INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2025
·
IF 5.2
Shulin Shen,Yanyan Zheng,Yueyue Xie,Xinzi You,Xuechao Chen,Binghui Xie,Jiaqi Weng,Qingqing Huo,Yunxiang Zhang,Meselhy R. Meselhy Zayed,Qinying Yan
Microneedle technology has emerged as a promising transdermal platform for transdermal delivery of Alzheimer’s disease therapeutics. However, conventional passive diffusion approaches face fundamental limitations in overcoming both skin and blood–brain barriers. To address these limitations, we developed a rocket-inspired gas-propelled microneedle system integrating nanostructured lipid carriers for enhanced dual-barrier penetration. The study combined fluid vortex generation with blood–brain barrier endothelial remodeling to achieve efficient drug delivery. Specifically, the system featured a hierarchical cavity design with borneol-modified huperzine A-loaded nanostructured lipid carriers (NLCs) (particle size: 89.6 ± 0.7 nm; zeta potential: –22.5 ± 0.5 mV; Hup A encapsulation efficiency: 83.40 ± 1.51 %; drug loading capacity: 2.63 ± 0.06 %) in primary cavities and a spatially isolated pneumatic initiator (ascorbic acid/sodium bicarbonate) in secondary cavities. Through multiphysics simulation coupled fluid dynamics with chemical reaction kinetics and mass transport phenomena, which revealed that acid-base reactions generate CO 2 microbubbles capable of producing rapid thrust forces. This microbubble-mediated propulsion mechanism achieved a 50 % increase in penetration depth (up to ∼ 1428 µm) relative to conventional microneedle platforms. Remarkably, this innovative hierarchical cavity design achieved a high drug loading capacity of 182 μg/array while preserving spatial isolation between the reactants and therapeutic payload. In vivo studies validated efficient brain delivery, as evidenced by a marked increase (p < 0.001) in cortical acetylcholine concentrations and amelioration of scopolamine-induced spatial memory impairments in rat models. This work established a preclinical proof-of-concept for the enhanced brain delivery of therapeutics in neurodegenerative disease through the synergistic integration of gas-propulsion physics and advanced nanocarrier engineering, offering new possibilities for overcoming biological delivery barriers.
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高影响因子
LANGMUIR
·
2025
·
IF 3.9
Yuqing Li,Can Liu,Xiaocong Tang,Bohao Liu,Wei Zhao,Yong Zhang
Metal nanoparticle surface modification is a simple and efficient method to realize highly sensitive detection for chemiresistive gas sensors. Although a few theoretical explanations for the complicated matching relationship in the sensing system constructed from the modified metal, semiconductor material, and target gas have been proposed, there are no corresponding specific evaluation parameters based on the metal sensitization mechanism, which are crucial for the guidance of high-performance sensing materials design. Herein, taking MnO2-based chemiresistive gas sensors as examples, the improvement effect of the metal nanoparticles modification on the gas-sensing properties of MnO2-based chemiresistive sensors toward HCHO and NH3 is investigated. Combined with the first-principle calculations based on density functional theory (DFT), a novel resonant coupling model based on the impurity energy levels, originating from charge transfer between target gas and metal, is first proposed to reveal the sensitization mechanism that the coupling strength between metal and target gas determines the carrier concentration of MOS. Coupling strength is closely positive correlated with the response, which provides an effective parameter to semiquantitatively describe the sensitization effect of metal nanoparticles on target gas. Our work establishes a model that clarifies the matching correlation in the sensing system and excavates new road to further comprehend the metal sensitization mechanism, which will provide an effective theoretical guide for the design of high-performance gas-sensing materials.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yu Zhang,Yuran Li,Yuting Lin,Xingfei Song,Fabing Su,Tingyu Zhu
To improve the activity of COS hydrolysis catalysts in a complex atmosphere is a significant challenge for blast furnace gas purification. Alumina-based hydrolysis catalysts were prepared with four alkali/alkaline earth metals (Na, K, Mg and Ca) respectively by the simple impregnation method to explore the chlorine-resistance mechanism of catalysts. Among four catalysts, Na/Al 2 O 3 and K/Al 2 O 3 catalysts showed a higher hydrolysis conversion of COS reaching 98 % for 12 h in the absence of HCl, due to the higher contents of weak basic sites as active sites for COS adsorption and more migratory oxygen species participating in COS hydrolysis. Especially, K/Al 2 O 3 has the highest catalytic activity in that it is easy to adsorb COS and H 2 O due to their high absolute adsorption energy. The presence of HCl inhibits the hydrolysis of COS owing to the acidification of active components and competitive adsorption with COS and H 2 O. It has been further found that HCl also inhibits the migration of oxygen species and deposition of sulfur species, but HCl still has a stronger inhibitory effect on COS hydrolysis than the deposition of sulfur species. The introduction of alkali metal as sacrificial sites protects the structure of alumina-based catalysts, avoiding the combination of HCl and Al-O to generate Al-Cl. Na/Al 2 O 3 has the best Cl-resistance mainly due to the high content of medium basic sites and great bond energy of Na-O with HCl. This research offers valuable guidance for the rational design and preparation of alumina-based catalysts with a good Cl-resistance and for the applications of blast furnace gas purification.
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POLYHEDRON
·
2024
·
IF 2.4
Wei Sun,Xue-Lu Hao,Wen-Qian Zhang,Zhen-Nan Li,Dong-Fang Zhang,Li Xu,Yi-Fan Kang
N -Oxide-functional isonicotinic acid N -Oxide (HINO) ligand has been selected to construct functional metal–organic frameworks (MOFs). And based on HINO ligand and Mn(Ⅱ) center, a novel N -Oxide-functional three-dimensional (3D) pillared microporous Mn(Ⅱ)-MOF, [Mn(INO) 2 ·CH 3 OH] n ( 1 ), has been constructed. MOF 1 has been characterized by single-crystal X-ray diffraction, powder X-ray diffraction (PXRD), thermogravimetric analyses (TGA), elemental analyses (EA) and infrared spectroscopy (IR). Structural analysis reveal that in MOF 1 , the N -Oxide group and carboxylic group of INO ligand connect Mn(Ⅱ) centers to form a one-dimensional (1D) Mn-O chain, and then the 1D chains are supported by INO ligands with two types of coordination modes to generate its 3D pillared microporous framework. Given the 1D Mn-O chains in MOF 1 , magnetic susceptibility measurements have been conducted, which show antiferromagnetic exchange interactions between Mn(Ⅱ) centers in the Mn-O chain. Given the porosity of MOF 1 and the N -Oxide sites and vacant carboxylic O sites on its pore surfaces, gas adsorption experiments of MOF 1 have been investigated by N 2 , CH 4 and CO 2 gases. MOF 1 displays good adsorption capacity, affinity and selectivity of CO 2 over CH 4 and N 2 , indicating its potential application in postcombustion CO 2 capture and gas separation.
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JOURNAL OF MEMBRANE SCIENCE
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2025
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IF 9
Huiling Wu,Liyin Fu,Xiang Li,Yongfeng Zhang,Tianjia Chen
The development of membranes capable of directly separating H 2 by harnessing the residual heat from the water-gas shift reaction represents a significant challenge in the field of membrane separation technology. In this study, an asymmetric preparation strategy was employed to construct porous membranes with ultra-thin dense layers for achieving high-efficiency H 2 separation. We developed a novel ultra-thin polymer-based dual-phase hydrogen separation membrane with a porous architecture (p-OPBI-PANI), designed for operation under elevated temperatures ranging from 120 to 300 °C. This membrane achieved an exceptionally thin dense layer of 200 nm through a non-solvent-induced phase separation (NIPS) process utilizing dibutyl phthalate (DBP), while polyaniline (PANI) nanofillers were strategically incorporated into the polybenzimidazole (PBI) matrix to enhance structural and functional properties. Systematic modulation of non-solvent and nanofiller concentrations enables precise optimization of membrane morphology and separation performance. The optimized membrane demonstrates remarkable H 2 permeance (120 GPU) coupled with exceptional H 2 /N 2 selectivity of 205, surpassing conventional polymeric membranes. Furthermore, it exhibits robust operational stability in complex gas environments containing sulfur compounds (e.g., H 2 S) and high humidity, maintaining consistent performance over prolonged operation (>100 h). This work introduces a versatile fabrication paradigm for asymmetric-polymer hydrogen separation membranes, offering significant potential for hydrogen purification in industrial applications under harsh operating conditions.
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高影响因子
SENSORS
·
2025
·Vol. 25
·期 9
·2753
·
IF 3.5
Junsheng Ding,Yingang Gui,Hua Huang
Ammonia (NH3) is a common agricultural gas, and its accurate detection is critical to agricultural production. In this study, nano-CuO/CeO2composites were prepared to achieve a wide range of ammonia detection at room temperature. Characterization data verified the composite heterojunction structure of CuO/CeO2, which demonstrates an outstanding large specific surface area for ammonia detection. It provides more active sites for NH3molecules, which brings a very high response to ammonia (70.3% @100 ppm NH3), a large detection range (0.5–200 ppm NH3), and a fast response/recovery time (13 s/17 s @20 ppm NH3). Systematic testing showed that the nano-CuO/CeO2composites also exhibit excellent extended-term stability and selectivity. Further studies showed that the p-n heterojunction structure of CuO/CeO2allowed the composite to retain its gas-sensitive properties to ammonia, in addition to the improved ammonia-detection range of the composite based on the synergistic effect of these two materials. The mechanism of CuO/CeO2heterojunction nanocomposites towards ammonia detection was also elucidated from a microscopic perspective at the molecular level. Finally, a triboelectric nanogenerator (TENG) that can be driven by wind power has been prepared, upon which the feasibility of the combination of the TENG and the ammonia sensor to realize environmental monitoring was investigated.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Yangsong Chen,Dekang You,Xin Pan,Youfang Zhang,Zhao Wang,Dean Shi,Weiwei Lei,Liqun Zhang,Robert K. Y. Li
The widespread utilization of elastomers causes severe environmental and health concerns, prompting the research of biobased high-performance elastomers for a sustainable elastomer industry. This work attempts to develop biobased elastomers with comparable properties with high-performance petroleum-based synthetic rubbers and natural rubber. A series of poly(1,5-pentylene itaconate-co-furanoate-co-ε-caprolactone) (PPeIFCL) polyesters were synthesized by using transesterification and melt polycondensation methods utilizing biomass-derived substituents. PPeIFCL polyesters were characterized in terms of chemical structure and thermal, mechanical, and gas barrier properties. PPeIFCL polyester macromolecule chains with an inherent angle of 129.4° between the carboxylates on furan moieties, combining the asymmetric poly(ε-caprolactone) diol oligomer and “odd–even” effect of the 1,5-pentanediol structure, provided adequate chain entanglements and strengthened their tensile strength and elasticity as validated by the mechanical tests and low-field NMR. Furthermore, PPeIFCLs exhibited impressive gas barrier properties compared to petrobased butyl rubber.
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ACS Sensors
·
2025
·
IF 9.1
Lihui Huang,Mengli Zeng,Yaolan Li,Zhiping Liu,Jun Zhang,Xinjian Feng
Electrochemical lactate biosensors with simultaneously high sensitivity and wide linear detection range are desirable for health monitoring. Nevertheless, the low oxygen level in biological fluids compromises oxidase enzymatic kinetics, which consequently results in a narrow linear detection range and/or low sensitivity. In this study, we addressed this issue by fabricating a solid/liquid/gas three-phase enzyme electrode with sufficiently high oxygen levels in the local reaction zone and much enhanced oxidase enzymatic kinetics. The three-phase enzyme electrode was fabricated by successively immobilizing H2O2 electrocatalyst and lactate oxidase (LOx) on a superhydrophobic porous carbon substrate. Owing to the much-enhanced oxidase enzymatic kinetics, the linear detection upper limit of the three-phase lactate biosensor was increased up to 40 mM, about 57-fold higher than that of the conventional two-phase system (0.7 mM), while a sensitivity as high as 22.28 μA mM–1 cm–2 was maintained. Moreover, a sweat lactate sensing device was fabricated based on the three-phase enzyme electrode and utilized for lactate detection in undiluted sweat during exercise. This three-phase enzyme electrode with both high sensitivity and wide linear range provides a new approach for the development of high-performance lactate sensing systems.
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高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2025
·
IF 7.8
Jing Bai,Qijia You,Yushuan Peng,Zhihao Li,Yuling Zhang,Qiulin Deng,Huiwei Liao,Faqin Dong,Xiaofeng Zeng,Zixun Yan
In this work, a novel calcium-aluminum layered double hydroxide-chitosan composite gel bead (LDH-CS) was synthesized for the efficient removal of Pb 2+ from high-salinity oil/gas field wastewater. The successful manufacture of CaAl-LDH by coprecipitation was achieved by utilizing CH 3 COONa to activate PG as an alternative to traditional calcium sources, thereby supporting the value-added use of industrial solid waste. Furthermore, the excellent compatibility between CS and LDH was confirmed through multiple characterization techniques, including SEM/EDS, FT-IR, XRD, and XPS. The greatest adsorption capability of LDH-CS was 827.9±9.6 mg g -1 under the optimal conditions of 0.2 g L -1 dosage, pH of 5, and 25 °C, as confirmed by batch experiments. Fixed-bed experiments confirmed that LDH-CS exhibits outstanding selective adsorption performance in high-salinity wastewater systems from actual oil/gas field, achieving a 99% removal efficiency for Pb 2+ . Compared with traditional powder adsorbents, the efficiency of solid-liquid separation after adsorption is substantially improved by embedding LDH powder in chitosan matrix in LDH-CS gel bead. This design prevents secondary pollution from suspended particles and ensures heavy metal release levels are well below safety limits. LDH-CS provides a practical, efficient and cost-effective technical solution for the treatment of lead-containing wastewater.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Zeng Ronghua,Zhuo Dali,Dong Xiaoyu,Tang Jiayuan,Liu Yuxin,Zhang Shu,Luo Hong,Xu Fengzhou,Zou Zhirong
Sulfide ions (S 2− ) are a hazardous pollutant present in our daily lives; thus, the accurate detection of S 2− is critical for human health. However, conventional analytical methods have the disadvantage of high costs, complex operations, and the need for laboratory analysis. In this work, a miniaturized analytical kit was established for rapid analysis of S 2− in water samples and food additives. In the presence of platinum nanoparticles (NPs), H 2 O 2 was decomposed to O 2 catalyzed by Pt NPs, resulting in a substantial increase in pressure inside the sealed reaction bottle. In the presence of S 2- , S 2− forms a Pt–S bond with Pt NPs and induces aggregation, thereby reducing the catalytic activity of Pt NPs, resulting in a decrease in O 2 production and a corresponding decrease in gas pressure. Thus, the analysis of S 2− was achieved by the measurement of gas pressure. S 2− concentrations were inversely proportional to the gas pressures within a linear range of 0.2–5 μg/mL. A portable analytical kit was fabricated for rapid analysis of S 2− in various samples, achieving recoveries of 90–109%, confirming its suitability as a potential analytical device for on-site environmental analysis and rapid food inspection. Graphical
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SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Chen Yang,Hongyan Zhang,Zhenhong Jia,Chu Chen,Haiyang Zhang,Xudong Li,Xiujuan Ma
A high-performance acetone gas sensor based on CdS/CdIn 2 S 4 (CISS) heterojunction was constructed by hydrothermal method, and the sensing mechanism of CdS on acetone adsorption was investigated through first-principles calculations grounded in density functional theory (DFT). Calculated results show that surface sulfur vacancies on the CdS facilitates the adsorption of acetone molecules, which due to the sulfur vacancy can expose a large number of Cd atoms, allowing the d electrons in the Cd atoms to participate in orbital hybridization with the p electrons in the acetone molecule. The more electrons involved in the hybridization, the higher the adsorption energy for acetone molecule. Experimental results show that the CISS2 sensor has a high response of 1350.45 for 1000 ppm acetone with good selectivity and repeatability. Furthermore, CISS2 sensor has a fast response/recovery time (13.1 s/1.85 s) to 10 ppm acetone at room temperature and achieves a low detection limit of 175 ppb. In addition, CISS2 sensor can distinguish normal people and diabetic patients by detecting the difference in acetone concentration in breath, indicating that the CdS/CdIn 2 S 4 gas sensor has potential applications in the field of personal medical services.
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高影响因子
ENERGY
·
2025
·
IF 9.4
Fei Wang,Yifan Xu,Peng Zhang,Daiming Liu,Guodong Zhang
Hydrates provide a new solution for the capture of associated petroleum gas, but poor generation efficiency of CH 4 hydrates under low pressure impedes their application. In order to achieve hydrate rapid and continuous generation under low pressure, a new hydrate generation process was presented. The thermodynamic promoters of tetrahydrofuran (THF) and 1,3-dioxolane (DIOX) were used to reduce hydrate generation pressure, while hydrate generation kinetics were enhanced by a nano promoter (-SO 3 - @PSNS), and a spiral-agitated reaction equipment was applied to achieve the integration of hydrate generation, separation and storage. Hydrate structures were evaluated by Raman spectra, and THF or DIOX hydrates were found to form first within the initial 2–5 min before CH 4 molecules enter hydrate cages. Exceptional hydration efficiencies were obtained at 1.5 MPa, and the t 90 for mixed CH 4 /THF and CH 4 /DIOX hydrates are only 29.3 min and 51.6 min, respectively. Hydrate conversion ratios in the storage tank are separately 56.9 % and 52.3 % for mixed CH 4 /THF and CH 4 /DIOX hydrates, and CH 4 storage densities increase by 185 % and 182 % compared with compressed CH 4 . Ultimately, the proposed process makes hydrate rapid and continuous generation under low pressure to be possible, it would accelerate the application of hydrates in APG capture.
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