JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2022
·
IF 5.062
Xin Chen,Duanxiu Li,Yanwen Duan,Yong Huang
Drug co-amorphization is an emerging technology to improve the pharmacokinetic properties of drugs and overcome their side effects. Herein co-amorphization of sinomenine (SIN), an anti-rheumatoid arthritis alkaloid, and an antihistamine drug tranilast (TRA) was investigated for the sustained release of SIN and alleviating its histamine-release adverse reactions. The full co-amorphization of SIN-TRA was determined by powder X-ray diffraction and modulated temperature differential scanning calorimetry , while their CO 2 − and N + –H stretching vibrations in FTIR and protonated nitrogen signals in N 1s X-ray photoelectron spectra suggest the proton transfer between SIN and TRA. These intermolecular interactions could also be observed in their 1D and 2D NMR spectra. All co-amorphous samples exhibited sustained SIN release and excellent physical stability. Therefore, our study not only characterized the strong intermolecular interactions between SIN and TRA, but also discovered a promising drug combination strategy for the sustained release of SIN and reduction of its side effects.
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CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Yuehuan Li,Lang Shi,Yu Mao,Yu Zhang,Hongqing Wang
It is still a challenge for photocatalytic reduction of uranyl and maintaining catalyst stability under aerobic conditions. Herein, a catalyst of sodium–potassium co-doped g-C 3 N 4 (CD-NaK) was obtained to remove Hexavalent Uranium (U(VI)) by photocatalytic reduction under aerobic conditions. And the CD-NaK was characterized by XRD, XPS and other methods. Furthermore, DFT calculations and XRD revealed that Na was doped in-plane while K was doped in-plane and interlayer, enhancing holes and electrons separation performance. Moreover, the removal rate of U(VI) could be achieved nearly 100% after 20 mins of visible irradiation in the presence of air over CD-NaK(30). The photocatalytic activity has the order: CD-NaK(30) > SD-Na > SD-K > CN. Additionally, when the atmosphere of the reaction system was air, the photocatalytic activity of CD-NaK(30) to uranyl was 4.6 times higher than that of pure nitrogen atmosphere in the present of benzyl alcohol, and CD-NaK(30) displayed good reusability and stability with the removal rate > 96% even after five cycles. Interestingly, the effect of the amount of oxygen on catalytic reduction and the role of oxygen were elucidated. Finally, a novel uranyl reduction mechanism has been supposed.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Qin Yang,Yujie Zhang,Jie Liang,Yongsong Luo,Qian Liu,Yingchun Yang,Xuping Sun
Sulfate radical based advanced oxidation processes (SR-AOPs) are regarded as a promising technology to degrade organic pollutants in water. Here, hydrothermally synthesized Co-glycerate (Co-G) microspheres are proposed as an efficient heterogeneous catalyst to activate peroxymonosulfate (PMS) for degradation of refractory organic pollutant rhodamine B (RhB) in aqueous solution. The presence of Co-G microspheres enhanced the degradation rate significantly with a short full degradation time (8 min) and a total organic carbon (TOC) removal exceeding 41% (10 min), thus implying the excellent catalytic performance of Co-G microspheres for PMS activation. Furthermore, the effects of PMS and catalyst concentration, initial pH value and co-existing ions on RhB degradation were investigated. Radical quenching and EPR tests identify that active species including SO 4 - ·, HO·, O 2 - · and 1 O 2 are involved in the degradation process. Additionally, a possible reaction mechanism of PMS activation by Co-G microspheres for RhB degradation was suggested. This study can provide a new insight for design of cobalt-based heterogeneous catalysts as activators to activation PMS for pollutants degradation.
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Gels
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2022
·Vol. 8
·期 5
·308
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IF 4.432
Zixuan Zheng,Guojie Liang,Li Li,Jing Liu,Xinbo Wang,Yi Sun,Kai Li
The weak inherent non-covalent interactions between carbon aerogel backbone nanoparticles obtained by the pyrolysis of conventional organic aerogel can lead to poor mechanical properties. When applied in the thermal protection system of a high-speed spacecraft, the preparation of carbon aerogel insulation materials with excellent formability and high mechanical strength still remains a huge challenge. This work reports an efficient approach for fabricating carbon foam-reinforced carbon aerogel composites by compounding the nanoporous polyimide aerogel into the microporous pre-carbonized phenolic resin-based carbon foam via vacuum impregnation, gelatinizing and co-carbonization. Benefiting from the co-shrinkage caused by co−carbonization, the thermal insulation capacity of the carbon aerogel and the formability of the pre−carbonized foam are efficiently utilized. The shrinkage, density and carbon yield of aerogels, pre-carbonized foams and the composites at different temperatures were measured to analyze the formation of the interfacial gap within the composite. The co-carbonization mechanism of the polyimide aerogels and phenolic resin-based pre-carbonized foams was analyzed through XPS, TG-MS, and FT-IR. Among the prepared samples, CF30-CPI-1000 °C with small interfacial gaps showed the lowest thermal conductivity, which was as low as 0.56 W/(m·K) at 1900 °C, and the corresponding compressive strength and elastic modulus were as high as 0.532 MPa and 9.091 MPa, respectively.Keywords:polyimide aerogel;carbon aerogel;thermal conductivity;shrinkage;co-carbonization mechanism
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Nano Energy
·
2022
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IF 19.069
Ruilin Hou,Yue Wang,Yinglun Sun,Junwei Lang,Shengrong Yang,Xingbin Yan
Aqueous electrolytes are important charge transport media in various electrochemical applications. However, the water splitting seriously limits the operation voltage of aqueous electrolytes. Thus, further widening the electrochemical stability window (ESW) of aqueous electrolytes is great of importance. Here, based on the high charge density and high electro-negativity of halogen anions (F - ), we proposed a “cation/anion with co-solvation” type 16 m KF aqueous electrolyte that can achieve a high conductivity of 196 mS cm −1 , a record 3.4 V ESW based on stainless steel mesh and even 6.72 V ESW based on Al metal electrode that is much higher than the highest value currently reported. Such excellent feature is attributed to the strong hydrogen bonds between the F - anions and the water molecules at high concentrations. This work is helpful to provide a new path for design of ideal high-voltage aqueous electrolytes and to understand the important role of anions in aqueous electrolytes at the molecular level.
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MACROMOLECULES
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2022
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IF 6.057
Wenbo Du,Handou Zheng,Yinwu Li,Chi Shing Cheung,Donghui Li,Heng Gao,Huiyun Deng,Haiyang Gao
The development of highly tolerable metal catalysts to polar monomers is of fundamental importance for the metal-catalyzed copolymerization of ethylene and industrial polar vinyl monomers under mild conditions but still remains a scientific challenge. In this paper, a neutral tridentate α-sulfonato-β-diimine nickel catalyst with an apical SO3–Ni coordination was initially designed and synthesized in three dimensions. Combining advantages of cationic diimine and neutral phosphine-sulfonato-type catalysts, the α-sulfonato-β-diimine nickel catalyst showed good thermostability and controllability as well as high tolerance toward polar alkyl acrylates. Copolymerization of ethylene and methyl acrylate (MA) produced branched ethylene–methyl acrylate (EMA) copolymers with both high molecular weight (Mn > 20 × 103) and high MA incorporation (up to 10 mol %), whose branching structure was similar to commercial EMA industrially prepared by radical polymerization under harsh polymerization conditions. Density functional theory calculations were also performed to illuminate the formation of the EMA copolymer with terminal MA units.
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Sustainable Energy & Fuels
·
2022
·Vol. 6
·期 10
·2602-2612
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IF 6.813
Haosheng Xin,Haiyong Wang,Song Li,Xiaohong Hu,Chenguang Wang,Longlong Ma,Qiying Liu
Catalytic conversion of renewable cellulose, instead of fossil resources, to high-value ethylene glycol (EG) is of great significance for reducing considerable worries regarding the energy problem. However, the EG production from cellulose is dependent on Ni and Ru based catalysts. Herein, encapsulated Co@C catalyst was firstly applied for EG production from cellulose combined with tungstic acid (TA). The mixing of the two catalysts in different ratios was compared and well-controlled, and the highest 67.3% yield of EG can be achieved. TA is used mainly to promote both the cellulose hydrolysis and the retro-aldol reaction of glucose to glycolaldehyde. Co@C catalysts are responsible for the hydrogenation of glycolaldehyde to EG. Compared with traditional noble metals and composite catalysts, the inexpensive and easily synthesized Co@C catalysts could greatly reduce the cost of production of EG. The Co@C catalysts encapsulated with outside graphene layers can keep high stability for at least 6 runs.
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EUROPEAN POLYMER JOURNAL
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2022
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IF 5.546
Jun Chen,Cong Liao,Xiao-Xiao Guo,Shi-Chang Hou,Wei-Dong He
Lead ion is a common heavy metal pollutant and extremely harmful to human health. Therefore, the research about the adsorption and removal of lead ion from sewage and the development of lead ion sorbents keeps greatly significant. In this study, poly(acrylic acid- co -acrylonitrile) (PAAN) cryogels were prepared by cryo-polymerization. After the treatment with hydroxylamine, the amidoximated PAAO cryogels were applied to remove lead ion from lead-contaminated water. The porous structure and high water permeability of the cryogel could fully facilitate the exposure of active sites to efficiently adsorb lead ion. PAAO cryogels showed a high adsorption capacity of 450 mg/g for lead ion. After the first adsorption–desorption cycle, the adsorption capacity of PAAO cryogels regenerated with alkali solution increased to 650 mg/g and remained in the next six cycles. The pseudo-second-order kinetic model and the intraparticle diffusion model fit the adsorption kinetics of lead ion well, indicating its chemi-sorption feature of PAAO cryogel sorbent. The FTIR and XPS studies suggested that carboxyl group of acrylic acid unit as well as the amidoxime group of modified AN unit contributed the enhanced adsorption ability for lead ion.
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DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 22
·8832-8839
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IF 4.569
Yihao Gao,Jie Bai,Tianning Zhou,Yaqiong Gong
In recent years, Co-based metal–organic frameworks (Co-MOFs) have received significant research interest because of their large specific surface area, high porosity, tunable structure and topological flexibility. However, their comparatively weak electrical conductivity and inferior stability drastically restrict the application of Co-MOFs in the synthesis of electrocatalysts. In this study, ZIF-67 was grown on nickel foam by a room temperature soaking method, and then Ir–Co(OH)2@ZIF-67/NF was assembled by a hydrothermal method. The prepared Ir–Co(OH)2@ZIF-67/NF nanosheets exhibit remarkable conductivity, larger electrochemical active surface area and wider electron transport channels. Only ultralow overpotentials of 198 mV, 263 mV, and 300 mV were needed for Ir–Co(OH)2@ZIF-67/NF to reach the current densities of 10 mA cm−2, 50 mA cm−2, 100 mA cm−2, meanwhile, no obvious degradation of the current density at 10 mA cm−2 was observed for about 16 h. This work may provide a promising strategy for developing high-performance MOF-derived materials as electrocatalysts for the OER under alkaline conditions.
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JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
·
2022
·Vol. 49
·期 3
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IF 4.258
Wang Lei,Zheng Peng,Hu Meirong,Tao Yong
Cellobiose, a natural disaccharide, attracts extensive attention as a potential functional food/feed additive. In this study, we present an inorganic phosphate (Pi) self-sufficient biotransformation system to produce cellobiose by co-expressing sucrose phosphorylase (SP) and cellobiose phosphorylase (CBP). The Bifidobacterium adolescentis SP (BASP) and Cellvibrio gilvus CBP (CGCBP) were co-expressed in Escherichia coli. Escherichia coli cells containing BASP and CGCBP were used as whole-cell catalysts to convert sucrose and glucose to cellobiose. The effects of reaction pH, temperature, Pi concentration, and substrate concentration were investigated. In the optimum biotransformation conditions, 800 mM cellobiose was produced from 1.0 M sucrose, 1.0 M glucose, and 50 mM Pi, within 12 hr. The by-product fructose and residual substrate (sucrose and glucose) were efficiently removed by treatment with yeast, to help purify the product cellobiose. The wider applicability of this Pi self-sufficiency strategy was demonstrated in the production of laminaribiose by co-expressing SP and laminaribiose phosphorylase. This study suggests that the Pi self-sufficiency strategy through co-expressing two phosphorylases has the advantage of great flexibility for enhanced production of cellobiose (or laminaribiose).
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Pharmaceutics
·
2022
·Vol. 14
·期 3
·603
·
IF 6.525
Dandan Hu,Xin Chen,Duanxiu Li,Hailu Zhang,Yanwen Duan,Yong Huang
Matrine (MAR), oxymatrine (OMAR), and sophoridine (SPD) are natural alkaloids with varying biological activities; matrine was recently used for the treatment of coronavirus disease 2019 (COVID-19). However, the short half-lives and rapid elimination of these matrine-type alkaloids would lead to low oral bioavailability and serious side effects. Herein, resveratrol (RES) was selected as a co-former to prepare their co-amorphous systems to improve the therapeutic index. The formation of co-amorphous MAR-RES, OMAR-RES, and SPD-RES was established through powder X-ray diffraction and modulated temperature differential scanning calorimetry. Furthermore, Fourier transform infrared spectroscopy and NMR studies revealed the strong molecular interactions between resveratrol and these alkaloids, especially OMAR-RES. Matrine, oxymatrine, and sophoridine in the co-amorphous systems showed sustained release behaviors in the dissolution experiments, due to the recrystallization of resveratrol on the surface of co-amorphous drugs. The three co-amorphous systems exhibited excellent physicochemical stability under high relative humidity conditions. Our study not only showed that minor structural changes of active pharmaceutical ingredients may have distinct molecular interactions with the co-former, but also discovered a new type of sustained release mechanism for co-amorphous drugs. This promising co-amorphous drug approach may present a unique opportunity for repurposing these very promising drugs against COVID-19.Keywords:co-amorphous systems;sustained-release;COVID-19;matrine-type alkaloids;resveratrol
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2022
·
IF 8.91
Hua Long,Xinyu Huang,Meijia Liu,Changhao Cui,Li Li,Yang Liao,Dahai Yan
The improper disposal of large amounts of solid waste (SW) has led to serious ecological and environmental problems, especially heavy metal (HM) pollution. Converter steelmaking has the potential to co-process SW, but the distribution of heavy metals (HMs) during converter steelmaking is unclear. In this study, the effects of smelting temperature and slag alkalinity on the distribution of typical HMs in the SW of steel samples, steel slag , and the gas phase were investigated in a specially-made induction furnace. The results showed that upon increasing the smelting temperature, As (As 2 S 3 ) was mainly distributed in the steel sample, and the HM-containing compounds Cr 2 O 3 , CrCl 3 , ZnCl 2 , ZnS, ZnO, PbCl 2 , PbS, and PbO were mainly distributed in the gas phase. Upon increasing the alkalinity within a certain range, the distribution of HMs in steel samples and steel slag increased gradually, while their distribution in the gas phase decreased. Thermodynamic calculations , Eh-pH diagrams, XRD patterns, and XPS spectra indicated that impurity elements in the hot metal and the CaO content affected the chemical reactions by which HM-containing compounds in the steel sample formed elemental HMs and those in steel slag existed as oxides; therefore, it is necessary to choose a suitable temperature and alkalinity for slag when disposing of different types of SW.
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