MOLECULAR THERAPY
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2025
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IF 12
Zhixuan Wang,Xinxuan Huang,Lifan Duan,Shujie Tian,Chenxi Shi,Yongbin Mou,Heng Dong,Yu Gao,Lixing Weng
This study explores the immunomodulatory effects of amlodipine, a widely used antihypertensive, on dendritic cell (DC) maturation and anti-tumor immunity. Using flow cytometry, ELISA, and single-cell RNA sequencing, we found that amlodipine significantly promotes DC maturation, evidenced by increased CD80 and CD86 expression and upregulation of genes like CCL4 and Saa3 related to T cell activation. Furthermore, when amlodipine was administered in conjunction with indocyanine green (ICG) or doxorubicin (DOX) therapy in murine models of 4T1 breast cancer and CT26 colon cancer, we observed a notable activation of CD8 + T cell. This combination therapy also resulted in elevated serum levels of cytokines such as TNF-α, IFN-γ, and IL-12, and the upregulation of CD8 + effector memory T cells indicative of a robust systemic immune activation, which ultimately contributed to the inhibition of tumor growth and a decrease in lung metastasis. Our research elucidates the immunomodulatory role of amlodipine in enhancing DC maturation and anti-tumor immune responses, suggesting a promising avenue for future cancer immunotherapy strategies and warranting further investigation in clinical trials.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Hui Yan,Weiwei Wang,Yue Ma,Yong Shang,Lingxiu Shu,Yun Wang,Yue Xu,Bo Wu,Xingang Ren,Xianliang Wu,Gang Wang
Thermally stable x Ba 5 Si 8 O 21 - (1- x ) Ba 2 Si 3 O 8 and x Ba 5 Si 8 O 21 - (1- x ) Ba 2 Si 3 O 8 - z wt% LiF ceramics were successfully synthesized via a conventional solid-state reaction method. In the x Ba 5 Si 8 O 21 - (1- x ) Ba 2 Si 3 O 8 (0.1 ≤ x ≤ 0.8) ceramics, only Ba 5 Si 8 O 21 and Ba 2 Si 3 O 8 phases coexisted, with their phase contents confirmed by the Rietveld refinements. The 0.4Ba 5 Si 8 O 21 -0.6Ba 2 Si 3 O 8 ceramic, composed of 40.98 wt% Ba 5 Si 8 O 21 and 59.02 wt% Ba 2 Si 3 O 8 phases, exhibited near-zero τ f and moderate Q × f values. The phase composition controlled the τ f and Q × f values of x Ba 5 Si 8 O 21 - (1- x ) Ba 2 Si 3 O 8 (0.1 ≤ x ≤ 0.8) ceramics. Moreover, the addition of 3 wt% LiF as a sintering aid reduced the sintering temperature of the 0.4Ba 5 Si 8 O 21 -0.6Ba 2 Si 3 O 8 ceramic to 875 °C, while no other secondary phases were detected in the 0.4Ba 5 Si 8 O 21 -0.6Ba 2 Si 3 O 8 - z wt% LiF ceramics. The 0.4Ba 5 Si 8 O 21 -0.6Ba 2 Si 3 O 8 -3 wt% LiF ceramic demonstrated a dense microstructure and favorable microwave dielectric properties ( ε r = 7.44, Q × f = 8293 GHz and τ f = 2.37 ppm/°C), highlighting its potential for low-temperature co-fired ceramic (LTCC) applications.
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Environmental Chemistry and Ecotoxicology
·
2025
·
IF 8.2
Zelian Yu,Xiaojia Li,Xiangxiang Li,Yina Guan,Tian Gao,Kai Zheng,Chunguang Liu
Nitrate in water promotes the generation of toxic nitrogen-containing organic compounds through photochemical reactions, raising the question of whether excessive nitrogen fertilizer use may also stimulate the formation of such compounds in plants. Bisphenol F (BPF), as a widely detected bisphenol compound in vegetables, was investigated for its nitrogenous derivatives' formation and potential toxicity within plant subcellular structures. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), six BPF-derived nitrogen-containing compounds were identified. ECOSAR software analysis and mouse hepatocyte experiments confirmed that these derivatives exhibit greater toxicity than BPF. Transcriptomic analysis and validation experiments with inhibitors revealed that, compared to mitochondria and the cytoplasm, chloroplasts possess unique conditions for the generation of nitric oxide radical (NO•) and nitrogen dioxide radical (NO 2 •), which promotes the formation of BPF-derived nitrogen-containing compounds. This study highlights the need for rational nitrogen fertilizer use and monitoring of bisphenol compounds in vegetables.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.2
Meina Jin,Xiaoyue Lun,Wei Mu,Yunhe Zhao,Zhengqun Zhang
The insect olfactory system serves as a critical detection mechanism, where odorant-binding proteins (OBPs) mediate recognition by binding odor molecules, thereby regulating behavioral responses. Here, we functionally characterized three male antennal-enriched OBPs (BodoOBP2, BodoOBP4, and BodoOBP8) from Bradysia odoriphaga. Fluorescence binding assays showed that these OBPs had significantly higher affinity for three sex pheromones than for five host plant volatiles, with BodoOBP8’s affinity for linolenic acid particularly outstanding (Ki = 0.44 μΜ, pH = 5.0). Molecular docking attributed these profiles to key pocket residues. RNA interference showed that dsRNA-treated males had significantly impaired female recognition. Furthermore, host-plant attraction assays showed a reduced Chinese chive orientation in dsBodoOBP2- and dsBodoOBP4-silenced adults. Our findings suggest that BodoOBP2 and BodoOBP4 mediate both pheromone communication and host-plant detection, while BodoOBP8 mainly transports pheromones. These results advance our understanding of olfactory mechanisms in Diptera and provide molecular targets for olfactory-based management of this pest.
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Materials Reports: Energy
·
2026
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IF 16.2
Jingyuan Rao,Yinlin Chang,Tao Liu,Yibin Wang,Ye Luo,Chuang Wang,Haozhe Zhang,Shiyue Zhu,Zetian Tao
Proton-conducting solid oxide fuel cells (H-SOFCs) hold great promise for sustainable energy conversion, yet their commercialization is hindered by the poor balance between electrochemical activity and long-term thermal-mechanical stability of conventional cobalt-based cathodes. In this work, we propose a self-derived secondary phase-induced thermal expansion gradient strategy to overcome this dilemma. Taking La 0.6 Sr 0.4 Ce x Fe 1- x O 3- δ ( x =0, 0.2, 0.3) as a model system, we demonstrate that Ce doping thermodynamically drives the in-situ formation of La 0.6 Sr 0.4 Ce x Fe 1- x O 3- δ , La x Ce 1- x O 2 , and LaSrFeO 4 secondary phases, which are tightly coupled with the parent perovskite lattice. Owing to their distinct thermal expansion coefficients (TECs), these phases establish an intrinsic graded thermal expansion structure that effectively mitigates thermal mismatch, alleviates interfacial stress, and prevents delamination during thermal cycling. Microstructural analyses confirm that the gradient buffering phases form coherent interfaces and construct multi-channel ion/electron transport networks, thereby preserving structural integrity. Electrochemical measurements reveal that La 0.6 Sr 0.4 Ce 0.2 Fe 0.8 O 3- δ exhibits significantly reduced polarization resistance and accelerated oxygen reduction reaction (ORR) kinetics compared with undoped La 0.6 Sr 0.4 FeO 3- δ . The optimized composition delivers an ohmic resistance of 0.06 Ω cm 2 at 700 °C and a peak power density of 1.73 W cm -2 at 700 °C, highlighting simultaneous enhancements in activity and durability enabled by the secondary-phase-engineered TEC gradient.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Xiaomin Luo,Weihua Shen,Yonghang Liang,Shanshan Wang,Zhiyun Du
Oxyresveratrol (OXY), a plant-derived polyphenol, exhibits promising bioactivities but encounters practical constraints owing to its poor water solubility and instability. To address these challenges, OXY-loaded nanocomplexes were fabricated via the antisolvent precipitation method using zein, sodium caseinate (SC), and sodium alginate (SA) as a delivery matrix. The optimized OXY-zein/SC/SA complexes possessed a median size centered at 220 nm, a surface potential of −32 mV, an encapsulation efficiency of 83.86 %, and a loading capacity of 9.45 %. Morphological observation (using Scanning Electron Microscopy and Transmission Electron Microscopy) confirmed the formation of a spherical core-shell structure. Evidence for the strategic construction of the complex framework was provided by a convergence of Fourier Transform-Infrared spectroscopy, X-ray Diffraction, and Nuclear Magnetic Resonance spectroscopy data. Thermogravimetric and Derivative Thermogravimetry profiles showed higher decomposition temperatures, confirming enhanced stability from the structural design. Molecular dynamics simulations revealed that stable binding between OXY-zein and SC was primarily driven by hydrogen bonding and surface complementarity, while SA modulated the microenvironment through structural rearrangement and steric shielding. Kinetic modeling indicated that the incorporation of SC and SA shifted the release behavior from Fickian diffusion to a complex mechanism governed by matrix erosion and structural relaxation. The stable nanocomplexes outperformed native OXY in radical scavenging capacity while also maintaining excellent biocompatibility with Caco-2 cells and high tolerance to fluctuations in salinity and pH. These findings elucidate the formation mechanisms of the OXY-zein/SC/SA system, establishing a theoretical framework for the delivery of hydrophobic polyphenols in functional foods and nutraceuticals.
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Sustainable Energy & Fuels
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2026
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IF 4.6
Rongtao Xiao,Ling Ma,Ya Zhang,Honggui Wang,Zhe Piao
Converting carbon dioxide and water into high-value chemicals using renewable energy sources such as solar and wind power is an effective strategy to simultaneously address the depletion of fossil energy and promote low-carbon emissions and alleviate the greenhouse effect. The electrocatalytic reduction of carbon dioxide (CO 2 RR) involves a multi-proton coupled electron transfer process, including multiple steps such as CO 2 adsorption, activation and hydrogenation. Although significant progress has been made in the electrocatalytic conversion of CO 2 RR to formate, achieving formate production that combines sustained high activity, high selectivity and high stability still faces severe challenges. This study developed a high-performance electrocatalyst, Bi 2 O 3 -In 2 O 3 @CuO, which was obtained by in-situ growth of core-shell nanowire structures on Cu foams. This structure takes Cu nanowires (NWs) as the core, and the outer layer was bismuth-indium metal oxide shell. The obtained catalyst exhibited excellent performance in CO 2 RR, with a current density reaching 28.4 mA cm -2 and a Faraday efficiency of formate as high as 88.7%.
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Materials
·
2026
·Vol. 19
·期 9
·1677
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IF 3.7
Fangsheng Liu,Enming Shi,Zhiqiang Cao,Yeqing Wang,Xuemei Ou,Zhen Wang,Xinyi Han,Shiru Le,Zhijiang Wang,Chunlong Cheng,Fangjun Jin
HighlightsAn in situ reduction–oxidation reconstruction method is proposed to regenerate sinter-degraded NiO-based monolithic ceramic catalysts, effectively reversing NiO agglomeration and coarsening caused by high-temperature sintering.The reconstructed catalyst exhibits remarkably boosted activity and long-term durability for methane oxidation in ventilation air, with robust thermal cycling and reversible steam tolerance.Structural and interfacial regulation synergistically increases active site density and optimizes mass transfer, offering a feasible route to develop sintering-resistant monolithic ceramic catalysts.Monolithic ceramic catalysts are a key technology for the industrial treatment of coal mine ventilation air methane (VAM). The preparation of straight-channel NiO/CeO2monolithic ceramic catalysts via phase inversion addresses critical bottlenecks for industrial VAM abatement. However, high-temperature sintering leads to irreversible NiO agglomeration and coarsening, severely reducing catalytic activity. In this study, an in situ reduction–oxidation reconstruction method is developed to regenerate sinter-degraded NiO. The reconstructed catalyst increases methane conversion from below 70% after sintering to over 95% at 550 °C and achieves full conversion at 600 °C. The catalyst maintains near 100% conversion during 400 h of continuous operation at 600 °C and shows no performance degradation over 15 thermal cycles. Moreover, the reconstructed catalyst exhibits excellent steam tolerance with fully reversible deactivation. The reconstructed catalyst presents a refined porous structure with BET surface area rising from 4.5 to 11.4 m2g−1, an elevated Ni3+/Ni2+ratio (1.47 to 1.97), a higher surface adsorbed oxygen proportion (36.8% to 48.7%) and significantly strengthened NiO-CeO2interfacial interaction. This work provides a facile and efficient in situ regeneration strategy, greatly enhancing the VAM oxidation activity and stability of sinter-degraded monolithic ceramic catalysts.
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PHYTOMEDICINE
·
2026
·
IF 11.3
Jing-hang Li,Xian-Feng Yu,Shu-Ming Shi,Tian Lan,dan Liu,Jia-hui Leng,Li-Ying Liu,Yu-Yan He,Guan-Lin Jia,Hong-jie Xu,Il-keun Kong,Ming-Jun Zhang,Yong-Xun Jin
Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that severely impacts female fertility. The natural dihydrochalcone trilobatin (TLB) has shown potential in managing metabolic diseases; however, its therapeutic effect on PCOS and the underlying mechanisms remain unexplored. Purpose To investigate the therapeutic potential of TLB for PCOS and to elucidate the mechanistic basis, focusing on glycolytic metabolism and mitochondrial function in granulosa cells (GCs). Methods A dehydroepiandrosterone (DHEA) -induced PCOS rat model was established and treated with two different doses of TLB or metformin.Therapeutic effects were assessed based on estrous cyclicity, ovarian morphology, serum hormone levels, and the HOMA-IR index. Key targets were identified through integrated metabolomics and bioinformatics analyses. The mechanism was further validated in vitro using dihydrotestosterone (DHT)-induced primary rat GCs, combined with molecular docking, cellular thermal shift assay (CETSA), drug affinity responsive target stability (DARTS) assay, co-immunoprecipitation (CO-IP), and Seahorse metabolic analysis. Results TLB administration alleviated estrous cycle disruption, improved ovarian morphology, and normalized serum testosterone, luteinizing hormone, and HOMA-IR index in PCOS rats. Metabolomics and bioinformatics analyses identified SIRT2 as a primary target of TLB. Mechanistically, TLB targets SIRT2, promoting the deacetylation of pyruvate kinase M2 (PKM2) at the K305 site. This deacetylation enhanced PKM2 tetramerization and enzymatic activity, thereby ameliorating the glycolytic imbalance in GCs, as evidenced by reduced pyruvate accumulation and restored lactate production. Furthermore, TLB, via the SIRT2/PKM2 axis, improved mitochondrial function, supported by the recovery of ATP production, mitochondrial membrane potential, and mitochondrial permeability transition pore integrity, ultimately suppressing GC apoptosis. Conclusion Our findings demonstrate that TLB alleviates ovarian PCOS phenotypes by targeting SIRT2 to promote PKM2 deacetylation at K305, which effectively corrects glycolytic flux and restores mitochondrial function in GCs.
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Surfaces and Interfaces
·
2026
·
IF 6
Jiangzhou Kong,Baowei Wang,Daoqi Liu
This study reveals the evolution of nitrogen-doping sites in CeO₂ and establishes their key role in designing sulfur-tolerant methanation catalysts. Through controlled thermal treatments, nitrogen was introduced into interstitial (N i ) and substitutional (N s ) lattice sites and their temperature-induced interconversion was elucidated. As temperature increases, lattice nitrogen escapes as NOₓ, accompanied by a dynamic evolution of oxygen vacancies (Oᵥ) that first increases and then decreases. This site-specific N doping not only raises the electron enrichment of CeO₂ and narrows its bandgap but also strengthens interfacial electron transfer from CeO₂ to Mo species (CeO₂–MoO₃), thereby enhancing the MSI (metal–support interaction). Consequently, MoO₃ precursor particles are downsized and, after sulfidation, this size effect propagates to MoS₂, yielding shorter lateral slabs and a higher fraction of catalytically active edge sites. Performance tests show that N500–MoS₂ achieves a CO conversion of 65.8 % at 500 °C, markedly outperforming the undoped counterpart. DFT calculations corroborate that N doping significantly lowers the Oᵥ formation energy and narrows the bandgap, facilitating electronic transitions and interfacial charge transfer. These findings provide a verifiable design strategy for high-efficiency, sulfur-tolerant methanation catalysts by tuning the lattice configuration and thermal evolution of nitrogen to jointly optimize support electronic structure, interfacial interactions, and edge-site exposure.
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BIOMACROMOLECULES
·
2026
·
IF 5.9
Lukang Shi,Zongjian Zhen,Jiacong Wu,Juan Han,Lei Wang,Yun Wang,Feng Lin
Water-in-water (W/W) emulsions offer high biocompatibility for enzymatic processes but are difficult to stabilize with conventional oil–water surfactants due to their ultralow interfacial tension. Here, we design a gelatin-stabilized PEG/dextran (PEG/Dex) emulsion platform enabling integrated “reaction–separation–recovery” biocatalysis. By tuning the pH and polymer concentration, programmable microarchitectures such as core–shell, Janus, or triple-phase droplets were achieved. In cascade oxidation of guaiacol, the compartmentalized system reached an 86% yield of tetraguaiacol─50% higher than isolated phases─due to efficient product partitioning into the PEG phase while enzymes were retained in the gelatin phase. Catalytic efficiency (kcat/Km) increased by 2.20-fold for glucose oxidase and 1.31-fold for horseradish peroxidase compared to buffer. Postreaction cooling (4 °C) triggered Gel gelation, enabling enzyme recovery with >70% activity retained after 3 cycles. This fully aqueous and recyclable platform demonstrates significant potential for enzyme engineering, bioactive compound synthesis, and green manufacturing.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Biao Zhou,Jiayi Li,Yanan Chong,Tan Li,Xinyu Yang,Keyou Yan
Controlling the exposure of anisotropic crystal facets provides a promising strategy to direct the migration of photogenerated charges and improve photocatalytic performance. Nevertheless, the underlying charge dynamics resulting from facet engineering in 2D Cs 3 Bi 2 Br 9 vacancy-ordered perovskite remain poorly understood. Herein, we synthesize two distinct morphologies of Cs 3 Bi 2 Br 9 single crystals (nanosheets and nanostrips) with different ratios of exposed (001) to elucidate this mechanism. Surface photovoltage mapping, selective photodeposition, and DFT calculations jointly confirm the existence of anisotropic charge separation driven by an intrinsic facet junction electric field (∼180 meV). This electric field directs photogenerated holes to accumulate on the (001) facets for toluene activation, while electrons migrate to the (010) facets. Benefiting from this intrinsic facet junction, medium-sized Cs 3 Bi 2 Br 9 nanosheets with optimal (001) facet exposure achieve a high benzaldehyde production rate of 692 µmol·g −1 ·h −1 with 87% selectivity, significantly outperforming other morphologies. This work provides the first demonstration of facet engineering in Cs 3 Bi 2 Br 9 , establishing a crystal-orientation design principle for efficient and selective photocatalytic organic transformations.
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