ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xia Yan,Hang Zhao,Xiaofeng Shi,Zhiyuan Yang,Jun Ma
The sensitivity and quantitative accuracy of surface-enhanced Raman scattering (SERS) are the main factors that restrict its application. Here, novel Au nanoscale convex polyhedrons (Au NCPs) were designed and fabricated to solve these problems via an embedded standard, including eight pods and six small protrusions. Spherical Au seeds regrew into different sizes of Au NCPs with a face-centered cubic structure. This morphology is due to the dual mechanism of the 4-aminothiophene (4-ATP) molecule that serves as an internal standard and a surface ligand regulator combined with the regulatory role of hexadecyl trimethyl ammonium chloride. The results show that Au NCPs were enclosed by high-index {12 9 1} facets, which greatly improved the local plasma resonance and reduced the lowest SERS detectable concentration of pyrene in standard seawater to 0.5 nM. An effective reference was produced by embedding 4-ATP with a relative standard deviation value less than 2.97% (in the same batch) and 3.92% (between different batches). Our research offers a new strategy for morphological regulation of metal nanocrystals, which is useful for the preparation of highly sensitive SERS substrates and trace analysis.
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ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Hongying Liu,Cairui Zhang,Chenwei Wang,Kai Fan,Yuqing Zhang,Lu Fang,Lihua Li,Chaoxiang Ren,Zheng-Zhi Yin,Zhong Lü
Promethazine (PMZ) is an effective antihistamine that is used as a nerve tranquilizer to treat mental disorders. However, drug abuse causes harm to the human body and also pollutes the environment to a certain extent. Therefore, it is crucial to develop a highly selective and sensitive biosensor for PMZ determination. An acupuncture needle (AN) was used as an electrode in 2015, and further research on the electrode's essence in electrochemistry is needed. In this work, a sensor based on a surface imprinted film coordinated Au/Sn biometal was first fabricated on AN via electrochemistry. The obtained cavities showed complementary and suitable sites for “N atom” electron transfer through the phenyl ring structure in promethazine, which is rigorous for the configuration near the interface. Under the optimal conditions, MIP/Au/Sn/ANE exhibits a good linear relationship in the range of 0.5 μM–500 μM, and the detection limit (LOD) is 0.14 μM (S/N = 3). The sensor exhibits good repeatability, stability, and selectivity and can be successfully used to analyze and detect PMZ in human serum and environmental water. The findings are scientifically significant for AN electrochemistry and the sensors have potential for in vivo medicamentosus monitoring in the future.
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Micromachines
·
2023
·Vol. 14
·期 4
·855
·
IF 3.4
Weizhuo Gao,Weixuan Jing,Yanrui Du,Zehao Li,Pengcheng Liu,Feng Han,Libo Zhao,Zhaochu Yang,Zhuangde Jiang
With polymerization duration and Au3+concentration of the electrolyte regulated, a desirable nitrate-doped polypyrrole ion-selective membrane (PPy(NO3−)-ISM) and Au solid contact layer of anticipate surface morphology were obtained, and the performance of nitrate all-solid ion-selective electrodes (NS ISEs) was improved. It was found that the roughest PPy(NO3−)-ISM remarkably increases the actual contact surface area of the PPy(NO3−)-ISMs with nitrate solution, which leads to better adsorption of NO3−ions upon the PPy(NO3−)-ISMs, and produces a larger number of electrons. The most hydrophobic Au solid contact layer avoids the formation of the aqueous layer at the interface between the PPy(NO3−)-ISM and Au solid contact layer, and ensures unimpeded transporting of the produced electrons. The PPy-Au-NS ISE for polymerization duration 1800 s and at Au3+concentration 2.5 mM of the electrolyte displays an optimal nitrate potential response, including a Nernstian slope of 54.0 mV/dec, LOD of 1.1 × 10−4M, rapid average response time less than 1.9 s, and long-term stability of more than 5 weeks. This indicates that the PPy-Au-NS ISE is an effective working electrode for the electrochemical determination of NO3−concentration.
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Small
·
2022
·Vol. 19
·期 11
·2204238
·
IF 15.153
Jing Wang,Jing Zhao,Fang Ma,Liuyun Gong,Yinliang Lu,Weiping Xiao,Hanmin Tang,Chengyi Gao,Yuetong Chen,Jun Ma,Zhan Gao,Jin Yan,Suxia Han
Over half of cancer patients are subjected to radiotherapy, but owing to the deficient amount of reactive oxygen radicals (ROS) and DNA double-strand breaks (DSBs), a fair number of them suffer from radiotherapy resistance and the subsequent short-term survival opportunity. To overcome it, many successes have been achieved in radiosensitizer discovery using physical strategy and/or biological strategy, but significant challenges remain regarding developing clinically translational radiosensitizers. Herein, a peptide-Au(I) infinite coordination supermolecule termed PAICS is developed that combined both physical and biological radiosensitization and possessed pharmaceutical characteristics including adequate circulatory stability, controllable drug release, tumor-prioritized accumulation, and the favorable body eliminability. As expected, monovalent gold ion endowed this supermolecule with high X-ray absorption and the subsequent radiosensitization. Furthermore, a peptide targeting CRM1, is assembled into the supermolecule, which successfully activates p53 and apoptosis pathway, thereby further sensitizing radiotherapy. As a result, PAICS showed superior ability for radiotherapy sensitization in vivo and maintained a favorable safety profile. Thus, the PAICS reported here will offer a feasible solution to simultaneously overcome both the pharmaceutical obstacles of physical and biological radiosensitizers and will enable the development of a class of nanomedicines for tumor radiotherapy sensitization.
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BIOELECTROCHEMISTRY
·
2023
·
IF 5
Xu Yang,Zheng-Zhi Yin,Guojun Zheng,Min Zhou,Hongyu Zhang,Junyao Li,Wenrong Cai,Yong Kong
Accurate detection of SARS-CoV-2 spike (SARS-CoV-2-S) protein is of clinical significance for early diagnosis and timely treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, a surface molecularly imprinted miniature biosensor was fabricated. Au nanoparticles (AuNPs), reduced graphene oxide (rGO), poly(methylene blue)/poly(ionic liquids) and poly(ionic liquids) were successively electrodeposited onto the pinpoint of an acupuncture needle (AN). The molecularly imprinted miniature biosensor was obtained after the template of SARS-CoV-2-S protein was removed, which could be used for sensitive detection of SARS-CoV-2-S protein. The linear range and limit of detection (LOD) were 0.1 ∼ 1000 ng mL −1 and 38 pg mL −1 , respectively, which were superior to other molecularly imprinted biosensors previously reported. The developed miniature biosensor also exhibited high specificity and stability. The reliability of the biosensor was evaluated by the detection of SARS-CoV-2-S protein in clinical serum samples.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
De Zhang,Mingxin He,Chongyang Qin,Zhuoqun Wu,Minhui Cao,Dejiang Ni,Zhi Yu,Pei Liang
The unreasonable spraying and random migration of acetamiprid may cause pollution of crops, soil and water resources in the environment, resulting in threatening ecosystem and human health. However, the monitoring of acetamiprid using mass spectrum in the environment encounters challenges due to high-cost instruments and complex processing time. Herein, we fabricated a rapid and reliable SERS method based on Ag@ZIF-8@Au platforms for tracing acetamiprid residues in the environment. In this method, a MOF material named ZIF-8 is coated with silver nanoparticles and distributed internally between AgNPs and AuNPs to enhance Raman signal, which can enrich pesticide molecules into the hotspots area provided by noble material and helps avoid the oxidation of silver nanoparticles. High sensitivity (LOD of 9.027 × 10 -10 M for acetamiprid, and SERS enhancement factor of 4.3 × 10 7 ), excellent reproducibility (6.496% or 7.198% RSD for 30 random points) and superior stability (3.127% RSD for 6 weeks) were achieved using the proposed method. Acetamiprid with concentrations from 10 -4 to 10 -9 M were successfully detected by SERS method. Furthermore, the linear detection models of acetamiprid in different environment matrices (lake water, tea leaves, tea garden soil, oranges and oranges orchard soil) were established and all the correlation coefficient (R 2 ) were higher than or equal to 95%, indicating the excellent adaptability of Ag@ZIF-8@Au platform in environment. The randomly spiked concentrations of acetamiprid were also tested with good recovery values and low relative error values, further confirming the reliability of the detection method.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2023
·
IF 3.1
Xiang Shuang,Guo Yong,Liu Xiaohui,Wang Yanqin
The interface between Au and support has attracted extensive interest because of its unique catalytic ability for hydrogen activation in catalytic hydrogenation/hydrogenolysis reactions. Herein, we create the Au-CoO-O V interface in the 1.0%Au/Co 3 O 4 -Rod-250 catalyst, which could dissociate H 2 via the heterolytic way to yield rich hydride species and achieve excellent catalytic performance in the hydrogenolysis of biomass-derived 5-hydroxymethylfurfural (HMF) to 2,5-dimethylfuran (DMF). The XRD and HRTEM analyses show that Au nanoparticles are uniformly dispersed on CoO-O V surface and in situ DRIFTS spectra show the enhancement of heterolytic dissociation of hydrogen (signals of Au—D and O—D vibration) compared with bare CoO (Co 3 O 4 -Rod-250). This work provides insights for fabricating highly active Au-support catalysts for catalytic hydrogenation/hydrogenolysis reactions.
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MOLECULES
·
2023
·Vol. 28
·期 14
·5355
·
IF 4.6
Keyan Chen,Shiqi Fu,Chenyu Jin,Fan Guo,Yu He,Qi Ren,Xuesheng Wang
Smartphone-assisted fluorescence and colorimetric methods for the on-site detection of Hg2+and Cl−were established based on the oxidase-like activity of the Au–Hg alloy on the surface of Au/Cu/Ti3C2NSs. The Au nanoparticles (NPs) were constructed via in-situ growth on the surface of Cu/Ti3C2NSs and characterized by different characterization techniques. After the addition of Hg2+, the formation of Hg–Au alloys could promote the oxidization of o-phenylenediamine (OPD) to generate a new fluorescence emission peak of 2,3-diaminopenazine (ADP) at 570 nm. Therefore, a turn-on fluorescence method for the detection of Hg2+was established. As the addition of Cl−can influence the fluorescence of ADP, the fluorescence intensity was constantly quenched to achieve the continuous quantitative detection of Cl−. Therefore, a turn-off fluorescence method for the detection of Cl−was established. This method had good linear ranges for the detection of Hg2+and Cl−in 8.0–200.0 nM and 5.0–350.0 µM, with a detection limit of 0.8 nM and 27 nM, respectively. Depending on the color change with the detection of Hg2+and Cl−, a convenient on-site colorimetric method for an analysis of Hg2+and Cl−was achieved by using digital images combined with smartphones (color recognizers). The digital picture sensor could analyze RGB values in concentrations of Hg2+or Cl−via a smartphone app. In summary, the proposed Au/Cu/Ti3C2NSs-based method provided a novel and more comprehensive application for environmental monitoring.Keywords:Au/Cu/Ti3C2NS;Au–Hg alloy;oxidase-like activity;smartphone;colorimetric detection
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JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Zhipeng Zhao,Qian Zhao,Le Zhou,Yi Wei,Biao Lei,Hongwen Zhang,Weiping Cai
Styrene , a prevalent volatile organic compounds (VOCs), is very harmful to atmosphere and humans. Consequently, the development of efficient detection technologies for styrene is of high importance, which is still in challenge! In this work, we crafted a layered double hydroxide (LDH) porous film-coated gold nanoarray, designed to act as a surface enhanced Raman spectroscopy (SERS) chip for the efficient and portable detection of gaseous styrene. This chip features a covering layer composed of cross-linked LDH nanosheets , notable for their porous structure and high specific surface area. When the covering layer is 100–300 nm in thickness, this composite chip has significant enrichment effect and strong SERS performance to gaseous styrene with a lowest detectable concentration below 1 ppb (4.64 ×10 -3 mg/m 3 ), and can response within 10 s, showing the rapid response and high sensitivity. Additionally, the chip has strong anti-interference capabilities and maintains excellent response to styrene, even in mixed benzene-VOCs gases. The exceptional SERS performances of this chip is ascribed to its LDH covering layer-induced styrene-enrichment and structurally-enhanced SERS performances. This study provides a simple route and practical chip for the rapid and ultrasensitive SERS-based detection of gaseous styrene, which is also potentially beneficial for the detection of other gaseous VOCs.
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SENSORS
·
2023
·Vol. 23
·期 13
·6184
·
IF 3.9
Xiyuan Dai,Li Wu,Kaixin Liu,Fengyang Ma,Yanru Yang,Liang Yu,Jian Sun,Ming Lu
We present a straightforward approach to develop a high-detectivity silicon (Si) sub-bandgap near-infrared (NIR) photodetector (PD) based on textured Si/Au nanoparticle (NP) Schottky junctions coated with graphene film. This is a photovoltaic-type PD that operates at 0 V bias. The texturing of Si is to trap light for NIR absorption enhancement, and Schottky junctions facilitate sub-bandgap NIR absorption and internal photoemission. Both Au NPs and the texturing of Si were made in self-organized processes. Graphene offers additional pathways for hot electron transport and to increase photocurrent. Under 1319 nm illumination at room temperature, a responsivity of 3.9 mA/W and detectivity of 7.2 × 1010cm × (Hz)1/2/W were obtained. Additionally, at −60 °C, the detectivity increased to 1.5 × 1011cm × (Hz)1/2/W, with the dark current density reduced and responsivity unchanged. The result of this work demonstrates a facile method to create high-performance Si sub-bandgap NIR PDs for promising applications at ambient temperatures.Keywords:Si sub-bandgap near-infrared photodetector;Schottky junction;internal photoemission;graphene
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ACS Sensors
·
2023
·
IF 8.9
Lixin Wang,Yuhong Liu,Jilin Yan,Huiling Li,Yifeng Tu
Coronary heart disease (CHD) poses an important threat to human health, and its pathogenesis is the formation of atheromatous plaques in coronary ventricles. Compared to other biomarkers, lipoprotein-associated phospholipase A2 (Lp-PLA2), which is involved in multiple processes of atherosclerosis, is a noticeable inflammatory biomarker related to CHD. Herein, using a multifunctional nanocomposite containing a CoFe Prussian blue analogue (PBA) and Au nanoparticles (AuNPs) (AuNPs@CoFe PBA) as a sensing substrate, an electrochemiluminescent (ECL) immunosensor was developed for the highly sensitive detection of Lp-PLA2. Benefiting from the synergistic effect of the PBA and AuNPs, the nanocomposite exhibits excellent peroxidase-like activity and can catalyze the luminol–ECL reaction, amplifying the ECL signal by ∼29-fold. Meanwhile, the enlarged specific surface area of the nanocomposite and the presence of abundant AuNPs allow the immobilization of more antibody proteins, thereby improving the sensing response of the immunosensor. When the target Lp-PLA2 is captured by the antibody on the sensor surface, the sensor emits a reduced ECL signal because of the increased mass and electron transfer resistance due to the formation of the immune complex. Under optimized conditions, the constructed ECL immunosensor exhibits a broad linear range from 1 to 2200 ng/mL and a low detection limit of 0.21 ng/mL. Additionally, the ECL immunosensor exhibits high specificity, stability, and reproducibility. This work provides a new approach to diagnose CHD and broadened the application of the PBA in the field of ECL sensors.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Honghong Feng,Yangjing Zhao,Yeping Li,Xueyong Qi,Song Shen,Shengwang Zhou
Nanotechnology provides the platform to develop functional nanocomposites with outstanding features, such as persistent luminescence (PL), photothermal conversion, magnetic resonance (MR), and so on, that has been incorporated in nanomedicine for diagnosis and therapy. Herein, the nanocomposites of ZnGa2O4:Cr3+ embedded in mesoporous silica coating surrounding gold nanorods (cGNR@MSNs) were developed for the codelivery of chemotherapeutic drugs and anti-CD40 antibodies. The nanocomposites were functionalized with tetrazaheterocycle linking divinylpyrimidine derivatives (DOTVs), which covalently capture anti-CD40 by disulfide re-bridging on the surface of cGNR@MSNs. The anti-CD40-mediated dual drug delivery system simultaneously realized the combination of chemo-, immuno-, and photothermal therapies, enhancing the synergistic effect of combination therapy for multiple tumor cells. Moreover, the nanodrug delivery system achieved multimodality imaging with fluorescence, PL, and MR modes for precise diagnosis. This study provides fascinating insights into the development of nanocomposite-based multimodality imaging strategies and imaging-guided combination therapies.
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