Discover Nano
·
2023
·Vol. 18
·期 1
·1-11
·
IF 0
Wang Xiaodan,Zhou Hua,Bai Lihui,Wang Hui-Qiong
The preparation of two-dimensional magnetic materials is a key process to their applications and the study of their structure and morphology plays an important role in the growth of high-quality thin films. Here, the growth, structure, and morphology of Cr 1+ δ Te 2 films grown by molecular beam epitaxy on mica with variations of Te/Cr flux ratio, growth temperature, and film thickness have been systematically investigated by scanning tunneling microscopy, reflection high-energy electron diffraction, scanning electron microscope, and X-ray photoelectron spectroscopy. We find that a structural change from multiple phases to a single phase occurs with the increase in growth temperature, irrespective of the Cr/Te flux ratios, which is attributed to the desorption difference of Te atoms at different temperatures, and that the surface morphology of the films grown at relatively high growth temperatures (≥ 300 °C) exhibits a quasi-hexagonal mesh-like structure, which consists of nano-islands with bending surface induced by the screw dislocations, as well as that the films would undergo a growth-mode change from 2D at the initial stage in a small film thickness (2 nm) to 3D at the later stage in thick thicknesses (12 nm and 24 nm). This work provides a general model for the study of pseudo-layered materials grown on flexible layered substrates.
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DOI
RESEARCH ON CHEMICAL INTERMEDIATES
·
2018
·Vol. 44
·期 7
·4001-4013
·
IF 1.674
Dong Zhen Ming,Wang Jia Na,Wang Wei,Chao Jian Bin,Wang Yu
A very simple Schiff Base derived from 1-Naphthylamine and 4-(Trifluoromethy) benzaldehyde (L) was prepared as a selective colorimetric and turn-on fluorescent sensor for hydrogen sulfate. In the CH 3 CN:H 2 O (3:2, v/v) solvent system, L shows a highly selective colorimetric response to HSO 4 − ions by changing its color from yellow to colorless immediately. In addition, the weakly fluorescent receptor L shows a highly selective enhancement of fluorescence intensity at 425 nm for HSO 4 − upon excitation at 320 nm. The recognition process is proven to be hardly influenced by the other tested competitive anions. The sensing is suggested to involve a hydrolysis process promoted by HSO 4 − which has been further supported by UV–Vis, 1 H NMR and HRMS spectroscopic studies. Applicability of L to detect HSO 4 − in tap water has been demonstrated. An easy-to-prepare test strip of L has also been made for the naked-eye detection of HSO 4 − in real samples.
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高影响因子
MOLECULAR DIVERSITY
·
2024
·
IF 3.9
Ding Shu-Yan,Yang Yu-Xuan,Liu Chuang,Quan Xu-Yin,Zhao Zi-Han,Jin Cheng-Hua
Four series of sulfonamide derivatives ( 13a – b , 14a – d , 15a – b , and 16a – d ) were synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) inhibitory activities. Of these, compounds 13b (IC 50 = 0.130 μM) and 15a (IC 50 = 0.130 μM) showed the highest inhibitory activities against ALK5 kinase, with activities similar to the positive control LY - 2157299 . Notably, we discovered that introduction of sulfonamide group at the 2-position of the central imidazole ring significantly increased ALK5 inhibitory activity. Compounds 13b and 15a did not show toxicity in A549 cells up to the maximum concentration of 50 μM, and effectively inhibited TGF-β1-induced Smad-signaling and cell motility in A549 cells. The results indicate that compounds 13b and 15a are worth of further development as anticancer agents.
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PubMed
高影响因子
Frontiers of Chemical Science and Engineering
·
2024
·Vol. 18
·期 12
·1-10
·
IF 4.3
Zhang Yue-Rong,Qin Zhen,Gu Song,Zhao Jia-Xin,Xiang Xian-Yue,Liu Chuan,Wang Yu-Zhong,Chen Li
To date, sustainable thermosetting polymers and their composites have emerged to address recyclability issues. However, achieving mild degradation of these polymers compromises their comprehensive properties such as flame retardancy and glass transition temperature ( T g ). Moreover, the reuse of degradation products after recycling for upcycling remains a significant challenge. This study introduces phosphorus-containing anhydride into tetraglycidyl methylene diphenylamine via a facile anhydride-epoxy curing equilibrium with triethanolamine as a transesterification modifier to successfully prepare flame-retardant, malleable, reprocessable, and easily hydrothermally degradable epoxy vitrimers and recyclable carbon fiber-reinforced epoxy composites (CFRECs). The composite exhibited excellent flame retardancy and a high T g of 192 °C, while the presence of stoichiometric primary hydroxyl groups along the ester-bonding crosslinks enabled environmentally friendly degradation (in H 2 O) at 200 °C without any external catalyst. Under mild degradation conditions, the fibers of the composite material were successfully recycled without being damaged, and the degradation products were reused to create a recyclable adhesive with a peel strength of 3.5 MPa. This work presents a method to produce flame retardants and sustainable CFRECs for maximizing the value of degradation products, offering a new upcycling method for high-end applications.
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高影响因子
JOURNAL OF FLUORESCENCE
·
2022
·Vol. 33
·期 3
·965-972
·
IF 2.525
Zheng Yabin,Li Chen,Li Quan,Zhang Taoyi,Chen Jing,Ji Wenxi,Wei Yun
Sodium tripolyphosphate, a food additive, is applied broadly in food industry. However, excessive accumulation of sodium tripolyphosphate can result in electrolyte abnormality of the body. Therefore, it is of great importance to investigate an effective method for the detection of sodium tripolyphosphate. In this work, nitrogen-doped carbon dots (NCDs) with constant fluorescence were fabricated using a domestic microwave oven. A ratiometric fluorescent probe was constructed in which NCDs were as internal standard, calcein & Eu 3+ were as the detection signal. The fluorescence of calcein at 515 nm was quenched by Eu 3+ , whereas the emission peak of NCDs at 446 nm was almost unchanged. Additionally, the fluorescence of calcein was recovered because of the strong interaction of sodium tripolyphosphate and Eu 3+ . The linear range for sodium tripolyphosphate was 0.5-6 µmol/L with detection limit of 0.12 µmol/L. Furthermore, the ratiometric fluorescent probe was applied for sodium tripolyphosphate detection in real milk samples.
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高影响因子
Virology Journal
·
2024
·Vol. 21
·期 1
·1-15
·
IF 4
Wang Ruilin,You Xiaojuan,Liu Xinwei,Fei Bing,Li Yifan,Wang Dan,Zhu Rui,Li Yongwei
Background Acinetobacter baumannii (AB) is a notable cause of hospital-acquired infections, with carbapenem-resistant Acinetobacter baumannii (CRAB) classified as a high-priority critical pathogen. Bacteriophage therapy is emerging as a promising alternative to combat drug-resistant bacterial infections. In this study, a lytic phage, HZY2308, was isolated from hospital sewage, and the biological properties, biosafety and anti-biofilm properties of phage HZY2308 were characterized and identified. Moreover, the antibacterial effect of phage HZY2308 in combination with antibiotics was investigated, and the apparent characteristics of phage-resistant strain AB48-R were demonstrated, which provided data support for further studies to elucidate the mechanism of generating phage resistance. Methods Phage HZY2308 was isolated by double agar plate method using clinical strain AB48 as the host bacterium. The morphology of phage HZY2308 was identified by transmission electron microscopy (TEM), and biological characteristics of phage HZY2308 were identified by host range, the efficiency of plating (EOP), sensitivity to temperature, pH, and chloroform, one-step growth curve, the optimal multiplicity of infection (MOI), and detection of endotoxin and cytotoxicity. Besides, the complete genome map of HZY2308 was constructed using CGview, and the phylogenetic tree of HZY2308 was constructed with MEGA. Additionally, the full genomic sequence of phage HZY2308 and the selected phage were compared using Easyfig. Checkerboard test of phage HZY2308 in combination with tigecycline (TGC) was performed to investigate their synergistic effect and bactericidal kinetics. The effect of HZY2308 on biofilm was investigated by semi-quantitative staining of biofilm with crystal violet, determination of bacterial activity in biofilm by 2,3-Bis (2-methoxy-4-nitro-5-sulfophenyl) -2 H-tetrazolium-5-carboxanilide (XTT) assay and observation of biofilm structure by fluorescence microscopy. Finally, Phage-resistant bacteria AB48-R were characterized by colony-forming capacity, morphology, growth curves, adsorption efficiency, and antibiotic susceptibility assays. Results A lytic phage, HZY2308, was isolated from hospital sewage, which exhibited advantageous traits such as a brief incubation period, large burst size, and robust stability. Safety assessments conducted at both genetic and cellular levels also have yielded positive outcomes. Besides, phage HZY2308 effectively inhibited AB biofilm formation and disrupted established biofilm structures. Furthermore, a synergistic antibacterial effect was noted when phage HZY2308 was combined with tigecycline. Interestingly, the phage-resistant strain, AB48-R was screened through natural selection. Compared to the wild strain AB48, the adsorption efficiency of the phage to AB48-R diminished. However, AB48-R’s sensitivity to antibiotics such as cefepime, gentamicin, amikacin, and tobramycin increased, indicating an evolutionary trade-off. Conclusions Phage HZY2308 shows strong antimicrobial potential, especially in combination with tigecycline, and the phage-resistant strain exhibits increased antibiotic sensitivity.
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PubMed
高影响因子
Nature Plants
·
2024
·
IF 15.8
Lin Ziwei,Guo Ying,Zhang Ruiyuan,Li Yiming,Wu Yue,Sheen Jen,Liu Kun-hsiang
Abscisic acid (ABA) regulates plant stress adaptation, growth and reproduction. Despite extensive ABA–Ca 2+ signalling links, imaging ABA-induced increases in Ca 2+ concentration has been challenging, except in guard cells. Here we visualize ABA-triggered [Ca 2+ ] dynamics in diverse organs and cell types of Arabidopsis thaliana using a genetically encoded Ca 2+ ratiometric sensor with a low-nanomolar Ca 2+ -binding affinity and a large dynamic range. The subcellular-targeted Ca 2+ ratiometric sensor reveals time-resolved and unique spatiotemporal Ca 2+ signatures from the initial plasma-membrane nanodomain, to cytosol, to nuclear oscillation. Via receptors and sucrose-non-fermenting1-related protein kinases (SnRK2.2/2.3/2.6), ABA activates low-nanomolar Ca 2+ transient and Ca 2+ -sensor protein kinase (CPK10/30/32) signalling in the root cap cycle from stem cells to cell detachment. Surprisingly, unlike the prevailing NaCl-stimulated micromolar Ca 2+ spike, salt stress induces a low-nanomolar Ca 2+ transient through ABA signalling, repressing key transcription factors that dictate cell fate and enzymes that are crucial to root cap maturation and slough. Our findings uncover ABA–Ca 2+ –CPK signalling that modulates root cap cycle plasticity in adaptation to adverse environments.
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PubMed
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 4
·1-13
·
IF 5.3
Li Guiyin,Yan Ruijie,Chen Wei,Wu Runqiang,Liang Jintao,Chen Jiejing,Zhou Zhide
Golgi protein 73 (GP73) is a new serum marker associated with early diagnosis and postoperative assessment of hepatocellular carcinoma (HCC). Herein, an electrochemical/fluorescence dual-signal biosensor was designed for determination of GP73 based on molybdenum disulfide/ferrocene/palladium nanoparticles (MoS 2 -Fc-PdNPs) and nitrogen-doped graphene quantum dots (NGQDs). GP73 aptamer (Apt) was labeled with NGQDs to form the NGQDs-Apt fluorescence probe. MoS 2 -Fc-PdNPs served not only as the fluorescence quencher but also as electrochemical enhancer. The sensing platform (NGQDs-Apt/MoS 2 -Fc-PdNPs) was formed based on the fluorescence resonance energy transfer (FRET) mechanism. In the presence of GP73, the specific binding of NGQDs-Apt to GP73 interrupted FRET, restoring the fluorescence of NGQDs-Apt at λ ex/em = 348/438 nm and enhancing the oxidation current of Fc in MoS 2 -Fc-PdNPs at 0.04 V through differential pulse voltammetry (DPV). Under the optimal conditions, the DPV current change and fluorescence recovery have a good linear relationship with GP73 concentration from 1.00 to 10.0 ng/mL. The calibration equation for the fluorescence mode was Y 1 = (0.0213 ± 0.00127) X + (0.0641 ± 0.00448) and LOD was 0.812 ng/mL (S/N = 3). The calibration equation of the electrochemical mode was Y 2 = (3.41 ± 0.111) X + (1.62 ± 0.731), and LOD of 0.0425 ng/mL (S/N = 3). The RSDs of fluorescence mode and electrochemical mode after serum detection were 1.62 to 5.21% and 0.180 to 6.62%, respectively. By combining the electrochemical and fluorescence assay, more comprehensive and valuable information for GP73 was provided. Such dual-mode detection platform shows excellent reproducibility, stability, and selectivity and has great application potential. Graphical Abstract
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PubMed
高影响因子
JOURNAL OF POROUS MATERIALS
·
2024
·Vol. 31
·期 3
·793-808
·
IF 2.5
Yang Zhaosheng,Tang Guoqiang,Li Yichuan,Niu Xiaoyue,Cheng Lingyao,Chai Yongming
TS-1 molecular sieve spherical membranes loaded on small-sized carriers with hierarchical pore structures and high framework-titanium contents could both exhibit high catalytic performances and facilitate the separation from the products after the reaction. In this paper, a simple in situ static crystallization method was used to achieve the construction of hierarchical porous TS-1 molecular sieve membranes on the surfaces of 400-µm spherical ZrO 2 carriers using cetyltrimethylammonium bromide (CTAB) and soluble starch as mesoporous templating agents. Through the catalyst characterization and performance evaluation, soluble starch was finally selected as the mesoporous templating agent, and the film-forming mechanism was investigated by examining the effects of the proportion of precursor liquid and the crystallization conditions. In the chloropropene epoxidation reaction, the effective utilization of H 2 O 2 and the selectivity of epichlorohydrin (ECH) reached 96.72% and 93.85%, respectively.
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高影响因子
CELLULOSE
·
2023
·Vol. 30
·期 14
·8997-9012
·
IF 5.7
Peng Qiao,Chen Yi,Fan Guozhi,Song Guangsen,Cheng Qunpeng
Holocellulose extracted from wheat straw was acetylated and used to prepare biodegradable composite film. An efficient catalytic system for the acetylation of holocellulose was explored by evaluating the influence of type and the amount of catalyst on the degree of substitution (DS) of acetylated holocellulose (AHC). The DS of AHC reached 2.16 when using p -toluene sulfonic acid and sulfuric acid as co-catalyst. AHC was further used to prepare composite film in the presence of reinforcer and plasticizer, and the influence of DS value of AHC on the properties of composite film was investigated. The tensile strength, elongation at break and Young’s modulus of the composite film derived from AHC with DS value of 2.16 were 9.51 MPa, 82.66% and 54.43 MPa when using chitosan and polyvinyl alcohol as the reinforcers, sorbitol and glycerol as the plasticizers. The UV-blocking performance and degradation of AHC-based composite film were also performed. It was found that about 90% UV light was absorbed and 59.2% was decomposed after biodisintegrating for 30 d. The excellent comprehensive performance of the AHC-based composite film reveals application prospect of holocellulose in the field of biodegradable materials.
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高影响因子
FIBERS AND POLYMERS
·
2024
·Vol. 25
·期 3
·797-805
·
IF 2.2
Zhang Xi,Shi Zhengjun,Xu Pengfei,Zhang Qi,Huang Xudong,Xing Guiying,Shao Linjun,Qi Chenze
Supported cobalt catalysts have attracted more and more attention for their easy separation and recyclability. Herein, cobalt-embedded pyridine functionalized polystyrene superfine fibers were readily fabricated by electrospinning. Then, the pyridine functionalized polystyrene and polystyrene molecules inside the fibers were cross-linked by paraldehyde to improve the fiber stability. The synthesis of pyridine functionalized polystyrene and cross-linking of polystyrene molecules inside the fibers were confirmed by FT-IR spectra. The fiber morphologies were characterized by SEM. The dispersion of cobalt species was analyzed by SEM–EDS, XRD and TEM. Finally, the Heck reactions were employed to evaluate the catalytic performance of this novel fibrous catalyst. The catalysis results show that this novel fiber catalyst exhibited excellent catalytic activity for the Heck reactions of aromatic iodides with alkenes to afford coupling products with yields over 80%. Moreover, due to the embedment of cobalt species and chelation of pyridine groups, this novel fiber catalyst can be reused five times with little loss of catalytic activity. In all, we have developed a highly active and stable supported cobalt catalyst, which holds great potential for green chemical processes.
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高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Pang Shukui,Yu Yanchao,Yan Xuexue,Wu Mianyuan,Liu Qiye,Zu Panru,Wu Canyao
A novel coumarinylhydrazone fluorescent probe L was designed and synthesized from 4-(diethylamino)salicylaldehyde, its structure was characterized by NMR, IR. Fluorescence emission spectra showed that in ethanol solution, probe L could form a 1:1 complex L-Cu 2+ with Cu 2+ to realize the "turn-off" detection of Cu 2+ with high specificity and sensitivity (3.7 × 10 –7 mol/L). Meanwhile, the complex L-Cu 2+ had a specific fluorescence-enhanced response to HPO 4 2− with a detection limits down to 5.6 × 10 –7 mol/L and was resistant to the effects of many common anions (NO 2 − , N 3 − , CO 3 2− , SO 3 2− , HPO 4 2− , I − , Br − , F − , HCO 3 − , SO 4 2− , NO 3 − , Cl − , CH 3 COO − , Cr 2 O 7 2− , S 2 O 3 2− , P 2 O 7 4− ). Detection mechanism could be HPO 4 2− captured Cu 2+ of the complex and released the free ligand L. At last, the complex L-Cu 2+ was successfully applied to the determination of HPO 4 2− in different environmental water samples, and the spiked recoveries ranged from 98.05% to 108.18% and the relative standard deviations of 0.75% ~ 2.9%, which had good application prospects. Graphical A new coumarin acyl hydrazone fluorescent probe L was designed and synthesized, which could specifically recognize Cu2+ and HPO42- in a relay manner. In addition, the probe had good prospects for practical applications.
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PubMed
高影响因子
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