JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2024
·Vol. 35
·期 19
·1-8
·
IF 2.8
Yan Shuai,Hu Wencai,Wang Sen,Liu Gaobin
In this paper, Sr-doped BaTiO 3 nanoparticles were synthesized via electrochemical method, leading to the successful preparation of Ba 0.67 Sr 0.33 TiO 3 (BST) powders. The phase composition and microstructure of the powders were characterized using X-ray diffraction small angle X-ray scattering, scanning electron microscopy (SEM), and transmission electron microscopy. The results show that the average grain size of the nanoparticles is in the range of 10–20 nm, and the particles with good crystallinity are obtained under the environment of 3 mol.L −1 NaOH concentration. Sintering at 1250 ℃ for 3 h yields nanoscale BST ceramics with a dense structure and an average grain size of about 300 nm. These fine-grained ceramic samples exhibit superior temperature stability compared to relatively coarser BST ceramics. Furthermore, due to their nanoscale grain size, extensive phase transitions result in a low dielectric constant as observed from the dielectric property data. This work presents a novel approach for preparing nanoscale powders and homogeneous ceramics applicable in various electronic applications.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Zhao Huanyu,Wang Wenjing,Liu Xueling,Wu Xiangying,He Yuxin,Gao Chenchen,Shi Qingying,Zhao Huabing,Meng Xuan
Sonodynamic therapy (SDT) is a promising ROS-mediated antitumor strategy, yet its therapeutic efficacy is frequently restricted by intracellular antioxidant defenses and insufficient ferroptotic amplification. Herein, we developed a multi-stimuli-responsive metal-organic framework (MOF)-based nanoplatform using disulfide-containing imidazole ligands coordinated with zinc ions, in which the sonosensitizer protoporphyrin IX (PpIX) was physically encapsulated (PIssI). Upon ultrasound irradiation, the nanocarrier generated excessive reactive oxygen species (ROS), while intracellular glutathione (GSH) was continuously depleted through thiol-disulfide exchange, resulting in glutathione peroxidase 4 (GPX4) suppression, lipid peroxide accumulation, and amplified ferroptosis. Meanwhile, protonation of imidazole groups in acidic lysosomal compartments induced lysosomal membrane permeabilization and dysfunction, which subsequently blocked autophagic flux and aggravated intracellular oxidative stress. Transcriptomic analysis, ferroptosis rescue experiments, redox biochemical assays, and lysosomal functional evaluation collectively demonstrated that the nanoplatform rewires lysosome-associated redox homeostasis rather than merely inducing transient oxidative injury. In CT-26 tumor-bearing mice, the tailored nanocarrier exhibited markedly enhanced tumor accumulation and antitumor efficacy with minimal systemic toxicity. Unlike conventional ROS nanomedicines that primarily rely on cytosolic oxidative damage, the current system converts lysosomes from metabolic recycling hubs into ferroptotic amplifiers through organelle-level redox regulation. This work highlights lysosomal dysfunction as an additional dimension for ferroptosis-sensitized SDT and provides a new strategy for ROS-amplified cancer therapy. Graphical abstract
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Nature Communications
·
2026
·
IF 18.1
Liao Renjie,Fu Defeng,Xu Zaoxu,Liang Han,Zhou Xiaoran,Chen Yiling,Liu Xueqi,Cheng Jiajun,Li Chen,Xia Huihua,Li Gailing,Feng Diewen,Chen Wei,Chen Yang,Chen Longchao,Huang Zihang,Chen Qingbin,Chen Dexia,Xuan Shuguang,Zhang Changling,Lu Yongyi,Wang Hui,Feng Taiqing,Bao Yuanye,Zhao Luyang,Liu Erkai,Wang Gufeng
The advent of spatial transcriptomics has dramatically expanded our ability to study the vast network of cell-cell interactions at the molecular level in tissue. Among current methods, sequencing-based approaches have great potential in discovery because of their unbiased capture of the whole transcriptome. In the last couple of years, the spatial resolution for the capture addresses has been improved from ~100 μm to <1 μm, well below the size of a mammalian cell. However, the capture efficiency of sequencing-based methods is generally low, which diminishes the effect of high capture resolution and negatively impacts subsequent data interpretation. Here, we introduce a spatial transcriptomic system, which provides ~1 μm capture resolution and a much higher capture efficiency. We demonstrate that as high as ~14,000 UMIs can be captured from mouse testis sample per 10 × 10 μm² area at a sequencing saturation of 0.43. Rare cells organized in single-cell-layers can be recovered when the data was analyzed at an effective resolution of 2 μm.
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Rice
·
2026
·Vol. 19
·期 1
·
IF 5.8
Shafi Ullah,Muhammad Ateeq,Dongliang Xiong,Atika Khan,Liwu Sui,Ehtisham Hassan Khan,Muhammad Waqas,Na Yang,Huang Jianliang
Cold stress significantly impairs the rice (Oryza sativa L.) growth and yield, particularly in temperate regions where abrupt temperature fluctuations often occur during the early growth stages. Given the need for novel strategies to improve crop cold tolerance, we evaluated the efficacy of iron oxide nanoparticles (Fe 2 O 3 ) in enhancing rice cold stress resilience. The reported mechanisms involve promoting plant growth and development, alleviating oxidative stress and inducing defense responses. Using RNA-seq, we analyzed the physiological and transcriptomic responses of rice to cold stress and Fe 2 O 3 treatment. Under cold stress, the NPs elicited a strong antioxidant response-elevating superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) activities, which led to a marked reduction in oxidative damage, as shown by decreased ROS and MDA levels. Transcriptomic analysis further revealed that NP treatment modulated key pathways related to carbohydrate metabolism, photosynthesis, hormone signaling, and antioxidant metabolism. Collectively, our findings establish that Fe 2 O 3 nanoparticles ameliorate cold stress by preserving chloroplast structure, stomatal architecture, reduce oxidative stress marker, enhancing antioxidant defense system and stabilize photosystem and providing a promising nanozyme-based approach for rice protection against cold induce damage.
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Nature Biomedical Engineering
·
2026
·
IF 26.3
Liang Sen,Li Jingtao,Li Qi,Jiang Tianhe,Tian Yajie,Han Qingquan,Jing Yafeng,Wang Shuai,Li Jieling,Wang Anhe,Bai Shuo
Gastrointestinal fistulas (GFs) represent one of the main causes of morbidity and mortality. While endoscopic techniques provide a minimally invasive approach to GF repair, offering advantages over conventional surgical approaches, the integration of endoscopic delivery with hydrogel sealants in user-friendly and easy processes approaches remains a great challenge. Here we develop a thermoresponsive positively charged poly( N -isopropylacrylamide) (PNIPAM)/Ga 3+ (PGa III ) hydrogel sealant, formed by slug-inspired biomimetic self-assembly. The PGa III integrated injectability and single-step-formed Janus-type adhesion to tissues, simultaneously featuring excellent biocompatibility, water/acid resistance, active shrinkage and antibacterial properties, enabling its effective ready-to-use biological sealant for endoscopic repair of GFs and prevention of postoperative adhesions. To validate the efficacy of PGa III in treating GFs, we demonstrate its effectiveness in repairing GFs and its convenience in non-invasive endoscopic surgery in living Sprague–Dawley rat and Bama miniature pig models. The proposed PGa III holds potential for the repair of fistulas in other organs in vivo, thereby promoting the establishment of safer and more effective clinical treatment options for related diseases.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 26
·1-14
·
IF 2.8
Zang Shihui,Pan Yusong,He Shuhuan,Huang Run
BiOCl/Ti 3 C 2 catalyst was synthesized via a hydrothermal method and combination with self-assembly technology. The crystal phase, microstructure, surface chemical state, and optical properties of BiOCl/Ti 3 C 2 catalysts were investigated using XRD, FTIR, SEM/TEM, XPS, and DRS technologies. The enhanced catalytic performance of BiOCl/Ti 3 C 2 catalysts were demonstrated by the degradation of the organic pollutants in visible light irradiation/Fenton-like synergistic system. The degradation results revealed that the catalytic degradation efficiency of the BiOCl/Ti 3 C 2 catalysts presents the first increasing and then decreasing trend with the rise of Ti 3 C 2 content. And the BiOCl/Ti 3 C 2 catalyst with 8-wt% Ti 3 C 2 exhibited highest degradation efficiency in the light irradiation/Fenton-like synergistic system, whose removal rate of RhB was 97.80% within 10 min, which was significantly higher than that in the sole visible light irradiation (83.58%, 10 min) and that in the sole Fenton-like system (only 3.11%, 10 min). The result verified that the visible light irradiation and Fenton-like system has a positive synergistic effect for enhancing the catalytic efficiency of the BiOCl/Ti 3 C 2 catalysts. The influence of environmental conditions such as catalyst dosage, H 2 O 2 dosage, and the anions on the catalytic performance were also investigated. The results showed that with the increase of catalyst dosage and H 2 O 2 dosage, the rate constant ( K value) also increased. The presence of Cl -1 in the system was advantageous for improving the catalytic degradation efficiency, whereas the presence of CO 3 2- in the system significantly inhibited catalytic degradation efficiency. The degradation mechanism revealed that the existence of Ti 3 C 2 in the BiOCl was beneficial for improving the ability of photo-generated charge carrier separation. The active free radicals such as singlet oxygen ( 1 O 2 ), superoxide radicals (· \({\text{O}}_{2}^{ - }\) ), and photo-generated holes (h + ) plays the main role for organic pollutants degradation.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2024
·
IF 4.7
Zhao Yanna,Bai Xiaowei,Zhang Yingying,Wang Yuqi,Li Yiqing,Yang Shuai
The preparation of high-performance recyclable epoxy vitrimer from bio-based feedstocks is of great industrial significance. Based on the above considerations, in this paper, we report a reaction of curing a bio-based epoxy monomer, propanetriol triglycidyl ether (GTE), with vanillin-derived diphenol monomer (VD) and 3-aminophenylboronic acid (M-APBA) as a curing agent, which resulted in the preparation of epoxy vitrimer films (EVB-X) with acylhydrazone bonds and cyclic boroxine dual dynamic response. Among them, the diphenol monomer VD supplies the flexible structure of the film, while the film showed a gradual increase in the boroxine six-membered ring structure with the gradual increase in the ratio of M-APBA, and the thermal and mechanical properties of the films are also gradually improving. By varying the ratio of VD to M-APBA in the material, EVB-3 was the most thermally stable, while T g was measured at 45 °C, the highest tensile strength (57.40 MPa), and the largest cross-linking density (3271 mol/m 3 ) among the four groups of films obtained from EVB-X films. In addition, the EVB films had excellent triple memory and could be largely degraded in acidic DMF and DMSO, with a gel content of 86.74% measured with EVB-3. Notably, the EVB scratches were completely healed at 100 °C for 1 h, indicating that EVB have excellent self-repairing properties, while the tensile strength could be recovered up to 28.98 MPa after heat treatment, and the strain repair rate could reach up to 89.42%, which provides good reprocessability.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Guo Jun,Duan Yulong,Jia Yunling,Zhao Zelong,Gao Xiaoqing,Liu Pai,Li Fangfang,Chen Hongli,Ye Yutong,Liu Yujiao,Zhao Meiting,Tang Zhiyong,Liu Yi
Assembly ubiquitously occurs in nature and gives birth to numerous functional biomaterials and sophisticated organisms. In this work, chiral hydrogen-bonded organic-inorganic frameworks (HOIFs) are synthesized via biomimicking the self-assembly process from amino acids to proteins. Enjoying the homohelical configurations analogous to α -helix, the HOIFs exhibit remarkable chiroptical activity including the chiral fluorescence ( g lum = 1.7 × 10 −3 ) that is untouched among the previously reported hydrogen-bonded frameworks. Benefitting from the dynamic feature of hydrogen bonding, HOIFs enable enantio-discrimination of chiral aliphatic substrates with imperceivable steric discrepancy based on fluorescent change. Moreover, the disassembled HOIFs after recognition applications are capable of being facilely regenerated and self-purified via aprotic solvent-induced reassembly, leading to at least three consecutive cycles without losing the enantioselectivity. The underlying mechanism of chirality bias is decoded by the experimental isothermal titration calorimetry together with theoretic simulation.
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Nano-Micro Letters
·
2025
·Vol. 17
·期 1
·1-11
·
IF 36.3
Liu Xianhu,Zhang Haoyu,Pan Yamin,Ma Jun,Liu Chuntai,Shen Changyu
As living standards improve, the energy consumption for regulating indoor temperature keeps increasing. Windows, in particular, enhance indoor brightness but also lead to increased energy loss, especially in sunny weather. Developing a product that can maintain indoor brightness while reducing energy consumption is a challenge. We developed a facile, spectrally selective transparent ultrahigh-molecular-weight polyethylene composite film to address this trade-off. It is based on a blend of antimony-doped tin oxide and then spin-coated hydrophobic fumed silica, achieving a high visible light transmittance (> 70%) and high shielding rates for ultraviolet (> 90%) and near-infrared (> 70%). When applied to the acrylic window of containers and placed outside, this film can cause a 10 °C temperature drop compared to a pure polymer film. Moreover, in building energy simulations, the annual energy savings could be between 14.1% ~ 31.9% per year. The development of energy-efficient and eco-friendly transparent films is crucial for reducing energy consumption and promoting sustainability in the window environment.
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Science China-Materials
·
2025
·
IF 7.4
Zhao Yuefang,Yang Huabin,Zhang Qirui,Lei Cheng,Zhou Na,Shi Rongrui,Shi Lei,Wu Jintao,Luo Houming,Mao Haiyang
This work proposes a fabrication technique that can achieve wafer-level preparation of flexible interdigital electrodes (IDEs) with high-density and large-thickness (HD<). Utilizing these HD< flexible IDEs, we developed a flexible humidity sensor that employs a composite material made of nanowire bundles with carbon quantum dots (CQDBs) for humidity sensitivity. In this device, the composite material facilitates high absorption and capillary condensation of water molecules across various relative humidity (RH) conditions, while the HD< IDEs enhance the effective sensing area. Consequently, we achieve a flexible humidity sensor with exceptional performance. This sensor not only boasts key attributes such as low cost, easy fabrication, and straightforward operation but also establishes a foundation for extensive humidity sensing applications. In comparison to other devices utilizing small-thickness and low-density IDEs, our sensor demonstrates remarkable 2.5-fold and 5.8-fold increase in sensitivity across humidity ranges of 7%–59% RH and 59%–97% RH, respectively. To explore the practical applications of the device, we demonstrate its functionality in diaper humidity detection. With characteristics of wearability and durability, the sensor shows significant potential for humidity monitoring in wearable electronics.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-18
·
IF 10.6
Yu Zhihang,Chen Yiqun,Li Jingjing,Chen Chang,Lu Huaxiu,Chen Siyuan,Zhang Tingting,Guo Tianruo,Zhu Yonggang,Jin Jing,Yan Sheng,Chen Huaying
Pathological conditions linked to shear stress have been identified in hematological diseases, cardiovascular diseases, and cancer. These conditions often exhibit significantly elevated shear stress levels, surpassing 1000 dyn/cm 2 in severely stenotic arteries. Heightened shear stress can induce mechanical harm to endothelial cells, potentially leading to bleeding and fatal consequences. However, current technology still grapples with limitations, including inadequate flexibility in simulating bodily shear stress environments, limited range of shear stress generation, and spatial and temporal adaptability. Consequently, a comprehensive understanding of the mechanisms underlying the impact of shear stress on physiological and pathological conditions, like thrombosis, remains inadequate. To address these limitations, this study presents a microfluidic-based shear stress generation chip as a proposed solution. The chip achieves a substantial 929-fold variation in shear stress solely by adjusting the degree of constriction in branch channels after PDMS fabrication. Experiments demonstrated that a rapid increase in shear stress up to 1000 dyn/cm 2 significantly detached 88.2% cells from the substrate. Long-term exposure (24 h) to shear stress levels below 8.3 dyn/cm 2 did not significantly impact cell growth. Furthermore, cells exposed to shear stress levels equal to or greater than 8.3 dyn/cm 2 exhibited significant alterations in aspect ratio and orientation, following a normal distribution. This microfluidic chip provides a reliable tool for investigating cellular responses to the wide-ranging shear stress existing in both physiological and pathological flow conditions. Graphical Abstract
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Journal of Coatings Technology and Research
·
2025
·
IF 2.8
Song Xiao,Zhou Chuanjiang,Yang Sijia,Liu Shengjie,Wu Zhaoqiang,Chen Hong
Polycarbonate (PC) substrates are widely used in our daily lives, but their inherent hydrophobicity makes them susceptible to changes in ambient temperature and humidity, which can cause fog that affects their light transmittance, limiting their use in applications that require high light transmittance, such as eyeglass lenses, automotive parts, and medical devices. In this study, P(HEAA- co -AEMA- co -BPA) transparent anti-fog coatings were prepared via one-step free radical copolymerization using N -(2-hydroxyethyl)acrylamide (HEAA), 2-aminoethylmethacrylate hydrochloride (AEMA), and 4-acryloyloyloxybenzophenone (BPA) as monomers. The hydrophilic HEAA monomer provides the coating with anti-fogging performance. The amino functional group in the AEMA segment reacts with the ester group on the surface of the PC substrate to form covalent urethane bonds during heat curing, and the hydrophobic BPA not only covalently binds with the PC substrate under UV irradiation but also prevents the anti-fogging performance of the anti-fog coating from being lost because of the absorption of too much water. The resulting transparent coatings have excellent anti-fogging effects in hot vapor tests and freeze–warm tests. Furthermore, the coatings exhibited good adhesion in the cross-cut tests. Quartz sand abrasion tests and wet cloth wiping tests also revealed that the coating has good abrasion resistance in both dry and wet states.
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