high-DP in-source CID for PEG1000 quantification; (ii) the introduction of μ-SPE for sample preparation in zebrafish tissues, achieving 1.5-fold signal enhancement; and (iii) the successful application of this platform to reveal organ-specific accumulation patterns of PEG1000. Graphical abstract
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Nature Communications
·
2026
·Vol. 17
·期 1
·6845
·
IF 18.1
Du Tao,Cheng Jiali,Hou Guanyi,Jiang Lei,Zhou Yanli,Wang Yu,Shi Zhengjun,Xu Jikun,Liao Xuepin,Shi Bi,Xiao Xiao
Lightweight, homogeneously high-strength, and sustainable structural materials exert a crucial role in advanced engineering fields. Bamboo can be processed into high-performance structural material if its mechanical strength and homogeneity are remarkably enhanced. Herein, we report a strategy to process natural bamboo into a lightweight, robust, and durable structural material (HoRo-Bamboo) with homogenously high strengths in both longitudinal (L) and transversal (T) directions through bonding network reconstruction technology. The process requires the dispersion of fibers through H 2 O 2 /O 3 treatment, followed by the introduction of Al 3+ and rapid pressing to reconstruct the ionic-hydrogen bonding network (IHBN). The as-prepared HoRo-Bamboo exhibits a low density of 0.83 g·cm −3 with superb high tensile strengths in both L (631 MPa) and T (628 MPa) directions, as well as the excellent environmental resistance and flame retardancy. Life cycle assessment shows that the carbon emissions from producing 1 kg of HoRo-Bamboo are 1.67 kg of CO 2 eq. Our approach enables bamboo to be an excellent alternative to existing structural materials, offering lightweight, super-robust, decarbonized, and sustainable features.
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Nature Communications
·
2026
·
IF 18.1
Fang Jiongchong,Chen Zuochao,Li Junqiang,Zhang Qing,Zeng Lin,Yang Yaoxian,Zhang Xueqiang,Zhang Hui,Gao Haifeng,Lu Xinxin,Ma Jugang,Xie Zhirun,Li Ailong,Yang Fuyuan,Ng Yun Hau,Zeng Guosong
Alkaline hydrogen evolution reaction holds immense promise for sustainable energy conversion due to its inherent compatibility with earth-abundant electrocatalysts and potential for large-scale, high-purity hydrogen production. However, sluggish kinetics remain a formidable bottleneck for its industrial deployment. Although incorporating oxophilic components is widely used to promote water activation, the catalytic role of oxygen-affinity-related sites is often interpreted statically, without considering dynamic evolution of local coordination under operating conditions. Here, we synthesize a crystalline-amorphous Ni/TiO 2 heterojunction via a grain-boundary segregation strategy and combine multi-modal operando techniques to directly visualize reversible, bias-induced reconstruction of the oxophilic component. These observations provide direct evidence that, at the Ni/TiO 2 interface, oxygen affinity is a tunable parameter encoded by nanoscale coordination and interfacial chemistry, and elucidate how its modulation governs water dissociation and hydroxyl handling. We demonstrate that the resulting four-coordinated Ti sites serve as highly efficient centers for water dissociation and hydroxyl adsorption, thereby synergistically optimizing the hydrogen adsorption/desorption energetics. This work offers a mechanistic and methodological basis for rational nano-heterointerfaces engineering in advanced electrocatalysts.
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MATERIALS AND STRUCTURES
·
2026
·Vol. 59
·期 6
·303
·
IF 3.9
Yin Jianhao,Liao Jiaxin,Kong Xiangming
The composition, moisture distribution, and microstructural evolutions of calcium-silicate-hydrate (C–S–H) in synthetic C–S–H (SynCSH) and hardened tricalcium silicate paste (HC 3 SP) during the first drying-resaturation (D-R) cycle were systematically compared using low-field 1 H-nuclear magnetic resonance (LF-NMR) and thermogravimetric analysis (TGA). The stoichiometric formulas of C–S–H in SynCSH and HC 3 SP were determined as C 0.9 SH 3.65 and C 2.0 SH 4.53 , respectively. Water contents of C–S–H quantified by TGA and LF-NMR exhibit good linear relationship. Three types of water, interlayer water, gel water and capillary water in C–S–H were identified by LF-NMR. Notable observations included the abnormal increase of interlayer water during the drying process and subsequent decrease during resaturation, along with irreversible decreases in capillary water and increases in gel water after D-R cycle, which were attributed to the rearrangement of C–S–H layered structures. SynCSH exhibited collapse of capillary pore structures following the D-R cycle, resulting in irreversible reductions in total water content. This finding confirms the validity of synthetic C–S–H as a model material for cementitious C–S–H research while highlighting its limitations in predicting the microstructural stability of real cement pastes under moisture cycling.
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Nature Communications
·
2026
·
IF 18.1
Jiafeng Lei,Yaqin Zhang,Weixing Wu,Ying Wang,Jun Fan,Yi-Chun Lu
Aqueous redox flow batteries are promising for long-duration energy storage. However, many of them (e.g. sulfur-based and organic-based flow batteries) suffer from sluggish kinetics with low energy efficiency and insufficient capacity utilization. Here, we propose relay catalysis as a universal strategy to achieve high reaction rates while minimizing overpotential, enabling high capacity and energy efficiency. Inspired by sequential electron transfer in cellular respiration, relay catalysis employs a low-overpotential catalyst (e.g., isoalloxazine) to initiate the reaction, seamlessly transferring control to a high-activity catalyst (e.g., quinone) to sustain charge propagation, breaking the trade-off between overpotential and catalytic rate. Using this strategy, we demonstrate polysulfide-ferrocyanide flow batteries with near full polysulfide utilization (S 4 2– /S 2 2– , 64 Ah L –1 negolyte ) and high stability over 3 months (> 500 cycles at 20 mA cm –2 , decay rate 0.00071% per cycle, 0.003% per day). We further extend this strategy to organosulfide- and azo-based batteries with various relay-catalyst couples. By mimicking biological electron relays, this approach not only redefines homogeneous catalysis for energy storage but also establishes a transformative platform for designing flow batteries with enhanced performance and scalability. Aqueous redox flow batteries are promising for large-scale energy storage, but many suffer from sluggish kinetics. Here, authors report a relay catalysis strategy to break the trade-off between overpotential and catalytic rate in sulfur- and organic-based flow cells.
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Nature Communications
·
2026
·
IF 18.1
Xu Xu,Chen Jian,Yang Zhuo,Zhou Zhiming,Zhang Xiaosa,Zeng Xinhui,Wan Yun,Chen Xiaomin,Kuang Wenxi,Shi Xiaoyan,Zhang Lingling,Zhou Xunzhu,Chou Shulei,Li Lin
Acetonitrile-based electrolytes have garnered significant attention for sodium-ion batteries due to their high ionic conductivity and favorable oxidation resistance. However, their practical implementation is hindered by an unsatisfactory anti-reduction ability, leading to poor compatibility with hard carbon anode and, consequently, rapid capacity degradation. Herein, we employ a widely used commercial carbonate ester solvent (ethyl methyl carbonate) to modulate the ion-dipole interactions in fluorine-free acetonitrile-based electrolytes. The relatively weak solvation ability of ethyl methyl carbonate facilitates more anions to participate the inner solvation sheath, thereby promoting the formation of robust electrode-electrolyte interface at a wide temperature range. This stabilized interface effectively suppresses continuous electrolyte decomposition, significantly improving the compatibility between fluorine-free acetonitrile-based electrolytes and hard carbon anodes. As a result, the optimized electrolyte enables stable operation of hard carbon ||Prussian blue full cells over a wide temperature range (25-100 °C), demonstrating a capacity retention of 62.5% after 600 cycles at 55 °C and 1.0 C. It is worth noting that Ampere-hour-level hard carbon ||Prussian blue pouch cells deliver consistent electrochemical performance at both 25 °C and 55 °C. This study elucidates the mechanistic role of cosolvent engineering in enhancing the reductive stability of fluorine-free acetonitrile-based electrolytes and provides a viable electrolyte design strategy for their practical implementation in sodium-ion batteries.
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Nature Communications
·
2026
·
IF 18.1
An Yechen,Mei Liang,Yang Ruijie,Cui Jun,Zhang Wenhai,Han Jing-Long,Jiang Wenli,Ren Ruiyun,Gao Xiaoxu,He Zhihui,Xu Haoran,Yan Ruifeng,An Quan-Fu,Li Zhiling,Cheng Haoyi,Tao Yu,Wang Aijie,Zeng Zhiyuan
Membrane-based separation offers a sustainable route for resource recovery from high-salinity organic wastewater, yet graphene oxide (GO) membranes remain constrained by poor selectivity, limited solvent stability, and challenges in scale-up. Here, we report a hydroxylated single-walled carbon nanotube (SWCNT-OH) reinforced GO membrane, in which SWCNT-OH promotes robust inorganic crosslinking with sodium tetraborate (Na 2 B 4 O 7 ) to form rapid transport channels for water and ions, while suppressing organic passage. This architecture enhances the moxifloxacin (MXF)/NaCl separation factor more than fivefold (from 4.2 to 22.2) and increases water permeability over fourfold (from 7.2 to 30.1 l m −2 h −1 bar −1 ). The membrane was scaled up to 11 m 2 and deployed for continuous treatment of MXF crystallization mother liquor over seven days, delivering a stable recovery of 10 kg MXF per day under industrially relevant conditions. These findings establish a scalable strategy for the design of robust nanocarbon-based membranes, advancing resource-efficient treatment of high-salinity wastewater.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 32
·23699-23713
·
IF 4.4
Hu Wenjin,Zhang Yong,Shu Xia,Xueru Zhang,Cui Jiewu,Wang Yan,Liu Jiaqin,Wu Yucheng
The escalating demand for 5G/6G communication technologies requires ultra-lightweight and high-performance electromagnetic interference (EMI) shielding materials. However, biomass-derived carbon materials often suffer from intrinsically low conductivity and poor interfacial adhesion with metallic coatings. In this work, we present a mussel-inspired interfacial engineering strategy to fabricate a high-performance silver-coated wood-derived carbon composite. By utilizing polydopamine (PDA) as a universal adhesive, a continuous silver conductive network was constructed via in-situ electroless plating, transforming the interface from weak physical adsorption to robust chemical coupling.This structural design synergistically combines conductive loss from the Ag network with dielectric loss and multiple scattering within the hierarchical porous carbon matrix. Consequently, the optimized composite (LCW/Ag) achieves an exceptional EMI shielding effectiveness (SE) of 66.43 dB in the x-band and 104.91 dB in the Ka-band, despite possessing an ultralow density of merely 0.327 g·cm⁻ 3 . The specific electromagnetic shielding efficiency (SSE/t) of LCW/Ag 800-60 in the Ka-band is 2333 dB·cm 2 ·g⁻ 1 . This remarkable performance, combined with the material’s low density, results in a superior specific shielding effectiveness.Furthermore, the silver coating significantly enhances the thermal stability and corrosion resistance of the carbon scaffold. This work presents a facile, eco-friendly route to fabricate advanced biomass-derived ceramic/carbon composites, demonstrating great potential for applications in next-generation aerospace and high-frequency electronic devices.
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