Nature Communications
·
2026
·
IF 18.1
Ye Guigui,Gao Yan,Yuan Wentao,Gu Juqing,Wang Jiaqiang,Yang Yujie,Li Qianqian,Li Zhen
Precisely controlling excited-state transitions is vital for advanced technologies, particularly for sensitive, long-lived triplet states. Unlike traditional research focused on the lowest-energy excited triplet state (T 1 ), this work focuses on the high-energy triplet state (T n ), which presents significant challenges due to its short-lived and elusive nature. By implementing an annulation strategy to tailor the size, geometry, and electronic properties of the π-conjugated systems, we achieve precise control over two distinct T n -mediated pathways, T n → S 1 → S 0 and T n → T 1 → S 0 transitions, using temperature as an external trigger. This approach enables temperature-modulated blue-to-red afterglow, characterized by an exceptionally high energy gap of up to 0.76 eV between the delayed fluorescence and phosphorescence. It offers an elegant solution to resolving the key challenge in T n manipulation, providing a blueprint for developing next-generation responsive organic semiconductors with tailored excited-state behavior.
✓ 已验证
DOI
PubMed
高影响因子
Chinese Medicine
·
2026
·Vol. 21
·期 1
·138
·
IF 7.4
Lu Yao,Rong Xinqian,Wei Lini,Yang Jingwen,Zhang Kaiqi,Tan Yong,Zhao Ning,He Xiaojuan,Lu Cheng,Li Li
Background Allergic asthma (AA) may result in repeated episodes of chest constriction and coughing. In its most serious manifestations, it can cause death by asphyxiation. Currently, no efficacious therapeutic interventions exist to avert or counteract these serious outcomes. Baicalein (BAI) is a core quality marker of the traditional Chinese medicine Scutellaria baicalensis , but the mechanism of its oral action remains unclear. Objective Assess the therapeutic efficacy of BAI in AA mice models and investigate its mechanism of action. Study design and methods Evaluate the efficacy of BAI on ovalbumin-induced AA mice. To assess alterations in the pulmonary and gut microbial communities, 16S rRNA sequencing was employed. The integrity and restoration of the lung and intestinal epithelial lining were evaluated via immunohistochemistry. Furthermore, gas chromatography–mass spectrometry quantified fecal levels of short-chain fatty acids (SCFAs) in AA mice, and flow cytometry was used to analyze the content of ILC2 cells in colon tissue. Finally, the role of beneficial bacteria and their metabolites in inhibiting AA was further confirmed through fecal microbiota transplantation (FMT). Results Oral BAI effectively alleviated AA-related lung epithelial damage and microbiota dysbiosis, while elevating the production of the tight junction proteins. Moreover, BAI mitigated colonic epithelial damage, inhibited ILC2s activation in the colon, enriched the abundance of gut probiotics capable of producing SCFAs, especially Akkermansia muciniphila (A. muciniphila) , and increased the content of SCFAs such as propionic acid in feces. The FMT experiment conducted after gavage with broad-spectrum antibiotics confirmed that BAI mediated reversal of microbial dysbiosis plays a key role in the treatment of AA, significantly increasing the expression of GPR41 mRNA in colon tissue and inhibiting the activation of ILC2s. Conclusion The potential prebiotic BAI mitigates AA via targeting A. muciniphila and its metabolites, which consequently inhibits epithelial damage and type 2 immune activation. Graphical
The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
PubMed
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2014
·Vol. 117
·期 4
·2127-2132
·
IF 1.694
Tang Hongbo,Su Yuchang,Hu Te,Liu Shidong,Mu Shijia,Xiao Lihua
In this work, different compositions of lanthanum hexaboride (LaB 6 ) and tin-doped indium oxide (ITO) nanoparticles were doped into poly(vinylbutyral) (PVB) matrix to prepare PVB/LaB 6 –ITO nanocomposite (PLINC) films by a solution casting method. X-ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, thermogravimetric analysis (TGA) and ultraviolet–visible–near infrared spectroscopy (UV–vis–NIR) were employed to characterize the PLINCs. The TGA and UV–vis–NIR results reveal that the nanocomposite films possessed outstanding thermal stability. The temperature where 5 % weight loss of the PVB matrix was improved after the addition of LaB 6 and ITO particles and the property for blocking near infrared light was also enhanced as compared with the case of pure PVB film.
✓ 已验证
DOI
高影响因子
CELLULAR ONCOLOGY
·
2026
·Vol. 49
·期 2
·55
·
IF 5.6
Xin Qi,Zhang Henan,Zhao Zheng,Xu Gang,Zhang Jihong
Purpose This study aims to investigate the role of AGAP2 in acute myeloid leukemia (AML), particularly its involvement in lipid metabolic reprogramming and AML progression, and to explore the underlying regulatory mechanisms. Methods AGAP2 expression was analyzed in CD34⁺ cells from AML patients stratified by cytogenetic risk. Functional assays, including knockdown and overexpression of AGAP2, were performed in KG-1 and HL-60 AML cell lines to assess effects on proliferation, apoptosis, differentiation, and lipid metabolism. mRNA sequencing and KEGG pathway analysis were used to identify relevant signaling pathways. Lipid accumulation was evaluated via Filipin III staining. The AMPK pathway activator GSK621 was applied to examine lipid deposition. In vivo tumor growth and survival were studied in a mouse model, and bone marrow infiltration of CD45⁺ cells was analyzed. The transcriptional regulation of AGAP2 by NR2F2 was assessed through promoter binding and functional rescue experiments. Results AGAP2 was highly expressed in CD34⁺ cells from AML patients, with higher levels in the poor-risk group compared to favorable- and intermediate-risk groups. Knockdown of AGAP2 induced apoptosis and differentiation, while its overexpression promoted cell proliferation. KEGG analysis indicated enrichment of differentially expressed genes in the AMPK pathway. AGAP2 was found to inhibit AMPK/ACC pathway activation. Overexpression of AGAP2 increased lipid deposition whereas GSK621 treatment reversed it. In vivo, AGAP2 knockdown suppressed tumor growth, improved survival, and reduced CD45⁺ cell infiltration in bone marrow. Furthermore, NR2F2 bound to the AGAP2 promoter and suppressed its transcription. NR2F2 overexpression reduced lipid accumulation, an effect reversed by AGAP2 overexpression. Conclusion AGAP2 promotes lipid deposition and AML progression by inhibiting the AMPKα/ACC pathway. NR2F2 acts as a transcriptional repressor of AGAP2, thereby attenuating AML development. These findings reveal a novel NR2F2/AGAP2/AMPK/ACC regulatory axis in AML, highlighting potential therapeutic targets for lipid metabolism-based interventions in leukemia. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chinese Medicine
·
2026
·Vol. 21
·期 1
·87
·
IF 7.4
Li Yuan,Han Dongyang,Liu Junjie,Qiao Yuxin,Wei Jiaoxia,Lu Haitao,Yao Li
Background Pulmonary hypertension (PH) is a severe pulmonary vascular disease lacking early diagnostic biomarker and effective therapeutics. Osthole has capability to alleviate pulmonary vascular remodeling targeting by decadienyl-L-carnitin (C10:2) in PH rats. We sought to explore the novel functional mechanism of C10:2 in cell proliferation, apoptosis, extracellular matrix remodeling, and energy biosynthesis of pulmonary vascular remodeling as well as new inventional mechanism of osthole. Methods Animal and cell models of PH were established using monocrotaline (MCT) and platelet-derived growth factor-BB (PDGF-BB). C10:2 biosynthesis was manipulated through the administration of exogenous C10:2 and etomoxir. Markers of pyroptosis and pulmonary vascular remodeling, as well as components of the C10:2/HSP47/NLRP3 axis, were evaluated using western blotting, ELISA, and biochemical assays. Results Osthole inhibited cell pyroptosis and alleviated pulmonary vascular remodeling by suppressing the expression of NLRP3, GSDMD, Caspase-1, IL-1β, IL-18, and C10:2 in PH rats. Additionally, C10:2 levels were positively correlated with the progression of pulmonary vascular remodeling in a time-dependent manner. C10:2, similar to PDGF-BB, promoted the proliferation of pulmonary arterial smooth muscle cells (PASMCs), accelerated extracellular matrix remodeling, inhibited apoptosis, activated AMPKα-1, and increased ROS accumulation, ultimately leading to mitochondrial dysfunction in PASMCs. Osthole attenuated C10:2-induced pulmonary vascular remodeling by downregulating proliferation markers (PCNA, cyclin A, CDK2), modulating apoptosis markers (Caspase-3, Bax, Bcl-2), inhibiting migration-related proteins (MMP2, MMP9, TGF-β), and reducing AMPKα-1 and ROS overaccumulation as well as HSP47 expression. Collectively, our findings reveal a novel role for C10:2 in accelerating pulmonary vascular remodeling by promoting proliferation, apoptosis resistance, extracellular matrix remodeling, and mitochondrial dysfunction through NLRP3 inflammasome activation. Mechanistically, osthole significantly inhibited pyroptosis and mitigated pulmonary vascular remodeling via the C10:2/HSP47/NLRP3 axis. Conclusion Our study identifies a novel function of C10:2 in promoting pyroptosis and accelerating pulmonary vascular remodeling through activation of the HSP47/NLRP3 axis. Furthermore, we demonstrate that osthole effectively inhibits C10:2/HSP47/NLRP3 axis-induced pyroptosis, thereby alleviating pulmonary vascular remodeling. These findings suggest that C10:2 may serve as a potential biomarker for PH diagnosis and provide a foundation for the development of novel anti-PH therapeutic strategies. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 6
·460
·
IF 3.2
Li Caixia,Ji Nan,Li Chenglong,Li Tianqi,Lu Peng,Ren Shuang,Ma Xiaoxuan
BiFeO 3 -BaTiO 3 (BF-BT) ceramics have emerged as a prominent research focus in the lead-free materials field in recent years due to their high Curie temperature and excellent ferroelectric and piezoelectric properties. In this work, 0.68BiFeO 3 -0.32BaTi 1- x (Fe 0.5 Nb 0.5 ) x O 3 + 0.1 wt.% MnO 2 ceramics (abbreviated as 0.68BF-0.32BT(FN) x -Mn, x = 0, 0.01, 0.02, 0.03, 0.04) were prepared by the conventional solid-state reaction method. The effects of Ti-site (Fe 0.5 Nb 0.5 ) 4+ substitution on the crystal structure, microstructure, dielectric, ferroelectric, and piezoelectric properties of 0.68BF-0.32BT ceramics were systematically investigated. It is confirmed from the XRD results that all the compositions consist of diphasic tetragonal (T) and rhombohedral (R) phases. Increase of B-site (Fe 0.5 Nb 0.5 ) 4+ substitution induces an expansion of unit cell volume, reduces the ferroelectric–paraelectric phase transition temperature ( T m ) monotonically from 471 °C at x = 0 to 445 °C at x = 0.04. The average grain size and piezoelectric properties increase by the substitution 2.0 mol% (Fe 0.5 Nb 0.5 ) 4+ complex cations for Ti 4+ in 0.68BF-0.32BT ceramics. Notably, the piezoelectric properties of this ceramic are improved through the grain size effect. Specifically, the 0.68BF-0.32BT(FN) 0.02 -Mn ceramics display optimal comprehensive electrical performance with T m = 461 °C, P max = 26.4 µC/cm 2 , P r = 18.1 µC/cm 2 , E C = 23.0 kV/cm, d 33 = 151 pC/N, k p = 0.298, Q m = 50.32, demonstrating the potential viability of BF-BT ceramics for high-temperature lead-free piezoelectric applications.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 15
·10173-10191
·
IF 4.4
Liu Zeng,Wu Fang,Zheng Liwei,Sun Xu,Xia Chenghui,Song Hongbing,Zhang Shuai,Qu Xiaofei,Shi Liang
Core–shell Bi 4 NbO 8 Cl@C plate-like heterostrutured photocatalysts were successfully prepared by one-step hydrothermal process, during which glucose solution exhibited reducibility and created amounts of oxygen vacancies for Bi 4 NbO 8 Cl, while a carbon layer was in situ deposited on Bi 4 NbO 8 Cl by glucose decomposition. The structure of Bi 4 NbO 8 Cl was stabilized and armored by the thickness-tailored C layer, which provides a superior performance in the removal of acidic Cr(VI)-contained contaminant water, and the optimal Bi 4 NbO 8 Cl@C achieved 373 folds than pristine Bi 4 NbO 8 Cl in photocatalytic Cr(VI) removal. Experimental results and density functional theory (DFT) calculations show that C layer is tightly coated on the surface of BNC. Furthermore, C–O covalent bonds, which act as electron transfer channels, are formed at the interface of BNC and C layer. This study provides an important reference for the synthesis of core–shell structured photocatalysts and the efficient removal of Cr(VI) from industry wastewater. Graphical
✓ 已验证
产品关联
DOI
高影响因子
Journal of Saudi Chemical Society
·
2026
·Vol. 30
·期 2
·19
·
IF 5.2
Zhang Qiuyun,Wu Hanhong,Chen Lianlian,Chen Liangfu,Fan Li,Deng Taoli,Ma Juan,Zhang Yutao
Metal–organic frameworks (MOFs) are recognized as a pivotal role in catalysis. Through control of MOFs synthesis conditions (e.g., time, temperature, ligand content, and agent type), offering the potential for improving catalytic performance and broadening application prospects of porous MOF-based composites. Based on this rationale, a series of HPW@UiO-67 catalysts with different organic ligand concentrations was fabricated via a simple one-pot hydrothermal method and evaluated for esterification activity. Characterization techniques such as FTIR, XRD, N 2 physisorption, SEM, EDX, TG, NH 3 -TPD, Py-FTIR, and XPS were systematically analyzed to determine the physicochemical properties of the synthesized composite catalysts. These analyses confirmed that the concentration of H 2 bpdc ligands significantly influenced the porous characteristics, surface morphology, and catalytic performance of the composites. Among the catalysts tested, the HPW@UiO-67–1 catalyst with the addition of 2 molar quality of H 2 bpdc exhibited superior activity in the production of biodiesel from oleic acid (OA) esterification than that of other synthesized catalysts, achieving a 93.9% conversion, which was primarily attributed to their mesopore surface area (465.8 m 2 /g), available multi-scale pore morphology structure, high acidity capacity (0.95 mmol/g), and abundant Brønsted and Lewis acidic sites. The optimal catalyst of HPW@UiO-67–1 exhibited good stability, and the cyclic experiments showed that the composite catalyst retained over 80% of its activity after four consecutive times. This work validated the synthesis strategic design of porous MOF-based hybrid materials for sustainable and efficient biofuels production. Graphical
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 4
·239
·
IF 5.4
Li Guangyan,Cheng Xiu,Zhu Minnan,Tian Yayang,Chen Linfeng
To address the need for rapid detection of profenofos (PFF) residues, we developed a self-cascaded colorimetric sensor using the bifunctional nanozyme Ce-UiO-66@His, prepared by doping histidine (His) into Ce-UiO-66. The introduction of His optimized the valence state distribution of cerium and increased the concentration of oxygen vacancies, thereby endowing Ce-UiO-66@His with enhanced phosphatase-like and laccase-like activities. Crucially, these two enzymes can efficiently catalyze in sequence under the same catalytic conditions, thereby achieving an integrated self-cascaded catalytic reaction of PFF. Specifically, the phosphatase-like activity hydrolyzes PFF to generate 4-bromo-2-chlorophenol, which is then oxidized by the laccase-like activity and coupled with 4-aminoantipyrine to form a red quinone-imine dye with strong absorbance. This self-cascaded, dual-recognition system provides exceptional selectivity and high sensitivity for PFF, with a detection limit of 0.71 µg/mL. Furthermore, by integrating smartphones and RGB recognition, a portable photo-colorimetric method was developed that realizes rapid and visual quantification of PFF. This work not only presents a new strategy for rapid monitoring of PFF residues but also offers insights into designing efficient biomimetic self-cascaded sensing systems. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Materials
·
2026
·
IF 7.7
Qian Changjin,Ma Minjun,Cheng Yanyang,Zhou Yan,Lv Shanshan,Li Feng,Yang Xiaobo,Wu Qikang,Wang Jin,Chen Zheng
The metal-support interactions (MSIs) play a significant role in regulating the electronic structure of metal species on oxide; however, they are often overlooked on carbon-based supports. In this work, hollow nitrogen-doped carbon (H-NC) supported Ru nanoparticles catalyst (Ru/H-NC) was prepared by a solvothermal method using H-NC as support and RuCl 3 as precursor. Subsequently, Ru/H-NC was annealed at different temperatures (Ru/H-NC t °C) to adjust the effect of MSIs between H-NC support and Ru nanoparticles. The X-ray photoelectron spectroscopy results showed that the MSIs between Ru species and H-NC support increased with the increase of temperature, and more electrons were transferred from Ru species to H-NC support, thus regulating the valence state of Ru. In hydrogen evolution reaction (HER), the as-synthesized Ru/H-NC 300 °C merely requires overpotential of 35.45 mV to achieve 10 mA/cm 2 at low Ru mass loading of 24.03 µg/cm 2 on the glassy carbon electrode. The cyclic voltammetry test revealed that the electrochemically active surface area increased first and then decreased with the increasing MSIs. Moreover, electrochemical impedance spectroscopy results showed that HER kinetics of Ru/H-NC t °C catalysts increased first and then decreased with the MSIs enhancement. The density functional theory calculations confirmed that the MSIs effectively optimize the adsorption strength of the key intermediates (H*, HO*) on Ru clusters, and thus greatly improve the catalytic performance of Ru/H-NC in HER.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 7
·517
·
IF 3.2
Zhu Guosong,Li Xiaoyuan,Pan Wenqian,Zhou Wei,Luo Heng,Hu Yue,Fan Xiaomeng,Li Yang
As electromagnetic environments become more complex, the design of novel electromagnetic wave absorbers (EWMs) that combine low-frequency absorption with multi-frequency response remains a significant challenge. Experimental validation demonstrates that controlling the crystallinity and morphology of the ZnO coating layer through process temperature can significantly influence the electromagnetic properties of YCo composite materials. Nevertheless, the establishment and description of the intricate relationship between process temperature and electromagnetic response remains a formidable challenge. In order to address this issue, a data-driven modeling and inverse design framework (SSA-GRNN-PSO) integrating sparrow search algorithm (SSA), generalized regression neural network (GRNN), and particle swarm optimization (PSO) is proposed based on limited experimental data. This framework facilitates precise prediction of the complex electromagnetic parameters of ZnO@YCo composites at varying processing temperatures. When combined with a multilayer structural design concept, it achieves multi-band inverse design. The final composite material, with a thickness of 19.1 mm, exhibited strong multi-band absorption characteristics, with a bandwidth of 7.452 GHz, and a reflection loss of − 25.47 dB in the 2–18 GHz range. Moreover, an optimized design with a thickness of 5.4 mm was achieved, which features a bandwidth of 7.416 GHz and a reflection loss of − 15.72 dB.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 7
·495
·
IF 3.2
Xie Yaochen,Liu Guangli,Wu Shiqi,Xu Zicong,Ye Jianheng,Qian Yannan
The development of deep-blue emitting perovskite quantum dots (PeQDs) has been significantly hindered by the surface defects and halide migration. To overcome these problems, a synergistic strategy combining strong quantum confinement and mixed-halide engineering was proposed to achieve highly efficient deep-blue emission. An excellent multidentate ligand 1-carboxymethyl-3-methylim-idazolium chloride (HOOCMIMCl) was introduced into CsPbBr 3 QDs, resulting in ultra-small monodisperse particles with an average diameter of 4.2 nm. The ultra-small CsPbBr 3 QDs exhibited deep-blue emission at 457 nm with a high photoluminescence quantum yield (PLQY) of 77%. Based on density functional theory (DFT) calculations and experimental results, HOOCMIMCl ligand also passivated uncoordinated Pb 2+ by C = O and reduced bromine vacancies (V Br ) through C = N in imidazole ring, improving the PLQY and stability of CsPbBr₃ QDs. It opens a new pathway for realizing highly efficient deep-blue emitting PeQDs with a tunable emission wavelength and offers a research basis for advancing high-performance PeLEDs in the deep-blue region.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）