CRYSTENGCOMM
·
2022
·Vol. 24
·期 24
·4399-4407
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IF 3.756
Delei Liu,Bing Jiao,Haijun Zhang,Shaowei Zhang,Jianghao Liu
By taking advantage of a microwave and molten-salt co-assisted boro/carbothermal reduction method (MSM-BCTR) and cheap raw materials such as HfO2/ZrO2, B4C and amorphous carbon, three types of (HfxZr(1−x))B2 (x = 0.25, 0.50 and 0.75) solid-solution powders with a single-crystalline rod-like morphology, high compositional uniformity, long lengths of 27.8–41.6 μm and high aspect ratios of 10.1–17.2 were successfully synthesized for the first time. And the required temperature conditions of 1100 °C for 20 min were significantly milder than that required by the molten-salt-assisted reduction method even using strong but high-price elemental boron as a reducing agent. These results demonstrated that the specific MSM-BCTR conditions characterized by molten-salt medium and microwave heating were capable of greatly enhancing not only the kinetics but also the thermodynamic favorabilities of the reactions for synthesizing HfB2 and ZrB2 as well as their solid solutions ((HfxZr(1−x))B2). More interestingly, the investigation on the crystalline growth mechanism of (HfxZr1−x)B2 indicated that under the MSM-BCTR conditions, residual amorphous carbon played an important role in enhancing the oriented growth of (HfxZr(1−x))B2, by preferential adsorption onto their {001} crystal planes and therefore greatly promoting corresponding specific surface energies. This study was expected to provide a feasible way of highly-efficiently and cost-effectively synthesizing ultra-high temperature ceramic powders with a highly-crystalline structure and uniform anisotropic morphology, which were favorable for promoting the oxidation resistance and toughness of their sintered products.
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高影响因子
INTERNATIONAL IMMUNOPHARMACOLOGY
·
2022
·
IF 5.714
Xue-qi Liu,Ming-ming Liu,Ling Jiang,Li Gao,Yao Zhang,Yue-bo Huang,Xian Wang,Wei Zhu,Han-xu Zeng,Xiao-ming Meng,Yong-gui Wu
Acute kidney injury (AKI) is marked by a fast deterioration of the kidney function that may be caused by a variety of factors. Recently, although our group found that PPBICA alleviated programmed cell death in AKI, poor water solubility limited its bioavailability. In this research, we screened a series of derivatives and found that C-316-1 had the best suppressive effect on preventing necroptosis and inflammation in cisplatin- and ischemia/reperfusion-induced AKI in vitro and in vivo with lower toxicity and better water solubility. Mass spectrometry results showed that C-316-1 bound to heat shock protein 90 (Hsp90), which was further confirmed by molecular docking and surface plasmon resonance. Additionally, the Hsp90 expression was upregulated in the blood and tissues of AKI patients. We discovered that C-316-1 decreased the RIPK1 protein level without affecting its mRNA expression. The proteasome inhibitor, MG132 restored the level of RIPK1 reduced by C-316-1, suggesting that C-316-1 limits necroptosis by promoting the degradation of RIPK1 rather than by reducing its production. Immunoprecipitation further showed that pretreatment with C-316-1 disrupted the Hsp90-Cdc37 protein–protein Interactions (PPIs). Thereby, C-316-1 inhibited the Hsp90-Cdc37 complex formation and led to a significant decrease in RIPK1, which in turn reduced necroptosis. Moreover, C-316-1 treatment did not protect against kidney injury in vivo and in vitro when Hsp90 was knocked down and R46, E47, and S50 in Cdc37 binding site of Hsp90 might form an important active pocket with C-316-1. These findings suggest that C-316-1 is a potential therapeutic agent against RIPK1-Mediated Necroptosis in AKI.
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PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Xiaoqi Zhao,Guoqiang Chen,Fan Wang,Han Zhao,Yuxi Wei,Lijuan Liu,Haibo Zhang
Fermented meat possesses plenty of microbial resources. In this study, a novel exopolysaccharide (EPS) secreted by the extreme salt-tolerant Bacillus subtilis LR-1 was researched. The optimal extraction conditions of EPS in fermentation broth (4 °C precipitation temperature, 80 mL/dL ethanol concentration, and 12 h precipitation time for maximum yield of 53.43 g/L) were determined through response surface methodology. The structural component of BL-P1, a purified polysaccharide, was glucose (82.95%) and mannose (13.58%), with an average molecular weight of 41.11 kDa by HPLC and HPGPC analysis. Congo red assay, FT-IR and NMR suggested that BL-P1 was a multi-branched hexasaccharide repeating unit with a tertiary helical structure. BL-P1 was mainly composed of 1,4,6-α-D-Glcp, 1,4-β-D-Glcp, 1,2-α-D-Manp, 1,3-β-D-Glcp, and T-α-D-Glcp at different locations, and contained a backbone fragment of →4,6)-α-D-Glcp-(1→4)-β-D-Glcp-(1→. The result of antioxidant activity showed that BL-P1 displayed strong quenching capacities on DPPH (77.65%) and hydroxyl radicals (93.23%). Additionally, the rheological behavior of BL-P1 showed thermal stability both during heating and subsequent cooling process and under the conditions of high concentration of NaCl and CaCl 2 , and had good synergistic thickening performance with gellan gum. In general, BL-P1 screened from the extreme salt-tolerant Bacillus subtilis LR-1 exhibited the potential application as a natural antioxidant and additive in functional food and related industries.
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JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2022
·
IF 10.319
Xiaofang Liu,Hengyang Wang,Bin Zhang,Sikang Zheng,Yao Chen,Hong Zhang,Xianhua Chen,Guoyu Wang,Xiaoyuan Zhou,Guang Han
SnSe, possessing strong lattice anharmonicity and structural anisotropy, has attracted massive attention in thermoelectric conversion. Herein, we demonstrate that simultaneously optimized electrical and thermal transport properties are achieved in SnS 2 -alloyed SnSe polycrystalline materials , which were fabricated via sintering the mixture of solution-synthesized SnSe microplates and SnS 2 nanoplates. Resulting from the increased carrier concentration, p-type (SnSe) 1– x (SnS 2 ) x ( x = 0.5%, 1%) samples obtain much-improved power factor between 300 K and 373 K, e.g. 0.72 mW m –1 K –2 at 300 K for (SnSe) 0.99 (SnS 2 ) 0.01 , which is enhanced by 53% compared to that of SnSe. Additionally, the existing point defects and planar defects effectively strengthen phonon scattering, thus reducing the lattice thermal conductivity , for example, 0.47 W m –1 K –1 at 773 K for the x = 0.02 sample. Eventually, a maximum zT of 0.80 at 823 K and an average zT of 0.52 over 300 – 823 K are obtained in the (SnSe) 0.99 (SnS 2 ) 0.01 sample, which are increased by 33% and 45% compared to those of SnSe, respectively. This study demonstrates a secondary phase alloying strategy to synergistically optimize the electrical and thermal properties of polycrystalline SnSe.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 8
·3901-3908
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IF 3.925
Zhiping Chen,Li Liu,Faxiang Shi,Wenwu Zhou,Zhiyuan Yang,Anning Zhou
A series of hierarchical SAPO-11 molecular sieves synthesized by adding mesoporogens with different alkyl chain lengths were prepared. The synthesized hierarchical SAPO-11s were characterized by XRD, SEM, N2 adsorption–desorption, TEM, NH3-TPD and Py-IR. The results showed that the physicochemical properties of the hierarchical SAPO-11s change with the increase of the alkyl chain length, and the hierarchical SAPO-11 molecular sieve synthesized with DTAB has the largest external surface area and pore volume, and the most medium and strong B acid sites. Furthermore, the 1-octene hydroisomerization reaction on Ni catalysts supported on hierarchical SAPO-11 was investigated and the experimental results showed that the alkyl chain length of the mesoporogen has an obvious influence on the hydroisomerization selectivity. The hierarchical Ni/SAPO-11 catalyst synthesized using DTAB has the highest selectivity of C8 isomers and the lowest cracking selectivity. These results indicate that DTAB is the most suitable mesoporogen for the synthesis of hierarchical SAPO-11 molecular sieves for 1-octene hydroisomerization.
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HUMAN GENE THERAPY
·
2023
·
IF 4.2
Dr. Zhiguang Chen,Ms. Qi Zhao,Mr. Ran Zhang,Dr. Lianghong Chen,Mr. Songlan Gao,Dr. Yu Wang,Dr. Tiegang Li,Dr. Jinqi Xue
Substantial advances have been made in understanding the role of partial PDZ and LIM domain (PDLIM) family’s proteins in skeletal-related diseases. Yet, little is known about the effect of Pdlim1 on osteogenesis and fracture repair. This study aimed to investigate whether direct gene delivery using an adenovirus vector carrying Pdlim1 (Ad-oePdlim1) or encoding shRNA-Pdlim1 (Ad-shPdlim1) could affect the osteogenic activity of pre-osteoblastic MC3T3-E1 cells in vitro, and influence the fracture healing of mice in vivo. We found that Ad-shPdlim1 transfection contributed to the calcified nodule formation in MC3T3-E1 cells. Downregulation of Pdlim1 enhanced the alkaline phosphatase (ALP) activity and increased the expression of osteogenic markers (Runx2, Col1A1, osteocalcin and osteopontin). Further analysis indicated that Pdlim1 knockdown could activate β-catenin signaling, as evidenced by the accumulation of β-catenin in the nucleus and the increase levels of downstream regulators such as Lef1/Tcf7, Axin2, Cyclin D1 and Sox9. By contrast, Pdlim1 overexpression resulted in inhibition of the osteogenic activity of MC3T3-E1 cells. In vivo, at day 3 after fracture, Ad-shPdlim1 adenovirus particles were injected into the fracture site of the femur of mice, and the process of fracture healing was evaluated by X-ray, Micro-CT and histological examination. Local injection of Ad-shPdlim1 promoted the early cartilage callus formation, restored bone mineral density and accelerated cartilaginous ossification, with the upregulation of osteogenic gene (Runx2, Col1A1, osteocalcin and osteopontin) expression and activation of β-catenin signaling. Thus, we concluded that inhibition of Pdlim1 contributed to osteogenesis and fracture healing by activating the β-catenin signaling pathway.
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PubMed
高影响因子
ACS Applied Energy Materials
·
2023
·
IF 6.4
Ronghuan Liu,Bihua Hu,Kai Wang,Baomin Xu,Xiao Wei Sun
Compared with polycrystalline thin films, perovskite single crystals without grain boundaries have better photovoltaic performance and stability. However, due to the extremely low solubility of all-inorganic perovskite in organic solvents and the complex phase diagram of CsPbBr3, directly growing large-sized CsPbBr3 perovskite single-crystal wires is challenging. Here, we have developed an airflow-assisted growth method for the rapid synthesis of large quantities of high-quality, dispersed, ultralong CsPbBr3 single-crystal wires under ambient conditions. This method is green (no additives) and low cost (no special treatment). The growth kinetics of single-crystal wires using this method have been elucidated, and their structural and optoelectronic properties were characterized. Some of the CsPbBr3 single-crystal wires synthesized by this method can exceed 1 mm in length with a low trap density of about 9.06 × 1011 cm–3. The constructed photodetector responsivity is up to 0.365 A/W and detectivity is over 3.3 × 1013 Jones, indicating great potential for optoelectronic applications. This low-cost, high-quality all-inorganic CsPbBr3 single-crystal wire growth method is highly scalable and may facilitate the research and application of all-inorganic perovskite single crystals.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2023
·
IF 6.9
Changjun Wu,Hong Chen,Jingru Tan,Danna Zhou,Haoshen Liang,Shijie Zhen,Hao Liu,Yuehui Wang,Kaiwen Lin
In pursuit of high-performance electrochromic conjugated polymers (ECPs), three benzotriazole-thiophene ECPs employing benzotriazole as acceptor and different thiophene repeating units as donors, namely, PBTz-T, PBTz-BT, and PBTz-TT, were synthesized via direct (hetero)arylation polymerization (DHAP). Meanwhile, following the above ECPs model, we investigated the effect of corresponding conjugated chain length of monomers on their optical, electrochemical and electrochromic properties. The results showed that along with the increase of the numbers of thiophene in the repeating unit of ECPs, the electronic and optical band gaps decreased, the UV–Vis absorption and fluorescence spectra showed significant bathochromic shift, and the electrochemical cycle stability gradually improved. PBTz-T exhibited giant coloration efficiency (916 cm 2 C −1 at 530 nm), which is one of the best results in the visible region. And higher coloration efficiency means less energy consumption, which holds great potential for various applications, including electrochromic back covers of smartphones. PBTz-BT displayed the highest transmittance (28% at 550 nm), and BTz-TT illustrated the fastest switching time (0.6 s/0.5 s for doping/dedoping process). Flexible electrochromic device (ECD) fabricated employed PBTz-T as functional layer gradually changed from red (reduction) to dark green (oxidation), and maintained good cycling stability.
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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
·
2021
·Vol. 25
·期 24
·11113-11127
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IF 5.31
Ting Liu,Shujia Chen,Xiaoli Xie,Hongqun Liu,Yongjuan Wang,Shengbin Qi,Linping Shi,Xue Zhou,Jiuna Zhang,Shuling Wang,Yijun Wang,Shengxiong Chen,Shiying Dou,Xiaoyu Jiang,Ruolin Cui,Huiqing Jiang
Triggering receptor expressed on myeloid cells-1 (TREM-1) exists in two forms: a transmembrane form and a soluble form (sTREM-1). The levels of sTREM-1 are elevated in supernatants of activated HSCs. However, the role of sTREM-1 in HSC activation and liver fibrosis remains undefined. Previous studies have primarily focused on the transmembrane form of TREM-1; we innovatively observed the function of sTREM-1 as a ligand in liver fibrosis and screened its receptor. Here, recombinant sTREM-1 was used as a stimulator which induced HSC activation and further aggravated liver fibrosis. Then, screening for sTREM-1 interacting membrane receptors was performed using pull-down assay followed by mass spectrometry, and the membrane receptor roundabout guidance receptor 2 (Robo2) was identified as a candidate receptor for sTREM-1. The interaction between sTREM-1 and Robo2 was verified by pull-down and immunofluorescence. The role of Robo2 on sTREM-1-induced HSC activation and its downstream signal pathways was assessed by knockdown of Robo2 in LX-2 cells. Furthermore, HSC-specific knockdown of Robo2 was achieved in a mouse model of liver fibrosis by using a recombinant adeno-associated virus (AAV) vector to confirm the role of the receptor, and we proved that Robo2 knockdown inhibited the activation of HSC and liver fibrosis, which also led to the inactivation of Smad2/3 and PI3K/Akt pathways in sTREM-1-induced HSC activation and liver fibrosis. In conclusion, sTREM-1 acts as a new ligand of Robo2; the binding of sTREM-1 to Robo2 initiates the activation of the downstream Smad2/3 and PI3K/Akt signalling pathways, thereby promoting HSC activation and liver fibrosis.
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PubMed
高影响因子
Solar RRL
·
2023
·
IF 7.9
Chenguang Zhou,Yibo Xu,Yue Li,Kaihuai Du,Xinzhu Li,Xu Dong,Lvzhou Li,Ningyi Yuan,Jianning Ding
Ultra-thin stainless-steel substrates with excellent water-oxygen barrier properties and high thermal and electrical conductivities are suitable for the fabrication of lightweight and flexible perovskite solar cells (FPSCs). However, the deposition of dense perovskite films on stainless steel by the solution method is crucial because short circuits caused by perovskite holes are fatal to parallel structures. Herein, a single crystal (SC) is incorporated into the precursor solution to reduce the formation of holes in perovskite films on smooth stainless-steel substrates. Additionally, a magnetic method is developed based on the properties of stainless steel to fix and fabricate FPSCs nondestructively on ultra-thin stainless-steel films with a thickness as low as 5 μm. Furthermore, 4,6-dimethyl-2-mercaptopyrimidine (DMI) was introduced to passivate the surface of the perovskite film, optimizing the contact properties of the perovskite heterojunction and adjusting the energy level of the perovskite/C 60 interface. Finally, ultra-thin FPSCs achieved a champion power conversion efficiency (PCE) of 20.24% on an active area of 1.012 cm 2 and a power-to-weight ratio over 3000 W kg −1 . Moreover, under continuous illumination, the stainless-steel substrates exhibited better photothermal stability than the polymer substrates. This method provides a basis for the fabrication of lightweight, low-cost, and large-area FPSCs.
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高影响因子
FOOD CONTROL
·
2022
·
IF 6.652
Bin Li,Zhirong Wang,Gang Yang,Shan Huang,Shenglan Liao,Kewei Chen,Muying Du,Zsolt Zalán,Ferenc Hegyi,Jianquan Kan
Aflatoxin contamination poses a significant threat to world health and has caused huge economic losses to countries worldwide. The application of volatile organic compounds (VOCs) has emerged as one of the most promising strategies for the prevention and control of fungal contamination. In this work, first, VOCs produced by six lactic acid bacteria (LAB) strains exhibited excellent inhibition activity against the growth of Aspergillus flavus . Then, gas chromatograph-mass spectrometry (GC-MS) identified 32 compounds from captured VOCs of LAB. In addition, partial least square (PLS) analysis revealed that 1-pentanal, 1-pentanol, glycidol, 1- hexanol and 1-heptanol are the compounds most related to antifungal effect in volatile profiles, demonstrating excellent inhibition against A. flavus on both potato dextrose agar (PDA) plates and red pepper powder in next antifungal assay. In vitro experiments revealed 1-pentanal to have the highest antifungal activity of the five VOCs, with a minimal inhibitory concentration (MIC) of 40 μL/L. Scanning electron microscopy (SEM) proved that exposure to 1-pentanal caused A. flavus to exhibit mycelial shriveling and failed conidia formation. Meanwhile, our results showed that fumigation with 1-pentanal had no adverse effect on the quality of red pepper powder. These results indicate that 1-pentanal, identified as the component with the highest antifungal activity in this study, is a promising bio-preservative with the potential to prevent A. flavus contamination of red pepper.
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高影响因子
Scientific Reports
·
2026
·
IF 4.9
Guo Haoran,Liu Yang,Wang Fan,Yang Xuewen,Liu Tianwen,Shi Yudong,Wang Jiao,Li Jianming
Thrombotic disease remains a major cause of morbidity and mortality, and rapid noninvasive visualization of active thrombi is still challenging. We designed and synthesized [ 18 F]TD-1, a novel tirofiban-derived positron emission tomography (PET) tracer targeting glycoprotein IIb/IIIa (GP IIb/IIIa) for thrombus imaging, and evaluated its preclinical imaging performance. P-Tiro was synthesized as the radiolabeling precursor, and [ 18 F]TD-1 was prepared via aromatic destannylation followed by quality control. [ 18 F]TD-1 was obtained in 12.1 ± 4.2% non-decay-corrected radiochemical yield, with radiochemical purity ≥ 98% and molar activity > 37 GBq/μmol, and remained stable in vitro for 4 h. Preliminary safety evaluation of TD-1 showed no evident adverse effects during the observation period. In healthy beagle dogs, serial PET/CT imaging suggested predominant hepatobiliary clearance, with additional renal excretion. In a canine pulmonary embolism model, positron emission tomography/computed tomography (PET/CT) visualized thrombi colocalized with embolic sites. Target-to-background contrast peaked at 15 min after injection, suggesting that 15 min may be a practical early time point for static imaging. These findings support further evaluation of [ 18 F]TD-1 as a tirofiban-derived PET tracer for thrombus imaging.
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