JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Qiuhong Yuan,Jingpeng Xiong,Lin Liao,Qiliang Zhang,Zhiwen Qiu,Guo-Hua Zhou
Well dispersed graphene and good interfacial bonding are crucial for the synthesis of aluminum (Al)-based composites with high performance. To achieve this goal, graphene oxide (GO) was used to fabricate Al-RGO (reduced GO) composites via the in-situ formation of Al 2 O 3 . Detailed microstructure analyses revealed two forms of interface structures present in the as-extruded material, specifically RGO/γ-Al 2 O 3 /Al and RGO/amorphous-Al 2 O 3 /Al, which formed from interfacial reactions between GO and the Al metal. The as-generated Al 2 O 3 (γ/amorphous) phases substantially improved the interface bond between RGO and the Al matrix. Meanwhile, RGO nanosheets were uniformly dispersed within the Al matrix without evident structural degradation. As a result, the incorporated RGO notably improved the mechanical properties of the composite, resulting in a 216.2% increase in yield strength and a 65.2% increase in microhardness for the composite containing 0.5 wt% GO compared to the pure Al. These findings provide a viable route into the synthesis of Al-graphene composites with high performance.
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高影响因子
Cell Reports
·
2026
·Vol. 45
·期 6
·
IF 7.7
Xinmiao Wang,Anxin Zhang,Chaonan Yu,Xingyuan Tang,Jiahui Wang,Fenglian Chen,Kun Jiang,Wen-Bing Yin,Weiguo Fang
Many microbial symbionts form distinct partnerships with different hosts. While the mechanisms specific to each partnership are well understood, the shared strategies that a symbiont uses to interact with disparate hosts remain understudied. Here, we report that the endophytic and entomopathogenic fungus Metarhizium robertsii deploys the farnesyltransferase inhibitor barceloneic acid A (BA-A) to modulate the physiology of insects and plants to develop parasitism and mutualism, respectively. During insect infection, BA-A inhibits host Ras protein farnesylation, reducing its cell membrane localization and suppressing MAPK/ERK phosphorylation and production of the hormone 20-hydroxyecdysone. This suppresses larval pupation and decelerates larval death by upregulating antibacterial peptides to kill gut-derived opportunistic pathogens in the hemocoel, prolonging M. robertsii ’s access to nutrient-rich larval hemolymph for maximal reproduction. BA-A also inhibits the plant farnesyltransferase, downregulating the defense-related protein PR2 to facilitate mutualism development. The BA-A biosynthetic gene cluster was characterized, which is activated during interactions with insects and plants.
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高影响因子
Analytical Methods
·
2026
·
IF 3
Junping Yang,Ziyu Song,Lu Huang,Ke Wen,Yuan Lu,Qian Liu
A one-pot bio-inspired synthesis approach was employed to fabricate five types of uricase nanoflowers (UOx-NFs), from which Mn-UOx-NFs with the highest catalytic activity were selected. The Mn-UOx-NFs were successfully integrated with magnetic-responsive Fe3O4@CeO2 quantum dots to create efficient loaded dual nanozymes (LDNs). The LDNs demonstrated excellent temperature and storage stability. After being reused 7 times, 18.5% of the enzymatic activity was still retained. Based on the LDNs, a reusable and sensitive colorimetric method for the detection of uric acid in urine was established. The colorimetric detection system exhibited a good linear relationship between uric acid concentration and optical density values at 652 nm within the range of 1–55 µmol L−1, with a detection limit of 0.37 µmol L−1.
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高影响因子
Sustainability
·
2021
·Vol. 13
·期 13
·7458
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IF 3.251
Xi Zhang,Juan Tang
Tourists’ perceptions of various risks at their travel destinations have crucial implications for destination management organizations and other tourism industry practitioners, which is growing into an unprecedented concern in the post-pandemic era. The Internet has boosted the global homestay industry. The perceived risk of homestay tourists requires further attention from researchers to promote the sustainable development of the homestay industry, especially in the post-pandemic era. To supplement and enrich the literature, this study aims to explore the relationships between tourists’ perceived risk, three dimensions of tourists’ emotional solidarity with hosts (feeling welcome, sympathetic understanding, and emotional closeness), and their customer loyalty towards the homestay industry in the post-pandemic era by taking the homestay industry of Guangzhou, China as the context, and employing SmartPLS for the empirical analysis. The results indicate that perceived risk has a significantly negative impact on emotional solidarity and customer loyalty, while emotional solidarity has a significantly positive impact on customer loyalty and plays a partial mediating role in the relationship between perceived risk and customer loyalty. The theoretical contributions of the article and the practical implications of the findings for the sustainable development of the homestay industry are discussed.
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JOURNAL OF CONTROLLED RELEASE
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2026
·
IF 12.4
Weiqi Zhang,Linjia Chen,Yahui Dong,Yinghua Zeng,Yongyu Chen,Yue Liu,Jingru Wang,Fujun Shi
Triple-negative breast cancer (TNBC) remains a formidable clinical challenge due to the lack of druggable targets and intrinsic resistance to conventional therapies. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, represents a promising therapeutic vulnerability in TNBC. Here, we identify solute carrier family 7 member 5 (SLC7A5) as a ferroptosis-suppressing prognostic target, and develop a tumor microenvironment (TME)-responsive camptothecin (CPT)-peptide conjugates (CPCs) nanoassembly for in situ delivery of the SLC7A5 inhibitor JPH203 to TNBC. The CPCs integrate an active tumor targeting motif, a CPT-based hydrophobic core that drives self-assembly, and a gelatinase-cleavable linker for enzyme-responsive disassembly. Upon TME-triggered release, JPH203 effectively blocks leucine uptake, suppresses mTORC1 signaling, disrupts iron and redox homeostasis, and synergizes with mitochondrial reactive oxygen species to induce potent ferroptosis, achieving an 81.2% tumor growth suppression rate in orthotopic 4 T1 models with favorable biosafety. Importantly, CPCs-JPH promotes dendritic cell maturation, activates CD8 + T-cell responses, and significantly improves survival outcomes in orthotopic 4 T1 tumor-bearing mice. This work establishes a multifunctional and enzyme-responsive nanoplatform that harnesses ferroptosis to overcome therapeutic resistance while concurrently engaging innate and adaptive immunity in TNBC.
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Xiao-Ya Wang,Wen-Qiang Gong,Fei-Feng Mao,Wei Hui,Xian-Lu Wu,Tiao Zhang,Yan Zhou,Jia-Yin Zhang,Duan-Jian Tao
The high-purity separation of gases with similar properties (e.g., SO 2 vs. CO 2 ) remains a major challenge for ionic liquid (IL) absorbents. In this work, we report the highly efficient and selective capture of SO 2 via SO 2 -triggered reversible solid–liquid phase transition in a series of tunable alkyl quaternary ammonium hydrogen sulfate ionic liquids (AQA-HSO 4 ). The results show that AQA-HSO 4 achieve ultrahigh IAST SO 2 /CO 2 selectivities (up to 855) and high uptake capacity (7.1 mmol g −1 ) at 293.2 K and 100 kPa. This superior performance is rooted in a rationally designed phase transition mechanism, where the modulation of alkyl chain lengths (from ethyl to hexyl) finely tunes the ionic microenvironment by balancing electron-donating and steric effects. Systematic investigations, including SO 2 absorption and kinetic analyses, in-situ FT-IR, DFT and COSMOtherm calculations, reveal that the [HSO 4 ] − anion serves as the primary active site, forming suitable cooperative hydrogen bonding and Coulombic interactions specifically with SO 2 , while remaining inert to CO 2 /N 2 . Kinetic analysis confirms that the spontaneous phase transition of AQA-HSO 4 drastically lowers the mass transfer energy barrier, enabling [N 4444 ][HSO 4 ] to reach 67% of its saturation capacity within 5 min. Additionally, [N 4444 ][HSO 4 ] exhibits outstanding stability and recyclability, with negligible capacity loss (<0.1%) after 20 absorption–desorption cycles, and can be fully regenerated under mild, energy-efficient conditions (depressurization to ∼20 kPa) without external heating. This work provides a promising strategy for developing next-generation, phase-transition-responsive absorbents for high-purity gas separation processes.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Chen Li,Ning An,Jingyue Zhang,Le Li,Wen Li
Shenling Baizhu (SLBZ) Formula, a classical traditional Chinese medicine, has long been used to treat digestive disorders and has been reformulated into modern dosage forms to improve patient compliance. However, whether these different formulations provide comparable therapeutic efficacy remains unclear. Given that polysaccharides are major bioactive constituents of SLBZ—implicated in modulating intestinal immunity, suppressing inflammation, and regulating oxidative stress—we focused on polysaccharides to evaluate potential efficacy differences across formulations. We extracted polysaccharides from SLBZ powder, pill, and granule formulations, characterized their structures, and assessed their therapeutic effects in rodent models of ulcerative colitis (UC) and irritable bowel syndrome (IBS-D). Polysaccharides from the powder and pill forms exhibited stronger anti-inflammatory and antioxidant activities than those from granules. Structurally, the powder- and pill-derived polysaccharides showed higher levels of uronic acids, more complex monosaccharide profiles, and larger molecular weights, which may underlie their enhanced efficacy. These findings provide insights into the structure–activity relationship of SLBZ polysaccharides in these rodent models.
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高影响因子
Food Bioscience
·
2026
·
IF 6.2
Linyu Mei,Zicheng Zhang,Yue Niu,Wenlong Deng,Jiwei Song,Yuan Yao,Ruien Yu,Yunpeng Shao,Xiujian Chou
In this study, a capillary coated with silver nanoparticles-modified zinc oxide nanorods (Ag/ZnO NRs) was developed as an ultrasensitive SERS substrate. The aggregation of Ag nanoparticles (Ag NPs) at the tips and sides of ZnO NRs generates high-density three-dimensional “hot spots”, which, together with the photocatalytic activity of Ag/ZnO and the extended light–analyte interaction time afforded by the capillary structure, enables efficient adsorption and in situ detection of trace pollutants. This substrate exhibits excellent SERS performance, achieving a detection limit of 10 -14 M for Rhodamine 6G (R6G), with a relative standard deviation of less than 12%, With in-situ and rapid detection of microplastics in different liquid environments such as seawater and various beverages, the detection limit of polystyrene microspheres is as low as 50 μg/mL. Therefore, our prepared substrate offers a highly sensitive and reusable solution for in-situ, real-time, and rapid monitoring of trace contaminants in liquid environments.
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MACROMOLECULES
·
2014
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IF 5.927
Bo Zhang,Hui Tang,Peiyi Wu
Dynamic thermal phase transition behavior of a thermoresponsive copolymer P(MEO2MA-co-PEGMA2080) synthesized by ATRP random copolymerization of 2-(2-methoxyethoxy)ethyl methacrylate(MEO2MA, Mn = 188 g/mol) and poly(ethylene glycol) methyl ether methacrylate (PEGMA, Mn= 2080 g/mol) in D2O was studied by means of infrared spectroscopy in combination with two-dimensional correlation analysis (2Dcos). Because of the absence of strong intermolecular hydrogen bonding interactions between polymer chains and the amphiphilic property of PEGMA2080 with long ethylene glycol segments, this copolymer exhibited an unusual thermally induced multistep aggregation process. In general, the change of hydrophilic side chain takes place before carbonyl groups and backbones during the whole process and thus the driving force of this phase transition process of P(MEO2MA-co-PEGMA2080) should be hydration changes of side chains. 2Dcos was finally employed to discern the sequence order of all the group motions during heating process in different temperature regions. It is concluded that during the phase transition P(MEO2MA-co-PEGMA2080) chains successively experience “unimers–clusters–micelles– aggregates” four consecutive conformation changes.
研究领域:
高分子科学
·
材料化学
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物理化学
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智能材料
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光谱学
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高影响因子
ACTA OPHTHALMOLOGICA
·
2023
·Vol. 102
·期 3
·e245
·
IF 3.4
James Loughman,Emmanuel Kobia-Acquah,Gareth Lingham,John Butler,Ekaterina Loskutova,David A. Mackey,Samantha S. Y. Lee,Daniel I. Flitcroft
Purpose The Myopia Outcome Study of Atropine in Children (MOSAIC) is an investigator-led, double-masked, randomized controlled trial investigating the efficacy and safety of 0.01% atropine eye drops for managing myopia progression in a predominantly White, European population. Methods Children aged 6–16 years with myopia were randomly allocated 2:1 to nightly 0.01% atropine or placebo eye drops in both eyes for 2 years. The primary outcome was cycloplegic spherical equivalent (SE) progression at 24 months. Secondary outcomes included axial length (AL) change, safety and acceptability. Linear mixed models with random intercepts were used for statistical analyses. Results Of 250 participants enrolled, 204 (81.6%) completed the 24-month visit (136 (81.4%) treatment, 68 (81.9%) placebo). Baseline characteristics, drop-out and adverse event rates were similar between treatment and control groups. At 24 months, SE change was not significantly different between 0.01% atropine and placebo groups (effect = 0.10 D, p = 0.07), but AL growth was lower in the 0.01% atropine group, compared to the placebo group (−0.07 mm, p = 0.007). Significant treatment effects on SE (0.14 D, p = 0.049) and AL (−0.11 mm, p = 0.002) were observed in children of White, but not non-White (SE = 0.05 D, p = 0.89; AL = 0.008 mm, p = 0.93), ethnicity at 24 months. A larger treatment effect was observed in subjects least affected by COVID-19 restrictions (SE difference = 0.37 D, p = 0.005; AL difference = −0.17 mm, p = 0.001). Conclusions Atropine 0.01% was safe, well-tolerated and effective in slowing axial elongation in this European population. Treatment efficacy varied by ethnicity and eye colour, and potentially by degree of COVID-19 public health restriction exposure during trial participation.
研究领域:
眼科学
·
儿童眼科护理
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临床药理学
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屈光不正研究
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Bolun Mei,Yueru Wang,Zhouxuan Zang,Ouyang Liu,Xu Liang,Guoji Liu,Han Sun,Xingchuan Yang,Li Xu
Calcination-driven Cu exsolution from a CuZr precursor tunes the Cu-ZrO 2 interfacial environment. • Catalysts with the optimal interfacial environment achieve ethanol selectivity approaching 90%. • Kinetic analysis and in situ DRIFTS support a dehydration‑hydrogenation pathway at the Cu-ZrO 2 interface. • DFT reveals that Cu-ZrO 2 interface converts high-barrier concerted dehydration into a lower-barrier stepwise route. The selective hydrogenolysis of ethylene glycol (EG) to ethanol is a critical step in the dimethyl oxalate (DMO)-to-ethanol process, yet the catalytically relevant Cu environment for this transformation remains insufficiently understood. Here, we prepared a series of CuZr catalysts with distinct Cu-ZrO 2 interfacial structures through calcination-induced structural evolution. Structural characterization reveals that calcination progressively redistributes Cu species from a more bulk-associated state in ZrO 2 to surface-enriched Cu, and ultimately to segregated Cu-rich domains. Among the catalyst series, calcination at an intermediate temperature of 550 °C gave the best performance. Ethanol yield scaled with the accessible Cu surface area, and both exhibited a volcano-type dependence on calcination temperature, whereas the Cu-normalized TOF decreased monotonically. This discrepancy underscores that exposed Cu alone cannot account for the catalytic behavior, and suggests an important contribution from coupled Cu-ZrO 2 interfacial environments. Kinetic analysis and in situ DRIFTS support a pathway involving dehydration-related transformation of EG followed by hydrogenation of carbonyl-type intermediates. DFT results further suggest that, relative to pristine ZrO 2 , the Cu-ZrO 2 interface stabilizes dehydration related carbon-containing intermediates, thereby enabling a more accessible stepwise pathway for EG dehydration and facilitating the subsequent hydrogenation to ethanol. These findings provide an interface engineering strategy for designing Cu-based catalysts in the DMO-to-ethanol process and related polyol hydrogenolysis reactions. Download: Download high-res image (129KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yizhen Cheng,Binyuan Wang,Pengwei Yan,Jimin Shen,Jing Kang,Shengxin Zhao,Xinwei Zhu,Linlu Shen,Shuyu Wang,Yang Shen,Zhonglin Chen
Adsorption is the first step of the interface mechanism, but the adsorption behaviors of ozone (O 3 ) and pollutants on the catalyst during catalytic ozonation have always been overlooked in previous works. In this study, a promising strategy for the in-situ decomposition of O 3 to trigger surface reactive oxygen species (ROS) by nitrogen (N)-doped biochar was proposed, which greatly improved the efficiency of O 3 utilization. Specifically, N -doped biochar (NBC700) with a high defect level ( I D /I G = 1.165) was achieved by a one-pot method. It showed good adsorption on O 3 and atrazine (ATZ), which promoted the in-situ formation of surface ROS, as well as resists the interferences of multiple coexisting anions (NO 3 − , Cl − , PO 4 3− , SO 4 2− and HCO 3 − ) on ATZ removal. In-situ Raman spectra revealed the interface catalytic mechanism of O 3 decomposition into adsorbed peroxide species (*O 2 ) and adsorbed atomic oxygen (*O). Additionally, OH was the dominant ROS and surface-O 3 further strengthened direct ozonation via intramolecular electron transfer. In this process, sp 2 -hybridized system with delocalized π electrons, electron-rich oxygen-containing functional groups, and conjugated heteroatoms were identified as the active sites, but defective sites with free electrons played the most important part according to the lowest adsorption energy (−13.12 eV) calculated by density functional theory (DFT). The degradation of ATZ included dechlorination and non-dechlorination pathways, which made the acute and chronic toxicity of most intermediate products both decrease to not be harmful to fish and green algae. This work provides a new perspective on the interface mechanism in catalytic ozonation for ATZ removal.
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高影响因子
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