FOOD CHEMISTRY
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2026
·
IF 10.4
Peilin Yang,Qian Zhao,Cong Lyu,Donghong Liu,Xingqian Ye,Huan Cheng
Sensomics techniques identified nine aroma-active compounds in soy sauce that enhance saltiness perception. • 2,3,5-TMP and Methionol significantly increased saltiness perception by over 43.8%, confirmed by OISE and TI analysis. • Hydrogen bonds, hydrophobic interactions and π-π interaction sites were crucial for odor recognition. This study combined sensomics strategies and molecular docking to systematically identify and validate key compounds enhancing saltiness in soy sauce, elucidating their binding mechanisms with saltiness receptors. Gas Chromatography-Olfactometry-Mass Spectrometry (GC-O-MS) revealed nine key compounds were identified for their saltiness-enhancing effects, which were further confirmed by Odor-Induced Saltiness Enhancement (OISE) values and Time-Intensity (TI) analysis. Notably, 2,3,5-trimethylpyrazine (2,3,5-TMP) and methionol significant enhanced perceived saltiness in a 0.6% NaCl solution compared to the control ( p < 0.05). Furthermore, the saltiness-enhancing effect of these compounds was most pronounced in the 0.6% NaCl solution, compared to 0%, 0.3%, and 0.9% NaCl solutions ( p < 0.05). Molecular docking suggested that increased perceived saltiness was likely mediated by the reduction in binding energy, alongside the formation of hydrogen bonds and hydrophobic interactions. This work highlights aroma compounds as a strategy for reducing sodium content in soy sauce while preserving flavor, offering implications for healthier design. Download: Download high-res image (77KB) Download: Download full-size image
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2026
·
IF 3.5
Qingmao Yang,Anyan He,Junyan Tan,Weichen Zhao,Haoyi Wu,Shengning Luan,Wei Feng,Chun Shen
Developing a novel EPCS combining GOase with Au/TiO 2 . • Achieving ∼92.3% DFF yield with ∼97.0% selectivity within 2 h in pure water. • The by-product H 2 O 2 is in-situ decomposed into O 2 by Au/TiO 2 . • •OH, •O 2 – and O 2 precisely required for GOase activation generated by Au/TiO 2 . 2,5-Diformylfuran (DFF), as the oxidation product of the biomass platform molecule 5-hydroxymethylfurfural (HMF), has attracted considerable attention because of its broad utility as a precursor for pharmaceuticals, renewable polymers, and other functional products. Efficient oxidation of HMF into DFF through biocatalysis in pure water is extremely desirable but still faces significant challenges: complex multi-enzyme systems and low reaction efficiency. Herein, we develop a novel enzyme-photo-coupled catalytic system (EPCS) combining GOase with Au/TiO 2 photocatalyst, achieving “waste-to-wealth”. The mechanism study reveals that the Au/TiO 2 acts as the role of “killing two birds with one stone”: in-situ decomposing inhibitory H 2 O 2 by-product into O 2 and H 2 O, thereby mitigating enzyme inhibition; and ingeniously generating reactive oxygen species (ROS) (hydroxyl radicals (·OH) and superoxide radicals ( )) and regenerative O 2 that precisely are required for GOase activation. Under visible light conditions, the EPCS achieves (92.3±1.4)% DFF yield with (97.0±0.8)% selectivity within 2 h, significantly outperforming the single enzyme system (DFF yield: (40.9±2.4)%). The “green chemistry” concept is implemented in the EPCS, which provides a generalizable strategy for developing efficient, green, and concise oxidation systems by turning a toxic by-product into catalytic promoters. Download: Download high-res image (335KB) Download: Download full-size image
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CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Mengdan Zhu,YaoDong Dong,Jinqiu Fu,Zheng Ren,Keke Zhang,Hanjie Ying
Triglycine (GGG), owing to its simple structure and well-defined hydrogen-bonding network, has become a representative model molecule in the fields of peptide coordination chemistry, bioconjugation, and drug delivery. However, the solid-state applications of this compound have long been constrained by its property uncertainty arising from polymorphism and extremely poor processability caused by anisotropic crystal habits. In this work, a new anhydrous polymorph (Form II) is reported for the first time, and its crystal structure is solved by single-crystal X-ray diffraction. The results demonstrated that the two anhydrous forms (Forms I and II) exhibit comparable thermodynamic stability and remain stable under both mechanical grinding and solution-mediated slurry conditions. In addition, spherical crystalline of GGG Form 2H were successfully obtained for the first time via antisolvent crystallization in a tetrahydrofuran system. The effects of the polymeric additives hydroxypropyl methylcellulose and polyvinylpyrrolidone on the sphericity, particle size distribution, and powder flowability of the spherical aggregates were systematically investigated. The aggregation mechanism of the spherical particles and the regulatory role of additives were further elucidated. This study provides new insights into the interplay among solvent environment, polymorphism, and crystal morphology, and offers a feasible strategy for morphology control of tripeptides
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Advanced Sensor and Energy Materials
·
2026
·
IF 12.3
Tingting Wang,Hao Song,Xiaohui Gong,Zongyu Han,Taoming Xu,Yanan Xu,Dan Zhao,Chuanxia Chen,Yizhong Lu,Jian Sun
Biothiol analysis is crucial for evaluating redox homeostasis and monitoring various physiological processes. However, conventional fluorescence-based strategies often rely on structurally complex probes and lack straightforward multi-target discriminative capabilities. Herein, we present a versatile, pre-synthesis-free fluorogenic platform driven by the target-responsive inhibition of in-situ polymer dot (PD) formation. We discovered that dopamine (DA) spontaneously condenses with N -[3-(trimethoxysilyl)propyl]diethylenetriamine (AEEA) to yield robustly fluorescent PDs. Biothiols, acting as highly reactive competitors, intercept the DA precursor via a preferential Michael addition, fundamentally suppressing PD formation and inducing a marked fluorescence decrease. This mechanism enables the rapid, highly sensitive quantification of glutathione (GSH), cysteine (Cys), and homocysteine (Hcy), with low limits of detection (LODs) of 0.095, 0.115, and 0.083 μM, respectively. Significantly, the introduction of a structurally distinct DA-DAMO analog facilitated the discrimination of these biothiols. This reaction-interference strategy was then successfully coupled with enzymatic cascades to evaluate glutathione reductase (GR) activity within 20 min, achieving a LOD of 0.046 mU/mL. The programmable analyte-dependent fluorescence outputs were successfully employed as signal readouts to construct molecular logic gates. This work establishes target-regulated in-situ nanomaterial formation as a powerful paradigm for biothiol sensing, enzyme assays, and advanced logic operations.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Bing Liu,Tingjun Dai,Wanying Wu,Binghan Wang,Tianye Hu,Yizhou Lin,Haoyang Sun,Hui Wei,Fei Sun
A highly stable Au@Au SERS nanolabels-based LFIA was developed for rapid FT analysis. • The AuNPs DTNB @Au exhibited high stability during a 90-day storage period with a RSD value of 7.71%. • The LOD of 2.27 fg mL −1 and the LDR of 10 fg mL −1 to 10 μg mL −1 were achieved. • The entire analysis process was completed within 15 min. Free testosterone (FT) serves as a crucial biomarker for endocrine assessment. Nevertheless, the rapid and accurate analysis of FT presents a significant challenge due to its low abundance and the interference from the matrix. In this study, we developed a lateral flow immunoassay (LFIA) integrated with gold-core gold-shell nanoparticles (Au@Au NPs)-based surface-enhanced Raman scattering (SERS) nanolabels for the rapid analysis of FT. The Raman signal molecules (RSMs) were embedded within the interstitial gap between the Au core and the Au shell, significantly contributing to SERS enhancement while also improving the stability of the SERS nanolabels. The proposed biosensor demonstrated a linear dynamic detection range (LDR) of 10 fg mL −1 to 10 μg mL −1 (R 2 = 0.9914) and a limit of detection (LOD) of 2.27 fg mL −1 , with the entire analysis process completed within 15 min. Additionally, the results indicated that the platform exhibited remarkable reproducibility, stability, and selectivity, along with reliable performance in human serum samples. This generates a simple, rapid, and highly sensitive strategy for FT detection, demonstrating considerable potential for point-of-care testing of low-abundance biomarkers. Download: Download high-res image (140KB) Download: Download full-size image
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2026
·
IF 6.7
Zewei Liu,Fuhang Huo,Liping Zhang,Yong Liu,Xianglong Li,Lei Zhang,Huarui Zhang,Zixian Pang,Linhua Jiang,Bin Li
A composite material synthesized from HCl-treated red mud and γ-Al 2 O 3 (Al 1 HRM 2 ), was developed to enhance CF 4 decomposition in our previous study. However, its catalytic performance requires improvement, as it suffers from poor stability. In this study, the low-cost and anti-HF-corrosive CaO was utilized to further boost the material's CF 4 decomposition efficiency and stability. Specifically, decomposition efficiency and stability increased by 30% and 2.25 times than that of Al 1 HRM 2 , respectively. At the microscopic level, it was observed that after CaO uniformly distributed across the catalyst surface, it enhanced the Al-O (Al-O-Al) stretching vibration, increased the number of oxygen vacancies, and simultaneously prevented the phase transition from γ to α. Additionally, CaO intensifies the characteristic peaks of strong L-acid sites, enhancing their CF 4 adsorption capacity and strength. Specifically, Al Ⅲ sites facilitate C-F bond cleavage to form AlF 3 , which undergoes fluorine-oxygen exchange with CaO to produce CaF 2 . This process effectively inhibits F + occupation of γ-Al 2 O 3 active sites, thereby promoting CF 4 decomposition. This study utilizes RM as a high-performance material for CF 4 pollution control, achieving the goal of treating waste with waste across the aluminum industry supply chain. It provides a new technological foundation for purifying difficult-to-treat Perfluorocarbons greenhouse gases.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Ling-qiao Tang,Hao-wen Zhang,Qiong Wu,Di-wen Jiang,Li Wang,Guo-liang Liu,Hai-jun Chen,Zong-kai Yan,Zhe-sheng Feng,Yan Wang
Due to the high electrical conductivity, large specific surface area, and abundant hydrophilic functional groups, MXene-based composites have garnered significant attention as candidate functional materials for humidity sensing. Nevertheless, it remains challenging to simultaneously achieve superior sensitivity, fast response kinetics, and reliable printability in flexible humidity sensors. Herein, a flexible printed humidity sensor based on a Sm 2 O 3 -modified MXene composite was developed, which features a hierarchical nanoflower architecture constructed via solvothermal synthesis. This architecture effectively suppresses MXene restacking while providing abundant mesoporous channels and interfacial sites, facilitating the adsorption and diffusion of water molecules. To further enhance the humidity response, NaCl was introduced to promote ionic conduction. The resulting sensor exhibits rapid response and recovery times (4.9 s and 4.3 s, respectively) and a large capacitance variation of 3357.7% over a wide relative humidity range (11-97% RH). In addition, the sensor demonstrates ultralow hysteresis, favorable repeatability, and excellent long-term stability, with negligible capacitance fluctuation after 10 days of storage. Moreover, proof-of-concept demonstrations were performed for non-contact finger proximity sensing, human respiration monitoring, plant microenvironment tracking, and skin-interfaced humidity detection, demonstrating the potential versatility of the proposed sensor. Collectively, this study presents a promising strategy for fabricating high-performance flexible humidity sensors, offering broad prospects for wearable health monitoring and intelligent human-machine interaction in next-generation Internet of Things systems.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zhicheng Wang,Xin Shi,Zizhen Peng,Wenzhong Ma,Yakai Lin,Hideto Matsuyama,Qiuyan Bi
A SISAIP strategy was developed to regulate interfacial PA formation. • SDS/NaCl regulation produced ultrathin PA layers with sub-nanometer pathways. • The membrane achieved S Li, Mg of 90.9 and permeance of 9.5 L m −2 h −1 bar −1 . • Stable operation and strong flux recovery were obtained under brine-relevant tests. The rapidly increasing global demand for lithium has stimulated the development of advanced membrane technologies for lithium extraction from salt-lake brines. Nanofiltration (NF) membranes with precisely regulated subnanometer transport pathways are highly attractive for Li + /Mg 2+ separation; however, the rational construction of selective layers that simultaneously deliver high ion selectivity and fast water transport remains challenging. Herein, we report a scalable surfactant–inorganic salt–assisted interfacial polymerization (IP) strategy, termed SISAIP, to fabricate high-performance polyamide NF membranes. Interfacial tension, dynamic light scattering, and UV–vis analyses indicated that sodium dodecyl sulfate enriched at the water/oil interface and regulated PEI transport across the interface, whereas NaCl modified the aqueous-phase microenvironment, moderated PEI diffusion toward the interface, and helped confine the interfacial reaction zone. This coordinated regulation produced an ultrathin PA selective layer with an apparent thickness of 11.2 ± 0.6 nm and compact subnanometer transport pathways. The optimized membrane achieved a water permeance of 9.5 L·m −2 ·h −1 ·bar −1 , an S Li,Mg of 90.9, and Mg 2+ rejection above 99.5%, corresponding to 578.6% and 437.9% increases in water permeance and S Li,Mg over the control T-IP membrane, respectively. The membrane also maintained stable performance during 120 h of continuous filtration and exhibited favorable fouling/scaling resistance, with a flux recovery ratio of 100% under organic-conditioned CaSO 4 scaling conditions. This SISAIP strategy provides a promising and scalable route for designing advanced NF membranes toward efficient lithium recovery from salt-lake brines.
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ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 30
·40353-40371
·
IF 7.8
Wang Tong,Wang Yingying,Xu Jianxiang,Zheng Yilu,Zhang Yanyan,Wu Yingli,Zhu Limin
Conventional chemotherapeutic agents are frequently limited by off-target toxicity and suboptimal therapeutic outcomes. Nanomedicines utilizing cell membrane camouflage provide a promising strategy for precise drug delivery and multimodal combination therapy. Herein, we designed a tumor-microenvironment-responsive cell-membrane-coated nanocomposite (designated as ZnO 2 @MO-D@Mn-CeO 2 @CM), which consists of a zinc peroxide (ZnO 2 ) core encapsulated within a drug-loaded mesoporous organosilica (MO-D, where D is doxorubicin for the 4T1 breast cancer model and daunorubicin for the C1498 leukemia model) layer, with the mesopores gated by manganese-doped cerium oxide (Mn-CeO 2 ) nanoparticles, and coated with a homologous cell membrane (CM). This nanocomposite enables the release of therapeutic components under acidic conditions and in the presence of elevated glutathione (GSH). It facilitates a combination therapy by integrating chemotherapy, enhanced chemodynamic therapy (CDT), ferroptosis induction, and immunomodulation. Our results demonstrate that this nanocomposite effectively suppresses the progression in 4T1 solid tumor and C1498 leukemia models, demonstrating its potential as a robust combinatorial strategy.
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BIOMACROMOLECULES
·
2026
·
IF 5.9
Wang Junpeng,Hao Feijing,Xu Chengwei,Lin Kai,Wang Hongxiang,Xing Yuanyuan,Liu Wentao,Liu Hao,Li Na,Xia Weidong
Infected
diabetic wounds are complicated by bacterial infection,
oxidative stress, and hyperglycemia, limiting conventional monotherapies.
Combination therapies suffer from uncontrolled release and poor responsiveness
to pathological cues. Here, we report a nanoparticle-cross-linked
hydrogel that integrates structural integrity with environment-triggered
delivery. We utilized self-assembled epigallocatechin gallate (EGCG)-tobramycin
(TOB) nanoparticles as dynamic cross-linkers within a phenylboronic
acid-modified gelatin network. The engineered system provides dual-stage
responsiveness: the hydrogel disassembles under the hallmark hyperglycemic
and acidic conditions of diabetic wounds, releasing the nanoparticles,
which then dissociate under acidity to synchronize drug release. Such
sequential disassembly acts as a synergistic “one-two punch,”
allowing EGCG to scavenge ROS and remodel the inflammatory microenvironment,
while TOB provides prolonged antibacterial action. In vivo , the system significantly reduced bacterial load, accelerated epithelial
regeneration, and promoted high-quality wound healing. By seamlessly
coupling nanocontrolled release with microenvironmental sensing, we
present a precision-engineered platform for the synergistic treatment
of recalcitrant diabetic wounds.
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Food Analytical Methods
·
2026
·Vol. 19
·期 10
·302
·
IF 3
Yu Haichao,Huang Jiayue,Zhao Jinfeng,Luo Wang,Li Jianjun,Liu Xiaojun
With the large-scale development of the food industry, hydrogen peroxide (H₂O₂), a potent oxidizing agent, has been illicitly used by some manufacturers for bleaching, decolorization, and preservation, making it a significant potential risk in the field of food safety. Therefore, elucidating the hazardous mechanisms of H₂O₂ residues in food is of paramount importance for strengthening food safety monitoring systems and safeguarding public health. In this study, a label-free and highly sensitive sensing platform based on 4-cyano-4'-pentylbiphenyl (5CB) liquid crystal (LC) microdroplets was developed for the detection of H₂O₂ and catalase (CAT). The sensor enables the detection of H₂O₂ and CAT by monitoring the distinct optical pattern transitions of dodecanal-doped 5CB liquid crystal microdroplets under various conditions using polarized optical microscopy (POM). The results demonstrate that under pH 11 conditions, the limit of detection (LOD) for H₂O₂ is 0.01% (w/v), and for CAT is 0.01 ng/mL. Fourier Transform Infrared Spectroscopy (FTIR) was employed to characterize the post-reaction system, verifying the chemical transformations. Furthermore, simulated testing on food samples was successfully conducted, suggesting that this sensor holds significant potential for applications in food safety, biomedicine, and analytical detection. However, the optical sensing platform is sensitive to changes in ambient humidity and temperature, which may limit its direct application in complex food matrices. Although the system enables intuitive interpretation of POM textures, future work should investigate matrix interference, quantitative image analysis, portable readout integration, and validation using authentic food samples.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Boyang Zhang,Zhiyong Zhang,Yangfan Li,Yangqi Wei,Xingmiao Huang,Chuncheng Chen,Hua Sheng,Jincai Zhao
Post-synthetic strategy modularly integrates CO 2 -to-CO and CO-to-C 2+ sites. • Redox mediator and confinement synergize to regulate cascade reactions. • Confined TEMPOL acts as PCET mediator, lowering CO 2 -to-*COOH barrier. • Inactive MOF is transformed into an efficient CO 2 -to-C 2+ electrocatalyst. Efficient electrochemical conversion of CO 2 to multi-carbon (C 2+ ) products requires the integration of two sequential functionalities: CO 2 activation to *CO and subsequent CO-initiated C-C coupling. Conventional strategies typically rely on the rigid, pre-designed incorporation of these two functional units during catalyst synthesis. In contrast, we propose a post-synthetic modification strategy that introduces a molecular CO 2 activation unit into a pre-formed catalyst scaffold, thereby enabling its spatially proximal coupling with intrinsic CO reduction sites. This concept is demonstrated by encapsulating 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL) into the pores of a tetrapyrazolylporphyrin copper-based metal–organic framework (FICN-8). Owing to the well-matched molecular dimensions, the confined TEMPOL and adjacent Cu nodes cooperatively define a cavity that spatially accommodates a CO 2 molecule. Reduced TEMPOL acts as a proton-coupled electron transfer (PCET) mediator, while spatial confinement regulates the local reaction environment, jointly lowering the free energy barrier for *COOH formation. The confined *COOH intermediate is subsequently converted to CO and further undergoes C–C coupling. As a result, FICN-8—originally inactive for CO 2 -to-C 2+ conversion (Faradaic Efficiency, FE< 0.6%)—is transformed into an efficient electrocatalyst, delivering a C 2+ Faradaic efficiency of 42.6% with a two-orders-of-magnitude enhancement in C 2 H 4 formation rate. Download: Download high-res image (123KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）