Regenerative Biomaterials
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2024
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IF 5.6
Lin Qiaoxia,Zhang Yonggang,Chen Luhua,Zhang Haoyue,An Chuanfeng,Li Chengze,Wang Qifan,Song Jinhui,He Wei,Wang Huanan
Development of piezoelectric biomaterials with high piezoelectric performance, while possessing excellent flexibility, biocompatibility, and biodegradability still remains a great challenge. Herein, a flexible, biocompatible and biodegradable piezoelectric β-glycine-alginate-glycerol (Gly-Alg-Glycerol) film with excellent in vitro and in vivo sensing performance was developed. Remarkably, a single, monolithic β-glycine spherulite, instead of more commonly observed multiple spherulites, was formed in alginate matrix, thereby resulting in outstanding piezoelectric property, including high piezoelectric constant (7.2 pC/N) and high piezoelectric sensitivity (1.97 mV/kPa). The Gly-Alg-Glycerol film exhibited superior flexibility, enabling complex shape-shifting, e.g. origami pigeon, 40% tensile strain, and repeated bending and folding deformation without fracture. In vitro, the flexible Gly-Alg-Glycerol film sensor could detect subtle pulse signal, sound wave, and recognize shear stress applied from different directions. In addition, we have demonstrated that the Gly-Alg-Glycerol film sensor sealed by polylactic acid and beeswax could serve as an in vivo sensor to monitor physiological pressure signals such as heartbeat, respiration, and muscle movement. Finally, the Gly-Alg-Glycerol film possessed good biocompatibility, supporting the attachment and proliferation of rat mesenchymal stromal cells, and biodegradability, thereby showing great potential as biodegradable piezoelectric biomaterials for biomedical sensing applications.
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ACS Food Science & Technology
·
2024
·
IF 2.6
Weihao Meng,Hongnan Sun,Tai-Hua MU,Marco Garcia-Vaquero
This study explored Pickering emulsions stabilized by chitosan (CS), chitosan-Laminaria japonica polyphenols (CP), and chitosan-Ascophyllum nodosum polyphenols (CB) as β-carotene delivery systems. Emulsion stability was analyzed using multiple light scattering and cryogenic-scanning electron microscopy (cryo-SEM). This research also focused on the effects of thermal treatment, ultraviolet irradiation, in vitro digestion, and 8-week storage on the chemical stability of encapsulated β-carotene. The results showed that polyphenols of CP and CB contributed to the generation of a stable three-dimensional (3D) network, providing stronger resistance and higher β-carotene stability against thermal treatment and ultraviolet irradiation. After in vitro digestion, all emulsions exhibited higher bioaccessibility than unencapsulated β-carotene. CP stored at low temperatures and in the dark possessed the highest β-carotene retention and lowest lipid oxidation without microbial growth. This study demonstrates the potential of chitosan-seaweed polyphenol-stabilized Pickering emulsions for the creation of hydrophobic bioactive compound delivery systems in the functional foods and nutraceuticals industries.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2025
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IF 4.6
Guangli Li,Nayu Chen,Yafeng Zhang,Tianyu Wang,Rui Zhu,Yuan Jin,Nanke Ma
Rhodamine B (RhB) is highly carcinogenic and is therefore prohibited as a food colorant. Hence, it is necessary to establish a simple but effective technique for the sensitive determination of RhB in foodstuff. Herein, an efficient voltammetric platform was established for the detection of RhB in chili oil based on flower-like β-Bi 2 O 3 microsphere/multiwalled carbon nanotube composites (β-Bi 2 O 3 /MWCNTs). Various microscopic and spectroscopic techniques confirmed the successful formation of β-Bi 2 O 3 /MWCNTs. Owing to the synergistic effect from β-Bi 2 O 3 microspheres and MWCNTs, the β-Bi 2 O 3 /MWCNTs demonstrated superior electrocatalytic activity for the oxidation of RhB as compared to the individual components. Electrochemical kinetics tests confirmed that the RhB electrooxidation was governed by an irreversible and adsorption-controlled process, and involved two electrons one proton transfer pathway. The oxidation peak currents of RhB were linearly correlated with RhB concentrations ranging from 0.05 to 100 μM with a low limit of detection (0.002 μM). The β-Bi 2 O 3 /MWCNT demonstrated strong anti-interfering ability against other azo colorants, and retained robust voltammetric responses for at least 14 days. Moreover, the concentrations of RhB in chili oil were accurately detected by the β-Bi 2 O 3 /MWCNT via second-order derivative linear scan voltammetry with satisfactory recovery. Overall, the β-Bi 2 O 3 /MWCNT/GCE shows great potential for in-situ analysis of trace amounts of RhB in various food matrices.
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Nanoscale
·
2025
·
IF 5.1
Jiasheng Wang,Tianyu Zhang,Jiliang Song,Fengxin Zhang,Hong Liu,Wan-Hui Wang,Ming Bao
Unsaturated alcohols (UOLs) are important fine chemical intermediates. Thus, it is of great significance to design and prepare catalysts for highly selective hydrogenation of CO of α,β-unsaturated aldehydes (UALs). In this paper, a fluffy mesoporous Al2O3-supported Ag–In2O3 catalyst (Ag-In2O3/f-m-Al2O3) was synthesized by employing a two-solvent method, in which Ag and In2O3 form a Mott–Schottky junction and lead to electron transfer from In2O3 to Ag. Electron-rich Ag repels the CC bond owing to “four-electron repulsion”, and electron-deficient In2O3 acts as the electrophilic site to adsorb the O atom of the CO bond, thus improving the selectivity towards UOLs. In addition to a larger specific surface area and smaller mass transfer resistance, the fluffy mesopore Al2O3 exhibits a large number of Lewis acid sites, which can further improve UOL selectivity. With the help of Ag–In2O3/f-m-Al2O3, high UOL selectivity can be obtained from UALs containing aliphatic, aromatic and heterocyclic groups. This elaborate design of the catalyst could contribute to the highly selective hydrogenation of UALs to UOLs.
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CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Xinlin Jiang,Zipeng Wu,Xiaoru Tan,Yichen Lin,Hui Xing,Yinglin Xuan,Dong Ma,Xin Cui
Hyperuricemia-related diabetic wounds are notoriously difficult to treat due to elevated uric acid (UA) levels, excessive reactive oxygen species (ROS), and chronic inflammation. Current therapies often fail to address these underlying causes, underscoring the need for innovative approaches that not only clear UA but also mitigate inflammation and promote tissue regeneration. In this study, we developed a polyrotaxane-based microsphere (HPR MS) system conjugated with 4,5-diamino-2-thiouracil (DT) to achieve high-affinity UA clearance without increasing cytotoxicity. By leveraging the molecular motility of the polyrotaxane structure, featuring β-cyclodextrin (β-CD) shuttles along the F-127 axis, we significantly improved the molecular recognition between DT and UA for enhanced UA absorption efficiency. In vitro experiments confirmed that HPR/DT MS rapidly reduced UA levels compared to control groups. Using a type 2 diabetic wound model, HPR/DT MS treatment effectively reduced UA levels, suppressed COX-2 expression, and transformed the immune microenvironment from a pro-inflammatory to a regenerative state in vivo . This was accompanied by enhanced M2 macrophage polarization, angiogenesis, and improved blood perfusion, resulting in accelerated wound healing. Overall, these findings highlight HPR/DT MS as a promising therapeutic strategy for hyperuricemia-related diabetic wounds, targeting the core pathological factors to improve wound repair.
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TALANTA
·
2024
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IF 5.6
Yongjing Liu,Dongting Huang,Chenxi Zhuo,Min Guo,Lirong Chen,Xiaofen Chen,Hua Li,Wei Xu
A series of supramolecular deep eutectic solvents (SURPADESs) consisting of β -cyclodextrin ( β -CDs) ( β -CD, HP- β -CD, M- β -CD) and l -lactic acid were synthesized and employed as chiral selector to investigate their chiral selectivity in capillary electrophoresis. Key elements influencing the separation efficiency, such as the ratio of HBA/HBD of SUPRADESs, the concentration of SUPRADESs, and buffer pH were thoroughly examined and deliberated upon. Under the optimum enantioseparation conditions, three SUPRADESs systems showed markedly enhanced chiral separation of model chiral drugs, in comparison with single CDs and dual chiral selectors composed by adding its two constituents CDs and l -lactic acid separately. Additionally, the Benesi-Hildebrand plot was employed to determine the binding constant for the inclusion complexes, and molecular modeling was used to explore the mechanisms behind the increased chiral separations in SUPRADESs. Results demonstrated that SUPRADESs exhibit significantly improved chiral selectivity efficiency by enhancing the host-guest encapsulation of the constituent β -CDs, which is attributed to the increased hydrogen bonding and hydrophobic interactions between chiral analytes and β -CDs and HBD of SUPRADESs. This work provides a possibility for SUPRADESs to be used as chiral selection in CE.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2025
·Vol. 26
·期 4
·1558
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IF 4.9
Jiabin Huang,Haotian Wu,Ranran Gao,Lan Wu,Mengyue Wang,Yang Chu,Yuhua Shi,Li Xiang,Qinggang Yin
L-ascorbic acid (vitamin C, AA) is widely present in plants, but humans lack the ability to synthesize it independently. As a potent reducing agent, AA is susceptible to oxidation, making the enhancement of its stability crucial. 2-O-β-D-glucopyranosyl-L-ascorbic acid (AA-2βG) is a stable natural derivative of AA with glycosylation, initially discovered in the fruits ofLycium barbarum. Understanding the biosynthesis of AA-2βG is crucial for enhancing its production inL. barbarum. While the established biosynthesis pathway of AA constitutes the upstream of AA-2βG biosynthesis, the conclusive step of β-glycosylation remains unclear. We identified aL. barbarumcultivar by UPLC, ZN01, with a high content of AA-2βG, and compared its leaves, immature fruits, and mature fruits to a normal AA-2βG contentL. barbarumcultivar for metabolomic and transcriptomic analysis. The RNA-seq and RT-qPCR analysis revealed that the expression levels of genes involved in the AA biosynthesis pathway did not consistently correlate with AA-2βG content, suggesting that the final glycosylation step may be a key determinant of AA-2βG accumulation. Subsequently, utilizing phylogenetic and co-expression analysis, we identified ten UDP-glycosyltransferases (UGTs) and three β-glucosidases (BGLUs) which may be involved in the crucial step of the conversion from AA to AA-2βG, and the UGTs’ activities were predicted through molecular docking. Lastly, we speculated that the presence of the glycosylation process of AA might have a crucial role in maintaining AA homeostasis inL. barbarum, and deliberated on potential correlations between AA, carotenoids, and anthocyanins. Our integrated multi-omics analysis provides valuable insights into AA-2βG biosynthesis inL. barbarum, identifying thirteen candidate genes and highlighting the complex interplay between AA, carotenoids, and anthocyanins. These findings have implications for improving AA-2βG content inL. barbarum.
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MATERIALS RESEARCH BULLETIN
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2025
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IF 5.7
Lanfei Wei,Jiaquan Liu,Qiuman Zhou,Shaolong Liu,Zhifeng Su,Yurong Yan
Bismuth trioxide (Bi 2 O 3 ) acts as an ideal material for supercapacitors because of its high theoretical specific capacity, but its crystal form and compact accumulation limit its specific capacitance below its theoretical value of 1370 F g -1 . In this study, a specific kapok fiber@chitosan-derived carbon (KCC) doping inside β/α hybrid-crystal Bi 2 O 3 (KCC-Bi 2 O 3 ) was constructed by KCC assisting to enhance the contact area between Bi-MOF and air during calcination. A specific capacitance of 1135 F g -1 at 1 A g -1 was obtained for KCC-Bi 2 O 3 , which matched 82.3 % of its theoretical value. An asymmetric capacitor, with KCC-Bi 2 O 3 as a negative electrode and NiCo-LDH as a positive electrode, exhibits a potential window of 1.6 V and an energy density of 17.3 Wh kg -1 at 800 W kg -1 . The result demonstrates that incorporating a KCC carbon source can significantly enhance the capacitance of mixed crystal form Bi 2 O 3 , highlighting its potential in supercapacitor applications.
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KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
·
2024
·Vol. 29
·期 1
·67
·
IF 1.6
Li Yang,Zhuanyun Du,Yuhang Peng,Wenyao Zhang,Wenli Feng,Ying Yuan
To target the pivotal BCR/ABL oncoprotein in chronic myeloid leukemia (CML) cells, tyrosine kinase inhibitors (TKIs) are utilized as landmark achievements in CML therapy. However, TKI resistance and intolerance remain principal obstacles in the treatment of CML patients. In recent years, drug repositioning provided alternative and promising perspectives apart from the classical cancer therapies, and promoted anthelmintic mebendazole (MBZ) as an effective anti-cancer drug in various cancers. Here, we investigated the role of MBZ in CML treatment including imatinib-resistant CML cells. Our results proved that MBZ inhibited the proliferation and induced apoptosis in CML cells. We found that MBZ effectively suppressed BCR/ABL kinase activity and MEK/ERK signaling pathway by reducing p-BCR/ABL and p-ERK levels with ABL1 targeting ability. Meanwhile, MBZ directly targeted the colchicine-binding site of β-tubulin protein, hampered microtubule polymerization and induced mitosis arrest and mitotic catastrophe. In addition, MBZ increased DNA damage levels and hampered the accumulation of ataxia-telangiectasia mutated and DNA-dependent protein kinase into the nucleus. This work discovered that anthelmintic MBZ exerts remarkable anticancer effects in both imatinib-sensitive and imatinib-resistant CML cells in vitro and revealed mechanisms underlying. From the perspective of drug repositioning and multi‐target therapeutic strategy, this study provides a promising option for CML treatment, especially in TKI-resistant or intolerant individuals.
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Materials Today Bio
·
2024
·
IF 8.7
Wenzhe Sun,Hongwei Lu,Pengqin Zhang,Lian Zeng,Bing Ye,Yi Xu,Jianan Chen,Peiran Xue,Jialin Yu,Kaifang Chen,Bin Wu,Xiao Lv,Xiaodong Guo,Yanzhen Qu
Severe burn injuries immediately trigger a sustained systemic and local stress response. During this process, the sympathetic nervous system releases large amounts of catecholamines, which bind to β-adrenergic receptors (β-AR) on cell membranes, negatively affecting skin regeneration. Additionally, recurrent bacterial infections make burn wounds difficult to treat, posing significant and ongoing challenges to burn care. To address these challenges, we pioneered the study of locally delivered propranolol for burn wound treatment, revealing its ability to antagonize norepinephrine (NE) and regulate the sympathetic nervous system. In this study, a Cu 2 ⁺-loaded anti-sympathetic hydrogel (copper ion cross-linked propranolol@gelatin/alginate, PNL@GA-Cu) was developed to remodel the challenging neuromodulatory microenvironment and accelerate the repair of the infected burn wound. The hydrogel system releases Cu 2 ⁺ and propranolol simultaneously during degradation, synergistically acting on local wound tissue. Cu 2 ⁺ exhibits dual effects of antibacterial activity and promoting angiogenesis, effectively killing Staphylococcus aureus and Escherichia coli while enhancing the expression of angiogenesis-related genes (CD31, VEGF). Meanwhile, propranolol can counteract the inhibitory effects of NE simulated chronic stress microenvironment on angiogenesis and mitigate sympathetic nerve innervation during the early stages of wound healing. Finally, the PNL@GA-Cu hydrogel significantly promoted the repair of third-degree full-thickness burns in SD rats. Approaches targeting the neural microenvironment for burn wound treatment has not been previously addressed in the literature. The anti-sympathetic PNL@GA-Cu hydrogel offers a promising strategy for treating infected burn wounds. Remodeling the neuromodulatory microenvironment could be an emerging strategy in tissue engineering.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Jiaqiao Yuan,Yamin Li,Zhan Ding,Anmei Yu,Yijie Zhang,Shuming Wen,Shaojun Bai
It is difficult to realize an effective separating of chalcopyrite and pyrite without using any depressants due to their similar physicochemical properties . Herein, a cyclic oligosaccharide carboxymethyl-β-cyclodextrin (CMCD) with carboxyl and hydroxyl groups was introduced for the first time as a novel environmentally friendly depressant for separating chalcopyrite from pyrite. The depression performance and adsorption mechanism of CMCD in the flotation separation of chalcopyrite and pyrite were investigated through micro-flotation experiments, molecular dynamics (MD) simulations, and a series of characterization tests. The flotation findings manifested that under weakly acidic conditions (pH=6.5±0.2), a high-quality copper concentrate with a copper recovery of 73.15 % and a grade of 28.06 % was obtained. CMCD exhibited superior inhibition of pyrite compared with other traditional inhibitors. The adsorption density of CMCD onto the pyrite surface was significantly higher than that of chalcopyrite, and the pre-treatment with CMCD hindered the attachment of sodium butyl xanthate (SBX) on pyrite but had a minor effect on chalcopyrite, as confirmed by contact angle, adsorption amount, and Atomic Force Microscope analyses. Moreover, X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy analyses robustly demonstrated that the carboxyl and hydroxyl groups in the CMCD molecule primarily reacted with the metal hydroxides on the pyrite surface through hydrogen bonding, leading to a more hydrophilic surface. MD simulations further confirmed at the molecular level that the affinity of CMCD for the pyrite surface was much greater than for chalcopyrite. In summary, CMCD shows promising potential as a depressant for separating chalcopyrite from pyrite.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Yunfei Sun,Yaping Wang,Yun Chen,Junchao Qian,Feng Chen,Zelong Zhou,Chaoya Han,Yu Shi,Xiaowang Lu,Chaoying Ni
Bisphenol A (BPA), a prevalent organic pollutant found in wastewater environment, is notorious for its resistance to natural degradation, raising significant ecological and human health concerns. In this study, a “signal-on” photoelectrochemical aptasensing system was designed for detecting BPA in real water samples with high specificity and sensitivity. One-dimensional (1D) β-FeOOH nanobelts were synthesized on a two-dimensional (2D) porous carbon nitride (g-C 3 N 4 ) through an in-situ growth procedure. The β-FeOOH/g-C 3 N 4 nanocomposites demonstrated superior photoelectric conversion efficiency due to several factors: (i) The 1D nanobelt-like structure of β-FeOOH shortens the charge transfer path within the nanocomposite, enabling directional and rapid migration of photoinduced charges from the interior to the surface. (ii) β-FeOOH possesses strong visible absorption capabilities, enhancing the utilization of g-C 3 N 4 under photoexcitation, resulting in the generation of numerous photo-induced carriers. (iii) The in-situ formation of the β-FeOOH/g-C 3 N 4 heterojunction establishes an intimate interfacial contact, facilitating the rapid separation and transfer of charges between β-FeOOH and g-C 3 N 4 . A photoelectrochemical aptasensing platform based on the photoactive material of β-FeOOH/g-C 3 N 4 detects BPA with reduced photocurrent owing to the presence of BPA-aptamer macromolecules on the electrode surface. This BPA detection system exhibits excellent linearity over a wide concentration range from 10 pM to 10 nM, with high sensitivity (a detection limit of 3.5 pM), stability, specificity, and repeatability. Furthermore, this research offers a straightforward and rapid sensing platform for monitoring BPA enriched water environments.
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