Nature Communications
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2024
·Vol. 15
·期 1
·1-15
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IF 14.7
Zhong Tianyan,Yi Hangjin,Gou Jiacheng,Li Jie,Liu Miao,Gao Xing,Chen Sizhu,Guan Hongye,Liang Shan,He Qianxiong,Lin Rui,Long Zhihe,Wang Yue,Shi Chuang,Zhan Yang,Zhang Yan,Xing Lili,Zhong Jie,Xue Xinyu
The proper axial length of the eye is crucial for achieving emmetropia. In this study, we present a wireless battery-free eye modulation patch designed to correct high myopia and prevent relapse. The patch consists of piezoelectric transducers, an electrochemical micro-actuator, a drug microneedle array, μ-LEDs, a flexible circuit, and biocompatible encapsulation. The system can be wirelessly powered and controlled using external ultrasound. The electrochemical micro-actuator plays a key role in precisely shortening the axial length by driving the posterior sclera inward. This ensures accurate scene imaging on the retina for myopia eye. The drug microneedle array delivers riboflavin to the posterior sclera, and μ-LEDs’ blue light induces collagen cross-linking, reinforcing sclera strength. In vivo experiments demonstrate that the patch successfully reduces the rabbit eye’s axial length by ~1217 μm and increases sclera strength by 387%. The system operates effectively within the body without the need for batteries. Here, we show that the patch offers a promising avenue for clinically treating high myopia.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
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2024
·
IF 3.1
Yu Xiaohong,Wang Minyang,Wang Dujun,Wei Ming,Li Fengwei,Lyu Yongmei,Liu Jinbin
Feruloyl glycerol (FG) has a variety of biological activities, but the green synthesis methods of FG remain rare. In this study, FG was prepared by a cascade reaction catalyzed by 4-coumarate coenzyme A ligase (4CL) and hydroxycinnamoyl acyltransferase 4 (HCT4). The cascade reaction carried out at solvent water and room temperature is more convenient and greener. Firstly, the product derived from the cascade reaction was characterized by TLC, HPLC, FTIR, and ESI–MS. The results showed that the product was FG. Secondly, the effects of temperature, pH, enzyme ratio, Mg 2+ concentration, and CoA concentration on the cascade reaction were investigated. Consequently, the highest reaction rate was obtained at 30 °C, pH 6, an enzyme ratio of 1:3, and Mg 2+ concentration of 5 mM. Finally, semi-preparative scale synthesis for FG was conducted. The production of FG reached 35.1 mM at 24 h with the FG conversion of 70.18%. In a word, a novel idea for the efficient and green synthesis of FG was proposed, which had great potential for industrial application. Graphical Abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
Zhang Yuanchi,Li Cairong,Guo Along,Yang Yipei,Nie Yangyi,Liao Jiaxin,Liu Ben,Zhou Yanmei,Li Long,Chen Zhitong,Zhang Wei,Qin Ling,Lai Yuxiao
Wet-tissue adhesives have long been attractive materials for realizing complicated biomedical functions. However, the hydration film on wet tissues can generate a boundary, forming hydrogen bonds with the adhesives that weaken adhesive strength. Introducing black phosphorus (BP) is believed to enhance the water absorption capacity of tape-type adhesives and effectively eliminate hydration layers between the tissue and adhesive. This study reports a composite patch integrated with BP nanosheets (CPB) for wet-tissue adhesion. The patch’s improved water absorption and mechanical properties ensure its immediate and robust adhesion to wet tissues. Various bioapplications of CPB are demonstrated, such as rapid hemostasis (within ~1-2 seconds), monitoring of physical-activity and prevention of tumour-recurrence, all validated via in vivo studies. Given the good practicability, histocompatibility and biodegradability of CPB, the proposed patches hold significant promise for a wide range of biomedical applications.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 11
·1-11
·
IF 5.3
Wang Xueyu,Wei Xin,Tong Runze,Yi Chunhui,Wang Yidi,Fu Yang,Yan Fanyong
Novel boron-doped carbon dots (BCDs) with extended afterglow characteristics were synthesized via a one-step solvothermal method using acrylamide, sulfosalicylic acid, and sodium tetraborate as protective matrices. The presence of boron from sodium tetraborate introduced an empty orbital, allowing it to form a more extended conjugated system with adjacent oxygen atoms, thereby lowering the energy level of the lowest unoccupied molecular orbital in the system. The phosphorescence emission of these BCDs exhibits a red shift over time from 450 to 500 nm. These BCDs have been effectively utilized to produce anti-counterfeit phosphorescent powder. Additionally, the BCDs display optimal fluorescence excitation at 330 nm and optimal emission at 420 nm. They demonstrate a detection limit for ciprofloxacin hydrochloride of 37 nM in the 1-100 µM concentration range and 26 nM in the 100-210 µM range. This fluorescence detection is governed by an inner filter effect. Real sample testing further confirms that these BCDs serve as excellent sensors for ciprofloxacin hydrochloride. Graphical Abstract
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ACTA MECHANICA SOLIDA SINICA
·
2024
·
IF 2
Liu Qiuhong,Sun Shuo,Wu Xiang,Chen Zhiqiang,Guo Hongjie,Duan Chen,Wang Zhengjin
Brittle materials, such as silicon, glass, and ceramics, are widely used in engineering via adhesive bonding. The assessment of adhesive strength of brittle materials to other adherends is essential for their applications. Compared with metals and composites, for which standard testing methods have been established, the experimental method for brittle adherends has been much less explored. During the adhesive strength test, the brittleness of these materials makes them prone to failure, rather than the interface. It remains a challenge to measure the adhesive strength of brittle adherends. Here we develop an experimental method to address this issue by using a strap joint specimen with a backing layer. We use a single crystal silicon wafer and two PCB (printed circuit board) strips as adherends to make a strap joint specimen. A steel backing layer is glued to the silicon wafer to prevent the failure of silicon. This method enables the measurement of adhesive strength up to 35 MPa. In contrast, that without backing layer can only measure the adhesive strength below 10 MPa. It is found that the backing layer can reduce the stress in the silicon remarkably, while it has much less effect on the stress in the adhesive layer. We confirm that the backing layer has a negligible effect on the measured adhesive strength but expands the working space greatly. Combining finite element analysis and experiments, we establish the phase diagram for the failure modes. This work provides guidance for the measurement of adhesive strength of brittle materials.
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Journal of Natural Medicines
·
2024
·
IF 2.5
Chen Ping,Zhang Xueer,Fang Qiaomiao,Zhao Zhongxiang,Lin Chaozhan,Zhou Yuan,Liu Fangle,Zhu Chenchen,Wu Aizhi
Betulinic acid (BA), a naturally occurring lupane-type triterpenoid, possesses a wide range of potential activities against different types of cancer. However, the molecular mechanisms involved in anti-cervical cancer about BA were rarely investigated. Herein, the role of BA in cervical cancer suppression by ROS-mediated endoplasmic reticulum stress (ERS) and autophagy was deeply discussed. The findings revealed that BA activated Keap1/Nrf2 pathway and triggered mitochondria-dependent apoptosis due to ROS production. Furthermore, BA increased the intracellular Ca 2+ levels, inhibited the expression of Beclin1 and promoted the expression of GRP78, LC3-II, and p62 associated with ERS and autophagy. Besides, BA initiated the formation of autophagosomes and inhibited autophagic flux by the co-administration of BA with 3-methyladenine (3-MA) and chloroquine (CQ), respectively. The in vivo experiment manifested that hydroxychloroquine (HCQ) enhanced the apoptosis induced by BA. For the first time, we demonstrated that BA could initiate early autophagy, inhibit autophagy flux, and induce protective autophagy in HeLa cells. Thus, BA could be a potential chemotherapy drug for cervical cancer, and inhibition of autophagy could enhance the anti-tumor effect of BA. However, the interactions of signaling factors between ERS-mediated and autophagy-mediated apoptosis deserve further attention. Graphical abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
·
IF 14.7
Tang Si,Liu Yaqing,Zhu Jianming,Cheng Xueyu,Liu Lu,Hammerschmidt Katrin,Zhou Jin,Cai Zhonghua
Understanding how organisms have adapted to persist in unpredictable environments is a fundamental goal in biology. Bet hedging, an evolutionary adaptation observed from microbes to humans, facilitates reproduction and population persistence in randomly fluctuating environments. Despite its prevalence, empirical evidence in microalgae, crucial primary producers and carbon sinks, is lacking. Here, we report a bet-hedging strategy in the unicellular microalga Haematococcus pluvialis . We show that isogenic populations reversibly diversify into heterophenotypic mobile and non-mobile cells independently of environmental conditions, likely driven by stochastic gene expression. Mobile cells grow faster but are stress-sensitive, while non-mobile cells prioritise stress resistance over growth. This is due to shifts from growth-promoting activities (cell division, photosynthesis) to resilience-promoting processes (thickened cell wall, cell enlargement, aggregation, accumulation of antioxidant and energy-storing compounds). Our results provide empirical evidence for bet hedging in a microalga, indicating the potential for adaptation to current and future environmental conditions and consequently conservation of ecosystem functions.
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BioNanoScience
·
2024
·
IF 3
Tahamtan Salman,Shamsabadipour Amin,Pourmadadi Mehrab,Khodabandehloo Amir Hossein,Ghadami Azam,Fathi-karkan Sonia,Rahdar Abbas,Pandey Sadanand
Quercetin (QC), a naturally occurring antioxidant, has demonstrated potential in the prophylaxis and therapy of various cancer types. Despite its biocompatibility and minimal side effects, its therapeutic efficacy is limited by its low physicochemical stability, poor solubility, and suboptimal bioavailability. This study proposes a novel approach to address these limitations and augment the pharmacokinetics of QC, specifically its half-life and overall delivery efficacy. The W/O/W was employed to load QC into a chitosan (CS)/Starch/graphene quantum dots (GQDs)/titanium dioxide (TiO 2 ) nanocomposite, serving as a stimuli-responsive nanocarrier. The CS/Starch hydrogel was synthesized via a physical crosslinking process to optimize biocompatibility. Subsequently, GQDs and TiO 2 were incorporated to induce porosity within the system. The porosity was examined pre and post QC integration using Brunauer–Emmett–Teller (BET) analysis. The successful incorporation of QC and the crystalline properties of the resultant drug-loaded nanocomposite, CS/Starch/GQDs/TiO 2 @QC, were confirmed through Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses, respectively. Morphological evaluations were conducted using zeta potential, dynamic light scattering (DLS), and field emission scanning electron microscopy (FESEM) to ascertain the size, stability, and homogeneity of the nanoparticles. The encapsulation and loading efficiencies, along with release kinetics, were assessed under varying pH (5.4 and 7.4) and temperature (37 °C and 42 °C) conditions. The results indicated Fickian diffusion as the primary QC release mechanism, exhibiting stimuli-responsive behavior. The cytotoxicity of the CS/Starch/GQDs/TiO 2 @QC nanocomposite was evaluated against the A549 cell line using the MTT assay, demonstrating enhanced cytotoxicity compared to QC alone. In light of these findings, the study advocates for the use of the CS/Starch/GQDs/TiO 2 nanocomposite as a biocompatible, porous, and stimuli-responsive nanocarrier for the sustainable delivery of QC in lung cancer therapy.
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ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
·
2024
·Vol. 47
·期 1
·1-18
·
IF 3.2
Gong Huichun,Ke Pingchao,Zhou Yipeng,Xu Lingling,He Guang,Jian Peng
Fluoride contamination is a serious environmental problem in lepidolite hydrometallurgy wastewater. The treatment of fluoride-bearing wastewater is challenging because of the presence of coexisting ions including lithium (Li + ), rubidium (Rb + ), silicate (SiO 3 2− ), sulfate radical (SO 4 2− ). However, aluminum-modified zeolite (Al@zeolite) with sufficient hydroxyl groups and high adaptability has unique advantages for eliminating fluoride from lepidolite hydrometallurgy wastewater. Al@zeolite was prepared on natural zeolite by an atmospheric process and then used for the adsorption of fluorine from fluoride-bearing wastewater produced by the lepidolite hydrometallurgy process. The results of material characterization confirmed the successful immobilization of aluminum within the zeolite pores and indicated the formation of zeolite-Al–OH. The zeolite host significantly enhanced the chemical stability of Al@zeolite against pH changes for a wide pH range of 2.0–10.0. The adsorbent had a surface area of 33.46 m 2 /g and demonstrated excellent capacity and selectivity for fluoride adsorption. Notably, a maximum adsorption of 98.6% was observed at a pH value of 6.0 for a duration of 20 min with a fluoride content of 20 mg/L, and the equilibrium concentration decreased to 0.4 mg/L. The results of fluorine adsorption showed that fluoride uptake onto Al@zeolite agreed well with the pseudo-second-order kinetic model and the Langmuir isotherm model. The reusability of the substance was evaluated for up to eight cycles following consecutive regeneration with 0.2 mol/L AlCl 3 . The exhausted Al@zeolite was effectively regenerated through simple alkaline treatment for recycling. The above results verified that Al@zeolite is a new kind of efficient defluoridation adsorbent for lepidolite hydrometallurgy wastewater with practical application prospects.
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RARE METALS
·
2025
·
IF 11
Pan Jia-Xin,Zhao Long-Sheng,Li Zheng,Feng Zong-Yu,Liu De-Peng,Chen Jun,Huang Xiao-Wei
To achieve selective leaching of ion adsorption rare earth, it is necessary to thoroughly reveal the differences in the adsorption mechanisms of aluminum and rare earth elements. In this study, we investigated the adsorption processes of Dy and Al on the surface of K–homoionic kaolinite using batch experiments and sequential chemical extractions. The results revealed that the adsorption of Dy and Al, as well as the desorption of K, followed the Langmuir model. The maximum ion-exchangeable capacity of Dy was higher (9.39 mmol·kg −1 ) than that of Al (6.30 mmol·kg −1 ). The ion exchange stoichiometry ratios of Dy–K and Al–K derived from the Langmuir model were 2.0 and 2.6. The analysis of X-ray absorption fine structure (XAFS) and density functional theory (DFT) revealed that Dy and Al were adsorbed onto kaolinite as outer-sphere hydrated complexes via hydrogen bonds. Dy was adsorbed as [Dy(H 2 O) 10 ] 3+ , and Al was adsorbed as [Al(OH) 2 (H 2 O) 4 ] + . In particular, the adsorption of Al resulted in protonation of the hydroxyl groups on the surface of the kaolinite. Based on the above insights, the higher ion exchange stoichiometry ratios are attributed to closer adsorption distances (6.04 Å for Dy and 3.69 Å for Al) and lower adsorption energies (− 223.72 kJ·mol −1 for Dy and − 268.33 kJ·mol −1 for Al). The maximum ion-exchangeable capacity is related to the change of the surface electrical properties of kaolinite. The zeta potential was increased to − 7.3 mV as the protonation resulted from aluminum adsorption, while Dy adsorption had a minor effect, maintaining a value of − 17.5 mV. Graphical abstract
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Nature Sustainability
·
2024
·
IF 25.7
Zhao Ziming,Li Tianyu,Zhang Changkun,Zhang Mengqi,Li Shenghai,Li Xianfeng
The growing global capacity for renewable energy generation necessitates the deployment of energy storage technologies with a combination of low cost, good performance and scalability. With these advantages, aqueous organic flow batteries have the potential to be the system of choice because they could store energy from organic redox-active molecules. Here we report naphthalene derivatives as organic redox-active molecules that exhibit high solubility (~1.5 M) and a stable redox-active framework with no obvious capacity decay over 40 days (50 Ah l −1 ) in an air atmosphere in flow batteries. We report a battery that runs smoothly even under continuous airflow without obvious capacity decay for ~22 days (more than 600 cycles). A series of spectral analyses and theoretical calculations reveal that the dimethylamine scaffolds improve the water solubility and protect the active centre, ensuring the stability of the molecules during the charge and discharge process. Owing to the success in kilogramme-scale molecular synthesis, pilot-scale stack expansion with notable cycling stability over 270 cycles (~27 days) is attained. The cost benefit evidenced by technoeconomic analysis together with the stability even under open-air conditions indicates the practical value of the present molecular system in grid-scale energy storage.
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Communications Biology
·
2024
·Vol. 7
·期 1
·1-15
·
IF 5.2
Zhang Wen,Cai Shuhui,Qin Lihong,Feng Yaru,Ding Menglei,Luo Zichen,Shan Jinjun,Di Liuqing
Aconiti Lateralis Radix Praeparata ( Fuzi in Chinese) is widely used in the clinical treatment of tumors. This study aims to explore the active fractions and underlying mechanisms of Fuzi in the treatment of non-small cell lung cancer (NSCLC). Fuzi alkaloids (FZA) is prepared and found to inhibit the growth of NSCLC both in vitro and in vivo significantly. A total of 53 alkaloids are identified in FZA by UPLC-Q-TOF-MS. Proteomics experiment show that 238 differentially expressed proteins regulated by FZA are involved in amino acid anabolism, pyrimidine metabolism and PI3K/Akt-mTOR signaling pathway. Metabolomics analyses identify 32 significant differential metabolites which are mainly involved in amino acid metabolism, TCA cycle and other pathways. Multi-omics research combined with molecular biological assays suggest that FZA might regulate glycolysis through PI3K/Akt-mTOR pathway to treat NSCLC. The study lays a foundation for the anti-cancer investigation of Fuzi and provides a possible scientific basis for its clinical application.
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