Exploration
·
2025
·
IF 22.5
Qingyuan Deng,Ao Hua,Shiyou Li,Zhijie Zhang,Xiang Chen,Qiang Wang,Xing Wang,Zhiqin Chu,Xiangliang Yang,Zifu Li
An extracellular acidic environment and an intracellular mildly alkaline environment induced by carbonic anhydrase 9 (CA9) play a critical role in self-renewal, invasion, migration, and drug resistance of cancer stem cells (CSCs) within hypoxic solid tumors. Here, we report an antitumor strategy leveraging hyperbaric oxygen therapy (HBO) to regulate tumor pH and boost hydroxyethyl starch-doxorubicin-copper nanoparticles (HHD-Cu NPs) against CSCs. HBO overcomes tumor hypoxia, downregulates pH-regulatory proteins such as CA9, and leads to intracellular accumulation of acidic metabolites. As a result, HBO promotes intracellular acidification of both tumor cells and CSCs, triggering efficient doxorubicin release and the potent copper-mediated chemical dynamic effect of subsequently administered dual-acid-responsive HHD-Cu NPs. The combination of HBO with HHD-Cu NPs not only eliminates tumor cells but also inhibits CSCs, altogether leading to potent tumor inhibition. This study explores a new function of clinical-widely used HBO and establishes a novel combination therapy for treating CSCs abundant hypoxic solid tumors.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2024
·
IF 4.1
Xiao Le-Ping,Qiu Lv-Ming,Wu Zhen,Wang Guo-Jie
To realize single-stimulus-induced simultaneous multi-behaviors in hydrogels is still quite challenging nowadays. Herein, an intelligent pH-responsive hydrogel (BP4VA/PAS) with rapid and high contrast changes in color, fluorescence, and shape simultaneously is reported. The BP4VA/PAS hydrogel is fabricated by incorporating styryl anthracene derivative (BP4VA) into copolymer networks (PAS) of acrylamide and sodium 4-styrene sulfonate. Under acid conditions, the protonation of BP4VA generates a rapid change with high color contrast from yellow to red and a fluorescence switch between bright green and weak red emission. At the same time, the electrostatic interactions between 2H-BP4VA 2+ and sulfonate anions suspended on PAS trigger BP4VA/PAS hydrogels to shrink. Upon alkaline treatment, the 2H-BP4VA 2+ /PAS hydrogel deprotonates and recovers to its original color, fluorescence, and shape. Furthermore, utilizing rapid and remarkable pH-responsive properties of BP4VA/PAS hydrogels, we successfully demonstrated its applications in biomimicry, camouflage, and multistage information encryption. Collectively, this work provided an elegant strategy to develop intelligent hydrogels in applications of biomimetic smart materials and information encryption.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yueang Jin,Xueqian Zhang,Yongchun Zhu,Jiajia Ye,Yitai Qian,Zhiguo Hou
Vanadium oxide has been extensively studied as a host of zinc ion intercalation but still suffers from low conductivity, dissolution, and byproduct accumulation during cycling. Here, we hydrothermally synthesize the VO2@MXene Ti3C2 (MV) composite and find that in the MV//3 M Zn(CF3SO3)2//Zn system, the double hydroxide Zn12(CF3SO3)9(OH)15·nH2O (ZCOH) uniformly covers VO2 during the charging process and dissolves reversibly during the discharge process. In situ X-ray diffraction of the MV combined with in situ pH measurements reveals that ZCOH acts as a pH buffer during cycling, which is beneficial to the cycling stability of batteries. And the theoretical calculation indicates that the decomposition energy required by ZCOH on the MV surface is lower than that on pure VO2, which is more conducive to ZCOH dissolution. The coin battery exhibits high-rate performance of 65.1% capacity retention at a current density of 15 A g–1 (compared to 0.6 A g–1) and a long cycling life of 20,000 cycles with a capacity retention of 80.7%. For a 22.4 mA h soft-packaged battery, its capacity remains at 72.1% after 2000 cycles. This work demonstrates the active role of ZCOH in the electrochemical process of VO2 and provides a new perspective for exploiting this mechanism to develop high-performance aqueous zinc-ion battery vanadium oxide cathode materials.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Chen-Yan Hu,Xin-Yu Yang,Li-Li Hu,Hao Liu,Jia-Nan Chen,Ling-Mei Gao,Zheng-Yu Dong
The enhanced degradation mechanism of micropollutants by sulfite (S(IV)) activated permanganate (Mn(VII)/S(IV)) process under different pH conditions were investigated in this study. The Mn(VII)/S(IV) process can significantly promote the degradation of sulfamethoxazole (SMX), ibuprofen (IBU), iohexol (IOX) and acetochlor (ACE). Compared with the permanganate (Mn(VII)) process alone, the degradation efficiency of SMX, IBU, IOX, and ACE in the Mn(VII)/S(IV) process increased by 51.6 %, 38.9 %, 43 % and 78.7 %, respectively. The pH value has a significant impact on the degradation of the four target pollutants. The mechanism of the Mn(VII)/S(IV) process was further explored using SMX as a model pollutant. Hydroxyl radicals (HO•), sulfate radicals (SO 4 •− ), and reactive manganese species (RMnS, Mn(III), and Mn(V)) were detected in the process. HO• plays an important role in the degradation of SMX under acidic conditions. At pH= 7, RMnS is the main reactive species. Under alkaline conditions, SO 4 •− plays an important role in the process. Mn(III) and Mn(V) can also be converted into other manganese species. In addition, the possible degradation pathway of SMX was proposed. This work reveals the important role of pH in the generation and transformation of reactive species, and demonstrates the enormous potential of the Mn(VII)/S(IV) process in controlling micropollutants. Considering the complexity of water matrix, future studies can explore the application of the Mn(VII)/S(IV) process in practical water treatment.
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ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Jie Song,Zhiwen Yuan,Lijun Chen,Yuhua Niu,Zhiqiang Wei
For the effective removal of phenol from the environment, photocatalytic synergistic adsorption is currently one of the key methods. By leveraging the polysaccharide backbone structure of sodium alginate (SA), Zinc hydroxystannate (ZHS) was introduced into the gel structure using a co-precipitation technique. Additionally, gangue waste was repurposed through a polymerization reaction. This approach not only enhanced the specific surface area of the gel material but also compensated for its limited absorption in the visible light spectrum. As a result, the PKSPGM@ZHS was successfully synthesized. The adsorption of Ph by PKSPGM@ZHS in the dark reaction phase aligns with the quasi-second-order kinetic model and the Langmuir model, it shows that this is a spontaneous exothermic process, and its photocatalytic process conforms to the Langmuir-Hinshelwood first-order reaction kinetics model, where ZHS undergoes a series of reactions to generate ·OH radicals from ·O 2 − in the presence of photocatalysis. Ph can be degraded to CO 2 and H 2 O through a series of reactions, thereby achieving complete removal of Ph from wastewater solutions, with a removal rate reaching up to 70 %. After 5 cycles of adsorption/photocatalysis tests, KSPGM@ZHS still h exhibits a high removal efficiency, with the removal rate remaining at 54.26%. This demonstrates its excellent recyclability.
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JOURNAL OF FOOD ENGINEERING
·
2024
·
IF 5.3
Yajuan Sun,Qiubo Wang,Chen Li,Ying Wang,Yi Mao,Cheng Yang,Yunxing Li
A food-grade Pickering emulsifier was fabricated using heat-assisted pH-shifting (HP) method for enhancing the emulsion stability. The emulsification performance of the modified pumpkin seed protein isolate (PSPI) nanoparticles was initially tested. The results showed that the modified PSPI had substantially improved emulsifying capacity, with the internal oil phase volume fraction reaching up to 80%, and the emulsion remaining stable after centrifugation at 10,000 g for 60 min and 30 days of storage. The data from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), UV–visible, intrinsic fluorescence and fourier transform infrared spectroscopy (FTIR) indicated that the primary, secondary and tertiary structures of PSPI were disrupted, resulting in changes in interfacial tension, wettability, particle size, and dispersibility of the protein, which promoted the adsorption of modified PSPI nanoparticles to the surface of oil droplets and improved the emulsion stability. Overall, the HP modified PSPI is a promising Pickering emulsifier for various applications.
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NANO
·
2016
·
IF 0.951
Wei Jiang,Juan Wu,Yewen Shen,Renbing Tian,Shuai Zhou,Wei Jiang
In order to improve the effects of medical therapy for cancer, we prepared magnetic nanocomposites (Fe 3 O 4 @SiO 2 –NH–NH 2 ) as doxorubicin (DOX) carriers via two different schemes. Scheme (I): the carriers were synthesized from magnetic silica nanoparticles (Fe 3 O 4 @SiO 2 ) via layer by layer modification, scheme (II): the carriers were obtained from amino-modified magnetic silica nanoparticles (Fe 3 O 4 @SiO 2 –NH 2 ) synthesized by one-step, and followed by surface modification. In order to load DOX effectively, the surface of the carriers were further modified to make the surface with a large number of hydrazine bonds which can form a pH-sensitive bond (hydrazone bond) with DOX. The two kinds of carriers both exhibited a size around 80 nm, high stability and superparamagnetic behavior. However, DOX-loaded carriers (Fe 3 O 4 @SiO 2 –DOX(2)) performed relatively poorer performance in terms of drug loading and releasing (the loading efficiency of DOX decreased from 67.33% to 42.15%, while the releasing efficiency of DOX decreased from 66.16% to 62.23% within 72 h at pH 4.0). Water-soluble tetrazolium salts (WST-1) assays in cancer cells (Hela) demonstrated that the Fe 3 O 4 @SiO 2 –DOX presented high anti-tumor activity, while the carriers were nearly nontoxic. Thus, the results suggested that the magnetic nanocomposites synthesized by the two different methods both can be employed to deliver DOX, while the carriers obtained via the first method may perform better and would be applied in the field of cancer therapy in the future.
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ANALYTICAL CHEMISTRY
·
2016
·
IF 5.886
Hong Huang,Fangyuan Dong,Yang Tian
Intracellular pH undertakes critical functions in the formation of a proton gradient and electrochemical potential that drives the adenosine triphosphate synthesis. It is also involved in various metabolic processes occurring in mitochondria, such as the generation of reactive oxygen species, calcium regulation, as well as the triggering of cell proliferation and apoptosis. Meanwhile, the aberrant accumulation of O2•– within mitochondria is frequently intertwined with mitochondrial dysfunction and disease development. To disentangle the complicated inter-relationship between pH and O2•– in the signal transduction and homeostasis in mitochondria, herein we developed a mitochondria-targeted single fluorescent probe for simultaneous sensing and imaging of pH and O2•– in mitochondria. CdSe/ZnS quantum dots encapsulated in silica shell was designed as an inner reference element for providing a built-in correction, as well as employed as a carrier to assemble the responsive elements for O2•– and pH, together with mitochondria-targeted molecule. The developed nanosensor demonstrated high accuracy and selectivity for pH and O2•– sensing, against other ROS, metal ions, and amino acids. The remarkable analytical performance of the present nanosensor, as well as good biocompatibility, established an accurate and selective approach for real-time imaging and biosensing of O2•– and pH in mitochondria of live cells.
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NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 19
·9075-9084
·
IF 3.925
Yanping Li,Ya Liu,Li Wang,Hongsheng Lu
Polyacrylamide and its derivatives are widely used in oilfields due to their efficient viscosity building and drag-reducing properties. At present, the commonly used products of polyacrylamide include two types: polymer powder and polymer emulsions. However, the low dissolution rate of powdered products and the instability of polymer emulsions limit their application. Here, we constructed a pH-sensitive inverse polymer emulsion of poly(acrylamide-co-acrylic acid-co-2-acrylamide-2-methylpropyl sulfonic acid), showing a phase separation and phase inversion from W/O to O/W at pH < 6 and pH > 8 due to a pH-switchable surfactant N,N-dimethylcyclohexylamine/Oleic acid complex (DM–OA). The demulsification or phase inversion of the W/O polymer emulsion can release the polymer that was originally in the aqueous phase, and the released polymer can quickly dissolve in water to perform its function of viscosity building and friction reduction. Therefore, this pH-sensitive modified-polyacrylamide polymer emulsion shows a fast dissolution rate with a dissolution time of about 1 min and a long storage stability. The utilization of stimuli-responsive surfactants to construct pH-responsive water-soluble polymer W/O emulsions provides a new approach to the preparation of water-soluble polymer emulsion additives that can be quickly dissolved and stored for long periods of time in water-treatment, papermaking and oil recovery fields.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Tongyao Lin,Jinglin Zhang,Dongliang Huo,Fengjuan Yang,Jingxian Zhang,Langhuan Huang,Sui-Ping Deng,Shaozao Tan,Huifang Chen
The implantation of medical devices is frequently accompanied by the invasion of bacteria, which may lead to implant failure. Therefore, an intelligent and responsive coating seems particularly essential in hindering implant-associated infections. Herein, a self-defensive antimicrobial coating, accompanied by silk fibroin as a valve, was successfully prepared on the titanium ( [email protected] ) for pH-controlled release of Cu 2+ . The results showed that the layer could set free massive Cu 2+ to strive against E. coli and S. aureus for self-defense when exposed to a slightly acidic condition. By contrary, a little Cu 2+ was released in the physiological situation, which could avoid damage to the normal cells and showed excellent in vitro pH-dependent antibiosis. Besides, in vivo experiment confirmed that [email protected] could work as an antibacterial material to kill S. aureus keenly and display negligible toxicity in vivo . Consequently, the design provided support for endowing the layer with outstanding biocompatibility and addressing the issue of bacterial infection during the implantation of Ti substrates.
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JOURNAL OF PHARMACY AND PHARMACOLOGY
·
2018
·Vol. 70
·期 6
·797-807
·
IF 2.309
Zhao Lichun,Sun Dandan,Lu Haibin,Han Bing,Zhang Guangyuan,Guan Qingxiang
ObjectivesA system of stearic acid (SA)-modified Bletilla striata polysaccharide (BSP) micelles was developed for the targeted delivery of docetaxel (DTX) as a model anticancer drug (DTX-SA-BSP).MethodsParticle size, zeta potential and DTX release in vitro were measured in release media at different pH values. Quantitative cellular uptake, cytotoxicity assay in vitro and antitumour efficacy in vivo were also evaluated. Cell apoptosis was assessed by flow cytometry.Key findingsDTX-SA-BSP copolymer micelles displayed pH-dependent properties in the respects of particle size, zeta potential and in vitro release behaviour ranging from pH 5.0 to pH 7.4. DTX-SA-BSP copolymer micelles showed higher release rate at pH 5.0 than that at pH 6.0 and 7.4. In vitro cytotoxic effect of DTX-SA-BSP copolymer micelles was higher than that of DTX injection. The results of high-performance liquid chromatography determination confirmed that DTX cellular uptake of micelles was enhanced compared with that of DTX injection. Anticancer activity in vivo further confirmed the enhanced tumour targeting and anticancer efficacy of DTX-SA-BSP copolymer micelles.ConclusionsThe above results show that DTX-SA-BSP copolymer micelles have pH sensitivity. SA-BSP copolymers are a promising carrier for delivering hydrophobic anticancer drugs.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Ning Xu,Qinglong Qiao,Yi Tao,Pengjun Bao,Yinchan Zhang,Wei Zhou,Jin Li,Zhifeng Li,Zhaochao Xu
Subcellular pH plays a key role to modulate protein structures or specific active sites to impact diverse biological processes. The heterogeneity and high dynamics of intracellular pH require probes that can detect pH in the vicinity of the protein and have a wide pH response range. Here, we reported a protein proximity ligation fluorescent probe for super-resolution imaging of subcellular pH dynamics. Relying on SNAP-tag protein labeling technology, the pH-sensitive fluorophore BG-NDM based on photo-induced electron transfer mechanism was localized to the adjacent positions of the target protein in different subcellular organelles. The equilibrium between the non-fluorescent aggregate and the fluorogenic monomer enabled BG-NDM to have the ability of wash-free super-resolution imaging in live cells. And the wide pH response ranges from pH 6 to pH 12 made the probe have the ability of recognizing pH dynamics. The pH changes around functional proteins during mitophagy, cellular alkalosis and acidosis were revealed. Through long-term super-resolution imaging, we could further record the pH dynamics around mitochondrial proteins COX8A during mitochondrial contacts, fusion and fission at the resolution of a single mitochondria.
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