JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2025
·
IF 1.6
Li Haozhe,Zhang Zhenyi,Zhou Fanglue,Huang Jiang
This study presents a modular adsorbent platform for uranium recovery using electron beam (EB) irradiation. A decoupled two-step synthesis involves initiator-free EB grafting of ionic liquids onto hollow mesoporous silica, achieving tunable grafting density (0.89 mmol/g at 50 kGy), followed by functionalization with uranyl-targeting groups. The optimal adsorbent HMS@IL-R1 demonstrates a uranium adsorption capacity of 185.9 mg/g, stable operation across pH 3–11, and 95.1% capacity retention after five cycles. Monte Carlo-optimized reactors enable scalable 100 g-batch synthesis, highlighting the efficacy and scalability of EB technology for a modular and practical pathway for nuclear resource recovery.
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2025
·
IF 4.8
Liang Long,Shao Xinyi,Zhou Huyi,Han Shanming,Li Hongbin,He Zhibin,Shen Kuizhong,Fang Guigan,Wu Ting
Rice straw can be a valuable fiber raw material as a substitute of wood for the pulp and paper industry. However, rice straw is underutilized due to technical challenges in the pulping processes. In this study, a novel bio-chemi-mechanical pulping combines high-temperature aerobic fermentation pretreatment with alkaline hydrogen peroxide impregnation and two-stage mechanical refining. Firstly, aerobic fermentation destroyed the fiber structure of rice straw, loosened the connecting bond between carbohydrates and lignin and made the surface of rice straw rough and porous through microbial decomposition of lignocellulose. Subsequently, the molecular structure of rice straw was further altered by the synergistic action of NaOH and H 2 O 2 , and the efficiency of mechanical refining was further improved based on aerobic fermentation pretreatment at high-temperature (max. ~ 65–70 °C). Experimental results show that under the optimal process conditions, the fermentation pre-treatment resulted in about 65% energy saving, 27% water retention value improvement, and 112% increase in tensile strength at a given pulp freeness. The objective of this study is to transform rice straw lignocellulosic biomass into high-quality pulp with improved physical properties, while simultaneously lowering energy consumption.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 193
·期 1
·15
·
IF 5.3
Zhang Yan,Yan Yuting,Huang Yue
An innovative electrochemical biosensor is proposed for the sensitive detection of ofloxacin (OFL) by integrating exonuclease I (Exo I)–assisted recognition-transduction strategy into the MXene/AuNP-enhanced electrochemical platform. Through ingenious design, the presence of OFL triggers the competitive displacement reaction and enables Exo I to hydrolyze the released single-stranded DNA probe containing the sequence of Pb 2+ -DNAzyme, protecting the signal probes on the electrode surface from DNAzyme cleavage, which eventually brings about a remarkable electrochemical signal positively related to the concentration of OFL. MXene/AuNPs with excellent conductivity, large specific surface area, and good chemical stability are employed as the electrode substrate to efficiently accelerate charge transfer and increase the loading capacity for signal probes, leading to the enhancement of signal output and endowing the biosensor with high sensitivity, rapid response, and fine robustness. Taking advantage of OFL recognition–initiated Exo I hydrolysis to DNAzyme, the electrochemical platform with “signal-off/on” mode can detect OFL with good specificity and reduced background interference. Benefiting from the synergistic effect of the involved sensing elements, the developed electrochemical biosensor achieves a low detection limit of 0.47 pg mL −1 with a broad linear range and exhibits satisfactory detection performance in real food samples, indicating potential practical applicability in food safety monitoring. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2025
·Vol. 83
·期 1
·31
·
IF 4
Huang Ruoxi,Yi Yaxin,Zhang Shiyu,Wang Jiaxin,Yuan Haikuan,Lu Jie
A stimulus-responsive drug delivery system holds promise for reducing adverse effects and enhancing the bioavailability of chemotherapeutic agents. In this study, amino-terminated dextran was utilized as a macromolecular initiator to prepare a range of amphiphilic dextran-b-poly(ε-benzyloxycarbonyl- l -lysine) (Dex-b-PZLL) copolymers with varying hydrophobic segment lengths via ring-opening polymerization (ROP). Folic acid (FA) was further grafted onto the dextran side chains via esterification (FA-Dex-b-PZLL), offering the potential tumor-specific recognition. The resulting copolymers were able to self-assemble into stable spherical micelles via dialysis and efficiently encapsulated the hydrophobic drug letrozole (LTZ). A systematic assessment was conducted on the drug encapsulation efficiency/loading capacity, drug release performance in vitro, and biocompatibility of the copolymers under aqueous conditions, indicating that these properties of the FA-Dex-b-PZLL micelles mainly depended on the copolymer composition. The optimized micelles, with a balanced hydrophilic/hydrophobic ratio, achieved a drug loading capacity with approximately 8.49% and an encapsulation efficiency with about 46.39%. Moreover, LTZ/FA-Dex-b-PZLL micelles exhibited pH-responsive release, with cumulative release rates within 72 h of 20.74%, 27.14% and 62.96% in phosphate buffer at pH 7.4, 6.5 and 4.5, respectively, indicating the accelerated release under acidic conditions. In addition, the micelles showed good cytocompatibility according to the CCK-8 assay. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Wang Yanting,Song Shiyu,Liao Xilin,Zhou Pei wen,Li Runchuan,Xing Mengxing,Lin Jia-Horng,Li Liang,Liu Rangtong
The rapid development of science and technology has led to the aggravation and complexity of electromagnetic radiation pollution. Therefore, multifunctional electromagnetic interference shielding materials have become increasingly indispensable. Based on the advantages of textile materials, the modular coupling assembly strategy was utilized to achieve the structural regulation of the multifunctional PP conductive composite film and effectively endowed it with excellent EMI shielding performance. In this study, the adhesive property of polydopamine was utilized to enhance the chemical reactivity of PP films. The construction of porous conductive structures and core–shell conductive structures of PPy inside and outside PP fibers was achieved by controlling the polymerization rate of pyrrole in a low-temperature environment. The macroscopic encapsulation of the hydrophobic layer enhanced the bonding strength between the PP substrate and the conductive layer. The results show that different concentrations of pyrrole affected the microstructure and EMI shielding performance. When the concentration of pyrrole was 0.8 mol/L, the surface contact angle and surface resistance of the PP composite film were 138.42° and 73 Ω, respectively. In addition, the shielding value of the PP composite film was as high as 28.02 dB, which could effectively shield 99.84% of electromagnetic waves. This preparation strategy of coupling multiple functional layers to realize multifunctional composite films provides research ideas for the structural design of multi-purpose smart wearable electromagnetic protection composite materials.
✓ 已验证
产品关联
DOI
高影响因子
Microfluidics and Nanofluidics
·
2025
·Vol. 30
·期 2
·9
·
IF 2.5
Zhang Zelong,Feng Shi,Li Hao,Ding Tianshun,Tao Shengyang
Microfluidics is pivotal in producing monodisperse microemulsions and microspheres. However, lower output efficiency hinders its practical application. Although multichannel droplet generators offer a promising solution for increased productivity, their design is inherently complex, and achieving uniform fluid distribution across channels is a significant challenge. Hence, in this paper, a novel rapid-design approach is introduced for multichannel droplet generators and employs topology optimization to enhance the structure, leading to significant improvements in droplet generation efficiency and uniformity. It can automatically generate a multichannel droplet generator structure that meets experimental conditions within five hours and is compatible with 3D printing technology. By employing topology optimization, the design achieves an average inter-channel flow rate variation of less than 1%, even with 81 channels, while reducing the inlet-outlet pressure drop by 19.75% compared to unoptimized configurations. The optimized device can produce both water-in-oil (W/O) and oil-in-water (O/W) droplets at a maximum throughput of 65 mL·min⁻¹, with a coefficient of variation (CV) below 5%, ensuring excellent monodispersity. Moreover, the topology optimization approach provides a comprehensive analytical framework for droplet generators with a matrix of microchannels, thereby facilitating rational design and scalability. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·
IF 15.7
Ren Yuqi,Cheng Miao,He Hongbin,You Changjun,Duan Lunbo,Sun Zhenkun,Peng Ruoxuan,Zhu Yuan-Hao,Zhang Hongyang,Zhou Jiancheng,Huang Kai,Guan Jie,Li Naixu
CO 2 -to-hydrocarbon fuel conversion via artificial photosynthesis is limited by catalyst poisoning under high O 2 partial pressures and sluggish C 2 -product formation. Herein, Ru 0.6 Cu 1 (Cu 0 –Cu 1+ )/CeO 2 catalysts with adaptive O 2 tolerance are prepared by O 2 -mediated dynamic interfacial reconstruction. Single-atom Ru doping at Ce lattice sites creates a trigonal prismatic coordination configuration, enabling proton-coupled electron transfer and accelerating H 2 O dissociation. Photothermal effect promotes O 2 -driven self-assembly of Cu 0 –Cu 1+ charge-gradient interfaces within Ru/Cu alloy clusters, thereby optimizing the adsorption behavior of * CHOCO intermediates and restructuring the C–C coupling pathway. Interfacial charge cascade transfer and geometric site synergy thermodynamically shift the product selectivity from C 1 to C 2 , as determined by operando spectroscopy and electronic structure analysis. Under concentrated solar irradiation, the catalyst produces 549 ± 20 μmol·g −1 C 2 H 4 with 74.3% selectivity and 0.5% solar-to-chemical energy conversion efficiency—25-fold higher than that in non-concentrated systems. Dynamic interfacial regulation facilitates precise carbon chain synthesis in complex reaction networks.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULAR NEUROBIOLOGY
·
2025
·Vol. 63
·期 1
·335
·
IF 4.3
Pan Gaowei,Liu Xiaoling,Zhang Xiaoyue,Gao Hao,Xu Ting,Li Kemin,Wang Lei,Ji Shangrong,Li Ting,Zhang Shengxiang
Monomeric C-reactive protein (mCRP) is a key acute phase reactant involved in inflammatory responses. Cerebral ischemia triggers persistent neuroinflammation. However, the effects of mCRP on global cerebral ischemia are poorly understood. In present study, mCRP was intracerebroventricularly injected to brain, and a bilateral common carotid artery ligation (BCAL) model was established in CX3CR1 GFP/+ mice. Behavioral tests were employed to evaluate spontaneous activity, rotarod performance (latency to fall), and forelimb grasping strength in mice. Nissl and Fluoro-Jade C (FJ-C) staining were used to assess neuronal injury. Skeletonization analysis and CD16/32, CD206 staining were used to assess microglial activation. RT-qPCR was applied to evaluate the changes of inflammatory factors and complement system. Primary cultured microglia and oxygen–glucose deprivation (OGD) model were used to verify the effects of mCRP on microglia in vitro . Results showed that mCRP treatment exacerbated behavioral performance post-ischemia. Nissl staining showed that mCRP caused a significant decrease in neuronal density. Additionally, FJ-C staining indicated an increase in degenerative cells after mCRP treatment. Immunofluorescence analysis revealed an increase in CD16/32 and CD206-positive microglia, and skeletonization analysis showed increased de-ramification of microglia following mCRP administration. RT-qPCR results further demonstrated that mCRP treatment upregulated the expression of pro-inflammatory and anti-inflammatory factors, as well as complement system components, in both brain tissue and primary cultured microglia following ischemia or OGD. These findings suggest that mCRP significantly enhances microglial activation, increases the level of inflammatory response, exacerbates neuronal loss and degenerative damage, and impairs behavioral performance after ischemia.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Wang Tingting,Li Dingxuan,Cheng Yuhuan,Zhang Yulian,Ye Jiannong,Chu Qingcui,Cheng Guifang
Homochiral zeolite imidazolate framework-8 (ZIF-8) combines the inherent characteristics of ZIF-8 with the chiral recognition function and open chiral channel, becoming one preferred choice for enantiomer separation. In this work, ZIF-8 with D-histidine as the chiral carbon center (D-His-ZIF-8) was introduced into the pores to enhance the extraction performance of hollow-fiber liquid-phase microextraction (HF-LPME). A novel method was developed for the selective and sensitive determination of chiral amino acids related to the nervous system by D-His-ZIF-8@HF-LPME coupled with capillary electrophoresis and laser-induced fluorescence detection. Under the optimal conditions, D-type amino acids could obtain higher enrichment efficiency than L-type ones due to the stronger geometry-dependent hydrogen-bonding interactions between L-type amino acids and the chiral channels of ZIF-8 materials modified with D-His, and the maximum enrichment factor reached 640 times (for D-serine). This developed method has been successfully applied to the analyses of four chiral amino acids (D/L-serine and D/L-aspartic acid) in exhaled breath condensate and saliva samples of healthy volunteers. The limits of detection were 0.030–0.30 nM (S/N = 3) in the real sample matrixes. This developed method meets the principles of green analytical chemistry and achieves a greenness score of 80 assessed by the analytical eco-scale tool. This proposed method provides one green alternative for the sensitive and accurate analyses of chiral amino acids in the non-invasive body fluids. Graphical abstract
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF FLUORESCENCE
·
2025
·
IF 3.1
Liu Yinuo,Dai Zhengyuan,Wang Ying,Fu Shanshan,Li Li,Ding Yaping
This study developed a fluorescent molecularly imprinted sensor (CDs@MIPs) for the highly selective detection of the anticancer drug 6-mercaptopurine (6-MP). 6-MP is an anti-cancer drug with myelosuppressive and hepatotoxic effects. If used improperly, it can cause serious adverse reactions in humans and other organisms. The sensor was fabricated via the sol-gel method using blue-emissive nitrogen-doped carbon dots (CDs) as the fluorophore and 3-aminopropyl triethoxysilane (APTES) as the functional monomer. The sensor leveraged molecularly imprinted technology to construct specific recognition cavities, which enabled highly efficient and sensitive detection of 6-MP. Under the optimal experimental conditions and at 325 nm excitation, with the increase of 6-MP concentration, the fluorescence intensity of the sensor at the emission of 415 nm gradually decreases. The sensor demonstrated a linear detection range of 5.0-120.0 µM (Y = − 6.55X + 792.39) with a detection limit of 1.67 µM (S/ N = 3). It exhibited strong anti-interference capability, excellent reproducibility and stable fluorescence performance. When applied to the detection of Mercaptopurine tablets, the method achieved recovery rate of 97.80%-108.63%, providing a highly sensitive and cost-effective analytical approach for clinical drug monitoring.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·
IF 15.7
Xu Hualiang,Yang Tiantai,Lei Yuan,Fu Xiaowei,Liu Zhimeng,Li Shanshan,Jiang Liang,Lei Jingxin
Conventional materials typically maintain a stable solid state under specific application conditions. However, materials that combine high mechanical strength with reversible switching states are highly desirable for advanced technologies. Here, we present hydrogen-bond nanoconfined self-destructive polymers (HNSPs) that have robust mechanics and reversible solid-fluid switching capability at 25 °C. Upon exposure to moisture, HNSPs spontaneously transition from solid to fluid, with humidity-tunable switching rates. HNSPs with weight ratios (Rm) of 1.7 is 1.69 times higher self-destructive rate than those with Rm of 2.1, and at 90% relative humidity (RH), Rm=2.0 samples exhibit an 804.27% higher self-destructive efficiency than at 60% RH. Heating can reverse the fluid back to a solid, enabling reversible, humidity-programmable behavior. Mechanistically, large ordered hydrogen-bond clusters, reduced chain entanglement, and abundant hydrophilic groups collectively facilitate switching. This work provides a simple yet versatile strategy for designing robust, switchable self-destructive polymers, broadening their potential in next-generation devices.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·10894
·
IF 15.7
Wang Shiyu,Zhou Ying,Zhao Wenchang,Li Yanhong,Tang Shuxian,Si Ting,Zhu Pingan
Directional droplet motion on solid surfaces, governed by Gibbs’ theory of minimizing surface free energy, traditionally relies on static surface gradients. However, such approaches face intrinsic constraints, including fixed transport directions and interdependence between transport distance and speed. Here, we introduce shape-evolving microfiber rails (SEMRs) that enable spontaneous droplet transport on initially non-gradient surfaces. Inspired by a domino-like mechanism, the SEMRs dynamically generate cascading gradients through shape deformations in response to droplet-surface interactions, diverging from conventional static-gradient designs. This adaptive strategy allows for steerable droplet motion, independent control over transport distance and velocity, and design flexibility for on-demand performance optimization. The SEMR’s versatility heralds advanced applications across analytical chemistry, cargo transport, electronics, and diagnostics, paving the way for advanced intelligent fluidic systems.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）