IONICS
·
2026
·
IF 3.4
Liu Xipeng,Wang Zhongjia,Zhou Zhangcai,Xin Guoxiang,Bao Jinxiao,Song Jinling
To address water pollution and limitations of existing photocatalysts, mannitol was used to fabricate tetragonal layered BiOX (X = Cl, Br, I) via a room-temperature precipitation method. Among them, BiOI with nanosheet structure exhibited broader light absorption, enhanced charge separation, and higher surface oxygen vacancies. These advantages enabled BiOI to degrade mixed pollutants (dyes, antibiotics, aromatic compounds) under visible light, achieving over 80% efficiency within 180 min. The main active species were h + and ·O 2 − . BiOI showed excellent recyclability and stability. This simple, eco-friendly synthesis offers great potential for treating complex industrial wastewater.
✓ 已验证
产品关联
DOI
高影响因子
BMC PLANT BIOLOGY
·
2026
·Vol. 26
·期 1
·1069
·
IF 5.6
Kang Wenjuan,Du Yuanyuan,Hou Wenlu,Han Yilin,Lu Baofu,Guan Jian,Shi Shangli
Background Improved symbiotic nitrogen fixation efficiency between alfalfa ( Medicago sativa L.) and rhizobia represents a green development strategy that addresses the demand for high‑quality protein, while also serving as a critical measure for safeguarding China’s food security. Currently, there is limited research on how rhizobium inoculation influences alfalfa growth and development through photosynthesis and respiratory metabolism. Furthermore, studies examining the impact of rhizobium strains with differing symbiotic effectiveness on these metabolic pathways remain scarce. Results The number of effective nodules per plant (7), nitrogenase activity (0.29 µmol·g − 1 ·h − 1 ), and leghemoglobin content (0.76 mg·g − 1 ) of the LL2 inoculation group were significantly higher than those of the QL5 group. The aboveground dry weight (0.59 g·10 plants − 1 ) of LL2 was also significantly greater than that of both the QL5 inoculation treatment and the uninoculated control. These results demonstrate that rhizobium strain LL2 is an efficient symbiotic match for ' Gannong No.9 ' alfalfa, whereas strain QL5 is an inefficient match. Metabolomic analysis revealed that, in leaves, seven differential metabolites were up-regulated in both photosynthetic and respiratory metabolism. Among these, Adenosine 5’-Diphosphate (ADP) was significantly higher in LL2 than in CK (Control) and QL5. In roots, nine differential metabolites were up-regulated. Among these, four metabolites—3-Phosphoglyceric acid, Uridine-5’-diphosphate-glucose, (2 S)-2-Isopropylmalate, and L-Glutamic acid—were present at significantly higher levels in LL2 than in both CK and QL5. Compared to the QL5 group, the LL2 inoculation group resulted in significantly higher contents of ADP in leaves and elevated levels of the root metabolites such as the photosynthetic carbon fixation intermediate 3-Phosphoglyceric acid, the glycosyl donor Uridine-5’-diphosphate-glucose, the respiration and nitrogen metabolism-related compounds (2S)-2-Isopropylmalate and L-Glutamic acid. Additionally, in nodules, the key metabolites trehalose-6-phosphate and alpha-D-glucose-6-phosphate (involved in sugar metabolism and the pentose phosphate pathway) were also significantly elevated Among these, ADP and alpha-D-glucose-6-phosphate participate simultaneously in photosynthetic, respiratory, and symbiotic metabolic pathways; 3-Phosphoglyceric acid is involved in both photosynthetic and symbiotic pathways; while (2S)-2-Isopropylmalate and L-Glutamic acid take part in respiratory and symbiotic pathways. Conclusions Following inoculation with LL2, the levels of key metabolites associated with photosynthesis and respiration underwent systematic changes in the leaves, roots, and nodules of the plants. The enhanced symbiotic nitrogen fixation and plant growth were associated with synergistic changes in the host plant’s photosynthetic carbon metabolism, respiratory energy metabolism, and nitrogen assimilation pathways. The findings of this study suggest potential strategies for enhancing nitrogen accumulation, possibly through modulating the energy balance of the symbiotic system, which could improve nitrogen fixation efficiency and ultimately increase legume yield and quality.
✓ 已验证
DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Lin Zhenyu,Chen Huanpeng,Ke Yujing,Xiao Hanyue,Li Chao,Wu Zilong,Gao Huixin,Huang Nanqi,Lu Lijuan,Sun Peng,Bian Yingjie
While iron homeostasis in cancer cells is well-established, its role in mediating crosstalk between tumors and CD8 + T cells within the tumor microenvironment (TME) remains largely elusive. In this study, we compare iron levels across primary tissues populated by CD8 + T cells. Contrary to the systemic iron deficiency commonly found in cancer patients, the TME exhibits marked iron enrichment compared to lymphatic fluid and peripheral blood, a phenomenon primarily attributed to tumor necrosis. However, this iron-overloaded TME is detrimental to CD8 + T cells, triggering their ferroptosis and dysfunction. Mechanistically, tumoral T cell receptor (TCR) hyperactivation and tumor-derived hepcidin cooperatively downregulate the iron exporter SLC40A1 in CD8 + T cells, leading to intracellular iron accumulation and ferroptosis. Both genetic restoration of SLC40A1 and iron chelation inhibit CD8 + T cell ferroptosis and restore their cytotoxic activity, thereby suppressing tumor growth. Finally, to enhance chimeric antigen receptor T (CAR-T) cell adaptability to the iron-overloaded TME, we engineer SLC40A1-overexpressing CAR-T cells. These engineered cells resist ferroptosis induced by the TME and elicit potent anti-tumor immunity.
✓ 已验证
DOI
PubMed
高影响因子
Scientific Reports
·
2026
·
IF 4.9
Jafari Seyed Mostafa,Masoum Saeed,Hosseini Elahe Seyed
In recent years, carbon dots have attracted considerable attention within the nanocarbon family due to their remarkable advantages and interesting properties such as high solubility, biocompatibility, tunable photoluminescence, and so on. Carbon dots can also be designed and synthesized according to the desired functionalities (such as sensors, biosensors, or drug delivery systems). In the present study, nitrogen- and boron-co-doped carbon dots (abbreviated as “NBCDs”) were successfully used as highly fluorescent and efficient nanocarriers to load two hydrophobic anticancer drugs, namely curcumin (CUR) and paclitaxel (PTX). The NBCDs were characterized before and after conjugation with CUR and PTX using spectroscopic techniques. After calculating the drug loading capacity (LC%) and adsorption efficiency (AE%) of the NBCDs nanocarriers, the drug release behavior was evaluated in two buffer media (pH 5.0 and pH 7.4) using the dialysis bag method for 72 h. Finally, the pH-dependent release behavior of the drugs was analyzed using several kinetic models.
✓ 已验证
DOI
PubMed
高影响因子
FIBERS AND POLYMERS
·
2026
·
IF 3.1
Niu Xuejuan,Huo Weiping,Wang Xiao,Xu Yuancheng,Lin Zheng
Regulating the interlaminar structure is an effective approach to tailoring the viscoelastic response of carbon fiber-reinforced polymer (CFRP) laminates. PEI/GnP@PEI nanofiber membranes prepared by electrospinning are embedded into CFRP laminates to modify the interlaminar region. The influence of membrane addition on interlayer microstructure is investigated, and the viscoelastic behavior of the main transition zone (MTZ) of the laminates with hybrid layup configuration is parameterized. Two quantitative indicators, the loss-modulus integral area (LMIA) and the full width at half maximum (FWHM) of the loss factor, are proposed to characterize energy-dissipation behavior and damping-response broadening of the laminates, respectively. A Williams–Landel–Ferry (WLF)-based dual-element viscoelastic model is established to describe the dynamic viscoelastic response within the MTZ. The correlation between the membrane microstructure and the MTZ-based quantitative indicators is analyzed. The results show that moderate GnP addition refines the PEI fibers, improves membrane coverage, and promotes a more uniform interlaminar network. Compared with CF/EP, the LMIA values of PEI-G0 and PEI-G1.5 increase by 64.1% and 86.3%, respectively. PEI-G2 shows a lower LMIA than PEI-G1.5, but it remains 68.5% higher than that of CF/EP. This work provides a basis for designing CFRP interleaves with improved stiffness retention and energy-dissipation behavior under dynamic thermal–mechanical conditions. Graphical
✓ 已验证
产品关联
DOI
高影响因子
Nature Catalysis
·
2026
·
IF 48.3
Su Hongyang,Zheng Jie,Mu Wenxiang,Guan Zixuan,Wang Pei,Zhang Ziyun,Meng Fanqi,Yan Xiaoying,Liu Peng,Ji Guiping,Nan Tianxiang,Zhang Hui,Cao Yidan,Liu Zhi,Lin Yuan-Hua,Li Wei-Xue,Chueh William C.,Hu Sulei,Chen Di
Understanding how atomic-scale surface structures govern catalytic pathways is central to advancing electrocatalysis yet remains poorly resolved in complex oxides. Here we develop an in situ titration platform integrating atomic layer-by-layer titration with reactivity quantification to dissect elevated-temperature oxygen incorporation reactions on (La 0.5 Sr 0.5 )FeO 3− δ . We reveal a volcano-shaped correlation between oxygen incorporation reaction activity and SrO termination layers, and find that a single-layer SrO termination maximizes performance. Microkinetic modelling and theoretical calculations reveal a rate-determining step shift with surface termination. The single-layer SrO termination optimally balances oxygen dissociation, incorporation and subsurface diffusion by modulating charge transfer and steric constraints. This platform paves the way to quantitatively correlate catalytic activity with surface atomic structures, offering atomically precise surface engineering methodologies for designing high-performance electrocatalysts in energy and environmental applications.
✓ 已验证
DOI
高影响因子
Neuroscience Bulletin
·
2026
·
IF 6.8
Chen Lin-Bo,She Xin-Yu,Jiang Xi,Wu Peng-Jian,Zheng Chang-Qing,Yao Jun
Parkinson’s disease (PD) is characterized by the progressive degeneration of midbrain dopaminergic (DA) neurons, leading to disruption of the nigrostriatal pathway and motor deficits. Here, we present an optimized protocol for generating human midbrain organoids (hMOs) suitable for homotopic transplantation, through sequential modifications. Homotopic transplantation of these optimized hMOs into the substantia nigra (SN) of 6-hydroxydopamine (6-OHDA)-lesioned PD mice resulted in significant graft survival, with a majority of grafted cells expressing the A9-specific neuronal marker GIRK2. The grafts reconstituted the nigrostriatal pathway, as confirmed by restored DA fiber density, elevated striatal dopamine levels, and retrograde AAV tracing. These structural improvements were accompanied by notable behavioral recovery, including reduced apomorphine-induced rotations, enhanced rotarod performance, and restored limb symmetry in cylinder tests. Our findings demonstrate that optimized hMOs, when transplanted into their native niche, can reestablish functional circuitry and alleviate motor deficits, providing an efficient and clinically relevant strategy for PD therapy.
✓ 已验证
DOI
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2026
·
IF 6
Liang Xiao,Wang Ying,Zhang Zhao,Zhu Maiyong,Li Songjun
Aluminum alloy is a crucial lightweight engineering material, but its performance in harsh environments is often limited by icing and corrosion. Superhydrophobic coatings offer a promising solution, yet poor durability and complex preparation hinder practical application. Herein, we address these challenges via an effective spraying strategy to construct a multifunctional integrated superhydrophobic coating on aluminum alloy. The coating combines a robust polymer matrix—comprising cross-linked epoxy resin and polydimethylsiloxane—with hydrophobically modified silica, creating a stable rough surface with low surface energy on the aluminum alloy substrate. The coating exhibits good superhydrophobic properties (with a contact angle of 153.1° ± 1.2° and a rolling angle of 6.6° ± 0.8°), appropriate mechanical durability against abrasion and peeling, high chemical stability in extreme conditions, and self-cleaning performance against representative contaminants. Electrochemical tests confirm its superior corrosion resistance (76.4% protection efficiency vs. bare Al). Notably, the coated alloy delays droplet freezing to 698 s at -10 °C and maintains a low ice adhesion strength of 52 ± 6 kPa. This work suggests a simple yet promising solution for aluminum alloy protection, integrating superhydrophobicity, durability, corrosion resistance, self-cleaning performance and anti-icing properties into a single coating.
✓ 已验证
DOI
高影响因子
IRANIAN POLYMER JOURNAL
·
2026
·
IF 2.9
Kim Ri Myong,Ryang Il Song,Oh Jun Hyok,Kim Jong Nam,Kim Yong Il,Kim Guk Chan,Ho Kuang Min,Hong Son Il,Son Ryong Chol
This study presents a sustainable approach for upcycling waste polyethylene terephthalate (PET) into a functional binder for ballpoint pen ink. PET was depolymerized via glycerolysis under systematically optimized conditions: PET-to-glycerol mass ratio of 1:1.1, catalyst loading of 0.6 wt%, temperature of 230 °C, and reaction time of 4 h. Comprehensive characterization by FT-IR, HPLC, and GPC elucidated the structural features and molecular composition of the depolymerization products. FT-IR confirmed the presence of hydroxyl end groups and preservation of ester linkages, providing evidence for a transesterification-based depolymerization mechanism. GPC analysis revealed a number-average molecular weight (M n ) of approximately 1,800 g/mol, confirming successful cleavage of PET chains into oligomeric fragments suitable for binder applications. HPLC analysis of the reaction effluent further corroborated the proposed reaction pathway, offering insights into the by-products generated during depolymerization. The formulated ink exhibited excellent performance characteristics: appropriate viscosity, rapid drying (≤ 19 s), thermal stability across − 20 to 40 °C, UV resistance exceeding 72 h, and storage stability over 340 days. These properties meet critical industry standards, demonstrating the practical viability of the upcycled product. This study successfully establishes a practical route to converting PET waste into commercially valuable materials, providing a cost-effective and sustainable alternative to conventional petrochemical binders in the stationery industry while contributing to plastic pollution reduction. Graphical abstract
✓ 已验证
DOI
高影响因子
BMC Oral Health
·
2026
·Vol. 26
·期 1
·1093
·
IF 3.8
Kim Soyeon,Lee In-Bog,Truong Van Mai,Lee Wanki,Park Young-Seok
Background This study aimed to quantitatively evaluate dentinal fluid flow reduction following brushing with desensitizing toothpastes using a sub-nanoliter fluid flow measurement system, and to determine the relationship between formulation viscosity and permeability reduction. Methods Bovine dentin specimens ( n = 10) were subjected to standardized brushing with six toothpaste slurries (Bamboo salt sensitive, Bamboo salt medicare, Colgate, Sensodyne, Median, and Reference slurry) for cumulative counts of 5,000 and 10,000 strokes under simulated pulpal pressure. The percent reduction in dentinal fluid flow (DFF) was calculated relative to baseline and a linear mixed-effects model was used to assess differences in DFF reduction among toothpastes and brushing stages. Toothpaste viscosity was measured using a rheometer and a correlation analysis was conducted to evaluate the association between viscosity and DFF reduction. Results One desensitizing toothpaste containing stannous fluoride demonstrated a significantly greater reduction in DFF compared with the reference slurry after 5,000 brushing strokes ( p < 0.05). No significant additional reduction was observed with continued brushing to 10,000 strokes, and no significant interaction between toothpaste type and brushing stage was identified. A positive association was observed between viscosity measured at 50 s⁻¹ and DFF reduction rate after 5,000 brushings (Spearman ρ = 0.77), although this association did not reach statistical significance. Conclusions Desensitizing toothpastes can induce measurable reductions in dentinal fluid flow, with stannous fluoride formulations demonstrating the greatest effect under the present experimental conditions. The majority of tubule occlusion occurred during the initial brushing phase (5,000), with limited additional benefit from continued brushing. Formulation viscosity may contribute to dentinal permeability reduction but does not appear to be the sole determinant of desensitizing efficacy.
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2026
·Vol. 33
·期 7
·294
·
IF 3.5
Fu Bingqing,Li Hongyan,Zhou Xueping,Yang Jun,Xu Yihua,Xiong Fangtao,Sha Lizheng,Zhao Huifang,Chen Xiaohong,Li Jing,Guo Daliang
To develop high-performance and environmentally friendly coating materials for self-adhesive heat-sealable paper, lignin-based waterborne polyurethane emulsion (ALWPU) was prepared by replacing 20 wt% of PPG with AlCl 3 demethylated modified lignin (AL), and used as self-adhesive coatings for kraft wrapping paper. The surface structure and physical properties of coated paper with different coating weights of ALWPU and water-based polyurethane (WPU) with AL were investigated, and the effects of heat pressing time, pressure and temperature on the T-peel strength and shear strength of self-adhesive paper were discussed and the heat-sealing process parameters were optimized by response surface methodology. The results indicated that at the same coating weight, the ALWPU coated paper exhibited significantly superior stiffness, burst strength, tear strength, dry/wet tensile strength, weather resistance, and thermal stability compared to the uncoated paper and WPU coated paper. When the coating weight was 8 g·m −2 , the coated paper with ALWPU exhibited a maximum T-peel strength of 10.6 N·cm −1 when the heat pressing time, pressure and temperature were respectively 3.3 min, 2.1 MPa, and 55°C, and the ALWPU coated paper achieved maximum shear strength of 5.8 MPa when the heat pressing time, pressure and temperature were respectively 3.3 min, 2.1 MPa and 50°C. This research provided a new insight for the high-value utilization of lignin and also provided a novel approach for efficient heat-sealing self-adhesion of paper packaging materials.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 9
·646
·
IF 5.4
Li Chunli,Zeng Linyun,Hong Ziyi,Xie Wenjia,Luo Tongxi,Pan Jialiang,Zhang Xinguo
Unique orange-emissive carbon dots (O-CDs) are synthesised via a solvothermal method by safranin T and 2,2’-dithiodibenzoic acid in ethanol. O-CDs show a maximum emission peak at 595 nm and a quantum yield of 81.63% when dissolved in dichloromethane. O-CDs are able to be fabricated into fluorescent hydrogels, powders and films exhibiting excellent fluorescence performance. The linear relationship is observed in the concentration range of 0-200 µM with R 2 of 0.9973, and the limit of detection is 0.19 µM. Meanwhile, this method is effectively utilized to analyze real food samples, such as egg yolk and milk, with recoveries ranging from 99.21% to 101.8%. Sensing mechanism is found to be the inner filter effect and dynamic quenching. Furthermore, O-CDs exhibit low toxicity and nice biocompatibility, facilitating the applications in bioimaging of B16F10-2 cells as well as zebrafish, and enabling VB12 detection in live cells. Therefore, the novel O-CDs developed present broad application prospects including food safety, biosensing, bioimaging and fluorescent films. Graphical
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）