INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Qingdi Kong,Xiaojie Zhang,Kangrui Ma,Yuefa Gong,Hong Peng,Wei Qi
It is a challenging task to remove heavy metal ions efficiently from the wastewater containing high concentrations of complexants. In this work, a novel PEI-modified chitosan/activated carbon composite adsorbent (PCA) was prepared and applied to the removal of Cu(II) from pyrophosphate plating rinsing wastewater. The main species of Cu(II) in the pyrophosphate wastewater was [Cu(HP 2 O 7 ) 2 ] 4− or [Cu(P 2 O 7 ) 2 ] 6− , which were denoted as [Cu(II)-PP] anions. The maximum adsorption capacity of PCA for Cu(II) reached 1.41 mmol g −1 under the condition of pH = 8 and molar ratio of pyrophosphate to Cu(II) = 4:1. The adsorption kinetic behavior of Cu(II) on PCA followed the Elovich model best and PCA attained adsorption equilibrium within 36 h. The thermodynamic studies showed that the adsorption process of Cu(II) by PCA was endothermic and spontaneous. The PCA fixed bed column was used to remove Cu(II) from simulated pyrophosphate plating rinsing wastewater. After three consecutive adsorption-desorption cycles, the adsorption performance, hydraulic conductivity , and mechanical stability of PCA column did not decrease. The FTIR and XPS analysis results indicated that [Cu(II)-PP] anions can be adsorbed on PCA by electrostatic attraction with protonated amine groups or coordination with the amine groups of PCA via ligand substitution.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Mengli Lu,Li Ma,Juncan Li,Jie Li,Miao Tong,Fuli Dai,Feiyu Song,Xueqiong Zhang,Tong Qiu
As a first-line drug for breast cancer chemotherapy, the effectiveness of doxorubicin (DOX) is challenged by high doses and high toxicity. Studies showed the combination of Tanshinone IIA (TSIIA) and DOX could enhance the efficacy of DOX for cancer and reduce the toxic effects to normal tissues. Unfortunately, free drugs are easily metabolized in the systemic circulation, which are less prone to aggregation at the tumor site to exert anticancer efficacy. In present study, we prepared a carboxymethyl chitosan-based hypoxia-responsive nanoparticles loaded with DOX and TSIIA for the treatment of breast cancer. The results demonstrated that these hypoxia-responsive nanoparticles not only improved the delivery efficiency of the drugs but also enhanced the therapeutic efficacy of DOX. The average size of nanoparticles was about 200–220 nm, the optimal drug loading and encapsulation efficiency of TSIIA in DOX/TSIIA NPs were 9.06 % and 73.59 %, respectively. Hypoxia-responsive behavior were recorded in vitro, while the synergistic efficacy is significantly exhibited in vivo and the tumor inhibitory rate was 85.87 %. Notably, TUNEL assay and immunofluorescence staining verified that the combined nanoparticles exerted a synergistic anti-tumor effect by inhibiting tumor fibrosis, decreasing the expression of HIF-1α and inducing tumor cell apoptosis. Collectively, this carboxymethyl chitosan-based hypoxia-responsive nanoparticles could have promising application prospect for effective breast cancer therapy.
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Food and Bioprocess Technology
·
2022
·Vol. 15
·期 12
·2762-2775
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IF 5.581
Hu Li,Qiu Weiqiang,Feng Yuhui,Jin Yingshan,Deng Shanggui,Tao Ningping,Jin Yinzhe
The effect of recycling ohmic heating on the deacetylation, structure, and properties of chitosan prepared from Portunus trituberculatus crab shells was investigated. The effect of six proteases on deproteinization was examined. Deacetylation was carried out using four cycles of heating, in which heating methods included cyclic water bath heating, cyclic ohmic heating, and a combination of recycling ohmic and water bath heating. The structure and properties of chitosan were determined by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), scanning electron microscope (SEM), dielectric properties, and rheological properties. A combination of many factors, including acid protease and pepsin, was chosen for complex proteolytic deproteinization. Ohmic heating took 2/5 of the time and used 1/2000 of the energy required for water bath heating. FTIR, DSC, dielectric properties, and SEM results showed that the chitosan characteristic after ohmic heating treatment met commercial requirements. Chitosan’s FTIR spectra and dielectric loss values at low frequencies after three cycles of combined ohmic and water bath heating were most similar to those of commercial chitosan without destroying its thermal stability. After the three cycles, the degree of chitosan deacetylation using combined ohmic and water bath heating reached 94.38 ± 0.21%, improving deacetylation compared with the traditional method.
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CHEMOSPHERE
·
2022
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IF 8.943
Jackson Nkoh Nkoh,Ke-wei Li,Yang-xiao-xiao Shi,Jiu-yu Li,Ren-kou Xu
Phosphorus (P) availability in highly weathered soils is significantly influenced by the contents of iron (Fe)/aluminum (Al) oxides, clay minerals, and organic matter. With the increasing interest in biofertilizers (e.g. chitosan), it is important to understand how they affect P adsorption profiles on colloids of weathered soils rich in Fe/Al oxides. Thus, the effect of chitosan on the adsorption of P to colloids of hematite, gibbsite , Oxisol , and Ultisol was studied through electrokinetic measurements, spectroscopic analysis , and adsorption edge/isotherm profiles. The presence of chitosan significantly improved the surface positive charge and the decreasing trend of surface positive charge was slower for chitosan-treated colloids compared to the control with increasing pH. At pH 5.0, all the colloids were positively charged, with the oxides containing more positve charges than the soil colloids. At this pH value, the surface coverage capacity of P was 99.1, 61.6, 50.5, and 37.5 mmol kg⁻ 1 for Oxisol, Ultisol, hematite, and gibbsite, respectively. This suggests that clay minerals in soil colloids were vital in enhancing P adsorption. In the presence of chitosan, the surface coverage capacity of P was increased by 111%, 173%, 647%, and 488% for Oxisol, Ultisol, gibbsite, and hematite, respectively. Drawing inferences from spectroscopic analysis, citric acid desorption profile, and zeta potential analysis, we suggest that chitosan (CH) enhanced P adsorption by promoting the formation of (i) citric acid “undisplaceable” inner-sphere P complexes such as [Colloid-OP- O -CH] and [Colloid-OP- N -CH] , (ii) citric acid “displaceable” outer-sphere P complexes such as {[Colloid- O -CH]-OP} and {[Colloid- N -CH]-OP} , and (iii) water “leachable or soluble” P complexes such as {[Colloid-CH] + PO 4 ³⁻} and {[Colloid-OP]⁻CH + } . Thus, applying chitosan as a biofertilizer (source of N) along with P in highly weathered soils could improve P availability while reducing P leaching .
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Zhi Chen,Zhi-Bo Zhang,Jun Zeng,Zhi-Jie Zhang,Shan Ma,Cong-Ming Tang,Jun-Qiang Xu
In this work, a polyethyleneimine-modified chitosan/Ce-UIO-66 composite hydrogel (PEI-CS/Ce-UIO-66) was prepared using the ex-situ blend method. The synthesized composite hydrogel was characterized by SEM, EDS , XRD, FTIR, BET, XPS, and TG techniques, while the zeta potential was recorded for sample analysis. The adsorbent performance was studied by conducting adsorption experiments using methyl orange (MO), which showed that PEI-CS/Ce-UIO-66 exhibited excellent MO adsorption properties (900.5 ± 19.09 mg/g). The adsorption kinetics of PEI-CS/Ce-UIO-66 could be explained by the pseudo-second-order kinetic model , and its isothermal adsorption followed the Langmuir model. Thermodynamics showed that the adsorption was spontaneous and exothermic at low temperatures. MO could interact with PEI-CS/Ce-UIO-66 via electrostatic interaction , π–π stacking, and hydrogen bonding . The results indicated that the PEI-CS/Ce-UIO-66 composite hydrogel could potentially be used for the adsorption of anionic dyes.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2022
·
IF 2.042
Yu Song,Qing Wang,Wenjuan Yang,Qilin Chen,Yafen Zhou,Limei Zhou
The chitosan-nickel oxide (CS-NiO) composite was synthesized and characterized by XRD, FT-IR, SEM, TEM, BET, and TG-DTG. The as-prepared composite was used as an adsorbent for the removal of Congo red (CR) dye from aqueous solution. Effects of various parameters such as solution pH, adsorbent dosage, initial dye concentration, contact time, and temperature on the adsorption of CR were investigated. The adsorption kinetics was found to conform to the pseudo-second-order kinetics model with good correlation. The adsorption of CR on the CS-NiO composite followed the Langmuir model and the maximum adsorption capacity at 25 °C determined from Langmuir model was 188.68 mg/g. The thermodynamic data revealed the spontaneous and endothermic nature of the adsorption process. The CS-NiO composite adsorbent can be separated from system effectively and easily, and maintained high adsorption efficiency even after five-time recycles. The aforementioned results demonstrated that the CS-NiO composite could be used as an efficient and low-cost natural adsorbent for the removal of CR from aqueous solution.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2022
·Vol. 31
·期 3
·1129-1143
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IF 4.705
Tang Qi,Qiu Chongpeng,Zhang You,Zhang Xuefeng,Yuan Zihui,Tan Hailu,Wang Lei,de Hoop Cornelis F.,Qi Jinqiu,Huang Xingyan
In this work, a novel nanocellulose/alum/chitosan/polyethyleneimine biohybrid aerogel (NACPBA) beads adsorbent was successfully prepared to remove diclofenac sodium (DS) from wastewater. The NACPBA beads adsorbent was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometer, and Brunauer–Emmett–Teller. A possible adsorption mechanism was also discussed. The experimental results showed that the adsorption process was followed by a pseudo-second-order kinetic model and Sips isotherm model with the calculated maximum adsorption capacity of 321.3 mg/g on DS. It was much higher than most of the previously reported works. The adsorption capacity of NACPBA beads on DS was increased rapidly within 120 min, especially in the first 60 min. Furthermore, after five regeneration cycles, NACPBA still retained a good adsorption capacity of 103.7 mg/g with a removal efficiency of 50%. Moreover, 95.4% of DS was removed from river water (simulated 5 mg/L DS-contaminated wastewater). The possible adsorption mechanism was primarily governed by electrostatic attractions and hydrogen bond interactions.
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Biomedical Materials
·
2022
·Vol. 17
·期 6
·065023
·
IF 4.103
Dewei Qiu,Ping Zhou,Jiawei Kang,Zhijun Chen,Zhiyong Xu,Hanwen Yang,Jun Tao,Fanrong Ai
The treatment of implant-associated bone infection remains a significant clinical challenge. However, bone scaffolds with antimicrobial activity and osteoinductive properties can prevent these infections and improve clinical outcomes. In this study, borosilicate bioglass and chitosan composite scaffolds were prepared, and then the surface was modified with nano-zinc oxide. In vitro and in vivo experiments showed that the chitosan/borosilicate bioglass scaffolds have good degradation and osteogenic properties, while the oxidized Zinc scaffolds have better antibacterial properties.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Yaru Xi,Zuoyi Xiao,Hui Lv,Haodong Sun,Shangru Zhai,Qingda An
Copper oxide (CuO) and copper (Cu) have been viewed as the prospective pseudocapacitive electrode materials for supercapacitors. Nevertheless, the poor electron transfer capacity, loading amount, and cycling stability limit their wide applications, which can be addressed by developing the CuO based heterojunction on conductive carbons. Here, a CuO/Cu@C comprising CuO/Cu nanoflowers and chitosan-derived N -doped porous carbon was compounded by simple mechanical mixing, freeze-drying, and carbonization. The composite heated at 700 °C exhibited a high specific capacitance of 2479F/g at 0.5 A/g and excellent cycling stability with capacitance retention of 82.43 % after 10 000 charge–discharge cycles. In addition, the asymmetric supercapacitor (ASC), i.e., CuO/Cu@C-700//AC assembled by CuO/Cu@C (as a positive electrode) and activated carbon (AC, as a negative electrode) displayed a great energy density of 76.87 W h kg −1 at 374.5 W kg −1 and kept as high as 25.83 W h kg −1 even at 14998 W kg −1 . Our work provides a new pathway to preparing transition metal oxide-based electrode materials with distinguished electrochemical performances.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2022
·Vol. 34
·期 1
·155-165
·
IF 3.348
Chengjun Peng,Guichun Wang,Yuxiao Wang,Maomao Tang,Xiaodong Ma,Xiangwei Chang,Jian Guo,Shuangying Gui
Periodontitis is a chronic inflammatory disease of tooth support tissues leading to progressive destruction of periodontal soft tissues as well as alveolar bone, and can be treated with anti-inflammatory and bone-protective agents to prevent disease progression. Caffeic acid phenethyl ester (CAPE) is a natural polyphenolic compound with anti-inflammation, anti-oxidation and bone tissue repair efficacy. In this work, we synthesized a thermosensitive hydrogel matrix of acetylated carboxymethyl chitosan (A-CC), and firstly applied for periodontal local drug delivery. The biocompatible CAPE-loaded A-CC hydrogel (CAPE-A-CC) has the advantages of forming a drug depot in situ, sustained release and precisely improving the drug concentration in the lesion sites compared with traditional systemic administration. In addition, CAPE-A-CC could significantly inhibit the expression of inflammatory cytokines of TNF-α, IL-1β, IL-6, and IL-17 in macrophages, and increased the expression of alkaline phosphatase (ALP) in human periodontal ligament stem cells (hPDLSC) related to osteogenesis. This study develops a novel in situ thermosensitive hydrogel delivery system to improve the therapeutic potential of natural active ingredient for periodontitis therapy.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Xin Wang,Xinyu Sun,Tong Bu,Ke Xu,Lihua Li,Mingyan Li,Ruixia Li,Li Wang
The elaborate design of an ingenious hydrogel-assisted photothermal therapy (PTT) platform is a promising strategy for treating bacterial wound infections. Herein, a new generation of germanene nanocrystals (Ge NCs) with excellent photothermal performance are prepared via an ice-bath sonication liquid-phase exfoliation technique. Whereafter, by crosslinking interaction between chitosan and zinc acetate, as well as self-assembly property between Ge NCs and chitosan, we successfully construct an innovative germanene-modified chitosan antimicrobial hydrogel (CS/Ge NCs 0.8 ) integrating capture and killing bacteria performances. When co-cultured with bacteria, CS/Ge NCs 0.8 hydrogel with the positive charge can adsorb and restrict bacteria in the range of PTT destruction. Once the near-infrared laser is introduced, CS/Ge NCs 0.8 hydrogel will effectively convert light energy into localized heat, further inducing bacterial death. By this entirely novel modality, CS/Ge NCs 0.8 hydrogel exhibits marvelous antibacterial property against E. coli and S. aureus in vitro. Furthermore, in vivo studies demonstrate that CS/Ge NCs 0.8 hydrogel possesses the ability to significantly rescue S. aureus -induced skin wound infections, suggesting CS/Ge NCs 0.8 hydrogel can be served as an antibacterial dressing. Strikingly, this is the first-ever report of CS/Ge NCs 0.8 hydrogel in the antibacterial field, which may spur a wave of developing Ge-based biomaterials to benefit biomedical applications.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Yanchen Fan,Mengyu Yin,Hongbo Chen
Chitosan is widely used as a dewatering flocculant , but whether it affects hydrogen production from sludge anaerobic fermentation is unclear. This study aimed to elucidate the role of chitosan in the dark fermentation of waste activated sludge for hydrogen production. The results showed that chitosan had a negative effect on hydrogen production from sludge. Chitosan at 30 g/kg total suspended solids reduced hydrogen accumulation by 56.70 ± 1.22 % from 3.94 ± 0.12 to 1.71 ± 0.10 mL/g volatile suspended solids. Chitosan hindered the solubilization of sludge by flocculation , which reduced the available substrate for anaerobic fermentation. In addition, chitosan interfered with the electron transport system by reducing cytochrome C and caused lipid peroxidation by inducing reactive oxygen species , thereby inhibiting the activity of enzymes involved in anaerobic fermentation. Hydrogen production was reduced because hydrogen-producing processes (i.e., hydrolysis, acidification, and acetification) were inhibited more strongly than hydrogen-consuming processes (i.e., methanogenesis , sulfate reduction, and homoacetogenesis). Furthermore, chitosan enriched the abundance of Spirochaetaceae sp. and Holophagaceae sp., which occupied the survival space of hydrogen-producing microorganisms . This study reveals the potential impact of chitosan on hydrogen production in dark fermentation of sludge and provide direct evidence that chitosan triggers oxidative stress in anaerobic fermentation.
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