Food Packaging and Shelf Life
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2022
·
IF 8.749
Pengquan Zhao,Jiandong Wang,Xinyu Yan,Zihui Cai,Lina Fu,Qi Gu,Lin Liu,Haojie Jin,Yujie Fu
In this study, the bioactive extract of Rosa roxburghii Tratt (RRT) leaves was incorporated into a chitosan/zein matrix to produce a food packaging film with higher antioxidant and antimicrobial activities. The natural deep eutectic solvent (NADES) was taken as the extraction solvent and green plasticizer to prepare the film matrix. The physical and structural properties of chitosan/zein films with different concentrations of RRT leaves extracts were characterized by infrared spectroscopy analysis , thermogravimetric analysis , X-ray diffraction and scanning electron microscope. The incorporation of RRT leaves extract significantly improved the mechanical properties , light barrier properties and water vapor permeability of the chitosan/zein films. Moreover, the films containing RRT leaves extract had better antioxidant activities and antibacterial activities, with the highest DPPH and ABTS radical scavenging activities of 88.17 % and 86.84 %, respectively, and also effectively inhibited the growth of microorganisms and extended the shelf life of blueberries and cherry tomatoes .
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Qian Liu,Zhenrong Tan,Dafeng Zheng,Xueqing Qiu
In order to improve the effect of anti-tumor drugs, a magnetic delivery system for targeted drug was reported. Firstly, aminated lignosulfonate (ALS) and carboxymethyl chitosan (CMCS) were used to fabricate nano Fe 3 O 4 to obtain pH-responsive magnetic Fe 3 O 4 /CMCS/ALS nanoparticles. Then the nanoparticles were loaded with doxorubicin hydrochloride (DOX), realizing the targeted delivery and controlled release of anti-tumor drugs. It was found that the amount of crosslinking agent and emulsifier were the key factors affecting the morphology and size of the magnetic nanoparticles. Under optimized conditions, the particle size was about 79.9–169.9 nm, exhibiting excellent pH responsiveness. When the drug-to-material ratio was 11:10, the DOX loading rate and the encapsulation rate of the nanoparticles was 48.68 % and 86.23 %. While the Fe 3 O 4 /CMCS/ALS-DOX particles could release 63.14 %, 56.71 %, and 14.28 % of DOX at pH 4.0, 5.3, and 7.4, respectively. The results showed that the Fe 3 O 4 /CMCS/ALS particles exhibited excellent drug loading and release behavior based on the pH responsiveness, which could be described by Langmuir adsorption model and Fick's law of diffusion respectively. MTT assay and Live/dead staining experiments also showed that the drug-loaded particles had obvious growth inhibition on cancer cells.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
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IF 8.2
Aoqi Li,Weiping Chen,Han Shi,Yingqing Ye,Peixin Gong,Bo Jiang,Bo Xiao
Phenylboronic acid (PBA) groups are effective in building glucose-responsive drug delivery systems. Chitosan (CS) offers distinct advantages in the construction of PBA-based biomaterials, such as biodegradability and biocompatibility. However, challenges still persist due to the limited solubility of CS. This study proposes an efficient approach to introduce PBA groups into CS chains within 1 h via the O-(7-azabenzotriazol-1-yl)- N , N , N′ , N′ -tetramethyluronium hexafluorophosphate (HATU)-mediated amidation between 3-carboxyphenylboronic acid (CPBA) and O-hydroxypropyl chitosan (HPCS). The results showed that a wide range of substitution degrees, from 0.15 to 0.78, could be finely controlled by the amount of CPBA added. Furthermore, the obtained novel carboxyphenylboronic acid-grafted hydroxypropyl chitosan (PBA-HPCS) derivative showed enhanced crystallinity and thermostability compared to HPCS, and it demonstrated solubility in an alkaline solution. Based on the reversible bonding between the boronic acid group and cis-1,2/1,3-diols, PBA-HPCS was successfully used as an efficient crosslinker for the preparation of hydrogels incorporating sorbitol and polyhydroxy polymers, such as guar gum and polyvinyl alcohol. These hydrogels exhibited rapid gelation , rapid self-healing, injectability, and responsiveness to glucose and pH. These findings suggest that PBA-HPCS holds promise for advancing the development of PBA-based biomaterials.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2023
·Vol. 140
·期 38
·e54440
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IF 3
Quan Xuan Duong,Nguyen Hanh Do,Hien Thanh Pham,Thu Hong Anh Ngo
This study endeavors to augment the antibacterial and anti-biofouling properties of thin-film composite polyamide membranes by subjecting them to modification with antibacterial chitosan and silver nanoparticle materials through the UV-induced graft polymerization technique. Various surface assessment methods were employed, and the efficiency of the membrane performance was demonstrated through the flux and the retention of the filtration process, which used calcium chloride as the foulant. Antibacterial, antifouling, and anti-biofouling capabilities were assessed through several tests. The findings revealed that the chitosan/silver nanoparticles-grafted membranes exhibited superior antibacterial and anti-biofouling abilities with consistent flux and enhanced retention, underscoring the prospective implementation of this approach in filtration systems to curtail biofouling and bolster overall efficacy.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2023
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IF 5.8
Xiyuan Yi,Yong Luo,Qi Zhou,Jun Wang,Zengtao Yang
Insulin therapy is the most effective way to control the blood glucose value of diabetic patients. The most effective administration route for insulin is subcutaneous injection because bioavailability for non-injection administration is low and unstable. However, patients often need a multiple daily insulin injection regimen to control basal and postprandial blood glucose, which causes various complications. Controlled pulsatile drug release technology using ultrasound as an external stimulus source is a very promising method to avoid multiple injections of insulin. However, most of the drug-loaded microbubbles used for ultrasound-mediated treatment have a short half-life, which limits their use in controlled pulsatile drug release. More importantly, how to control insulin release is still a challenge. In this paper, chitosan poly-acrylic acid nanobubbles as drug carriers of insulin were prepared to achieve a visually controlled pulsatile release of insulin triggered by focused ultrasound. The experimental results in vivo demonstrated that nanobubbles were stable enough to achieve long-term visualization for 7 days after intramuscular injection in rats. Under the guidance of ultrasound imaging, it is visible to find the position and observe the gray values change of nanobubbles. Thus, when triggered by focused ultrasound, the amount of insulin could be accurately pulsatile released from nanobubbles. In vivo experiments in rats showed that the visually controlled pulsatile release of insulin could be achieved for a long time, up to 3 consecutive days. The blood glucose level could be repeatedly reduced by focused ultrasound irradiation with just one injection. Our research provided a promising way for visually controlled pulsatile release of insulin, which would significantly reduce the injection frequency of insulin.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Lijun Jing,Jun Lin,Qiqi Fei,Haowei Tang,Xiaodi Yang,Chong Sun
Caffeic acid (CA) and ferulic acid (FA), as the simple phenolic acids, widely exist in plants and food. In this experiment, a novel method based on graphite-like carbon nitride (g-C 3 N 4 ) and chitosan (CS) was applied to determinate CA and FA in food samples. X-Ray diffraction (XRD), fourier transform infrared spectrometer (FTIR), ultraviolet visible spectrophotometer (UV- vis ) and transmission electron microscope (TEM) were illustrated that g-C 3 N 4 was synthesized successfully and had a unique two-dimensional structure. Under the optimized conditions, including the scan rate, pH and so on, the modified electrode had a sensitive response to CA and FA in the range of 1-30 μg/mL and 5-30 μg/mL with the detection limits of 0.354 μg/mL and 4.964 μg/mL (S/N=3), respectively. The electrochemical method showed satisfactory results and provided a new approach to determinate phenolic acids with many advantages, such as rapid response, easy operation, low cost and highly sensitive.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Mi Wu,Shun Mao,Xu Liu,Yunen Liu,Peifang Cong,Jianhua Lv,Huaqin Tian,Yan Zhao
Self-gelling and bioadhesive powders offered promising effective hemostats to suit irregularly shaped, complex and non-compressible wounds for clinical applications. In the current study, chitosan based polyelectrolyte complex coacervate were simply prepared by mixing high concentrations (10 %) of low molecular weight chitosan (CS) and polyacrylic acid (PAA) solutions. Obtained by lyophilization, the physical cross-linked polyelectrolyte complex powders would form a gel within 5 s upon hydration, which demonstrated excellent mechanical properties, significant antibacterial activities, strong and lasting adhesion on wet tissues in physiological environment. In vitro blood clotting assays showed that the CS/PAA powders could remarkably aggregate blood cells and accelerate blood clotting process. As studied by diverse hemorrhage models, including rat tail, liver and heart injuries and dog incision, CS/PAA powders significantly facilitated the decrease of blood loss as well as hemostatic time by creating robust physical barriers and promoting blood clot formation on the bleeding sites. These outstanding properties in terms of easy preparation, rapid self-gelling, strong wet adhesion, effective hemostasis and shape-adaptability endowed CS/PAA polyelectrolyte complex powders with great potential in managing acute hemorrhage of non-compressible trauma.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Shan Wang,Yingxin Xu,Shufen Chen,Baoyou Shi,Haoming Xu,Wande Ding,Xin Huang,Kefeng Zhang
Due to seasonal algal outbreaks in source water, the sand filtration (SF) suffering high load exhibited poor performance in turbidity and organic matter (OM) removal. However, the filtration performance is highly dependent on the state of contaminants. This study aims to improve removal efficiency of turbidity, algae and DOM by coupling a novel green titanium sulfate-chitosan (TS-CTS) compound filter aids with/without ferrate (VI) pre-oxidation. The results indicated that the turbidity decreased to 0.25 NTU and chlorophyll a removal up to 73.5% with TS/CTS (0.8/0.3 mg/L) filter aids were utilized, while the filtration cycle was not significantly shortened. The introduced Fe(VI) (5 mg/L, 10 min) before micro-flocculation realized moderate pre-oxidation and formed in-situ Fe(III), improved algae cells removal and effectively controlled of 2-methylisoborneol (＜10 ng/L) as well as the disinfection by-product precursors as polysaccharides and amino acid-like proteins. Positively charged in-situ Fe(III) as a dual-coagulant facilitated Ti hydrolysis and promoted the clustering, cross-linking, formed Ti-AOM/NOM-Fe complexes. Under the adsorption bridging and adsorption electro-neutralization of TS-CTS and in-situ Fe(III), the microflocs were formed, migrated, adhered and ultimately retained in filter layer media. This study can provide guidance for technological and agent selection in algae-laden surface water treatment.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Ke Wang,Fayong Li,Xiaoyan Sun,Feiyan Wang,Dong Xie,Yen Wei
It is of great significance to develop natural renewable polymer materials for different applications. Herein, the nano-sized hexagonal boron nitride nanosheets (hBNNSs) were facilely exfoliated through liquid-nitrogen, microwave, and ultrasonication treatments, and novel chitosan/hBNNSs (CS/hBNNSs) films were fabricated via solution casting. The obtained transparent CS/hBNNSs films demonstrated outstanding UV shielding ability with 98.51 % UV-A and 96.40 % UV-B lights being resisted. Compared to those properties of CS film, the oxygen permeability (OP) and carbon dioxide permeability (CO 2 P) of CS/hBNNSs films are significantly lowered by 96.35 % and 94.06 %, respectively, which are much better than CS/graphene oxide or other CS nanocomposite films. Moreover, the addition of hBNNSs in CS films also obviously improves their water vapor barrier ability, thermostability , mechanical properties, and antibacterial activity . The CS/hBNNSs films and the strategy developed in this work prove their great prospect in producing high-performance packaging films with desirable excellent UV shielding and oxygen barrier qualities.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Jie Yu,Hongping Quan,Zhiyu Huang,Junbang Shi,Shihao Chang,Lilong Zhang,Xuewen Chen,Yuling Hu
The high viscosity of heavy oil made it difficult to exploit and transport heavy oil in pipeline. In this research, N -[(2-hydroxy-3-trimethylammonium) propyl] O -stearoyl chitosan tetraphenylboride (sc-CTS-st) was synthesized from chitosan, 2, 3-epoxy-propyl trimethyl ammonium chloride, sodium tetraphenylboron and stearyl chloride. sc-CTS-st contains long chain saturated aliphatic hydrocarbon, hydroxyl group and benzene ring, which could be dissolved in heavy oil fully and interacted with asphaltene. At 50 °C, the viscosity of heavy oil could be reduced to 13,800 mPa·s at most, with a viscosity reduction rate of 57.54 %. SEM and XRD showed that sc-CTS-st could affect the supramolecular accumulation structure of asphaltenes. Using FT-IR, sc-CTS-st could interact with asphaltene in the form of hydrogen bonds using the polar parts of the molecule, thereby weakening the self-association between asphaltene molecules. Molecular simulation was used to demonstrate the interaction mechanism between chitosan derivatives and asphaltenes. sc-CTS-st interacted with asphaltene through chemical bonding and influenced the self-association of asphaltene molecules. In addition, the non-polar portion of sc-CTS-st molecules could form a coating on the outside of the asphaltenes stacking structure, thus shielding or reducing the polarity of the stacking structure surface.
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Advanced Healthcare Materials
·
2023
·Vol. 12
·期 30
·2300746
·
IF 10
Jianwen Zhang,Xinyu Pei,Yihan Liu,Xianlan Ke,Ya Peng,Yajun Weng,Qinyong Zhang,Junying Chen
There is an urgent need to develop a series of multifunctional materials with good biocompatibility, high mechanical strength, hemostatic properties, antiadhesion, and anti-infection for applications in wound care. However, successfully developing multifunctional materials is challenging. In this study, two superhydrophobic composite coatings with good biocompatibility, high mechanical strength, strong antifouling and blood repellency, fast hemostasis, and good antibacterial activity are prepared on cotton fabric surface by simple, green, and low-cost one-step dip-coating technology. The results discussed in the manuscript reveals that the two superhydrophobic composite coatings can maintain good mechanical stability, strong water repellency, and durability under various types of mechanical damage, high-temperature treatment, and long-term strong light irradiation. The coatings also exhibit good repellency to various solid pollutants, highly viscous liquid pollutants, and blood. In vitro and in vivo hemostatic experiments show that both composite coatings have good hemostatic and anticlot adhesion properties. More importantly, this superhydrophobic coating prevents bacterial adhesion and growth and released Cu 2+ and Zn 2+ ions and chitosan to achieve bactericidal properties, thereby protecting injured skin from bacterial infection. The two superhydrophobic coatings enhance the antifouling, antiadhesion, hemostatic, and antibacterial functions of blood-repellent dressings and therefore have broad application prospects in medical and textile fields.
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ACS Applied Polymer Materials
·
2023
·
IF 5
Aowei Lv,Xue Lv,Song Tian,Ting Xie,Xiaoyan Xu,Shulin Sun
Conductive hydrogels, as a flexible electronic material, have found emerging applications in the fields of wearable devices, health monitoring, and electronic skin. However, the current conductive hydrogels lack antimicrobial properties and excellent mechanical properties, which severely limit their applications in wearable and biological interfaces. Herein, a conductive nanocomposite hydrogel consisting of silver nanowires (AgNWs), carboxylated carbon nanotubes (c-MWCNTs), chitosan (CS), and polyacrylamide (pAAm) was prepared by in situ free-radical polymerization without adding any cross-linking agents. Ingeniously, physical interactions (hydrogen bonding) endow the hydrogels with excellent tensile strength (503.64 kPa), ultrahigh tensile (16,000%), high toughness (22.8 MJ·m–3), and self-healing properties. Remarkably, hydrogels based on AgNWs and CS exhibit excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis. Simultaneously, under the synergistic effect of AgNWs and c-MWCNTs, the fabricated conductive hydrogel sensor exhibits excellent strain sensitivity (gauge factor = 10.42, up to 900%), high conductivity, and fast response time (200 ms). The c-MWCNTs-AgNWs-based hydrogel sensors can sensitively and stably detect human activities, which show that pAAm/c-MWCNTs@CS-AgNWs hydrogels have great potential in the fields of human activity monitoring, e-skin, and soft electronic devices.
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