INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Hai Wang,Yeqing Wang,Hua Xu,Hang Zhou,Liang Wang,Xiangju Meng,Feng-Shou Xiao
Hydration of nitriles has been practically used for the production of amides, wherein the homogeneous catalysts including acids/bases and metal complexes are generally employed. Here, we report that nanorod manganese oxide (NR-MnO2) as a sustainable and low-cost heterogeneous catalyst is highly active and selective for the hydration of aromatic, heterocyclic, and aliphatic nitriles into the corresponding amides. The catalytic properties of NR-MnO2 significantly outperform that of commercial Pd/C and Ru/C catalysts and even the state-of-the-art homogeneous catalysts in the literature. In the continuous recycling tests, the NR-MnO2 catalyst exhibited excellent durability with negligible deactivation, which offers a good opportunity for practical production of these chemicals in the future.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 46
·27032-27041
·
IF 3.049
Ding Ding,Bowei Du,Chao Zhang,Fakhar Zaman,Yaqin Huang
To date, many researchers have developed active components that are derived from seafood processing for the purposes of healthcare. Here, an antioxidant collagen peptide was obtained from skipjack tuna (Katsuwonus pelamis) bone by using a combination of trypsin and chymotrypsin as the catalyst. The amino acid sequence of the peptide was identified as Ser–Ser–Gly–Pro–Pro–Val–Pro–Gly–Pro–Met–Gly–Pro–Met–Gly–Pro–Arg (SSGPPVPGPMGPMGPR) by liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry (LC-ESI-QTOF-MS) analysis. We found that the as-prepared collagen peptide can efficiently scavenge DPPH radical (IC50 3.149 mM), superoxide anion radical (IC50 3.803 mM) and ABTS radical (IC50 9.489 mM). In addition, it has been found that the methionine (Met) residue in the collagen peptide could provide a precise active site during the scavenging of DPPH radicals by Fourier transform infrared spectroscopy (FTIR) analysis and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry analysis. These results suggest that the peptide can find wide uses in the food, cosmetic and pharmaceutical industries.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Yulin He,Ying Li,Yaochun Liu,Nianchun Yao,Jiamei Li,Yang Liu
Inspired by the WO 3 transition metal semiconductor, a simple liquid phase WO 3 coating strategy is introduced to improve the surface stability of LiNi 0.5 Co 0.2 Mn 0.3 O 2 . The electrochemical performance of WO 3 -coated LiNi 0.5 Co 0.2 Mn 0.3 O 2 is improved at both a high cut-off voltage (4.5 V) and high temperature (50 °C). With the WO 3 (0.6 wt%) coating amount optimized, the material capacity retention is maintained at 138 mAh g −1 and 170.9 mAh g −1 at 25 °C and 50 °C after 200 cycles compared with 107.8 mAh g −1 and 143.9 mAh g −1 , respectively, for pristine NCM523. The WO 3 -coated sample also exhibits a better rate capability, maintaining 126 mAh g −1 at 25 °C in the voltage range of 3–4.5 V at the current density of 5 C. The enhanced properties of the WO 3 -coated LiNi 0.5 Co 0.2 Mn 0.3 O 2 due to the WO 3 coating layer result from the interface that prevents immediate contact between the electrolyte and the active material as well as the lower polarization and electrochemical resistance of the battery. SEM, TEM, XPS and EIS further reveal these improved electrochemical performances, which indicate the success of the approach for regenerating NCM523.
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2019
·
IF 5.026
Qian Lei,Junjian Zheng,Jinxing Ma,Xueye Wang,Zhichao Wu,Zhiwei Wang
An electrochemical dynamic membrane filtration (EDMF) system for simultaneous solid-liquid separation (also protecting electrodes against fouling) and sewage disinfection was developed. At a low voltage of 2.5 V, efficient disinfection performance was achieved in the EDMF, with ~100% log removal efficiency (no detectable bacteria in the effluent). Results also demonstrated that the EDMF system, operated at membrane flux of 100 L/(m 2 h), could maintain long-lasting bacterial disinfection efficiency of real wastewater (~100% log removal) in continuous flow tests. Transmembrane pressure (TMP) increased from 0.8 kPa to 22 kPa within 80 d (one operation cycle), and cleaning of EDMF could effectively restore TMP and biocidal behaviors for subsequent filtration cycles. In contrast, without dynamic membrane, the disinfection efficiency was decreased from initial ~100% log removal (with no detectable live bacteria) to ~44.4% log removal within 7 d. Reactive oxygen species (ROS)-mediated oxidation was responsible for bacteria disinfection in the EDMF, and HO• and H 2 O 2 generated in this system played a dominant role, causing damage to cell membranes and K + leakage from cytosol. Moreover, catalase and superoxide dismutase for intracellular ROS attenuation were inhibited, resulting in the increase of intracellular oxidative stress and thus high-efficient disinfection. These results highlight the potential of EDMF system to be used for wastewater treatment and disinfection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Carbon Letters
·
2019
·Vol. 30
·期 4
·389-397
·
IF 1.807
Liu Guijing,Shi Yanying,Wang Lei,Song Yadong,Gao Shanmin,Liu Dong,Fan Leqing
Polypyrrole (PPy) decorated on reduced graphene oxide (rGO) films is successfully prepared with pyrrole (Py) monomers and rGO through one-step combining oxidation with polymerization reaction. Compared with the pure individual components, rGO/PPy compound turns out better electrochemical characteristics owing to the introduction of rGO sheets, which improves the specific surface area and the conductivity of composite material. When the amount of rGO is 10% of the total, the rGO/PPy compound delivers the best capacitance of 389.3 F g −1 at 1.0 A g −1 in a three-electrode system and 266.8 F g −1 at 0.25 A g −1 in the symmetric supercapacitor system. In addition, asymmetric device (rGO/PPy//AC) has been successfully fabricated using optimized rGO/PPy compound as positive electrode, activated carbon as negative electrode (AC) and 1 M Na 2 SO 4 aqueous solution as electrolyte. The device obtains long cycle stability under the high-voltage region from 0 to 1.6 V, meanwhile displaying the satisfied energy density of 19.7 Wh kg −1 at 478.1 W kg −1 . Besides, the rGO/PPy//AC device presents satisfactory rate capability and long life time.
✓ 已验证
产品关联
DOI
高影响因子
Materials Express
·
2019
·Vol. 9
·期 7
·741-748
·
IF 1.465
Chi Kuan-Neng,Hu Rong,Yang Yun-Hui
In this work, a neoteric photoelectrochemistry (PEC) sensor on account of perylenediimide (PDI) by coupling with ascorbic acid (AA) responsive decomposition of cobalt oxyhydroxide (CoOOH) nanosheets was developed. PDI is a kind of organic photoelectric material with strong photoelectrochemical
properties in aqueous solution. When the surface of the PDI is modified by CoOOH, the photoelectric properties of the PDI could be effectively decreased. However, when AA is present, CoOOH is reduced to Co2+ while the photoelectric properties of PDI are restored. The photoelectric
sensor constructed thereby exhibits high selectivity and transient response, and is simple in operation, low in cost and short in time, and provides a novel detection method for small molecule ascorbic acid. In the case of a signal-to-noise ratio of 3, the detection limit is 33.4 nM. This
paper opens a new PEC method to detection of AA.
✓ 已验证
产品关联
DOI
高影响因子
ORGANIC ELECTRONICS
·
2020
·
IF 3.31
Shuo Wang,Yu Zhu,Chengyan Wang,Ruixin Ma
Inverted perovskite solar cells with NiO x hole transport layer (HTL) have attracted abundant attention due to low-cost fabrication and high device-efficiency. However, the further development of NiO x -based inverted perovskite solar cells (PSCs) would be restricted by the unsatisfactory electrical properties in pristine NiO x and the non-ideal charge transfer between perovskite and NiO x . In this work, a facile and effective method was designed to regulate the electronic property of NiO x HTL and make an alteration to the interface between the perovskite and NiO x . NH 4 F was used as an interfacial modifier to enhance the charge transfer between the perovskite layer and NiOx. The NiO x -F layer was generated with high transmittance and low trap density . Besides, the power conversion efficiency of the device was improved from 17.17% to 18.94% with the improvement of short-circuit current (J sc ) by using the structure of ITO/NiO x /NH 4 F/MAPbI 3 /PCBM/BCP/Ag. Finally, the device with NH 4 F exhibited better stored stability in the dry condition compared with the control device.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Weidong Han,Linlin Shi,Binbin Xie,Jianqin Wan,Lulu Ren,Yuchen Wang,Xiaona Chen,Hangxiang Wang
Combinatorial regimens that rationally pair molecular inhibitors with standard cytotoxic chemotherapeutics are used to improve therapeutic outcomes. Simultaneously engineering these therapies within a single nanocarrier that spans cytotoxic, antiangiogenic, and anti-invasive mechanisms and that enables the delivery of unique drug combinations remains a technical challenge. In this study, we developed a simple and broadly applicable strategy in which ultrastable cytotoxic nanoparticles with an established excellent antitumor efficacy and π-rich inner core structure supramolecularly stabilized the antiangiogenic molecular inhibitor apatinib to create a synergistic drug delivery system (termed sTKI-pSN38). This small-sized nanoparticle accomplished the sequential release of both encapsulated drugs to exert antimetastatic, antivascular, and cytotoxic activities simultaneously. In xenograft models of hepatocellular carcinoma, a single intravenous administration of sTKI-pSN38 elicited robust and durable tumor reduction and suppressed metastasis to lymph nodes. Interestingly, sTKI-pSN38 treatment alleviated intratumoral hypoxia, which could contribute to impaired tumor metastasis and reduced drug resistance. Collectively, this nanotherapeutic platform offers a new strategy for cancer therapy by simply engineering a drug cocktail in conventional nanoparticles and by enabling the spatiotemporal modulation of drug release to enhance the synergy of the combined drugs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2019
·
IF 10.273
Lu Lu,Xiaojing Zhao,Tiwei Fu,Ke Li,Ye He,Zhong Luo,Liangliang Dai,Rui Zeng,Kaiyong Cai
Various obstacles impede the chemotherapy efficiency of glioma in clinic, such as blood brain barrier (BBB) and blood brain tumor barrier (BBTB). Ligand-mediated polymeric micelles have shown great potential for improving the efficiency of glioma treatment. Herein, we developed a disulfide bond-conjugated prodrug polymer consisted of camptothecin (CPT) and polyethylene glycol (PEG) with further modification of iRGD peptide. The polymer of CPT-S-S-PEG-COOH could self-assemble into nanosized polymeric micelles with diameter around 100 nm, and loaded with photosensitizer IR780 for combination therapy. The micelles displayed good stability with controlled drug release under physiological environment. Importantly, the iRGD modified polymeric micelles demonstrated favorable ability to cross the BBB and target glioma cells via αv β integrin and neuropilin-1-mediated ligand transportation in vitro and in vivo . The whole synthesis process is simple and the drug loading content of CPT in the [email protected] micelles was higher than 10%. Moreover, [email protected] micelles combined chemotherapy with photodynamic therapy (PDT) displayed more excellent tumor-killing capability than the other groups. Thus, both in vitro and in vivo studies suggested that the targeting prodrug system could not only effectively cross various barriers to reach at glioma site, but also significantly enhance the antitumor effect with laser irradiation . Our findings consequently suggested that [email protected] micelles with laser irradiation are a promising drug delivery system for glioma therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CORROSION SCIENCE
·
2019
·
IF 6.355
Kai Zhang,Jiamin Lu,Jin Li,Daquan Zhang,Lixin Gao,Hao Zhou
Triazole (TTE) film is assembled on copper surface via click chemistry reaction between p-toluenesulfonyl azide (TA) and 3-butyne-1-ol (BTO). The mechanism of promoting the formation of TTE film by sodium thioacetate (STG) is investigated by electrochemical methods and surface analysis techniques. It shows STG coordinates with Cu(I) to avoid the solvation reaction of Cu(I) in aqueous solution. The STG-Cu(I) complex is an excellent catalyst for the click reaction between TA and BTO. The presence of STG promotes the click-assembly process on copper surface and improves the protection of TTE film against copper corrosion effectively.
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2019
·Vol. 37
·期 6
·548-559
·
IF 2.804
Xu Wei-Ke,Tang Jing-Yu,Yuan Zhang,Cai Cai-Yun,Chen Xiao-Bin,Cui Shu-Quan,Liu Peng,Yu Lin,Cai Kai-Yong,Ding Jian-Dong
Bacterial infection is a very troublesome issue in wound treatment, which stimulates exudate formation and severely delays the healing process. Herein, a thermogelling dressing system composed of two triblock copolymers of poly(D,L-lactic acid- co -glycolic acid)- b -poly(ethylene glycol)- b -poly(D,L-lactic acid- co -glycolic acid) (PLGA-PEG-PLGA) with different block lengths was developed to deliver teicoplanin (TPN), a glycopeptide antibiotic, for cutaneous wound repair. The TPN-loaded thermogel was a free-flowing sol at room temperature and formed a semi-solid gel at physiological temperature. In vitro studies demonstrated that the TPN-loaded thermogel system exhibited desired tissue adhesiveness and realized the sustained release of TPN in a fast-followed-slow manner for over three weeks. Furthermore, a full-thickness excision wound model in Sprague-Dawley (SD) rats was constructed to assess the efficacy of TPN-loaded thermogel formulation. Gross and histopathologic observations implied that treatment with the thermogel formulation reduced inflammation response, promoted disposition of collagen, enhanced angiogenesis, and accelerated wound closure and maturity of SD rats. The combination of the bioactivity of TPN and the acidic nature of the thermogel matrix was responsible for such an enhanced wound healing process. Consequently, the TPN-loaded PLGA-PEG-PLGA thermogel is a good candidate of wound dressing for full-thickness excision wound healing.
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 1
·86
·
IF 3.164
Rui Zhu,Renjie Chen,Yunxia Duo,Saigang Zhang,Delong Xie,Yi Mei
A simple and versatile route for industrial scale synthesis of adipicdihydrazide (ADH)/polymer hybrids with excellent performance of formaldehyde degradation is proposed in this paper. The ADH compound is uniformly dispersed in poly(methyl methacrylate-butyl acrylate-methacrylic acid) (P(MMA-BA-MAA)) latex, which is validated by UV and dispersibility tests. The results illustrate that ADH has excellent compatibility and dispersion stability without affecting the film formation of the polymer latex. Furthermore, scanning electron microscope (SEM) and mapping analysis of the hybrid films also demonstrate that ADH is homogenously dispersed in the polymer matrix. Compared with neat polymers, the thermal properties of hybrid films are improved, for example,T0.5increases by 8.3 °C. According to qualitative tests of the 4-amino-3-hydrazino-5-mercapto-1,2,4-triazol-red/green/blue (AHMT-RGB) method, the hybrid films demonstrate high formaldehyde removal efficiency. On the basis of the semi-quantitative test of Fourier Transform infrared spectroscopy (FTIR) measurements, the rate of formaldehyde degradation can reach 1.034 × 102mol/(h·m3) for the hybrid film with 5 wt% ADH.Keywords:adipicdihydrazide;formaldehyde degradation;polyacrylate latex;hybrid film
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）