JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Yu Su,Haobo Wen,Ke Hu,Cuiping Wen,Ping Wang,Lulu Zhao,Gang Zou,Wei Jiang,Yaxi Chen,Yunfei Zhao,Qiu Li
The multifaceted pathogenesis and multi-cellular involvement of diabetic nephropathy (DN) stand in stark contrast to the inadequacy of conventional single-target therapeutic strategies. This disparity underscores the urgent need for novel drugs with comprehensive targeting capabilities. Herein, the SREBP cleavage-activating protein/sterol regulatory element-binding proteins (SCAP/SREBPs) pathway was identified as a central driver in DN, where its activation in key renal parenchymal cells promotes lipid metabolic disorders and inflammation, thereby exacerbating renal injury. Guided by this discovery, we screened a 245-member nanoparticle library comprising SCAP inhibitors self-assembled with chitosan, and identified chitosan-lycorine nanoparticles (CLNPs) as the optimal candidate. Owing to its efficient intestinal absorption and significant accumulation in mesangial and proximal tubular epithelial cells, oral CLNPs strongly alleviated renal injury in a murine model of DN by counteracting lipid accumulation and inflammation, consistent with SCAP/SREBPs pathway inhibition. Critically, CLNPs prevented hepatotoxicity from free lycorine, which reduced mortality and enabled safer prolonged therapy. Together, our findings demonstrate the viability of CLNPs for DN, thereby offering a generalizable strategy for combating complex diseases through a single combinatorial agent that counters multiple co-existing pathological injuries.
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Nanomaterials
·
2026
·Vol. 16
·期 6
·378
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IF 4.8
Hao Li,Lin Zhang,You Long,Chao Shen,Song Zhang,Fang Chen,Nan Chen,Chenghong Huang
Paclitaxel is a first-line anticancer drug, but its low water solubility impedes bioavailability. The purpose of this study is to estalish a delivery strategy via carboxymethyl chitosan (CMCS)-encapsulated 6-deoxy-6-mercapto-β-cyclodextrins (dmβCDs)-modified concave cubic gold (CCGs) to achieve PTX release. CCGs were initially synthesized by the one-pot method and further modified by dmβCDs, the dmβCDs can effectively capture PTX molecules, followed by encapsulation with CMCS, and then prepare pH-responsive CMCS/dmβCDs/CCGs nanocarriers after lyophilization. Results indicated that desirable hexagonal CCGs with 50 ± 5 nm size can be obtained by adjusting H 2 O 2 and HClO concentration. FT-IR, Raman and XRD spectra had confirmed dmβCDs successfully grafted to the surface of CCGs. Drug loading experiments demonstrated that the nanocarrier encapsulated PTX in amorphous powder or molecular form have a capacity of 55.05 µg/mL. Drug release experiments revealed PTX release from CMCS/dmβCDs/CCGs nanocarriers carrying a typical pH-responsive profile and indicating earlier release in an acidic environment than in a neutral or alkaline environment. The proposed method can be utilized to effectually achieve high-efficiency solubilization and targeted release inside tumor cells of PTX.
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FOOD HYDROCOLLOIDS
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2026
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IF 13.8
Chunling Nie,Yefan Niu,Weina Guo,Pengrui Wu,Yijun Liu,Zhonghui Shen,Zhihong Song,Xindi Wei,Yanbo Wang,Hong Zeng,Jianguo Wang
Water-in-water (W/W) Pickering emulsions have aligned with the increasing consumer demands for health foods due to their entirely aqueous formulation with oil-free. In this work, Pullulan (PUL) and Hydroxypropyl methylcellulose (HPMC) were used to construct polysaccharide-based W/W Pickering emulsion system. PUL and HPMC concentrations played crucial roles in droplet sizes and phase behavior of PUL/HPMC Pickering emulsions. Cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) were used as stabilizers to prepare PUL/HPMC Pickering emulsions and the stabilization mechanisms were investigated. PUL/HPMC Pickering emulsions stabilized by CNCs with a rigid rod-like structure and strong interfacial adsorption capacity exhibited smaller and more uniform droplet morphology and higher storage stability, whereas the flexible fibrillar CNFs tended to form entangled networks in the continuous phase and bridge droplets, resulting in droplet deformation and coalescence. Furthermore, environmental stability of PUL/HPMC Pickering emulsions revealed that increasing CNCs concentration could significantly enhance their centrifugal and thermal stability. This work would provide a novel insight into the stabilization behavior of nanocellulose with different morphologies in W/W Pickering emulsions and broaden potential applications of W/W Pickering emulsions in functional food fields.
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FUEL
·
2026
·
IF 7.8
Bohan Zhang,Chang Wen,Zhaoxi Ye,Haozhuo Huang,Qingsong Hua,Ke Liu,Tianyu Liu,Zijian Zhou,Zhengkai Tu
Developing highly efficient and durable bifunctional electrocatalysts for both the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in acidic environments is vital for advancing proton exchange membrane water electrolysis (PEMWE) technology. Herein, we report the design and synthesis of a three-dimensional Pt-RuO 2 -based catalyst supported on reduced graphene oxide (rGO), denoted as 3D Pt-RuO 2 /rGO, which exhibits outstanding bifunctional electrocatalytic activity by tuning its electronic structure and the binding strength of reaction intermediates. The 3D porous architecture not only facilitates fast charge transfer and mass transport of the catalysts but also increases the exposure of active sites. Remarkably, 3D Pt-RuO 2 /rGO delivers low overpotentials of only 200 mV for OER and 14 mV for HER at 10 mA cm −2 in 0.5 M H 2 SO 4 . It also enables overall water splitting (OWS) at a cell voltage as low as 1.48 V at 10 mA cm −2 , outperforming conventional noble metal-based materials (NMBs). Furthermore, a 3D Pt-RuO 2 /rGO||3D Pt-RuO 2 /rGO MEA delivered a low cell voltage of 1.549 V at 1 A cm −2 and maintained stable operation for 300 h in a PEM single-cell electrolyzer. Operando differential electrochemical mass spectrometry (DEMS) shows that the OER of 3D Pt-RuO 2 /rGO under acidic conditions follows the adsorption evolution mechanism (AEM). Density functional theory (DFT) calculations further reveal the synergistic interaction between oxygen vacancies and the metal/oxide heterointerface. This interface-vacancy synergy not only facilitates the exposure of abundant active sites, but also promotes electron transfer from Pt to RuO 2 , thereby optimizing the kinetics of water dissociation. This work provides valuable insight into the rational design of bifunctional electrocatalysts for high-efficiency acidic water electrolysis and highlights the potential of 3D heterostructured materials for future PEMWE systems.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2026
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IF 3.9
Honghong Chen,Congcong Li,Youlei Tu,Shaoyun Guo,Jiabin Shen
Conventional polymer-based radiative cooling materials often exhibit limited functional integration and poor stability under complex environmental conditions, restricting their application in multifunctional practical scenarios. Here, a multifunctional anisotropic polytetrafluoroethylene (PTFE) based aerogel was fabricated by constructing a directional porous architecture via unidirectional freezing, combined with the incorporation of fluorosilane-modified silica (SiO2) nanoparticles. The tailored structure effectively suppressed shrinkage and deformation during sintering, enhanced porosity and surface hydrophobicity, and imparted excellent oleophilic absorption capacity. Benefiting from the high infrared emissivity of the Si–O–Si network in the atmospheric window (elevated to 94.5%) and the structure-induced solar reflectance (increased to 94%), the aerogel achieved all-day passive radiative cooling with temperature reductions of ∼10.1 °C during the daytime and ∼4.3 °C at night under outdoor conditions. The structural design strategy proposed in this work provides insights into developing highly stable and multifunctional radiative cooling materials, and also opens possibilities for multifunctional energy conservation applications of PTFE-based aerogels.
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ANALYTICAL CHEMISTRY
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2026
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IF 7.3
Zhongyue Zhou,Linyu Zhu,Xintong Xiao,Hairong Ren,Cunhao Cui,Fei Qi
As an abundant, renewable aromatic resource, lignin remains underutilized due to its complex and recalcitrant structure. Molecular-level elucidation of liquid-phase catalytic depolymerization of technical lignin is further hindered by structural heterogeneity and limited accessibility of intermediates under high-pressure conditions. Herein, a decoupled double-bed flow-through reactor integrated with online high-resolution mass spectrometry (HRMS) is employed to investigate the catalytic depolymerization of alkali Kraft lignin. Spatial separation of thermal solvolysis and catalytic hydrogenolysis enables independent characterization of products from each bed. Online HRMS resolves thousands of molecular species from monomers to oligomers up to heptamers, revealing a pronounced shift toward lower degrees of polymerization and reduced unsaturation after catalytic hydrogenolysis. Ring and double bond equivalents–carbon number, van Krevelen, and tandem MS analyses indicate extensive hydrogenation, partial deoxygenation, and the cleavage of β-O-4 linkages, with C–C interunit linkages, either native or formed via condensation, largely preserved in the residual dimers and oligomers. Continuous online monitoring captures the evolution of individual products, highlighting progressive depolymerization and suppressed recondensation under flow-through conditions. This work demonstrates online HRMS as a powerful operando tool for resolving structure–reactivity relationships in lignin depolymerization and provides molecular-level insights relevant to catalytic biomass valorization.
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Analytical Methods
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2026
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IF 3
Wei Liu,Yanhua Sun,Zhiyong Zhu,Zi Li,Hongfang Li,Qiongyao Zeng
This study synthesized nitrogen-doped mesoporous carbon (NMC) using Zn-MOF-8 as a template, followed by the preparation of ZIF-08/NMC composites via π-π adsorption interactions between ZIF-08 and NMC. The composite was characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), and electrochemical methods. The resulting ZIF-08/NMC/GCE electrode demonstrated stable and sensitive detection of hesperidin. The modified electrode exhibited a broad linear range from 0.8 to 120 μM with a detection limit of 0.16 μM (signal-to-noise ratio ≥3). Furthermore, the sensor demonstrated excellent stability, repeatability, and interference resistance, and was successfully applied for hesperidin detection in real samples.
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SENSORS AND ACTUATORS B-CHEMICAL
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2026
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IF 8.3
Zhihua Zhao,Bingbing Wang,Yao Wang,Huiqin Li,Zhenzhen Yang
Ammonia (NH 3 ) is a toxic and pungent gas with significant implications for environmental monitoring, industrial safety, and human health. Therefore, the development of high-performance sensors for NH 3 detection at room temperature is of great necessity. This work develops a Bi 2 MoO 6 /Ti 3 C 2 T x 2D/2D heterostructure-based NH 3 gas sensor. The material demonstrated outstanding NH 3 sensing characteristics, involving high sensitivity (R a /R g =25.6 at 100 ppm), quick response time (21 s), and quick recovery time (72 s) at room temperature. Meanwhile, the sensor demonstrated prominent stability, repeatability, humidity-resistant, and an optimal operating temperature for NH 3 detection. Density functional theory (DFT) simulations were applied to examine the adsorption behavior of NH 3 on the Bi 2 MoO 6 /Ti 3 C 2 T X surface, which shed light on the sensing process. Additionally, a prototype detection system was developed to monitor NH 3 emissions from spoiled fish samples, illustrating how this sensor could be applied to monitor food safety.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 4
·270
·
IF 5.4
Wang Yuqing,Liu Yutong,Liu Ziqi,Wang Xinyue,Yu Menglu,Gao Guanghui,Zhao Yunli,Hong Jing
A novel MXene nanosheet-supported Fe₃O₄@Ag nanozyme, designed for the dual-mode colorimetric and surface-enhanced Raman scattering (SERS) detection of the pesticide thiram in fruits is presented. The composite ingeniously integrates three key functions: magnetic enrichment, SERS signal amplification, and peroxidase-like nanozyme activity. The resulting nanozyme sensor demonstrates high sensitivity and specificity for thiram detection. The colorimetric method showed a linear range of 0.05 µM to 30 µM with a LOD of 0.016 µM, while the SERS method exhibited a linear range of 10 − 4 M to 10 − 8 M with a LOD of 3.44 × 10 − 9 M. This performance satisfies the demands for agricultural safety monitoring. The present work highlights the significant potential of the developed colorimetric-SERS dual-mode nanozyme platform for on-site pesticide residue determination .
Section
Graphical
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Petroleum Science
·
2026
·
IF 6.4
Yuan Gao,Lei Yang,Sheng Huang,Tao Zhen,Miao Xu,Zao-Yuan Li,Zi-Yan Ren,Xin-Zhe Zhou,Hai-Bo Cheng,Xing-Yu Peng,An-Ming Liao
During cementing operations, unavoidable contact between water-based mud (WBM) and oil well cement (OWC) often degrades OWC performance. This is particularly problematic in natural gas or offshore wells, where zonal isolation failure can result in gas or liquid leakage, posing significant environmental and safety risks. To alleviate this problem, a masking agent was incorporated into the OWC to suppress contamination. The masking agent functions by shielding the active sites on cement particles and chelating metal ions, thereby inhibiting the cross-linking between WBM and OWC. Experimental results demonstrated that the addition of 0.5% of the masking agent increased the thickening time of the contaminated OWC system by 276%, while also doubling both its fluidity and compressive strength. To gain a more comprehensive understanding of the underlying mechanism, quantum chemistry and molecular dynamics simulations were employed. The results indicate that the masking agent exhibits superior adsorption properties, allowing it to compete effectively with the polymers for reaction sites. Overall, this study emphasizes the critical role of the masking agent in mitigating WBM contamination and proposes a viable strategy to improve the safety and quality of cementing operations. Furthermore, this approach can reduce or eliminate the need for spacer fluids, thereby addressing environmental challenges associated with the disposal of wellbore waste fluids.
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LANGMUIR
·
2026
·
IF 4.4
Yong Wang,Chunxiao Yan,Weiye Liang,Qiang Zhang,Gang Cheng,Jicheng Dong,Lin Jin,Huan Tang,Fang Cheng,Lijun Zhang
Orthokeratology (OK) lenses for myopia correction are susceptible to biofouling by tear-derived biomolecules, escalating the risks of ocular infection and inflammation. Prevailing studies that rely on end point protein quantification fail to capture the real-time kinetics of fouling formation. Here, we fabricated a UV pressure-assisted polymer-grafted quartz crystal microbalance with dissipation monitoring (QCM-D) sensor exhibiting exceptional stability, nanoscale smoothness (RMS roughness ≈2 nm), and interfacial peel resistance. This platform enables in situ tracking of adsorption/desorption kinetics for four critical tear components: native/denatured lysozyme and oxidized/native lecithin. Key findings reveal a flow-dependent fouling behavior, wherein low flow rates increase biomolecule adsorption by 37–80% compared with higher flows. We further identify denatured lysozyme and native lecithin as resilient contaminants characterized by a stronger deposition affinity and pronounced resistance to elution. Quantitative screening of multipurpose solutions (MPSs) demonstrates that MPS #2 achieves 20–100% elution rate across biomolecules, outperforming commercial benchmarks. By leveraging dissipation–frequency (D–F) analysis, we clarify the fundamental mechanisms of biofouling formation at the molecular level. Collectively, this work establishes three critical advances: (1) a real-time biofouling diagnostic platform for OK lens interfaces, (2) molecular design principles for antifouling materials based on adhesion remodeling theory, and (3) an accelerated MPS formulation screening paradigm for ocular device safety.
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BME Frontiers
·
2026
·
IF 9.1
Xingfang Qiao,Yiwen Hao,Yinglan Yu,Zhe Qiang,Xingjian Wen,Yanlei Guo,Zhen Wu,Hao Shao,Lei Luo
Objective: This study aims to engineer a tigecycline–hemoglobin nanoparticle (TIG–HBNP) system to enhance the targeting effect of tigecycline (TIG) on Klebsiella pneumoniae , thereby improving its antibacterial efficacy. Impact Statement: This study represents the first report of loading TIG onto hemoglobin (HB) nanoparticles. This system utilizes the iron dependence of K. pneumoniae to enhance the targeting ability of TIG and increase the drug concentration at the infection site, thereby enhancing the antibacterial activity and providing a promising strategy for combating drug-resistant gram-negative bacterial pneumonia. Introduction: K. pneumoniae is a gram-negative bacillus that causes severe primary pneumonia with high pathogenicity and increasing drug resistance. TIG is a key therapeutic option, but its clinical effectiveness is limited by extensive systemic distribution and insufficient drug concentration at infectious foci. HB serves as a promising protein nanocarrier and provides iron, an essential nutrient for K. pneumoniae growth, suggesting great potential for targeted antibiotic delivery. Methods: Molecular docking was performed to analyze the binding affinity and interaction between HB and TIG. TIG–HBNP was fabricated via a drug–protein self-assembly approach. The nanoparticles were characterized in terms of particle size, zeta potential, drug-loading efficiency, morphology using transmission electron microscopy and atomic force microscopy, stability, and biocompatibility. Targeting capability was evaluated. Pharmacokinetic profiles and antibacterial activity were further assessed. Results: Molecular docking verified stable binding between TIG and HB. TIG–HBNP exhibited a uniform spherical morphology, a particle size of approximately 200 nm, a negative surface charge, and a drug-loading efficiency exceeding 20%. The nanoparticles showed favorable stability and safety. Enhanced targeting to K. pneumoniae was confirmed in both in vitro and in vivo models. Improved pharmacokinetic behavior and enhanced antibacterial activity against K. pneumoniae were also observed. Conclusion: TIG–HBNP enhances TIG’s therapeutic efficacy against K. pneumoniae infections. Furthermore, HB holds promise as a versatile carrier for diverse antibiotics, offering a scalable platform to combat multidrug-resistant pathogens.
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