Small
·
2025
·
IF 12.1
Chenggong Zhu,Qunfang Huang,Ruijie Fu,Zhen Xun,Qishui Ou,Yunlei Xianyu,Can Liu
Hepatitis B virus (HBV) infection remains a significant global public health issue, and rapid detection of HBV DNA is crucial for disease prevention and control. However, traditional methods for HBV DNA detection are limited by their reliance on precise instruments and single readout, which can hardly meet the requirements of on-site detection. In this study, the Mg 2+ -enhanced trans-cleavage activity of clustered regularly interspaced short palindromic repeats/associated protein 12a (CRISPR/Cas12a) is reported and coupled with loop-mediated isothermal amplification (LAMP) and Au@Pt nanoparticles as a signaling reporter for on-site detection of HBV DNA. This triple-modal biosensing strategy enables multiple signal readouts including UV–vis spectrum, RGB value, and temperature with high sensitivity and accuracy. The linear detection ranges using UV–vis spectroscopy, RGB color recognition, and photothermal modes are from 50 to 10,000 copies µL −1 , with the limitation of detection of 24.07, 39.65, and 23.33 copies µL −1 , respectively. This biosensing strategy is further employed for the qualitative detection of HBV DNA in 48 serum samples, achieving sensitivities of 100%, 100%, and 95.24% for triple modes. This work offers a promising tool of next-generation LAMP-CRISPR/Cas12a for the rapid and portable detection of nucleic acids.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Zhongshun Wang,Qunyan Zhu,Chang Liu,Kun Chen,Yuheng Fu,Bingbing Xie,Lin Zhang,Wensheng Yang
Achieving highly sensitive surface-enhanced Raman scattering (SERS) detection requires precise collection of trace target analyte molecules into small hot spot regions. In this study, we propose a convenient and cost-effective method to construct a high-performance SERS platform based on the super-hydrophobic delivery (SHD) effect to overcome the diffusion limit during sample evaporation. A paper based super-hydrophobic substrate (PBSH substrate) was employed as a concentrator to enrich the analytes, along with SiO 2 @Au core-satellite structures (SiO 2 @Au CSSs) to form “molecule in hot spot” matrices. Benefiting from the SHD effect and the high SERS activity of SiO 2 @Au CSSs in three-dimensional space, we achieved excellent SERS sensitivity and reproducibility. This platform exhibits a good linear response for detecting Rhodamine 6G (R6G) across concentration ranges from nanomolar (10 −7 M) to femtomolar (10 −13 M) levels, with a low relative standard deviation (RSD) of 6.42 % observed across 30 randomly selected spots. Moreover, the platform enables sensitive detection of various contaminants and multicomponent residues of pesticides and organic dyes in real samples, exhibiting great practical potential in the field of food safety.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2024
·
IF 20.2
Tianwei Dou,Yangyang Zhu,Zhanyu Chu,Lei Sun,Zhijun Li,Liqiang Jing
TiO 2 mesoporous hollow nanofibers with excellent mass diffusion is an attractive photocatalytic material to remove toxic gaseous pollutants like CO, while it is highly desired to improve the photogenerated charge separation and O 2 activation. Herein, the Au nanoparticles inner-loaded TiO 2 mesoporous hollow nanofibers (Au@TO MPHNFs) have been controllably fabricated by one-step coaxial electrospinning, in which it is crucial to use polyethyleneimine as porogen and stabilizer for mesoporous and TiO 2 in nanofibers shell. Concurrently, a stepwise phase transfer technique is employed to realize the uniform and stable dispersion of the Au in the paraffin oil as core precursor. The Au@TO MPHNFs exhibits 2.7 and 7.4-fold CO photooxidation enhancement compared with commercial P25 and TO MPHNFs, respectively. The enhanced photoactivity can be attributed to the creation of the mesoporous hollow structure for facilitating better mass transportation, and the incorporation of Au nanoparticles for efficient charge separation and O 2 activation. Meanwhile, the photothermal effect of Au expedites intermediaries transformation and product desorption.
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TALANTA
·
2025
·
IF 6.1
Qiujin Li,Jianing Ren,Kexin Feng,Jixian Gong,Zheng Li,Xiuming Liu,Jianfei Zhang
Wearable glucose sensors have received widespread attention for their ability to provide real-time and continuous physiological information through non-invasive detection of glucose in sweat, which is significant to wellness assessment and management. However, there are still challenges of glucose catalysis and sweat sampling in developing efficient wearable glucose sensors. Here, we report a flexible wearable electrochemical sensor based on a Janus nanofiber membrane for efficient sweat collection and glucose detection. Leveraging the high reducing capability of MXene, gold nanoparticles (AuNPs) were synthesized in situ, and then functionalize the screen-printed carbon electrode (SPCE) substrate. The synergistic effect derived from the high specific surface area and superior redox activity of MXene-Au composites, as well as the efficient immobilization of glucose oxidase (GOx) make the sensor with high sensitivity and accuracy. A polyurethane/polyvinyl alcohol (PU/PVA) Janus fiber membrane, fabricated via electrospinning, served as a rapid unidirectional water transport component for active sweat collection. This electrochemical sensor exhibits a wide linear range encompassing the typical physiological glucose concentration profile in sweat, with a sensitivity of 0.33 μA μM −1 cm −2 and a detection limit of 13.0 μM. The sensor demonstrates excellent selectivity for glucose with good reproducibility and stability, suggesting significant promise for providing a new strategy towards non-invasive glucose monitoring.
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Nano-Micro Letters
·
2023
·Vol. 15
·期 1
·1-13
·
IF 26.6
Gao Manyi,Tian Fenyang,Zhang Xin,Chen Zhaoyu,Yang Weiwei,Yu Yongsheng
A hybrid co-catalysts system comprising Au nanoparticles (NPs) and PtSAs with different functions was constructed on the polymeric carbon nitride (PCN) surface by double-solvent method.
For the dual co-catalysts, the Au NPs absorb relatively long-wavelength light to produce plasmonic hot-electrons, and the adjacent Pt single atoms (PtSAs) can trap the plasmonic hot-electrons effectively for H 2 evolution.
The PtSAs–Au 2.5 /PCN exhibits excellent broad-spectrum photocatalytic H 2 evolution activity with the H 2 evolution rate of 8.8 mmol g − 1 h − 1 at 420 nm and 264 μmol g − 1 h − 1 at 550 nm, respectively.
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Nanoscale
·
2025
·
IF 5.1
Mi Li,Haorong Cheng,Yang Song,Xinxin Shi,Tongxiang Li,Yan Chen,Zhao Li,Lin Tian
The rapid detection of sulfide compounds including glutathione (GSH) and Na2S2O8 is of great interest because they play an essential role in the process of food processing. Here, we design a colorimetric/smartphone dual-mode sensing platform to detect GSH and Na2S2O8 simultaneously, depending on gold nanoparticle-decorated MnO2 nanosheets (Au/MnO2 NSs). Because of the distinct structure, Au/MnO2 possesses superior catalytic activity similar to native oxidase capable of catalysing the directly oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB) under near-neutral pH conditions. Meanwhile, this catalytic reaction results in an obvious color change or the solution, which senses GSH and Na2S2O8 through redox and diazotization reactions. The designed sensor enables value-assisted and visual determination of GSH and Na2S2O8 with limits of detection of 2.3 nM. Based on the dual-modal sensing system, a smartphone-mediated “all-in-one” sensing platform is designed to realize the real-time and intelligent monitoring of GSH and Na2S2O8. This work provides a new avenue to construct multifunctional sensors to achieve the visualization and portable determination of sulfide compounds.
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TALANTA
·
2024
·
IF 5.6
Gao-feng Wu,Jian Zhu,Guo-jun Weng,Hao-yu Cai,Jian-jun Li,Jun-wu Zhao
The development of an ultra-sensitive detection method for carbohydrate antigen 19-9 (CA19-9) is very important for the early diagnosis of pancreatic cancer. In this work, we developed a new strategy to achieve a variety of Au–Ag hybrid nanoparticles from janus to core-satellite which is controlled by the volume of AgNO 3 and the concentration of benzimidazolecarboxylic acid (MBIA). With the volume of AgNO 3 increased, Au–Ag hybrid nanoparticles changed from janus to core-satellite and the characteristic absorption peak showed two opposite trends. The size and number of Ag islands were determined by the concentration of MBIA. Au–Ag core-satellites nanoparticles with a large number of small-sized Ag have the highest SERS intensity. Then we used them as SERS nanotags and Au-Polystyrene nanospheres modified by captured anti-CA19-9 antibody as solid substrates to realize the ultra-sensitive detection of CA19-9 with a low limit of detection of 1.25 × 10 −6 IU/mL and a wide linear range of 1.00 × 10 −5 -1.00 × 10 4 IU/mL. This work not only demonstrates that MBIA and AgNO 3 were the key factors in the growth of Au–Ag hybrid nanoparticles from 2D to 3D structure but also supplies an ultra-sensitive detection method for CA19-9 which has a potential practicability in the clinical early diagnoses of pancreatic cancer.
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International Journal of Minerals Metallurgy and Materials
·
2026
·Vol. 33
·期 6
·1870-1885
·
IF 8.8
He Baili,Kou Jue,Sun Chunbao,Li Yue,Li Xiaolin,Temirov Uktam,Chang Ziyong
The development of effective adsorbents is crucial for the sustainable recovery of noble metals from secondary resources. In this study, MIL-101(Cr)-Tu, a Cr-based metal–organic framework (MOF) modified with thiourea, was successfully prepared by double-phase encapsulation followed by post-synthetic modification. At 298 K, the largest adsorption capacities of Au(III), Pd(II), and Pt(IV) by MIL-101(Cr)-Tu were (1230.83 ± 8.72), (330.41 ± 7.29), and (315.58 ± 13.67) mg·g −1 , respectively. The uptakes of Au(III), Pd(II), and Pt(IV) increased with temperature. The adsorption data fit well to both the Langmuir and pseudo-second-order kinetic models, indicating that the adsorption process conformed to monolayer adsorption and chemisorption. Mechanistic analysis revealed that the amino and thiourea groups facilitated the adsorption of noble metals through coordination and electrostatic attraction. Notably, Au(III), Pd(II), and Pt(IV) interacted strongly with the thiourea groups owing to their “soft–soft” interactions. Moreover, Au(III) was reduced to Au(I) and Au(0), Pt(IV) was reduced to Pt(II), and the amino groups were oxidized to NO 2 . The adsorption of Pd(II) did not involve redox reactions. Additionally, MIL-101(Cr)-Tu exhibited strong selectivity for noble metals and excellent reusability, demonstrating its great potential for the extraction of noble metals from secondary resources.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2026
·
IF 4.4
Jin-yuan Li,Xin Li,Guo-jun Weng,Jian-jun Li,Jun-wu Zhao,Jian Zhu
The catalytic performance of the hollow-structured triangular nanoprisms is stronger than that of the deposited-structure. • A simple colorimetric method is established for the detection of ascorbic acid with low detection limit and high selectivity. • The detection limit is 2.93 μM for the Pt-Ag-Au triangular nanoprisms with hollow structure. • The Pt-Ag-Au triangular nanoprisms with hollow structure has a wide detection range of 100–1000 μM. Compared with monometallic nanomaterials, multimetallic nanomaterials are composed of multiple metals and exhibit many special optical properties. In recent years, novel platinum-based multimetallic nanostructures have attracted attention due to their excellent catalytic performance, and have potential applications in the fields of biosensing, medical imaging and catalysis. However, how the morphology and structure of nanoparticles affect their catalytic properties remains a new and intriguing question. This paper investigates the catalytic properties of Au@AgPt triangular nanoprisms by reducing 4-nitrophenol (4-NP) in the presence of sodium borohydride (NaBH 4 ). It was found that the prepared Au@AgPt triangular nanoprisms had good catalytic performance. What's more, the catalytic performance of the hollow-structured Au@AgPt triangular nanoprisms was stronger than that of the deposited Au@AgPt triangular nanoprisms. A simple colorimetric method for detecting ascorbic acid (AA) was established using the catalytic properties of Au@AgPt triangular nanoprisms. The detection limit of AA was 2.93 μM for the hollow-structured Au@AgPt triangular nanoprisms, with a very wide detection range of 100–1000 μM. This detection method achieved a low detection limit for AA and a high selectivity against interfering substances, which has broad application prospects in the fields of food safety testing and monitoring of metabolic levels and health conditions. The prepared Au@AgPt triangular nanoprisms had good catalytic performance. A simple colorimetric method for detecting AA was established using the catalytic properties of Au@AgPt triangular nanoprisms. This detection method achieved a low detection limit and a high selectivity, which has broad application prospects in the fields of food safety testing and monitoring of metabolic levels and health conditions. Download: Download high-res image (110KB) Download: Download full-size image
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Runzi Zhang,Shunbi Xie,Xiaoyu Yang,Wanyi Xiong,Yi He
Currently, surface-enhanced Raman scattering (SERS) biosensors face practical challenges, including SERS substrate waste and unsatisfactory detection results. Accordingly, the highly efficient and regenerable SERS substrate HOF@Au was collaborated with a target-triggered identifying-cleaving-rolling-assembly cycling nanodevice (ICRACN) as a cascade signal amplification system to achieve an ultrasensitive detection of roxithromycin (RXM). In this system, abundant Au nanoparticles (NPs) were reduced in situ on the surface of alkali-resistant HOF-102 to form a uniform and high-enhancement SERS substrate HOF@Au, thereby enhancing the accuracy and stability of the sensor. Furthermore, aptamer-mediated specific recognition, efficient cleavage activity of DNA nanorollers, and a pH-responsive DNA triplex structure were engineered to construct ICRACN. In the presence of the target, it was specifically recognized by the aptamer, leading to the activation of the DNAzyme. Meanwhile, the dynamic nanorollers were triggered to initiate cleavage of a specific site along a defined pathway, enabling highly efficient signal amplification. Concurrently, the triplex structure formed by the two single-stranded DNA atoms on the SERS substrate was opened, allowing the capture of the SERS tag and generating a pronounced SERS signal. The proposed strategy achieved the sensitive detection of RXM with a low limit of detection of 3.97 × 10–14 mol/L. Moreover, modulation of pH induced reversible folding and unfolding of the triplex structure to facilitate regeneration of the SERS substrate, which simplified operational procedures and reduced detection costs. As a result, this work presents a novel, regenerable SERS biosensor and offers valuable insights into the design of multifunctional sensing platforms for analytical applications.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 6
·413
·
IF 5.4
Hu Xiaoping,You Nana,Xu Fuli,Liu Gen,Du Fangxin
A portable, high-throughput visual sensing platform was constructed for the effective detection of catechol (CA), on the basis of the single-electrode electrochemistry system (SEES) and a self-enhanced electrochemiluminescence (SEECL) material, namely Au-Ru@Zn metal-organic framework (MOF). It was found that Ru(bpy) 3 2+ and oxalate co‑encapsulated within the Ru@Zn MOF generated a SEECL signal. To further amplify the SEECL response, tripropylamine (TPA) was introduced as an exogenous co-reactant, synergizing with endogenous oxalate to establish dual ECL pathways. The oxidation product of CA, semiquinone radicals, is proposed to effectively quenched photoexcited Ru(bpy) 3 2+ * species and competitively consume the precursor Ru(bpy) 3 3+ by reducing it to Ru(bpy) 3 2+ , thereby causing the ECL signals of Au-Ru@Zn MOF to be significantly quenched. Under optimal experimental conditions, the Au-Ru@Zn MOF-modified SEES exhibited excellent ECL response performance toward CA, with a linear detection range from 1.0 × 10⁻ 9 to 5.0 × 10⁻ 4 mol·L⁻ 1 and a detection limit as low as 7.94 × 10⁻ 10 mol·L⁻ 1 (S/ N = 3). Additionally, the proposed SEES successfully detected CA in tea with the recoveries ranging from 98.8% to 101.0%. This work offers a novel approach for the sensitive detection of CA and has significant application possibilities in the realm of food safety monitoring with the benefits of high throughput, portability, and low cost. Graphical abstract The alternative text for this image may have been generated using AI.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yumei Li,Xingjun Zhao,Linna Chang,Yanan Hu,Shibo Xu,Xiuli Ren,Xifan Mei,Zhenhua Chen
Antimicrobial hydrogels with NIR and enhanced mechanics benefit diabetic wound healing. • Au/MXene modifies gel network intermolecular interactions, regulating hydrogel mechanics. • NIR-triggered hyperthermia promotes wound healing via ROS/EGCG release. Biological hydrogels are ideal wound dressings due to their moisturizing, biocompatible, and drug delivery properties. Polyvinyl alcohol (PVA) and sodium alginate (Alg)-based injectable hydrogels show great potential in wound repair; however, simple hydrogels lack antimicrobial properties and cannot effectively prevent and control infections. Herein, Au@Ti 3 C 2 -E composites were obtained by anchoring gold nanoclusters on the surface of ultrathin Ti 3 C 2 nanosheets (1.5 nm) and modifying them by grafting epi gallocatechin gallate (EGCG). Under 808 nm laser irradiation, Au@Ti 3 C 2 -E@H exhibited good photothermal effects. Interestingly, elevated temperature can act as a “switch” that significantly enhances the Fenton-like catalytic activity of gold nanoclusters (3–5 nm) and promotes the release of EGCG grafted on the surface. The inhibition results showed that Au@Ti 3 C 2 -E@H achieved 94.5% and 93.0% kill rates of Methicillin-Resistant Staphylococcus Aureus (MRSA) and Ampr Escherichia coli ( E.coli ) through higher Reactive Oxygen Species (ROS) generation efficiency and disruption of bacterial biofilms. Molecular biology results showed that Au@Ti 3 C 2 -E@H significantly upregulated Vascular Endothelial Growth Factor (VEGF), Basic Fibroblast Growth Factor (bFGF), Epidermal Growth Factor (EGF) and Platelet Endothelial Cell Adhesion Molecule-1 (CD31) nearly threefold and downregulated Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), and Matrix Metalloproteinase-9 (MMP-9) nearly fourfold, which could promote angiogenesis and epithelial repair. After 21 days of the treatment cycle, the diabetic rats achieved a wound healing rate of 99.2%. Au@Ti 3 C 2 -E enhances the mechanical properties and antibacterial effects of hydrogels, synergizing photothermal and nanozyme activities to provide a promising solution for the repair of diabetic wounds infected with drug-resistant bacteria. Download: Download high-res image (168KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）