Nature Communications
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2026
·
IF 18.1
Wang Wei,Qiao Wang,Chen Zhuo,Chen Jialei,Chen Shan,Zhao Zhuang,Liao Xuelong,Song Wenge,Huang Rong,Lu Tiantian,Li Youzeng,Liu Haonan,Sun Jiacheng,Xu Xing,Yan Zhenhua,Zhao Qing,Liu Zhongfan,Chen Jun,Wang Huan
Low-temperature Li||CF x batteries undergo performance degradation due to the insulating nature of CF x and sluggish Li + kinetics. Herein, we present a dual-modification strategy integrating porous positive electrode architecture design with customized electrode-electrolyte interphase engineering to overcome these limitations. Our approach features: (i) plasma-enhanced chemical vapor deposition-constructed mesoporous CF x with conformal carbon coating, and (ii) electrolyte-mediated in situ formation of a sulfur-rich inorganic interphase layer on CF x surface. The engineered porous framework establishes efficient Li + diffusion channels, while the electrolyte-derived interphase significantly enhances Li + transport and desolvation kinetics. Moreover, the carbon coating substantially improves electronic conductivity and suppresses LiF stacking. The optimized Li||CF x system delivers capacities of 428.4 mAh g −1 at −50 °C and 2 A g −1 , and 333.4 mAh g −1 at −70 °C and 0.1 A g −1 . Practical 5 Ah pouch cells deliver competitive specific energies of 470 and 332 Wh kg −1 at −50 and −70 °C under 0.01 A g −1 , respectively.
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JOURNAL OF NANOPARTICLE RESEARCH
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2026
·Vol. 28
·期 9
·221
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IF 3.5
Li Rongye,Zhu Congying,Song Xiaoping,Zhang Xiaodong,Hamdi Marwa,Chen Jiahong
Recent advances in polymeric nanocarriers have highlighted the potential of amphiphilic block copolymers for the simultaneous delivery of chemotherapeutic agents with different physicochemical properties. In this study, asymmetric poly(ethylene glycol)-b-polylactide-b-poly(ethylene glycol) (PEG- b -PLA- b -PEG) triblock copolymers were synthesized via ring-opening polymerization, end-group functionalization, and click coupling, and subsequently evaluated as biodegradable nanocarriers for the co-delivery of paclitaxel (PTX) and cisplatin (CDDP). The copolymers were characterized by 1 H nuclear magnetic resonance (NMR) spectroscopy and gel permeation chromatography (GPC). Self-assembly in aqueous media yielded spherical micelles with uniform size distributions, as confirmed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The micelles exhibited efficient encapsulation of PTX and CDDP with high drug-loading capacities and encapsulation efficiencies. Hydrolytic degradation studies conducted at 37 °C for 45 days revealed progressive cleavage of the ester bond, reduction in molecular weight, and gradual disintegration of the micellar structure. In vitro release studies of single- and dual-drug-loaded micelles demonstrated sustained release of both drugs over time. Analysis of the release data using the Korsmeyer–Peppas model provided insight into the release behavior and suggested contributions from both diffusion and polymer degradation processes. The biocompatibility of the unloaded triblock copolymer micelles was assessed through cytocompatibility, hemocompatibility, and zebrafish embryo assays, which indicated low intrinsic toxicity and minimal hemolytic activity. Collectively, these results demonstrate that PEG- b -PLA- b -PEG triblock copolymer micelles can be recognized as biodegradable carriers capable of dual-drug encapsulation and sustained release, providing a useful platform for further investigation of combination drug delivery systems. Graphical abstract Asymmetric PEG- b -PLA- b -PEG triblock copolymers were synthesized and self-assembled into uniform micelles capable of co-encapsulating Paclitaxel and Cisplatin. The micellar architecture provided controlled degradation and synchronized dual-drug release over 45 days. The combination of tunable structure, sustained release, and excellent biocompatibility highlights these triblock copolymer micelles as efficient nanocarriers for combinational cancer therapy
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 9
·634
·
IF 5.4
Li Ce,Zeng Yutong,Wei Keyi,Li Xinyan,Wang Yan
Three exosome fluorescence-labeling workflows based on azide-functionalized cholesterol anchoring and copper-free click chemistry were systematically optimized and comparatively evaluated. A549 cell-derived exosomes were used as the primary model. By varying the sequence of azide introduction and fluorescent click reaction, one-step, two-step, and three-step protocols were compared. Under the tested conditions, the two-step protocol provided the most favorable overall balance among exosome recovery, fluorescence intensity normalized to exosome particle concentration, dye consumption, reaction volume, and operational simplicity. After labeling, the exosomes retained their typical morphology, particle size distribution, while the representative exosome-associated proteins CD63, CD81, and TSG101 remained detectable. The fluorescence intensity of the labeled exosomes showed a strong linear correlation with particle concentration, supporting its potential for rapid quantitative analysis. Cellular uptake experiments confirmed the feasibility of the labeled exosomes for in vitro imaging, and fluorescence remained detectable during the 24-h in vivo observation period. Overall, this study identifies an optimized two-step workflow for exosome fluorescence labeling and provides a practical approach for exosome visualization and tracking under the evaluated experimental conditions. Graphical abstract
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Nature Metabolism
·
2026
·Vol. 8
·期 8
·1713-1729
·
IF 27.5
Deng Jiangming,Meng Wen,Yang Yuanqin,Xiao Ting,Jin Zhangliu,Wang Jing,Li Qing-xin,Xie Lingxiang,Hu Jingyi,Song Rong,Hu Yibo,Chu Yi,Li Qing,Jin Ping,Wang Zheng,Wu Irene XY,Liu Feng,Xiao Yang
The gut constantly interacts with both pathogens and dietary signals, but how it balances immune and metabolic responses remains unclear. Here we show that intestinal cGAS, a key DNA sensor, acts as a regulator linking gut immunity to whole-body metabolism. We show that cGAS signalling is activated in the intestines of humans and male mice with obesity, leading to increased type I interferon production and heightened immune activity in intestinal cells. Strikingly, deleting cGAS specifically in intestinal epithelial cells enhances energy expenditure, protects against diet-induced obesity and improves metabolic health. These effects depend on the gut microbiota, particularly Lactobacillus murinus and its metabolite indole-3-acetic acid (IAA), which promotes adipose thermogenesis. Our findings position intestinal cGAS as a key driver of obesity through gut-to-fat signalling and suggest that targeting the intestinal cGAS–microbiota IAA axis could offer promising strategies to combat obesity and related metabolic diseases.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 9
·628
·
IF 5.4
Li Fuping,Li Baoyu,Li Rong,Men Xue,Gao Lian-Xun,Wu Chengxin,Yang Wenrong,Pang Pengfei,Zhang Yanli
A fluorescent switch nanoprobe based on boric acid-functionalized europium-based metal–organic framework (BA-Eu-MOF) integrated with a visual analysis platform assisted by smartphone was established for the sensitive detection of Hg 2+ and glutathione (GSH). The probe was fabricated with 5-boronoisophthalic acid as ligand and europium ions as metal node, which enables specific recognition of Hg 2+ through a transmetalation mechanism. Upon the introduction of Hg 2+ , the red fluorescence of the probe was quenched (“off” state). When GSH is added, because its thiol groups have a stronger binding affinity for Hg 2+ , it competitively extracts Hg 2+ from the BA-Eu-MOF/Hg 2+ complex, leading to fluorescence recovery (“on” state). Based on this “on-off-on” mode, the quantitative detection of Hg 2+ and GSH was achieved with detection limits of 0.67 nM and 0.087 µM. Furthermore, the intelligent sensing platform for quantitative detection of analytes was developed by utilizing a smartphone Color Grab App with detection limits of 9.57 µM and 2.32 µM, respectively. Both modes were successfully employed to the detection of Hg 2+ and GSH in actual samples with spiked recoveries ranging from 88.9% to 108.0%. Benefiting from the porous characteristics of MOF and the specific recognition capability of the boric acid group, the proposed probe exhibits notable advantages including facile preparation, operational simplicity, high sensitivity, and excellent selectivity. This study provides a facile, reliable and field-applicable novel detection strategy for environmental monitoring and the investigation of interactions between heavy metals and biomolecules. Graphical
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Huo Ming-Wei,Liu Jing-Yi,Zhang Ye-Chao,Feng Xin,Gu Le-Yan,Ping Cai-Yi,Qu Yan-Kai,Pan Honghao,Guo Beizhen,Jin Bihe,Tang Yongan,Cao Qing-Ri
Androgenetic alopecia (AGA) is a widespread condition characterized by progressive follicular miniaturization and hair loss, yet current topical therapies are often limited by insufficient follicular retention and undesired systemic exposure. Herein, we report cationic nanoemulsions specifically designed to promote follicle-associated delivery of two clinically approved anti-AGA drugs with reduced systemic exposure, thereby achieving potent therapeutic efficacy against AGA. The two anti-AGA drugs, minoxidil (MXD) and finasteride (FNA), are incorporated into a cationic polymer-coated nanoemulsion with a favorable nanoscale droplet (72.64 nm), high encapsulation efficiency (90.46% for MXD and 92.44% for FNA), and positively charged surface (zeta potential 51.2 mV). This cationic interface promoted local cutaneous retention and preferential follicle-associated localization, while substantially reducing systemic absorption. In testosterone-induced AGA mouse models, the dual-drug-loaded nanoemulsion outperformed commercial MXD tincture and single-drug formulations in promoting hair regeneration by inhibiting 5α-reductase-mediated dihydrotestosterone production and TGF-β1 signaling, while activating β-catenin and VEGF pathways to reprogram the follicular microenvironment. Importantly, repeated topical application showed good skin compatibility and no obvious systemic toxicity under the tested conditions. These findings highlight a cationic surface-functionalized nanoemulsion strategy that enhances follicle-associated retention while limiting systemic exposure, offering a clinically translatable approach for AGA therapy. Graphical Cationic nanoemulsions achieve follicle-associated delivery with reduced systemic exposure, enabling safer therapy for androgenetic alopecia
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Journal of Central South University
·
2026
·
IF 4.7
Lai Yuhua,Wang Chengcheng,Ge Lin,Chang Jin,Liu Jinhua
To address the challenges of complex preparation procedures, high organic solvent consumption, and poor environmental stability of products in conventional phosphor synthesis, this study proposes a simple, low-cost, solventfree one-step melt synthesis strategy, by which a series of Zn 2+ -doped manganese-based coordination polymer phosphors, Mn 1− x Zn x (OAc) 2 (OAc=acetate), were prepared. During heating, Mn(OAc) 2 ·4H 2 O releases its crystallization water to form a homogeneous molten phase, thereby yielding octahedrally coordinated anhydrous Mn(OAc) 2 . Systematic investigations reveal that the optimal Zn 2+ doping concentration ( x =0.2) significantly enhances luminescence performance by suppressing defect-related non-radiative decay pathways and mitigating energy transfer between Mn 2+ ions. The optimized Mn 0.8 Zn 0.2 (OAc) 2 phosphor achieves a photoluminescence quantum yield of 28.7% and a lifetime of 1.03 ms, while its PL intensity at 140 °C is enhanced by 54% compared with Mn(OAc) 2 , demonstrating excellent thermal stability. By integrating this red-emitting phosphor with commercial blue and yellow phosphors onto UV chips to fabricate full-spectrum white LEDs, ideal white light emission with CIE coordinates of (0.34, 0.35) is realized. This work provides a simple, environmentally benign, and scalable route for preparing high-performance Mn(II)-based coordination polymer phosphors for next-generation solid-state lighting applications.
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npj Climate and Atmospheric Science
·
2026
·
IF 9.6
Xue Yining,Li Ruoqi,Li Zhiwanxin,Zhang Junjie,Jiao Yutao,Cao Shengli,Yue Zhao,Sun Hongwen,Song Shaojie,Wang Lei
Although atmospheric brown carbon exerts warming effects by absorbing shortwave radiation, its sustainability is limited by photobleaching. In contrast, synthetic ultraviolet (UV) filters can dissipate absorbed UV radiation as thermal energy and retain structural stability. However, their atmospheric heating effects remain poorly understood. We designed a vacuum calorimetric chamber to quantify the heating potential (HP) of synthetic UV filters. The HP of four typical synthetic UV filters was 12–31 W mg −1 , greatly exceeding that of p -coumaric acid (5.39 W mg −1 ), a natural UV filter, and 4-nitrocatechol (6.36 W mg −1 ), a widespread brown carbon chromophore. Unlike p -coumaric acid, which undergoes photobleaching, synthetic UV filters maintain stable HP under UV radiation. Although four synthetic UV filters constituted only 0.02‰–0.35‰ of the total atmospheric organic matter (AOM), they collectively contributed 1.6–39.5‰ to the HP of AOM. Based on global consumption of synthetic UV filters, preliminary projections indicate that Temperate North America, Central Asia, and Boreal North America are key regions highly susceptible to atmospheric heating induced by these chemicals. Synthetic UV filters are non-negligible anthropogenic contributors to atmospheric heating, shedding new light on an unrecognized climate forcing agent.
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Stem Cell Reviews and Reports
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2026
·
IF 4.9
Lv Yan,Du Yongjun,Peng Zhi,Ma Chengjie,Li Zhenggang,Xu Rui,Hou Jianhong,Lu Sheng
Osteoporotic fracture is the most severe complication of osteoporosis, and impaired bone regeneration and delayed healing after fracture remain major clinical challenges. Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (BMSCs) may play a critical role in promoting bone regeneration after osteoporotic fracture. Enhancing their osteogenic potential and elucidating the underlying mechanisms may contribute to accelerated fracture healing. In this study, resveratrol-stimulated BMSC-derived EVs (Res-EVs) were isolated using differential centrifugation combined with ultracentrifugation. We found that compared with EVs secreted by BMSCs under normal culture conditions (Nor-EVs), Res-EVs significantly enhanced BMSCs osteogenic differentiation capacity. Analysis of miRNA sequencing data identified miR-19a-3p as significantly downregulated and PC-3p-83,608 as significantly upregulated. The reliability of the sequencing data was validated by qPCR results. By transfecting BMSCs with inhibitor and mimic of miR-19a-3p, we found that miR-19a-3p was a negative regulator of osteogenic differentiation. Bioinformatics prediction and dual-luciferase reporter assays confirmed that miR-19a-3p directly targets Raf1. Western blot results indicated that miR-19a-3p regulates osteogenic differentiation of BMSCs by targeting Raf1. In vivo experiments further demonstrated that Res-EVs treatment enhanced repair at osteoporotic fracture sites and increased the expression of RUNX2 and RAF1. Collectively, these findings indicate that Res-EVs promote bone regeneration at osteoporotic bone defect sites in rats, with the miR-19a-3p/Raf1 axis representing a potential underlying mechanism.
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CATALYSIS LETTERS
·
2026
·Vol. 156
·期 9
·245
·
IF 2.5
Xia Ruixin,Song Jiahe,Guo Bao,Sun Daolai,Lv Jianhua
An ionic liquid-grafted catalyst, denoted as IL@MIL-101-NH 2 , was synthesized by introducing a novel functionalized bis-imidazolium ionic liquid containing carboxyl groups into the MIL-101-NH 2 (Cr) using a simple one-step method. The structural features of the catalyst were characterized by FT-IR, XRD, XPS, BET, SEM and so on, and its catalytic performance in the cycloaddition reaction of carbon dioxide (CO 2 ) with propylene oxide (PO) to propylene carbonate (PC) was investigated. The results demonstrated that IL@MIL-101-NH 2 exhibited excellent catalytic activity. Under the conditions of 110 °C, 2 MPa, 3 h, and a catalyst loading of 3.0 wt%, a PO conversion of 95.1% and a PC selectivity of 98.7% were achieved. The superior catalytic performance of IL@MIL-101-NH 2 was attributed to the synergistic effect among the Cr 3+ metal active centers, nucleophilic Br − species and hydrogen-bond-donating –COOH groups. In addition, the catalyst maintains good catalytic performance after four consecutive cycles, indicating its favorable stability and promising application potential. Graphical
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METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
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2026
·
IF 3.3
Zhang Ba,Zhou Shiwei,Wei Yonggang,Li Bo,Wang Hua
The migration of Pb in matte–slag interface and substitution behavior in slag are crucial for its efficient removal and solidification during copper smelting. This study investigated the migration behavior of PbS/PbO in matte–slag interface and substitution mechanism of PbO in fayalite. The results show that PbS is primarily incorporated into matte by forming solid solutions with Cu 5 FeS 4 and Cu 2 S. The enhanced interaction between PbS and FeO with rising temperature increases the Pb content in slag from 7.86 pct at 1100 °C to 9.66 pct at 1250 °C. Decreasing the Fe/SiO 2 of slag from 2.2 to 1.6 lowers PbO activity in slag, thereby increasing the Pb content in the migrated slag from 8.46 to 16.09 pct. While PbO migrates into slag for its higher solubility in oxide-based slag and combines with silicates such as fayalite. Regarding the substitution mechanism, the unit cell volume of Fe 2 SiO 4 decreases from 308.45 to 307.55 Å 3 with increasing PbO addition from 0 to 15 pct revealing the destructive role of PbO on the crystal structure. Mossbauer spectroscopy reveals that the Pb 2+ provided by PbO substitute for Fe (M2 sites) in the octahedral crystal structure of fayalite, resulting in lattice structural changes and forming Fe 2− x Pb x SiO 4 . The Fe 2+ released from the substitution is incorporated into Fe 3 O 4 along with O 2− from PbO and original Fe 3+ . The findings provide a theoretical basis for achieving Pb targeted removal and reducing environmental pollution, and offer insights for unstable Pb‑bearing phases solidification during copper slag resource recycling.
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JOURNAL OF FLUORESCENCE
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2026
·
IF 3.4
Ye Shenyi,Cai Jingrui,Ding Ruyu,Zhu Hang,Xiao Jiecheng,Liu Tianhui,Zhao Chengfei
In this study, nitrogen-doped carbon quantum dots (N-CQDs) are synthesized from citric acid and tetraethylenepentamine via a one-step melting method. Leveraging the fluorescence quenching of N-CQDs by Fe 3+ through a combined static quenching and inner filter effect mechanism, an “on–off–on” fluorescent sensing platform was constructed for the detection of captopril (CAP). The method relies on the competitive chelation of Fe 3+ by the thiol and carboxyl groups of CAP, which displaces the metal ions from the N-CQD surface and restores the quenched fluorescence. Under optimized conditions, the sensor exhibited a detection limit of 0.0620 mmol/L and a linear response spanning 0.1–1 mmol/L. The method was successfully applied to the determination of CAP in commercial tablet formulations, with recoveries meeting the acceptance criteria of the Chinese Pharmacopoeia (2020 Edition). The proposed approach offers a simple, rapid, and sensitive strategy for the quantitative analysis of CAP in pharmaceutical products.
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危险品化学品经营许可证（带存储）