ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Juntao Huang,Saifei Wang,Zhifei Zhang,Mingli Chen,Han Wang,Haihua Huang,Qian Wang,Jigong Hao,Wei Li,Juan Du,Mahesh Kumar Joshi,Peng Fu
Ceramic dielectric capacitors have gained significant attention due to their ultrahigh power density, current density, and ultrafast charge–discharge speed. However, their potential applications have been limited by their relatively low energy storage density. Researchers have employed various approaches to enhance their energy storage density. In this study, (1 – x)(Bi0.5Na0.5)0.7Sr0.3TiO3–xCa(Mg1/3Ta2/3)O3 ceramics were prepared via a solid-phase reaction, and the effect of their structure on the energy storage properties was investigated. The results indicate that the introduction of Ca(Mg1/3Ta2/3)O3 significantly alters the multiscale structures of the (Bi0.5Na0.5)0.7Sr0.3TiO3 ceramic, including the transformation from the T-phase to the C-phase, refinement of ceramic grains, and the formation of polar nanoregions (PNRs), accompanied by an increase in the bandgap and relaxation degree. These structural changes collectively contributed to the improved overall energy storage properties of the modified ceramics. Notably, the 0.92(Bi0.5Na0.5)0.7Sr0.3TiO3–0.08Ca(Mg1/3Ta2/3)O3 ceramic demonstrated a recoverable energy storage density (Wrec) of 8.37 J/cm3 with an energy storage efficiency (η) of 87.7% at an electric field of 530 kV/cm. It also exhibited good temperature stability (25–120 °C), frequency stability (1–100 Hz), and fatigue stability (1–105). Furthermore, it displayed exceptional charge and discharge properties, with the discharge energy density (WD), discharge time (t0.9), current density (CD), and power density (PD) attaining 4.06 J/cm3, 35.2 ns, 2143.28 A/cm2, and 460.71 MW/cm3, respectively. These findings suggest that modified (1 – x)(Bi0.5Na0.5)0.7Sr0.3TiO3–xCa(Mg1/3Ta2/3)O3 ceramics are promising candidates for high-power pulsed electronic systems.
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Chen-Yuan Ma,Yu-Ming Pan,Pei Han,Mei-Hong Duan
Development of new birefringent crystals with enhanced properties remains an ongoing research priority. Through the exploration of guanidinium-containing oxalates with the structural modulation of Pb 2+ and Cl - , a new birefringent crystal, [C(NH 2 ) 3 ]Pb(C 2 O 4 )Cl·H 2 O (GPCCH), was successfully obtained. GPCCH was characterized by two types of π-conjugated building units, which contributes to the coexistence of a wide bandgap of 3.98 eV and a large birefringence of 0.24@546 nm. These findings highlight the synergistic role of π-conjugated building units and partially-chlorinated lead-containing units played in generating fascinating UV birefringent crystals.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2025
·Vol. 39
·期 5
·e70103
·
IF 0
Palanisamy Vasudhevan,Dong Yu,Ruoyu Zhang,Mysoon M. Al-Ansari,Velu Manikandan,Hui Ma,Saurav Dixit,Shengyan Pu
Chlorinated aromatic chemicals are highly hazardous, transmissible, and bioaccumulative. Developing an economically feasible catalytic method to facilitate the effective removal of chlorinated aromatic pollutants is critical for contamination prevention. The current study extensively investigated the utilization of organic ligands such as citrate (CA) and ethylenediaminetetraacetic acid (EDTA) to increase Fe(II)-activated persulfate (PS) for 4-chlorophenol (4-CP) and 3-chlorobenzoic acid (3-CB) degradation in water. The decomposition and consumption ability of persulfate in PS alone and Fe(II)/PS systems for 4-CP and 3-CB was very low because of the rapid utilization as well as discontinuous availability of Fe(II), which indicates the decline of Fe(III) to Fe(II). But, when using the citrate/Fe(II)/PS and EDTA/Fe(II)/PS combinations, the degradation of 4-CP and 3-CB was 78.86%, 75.01% and 84.84%, 80.99% within 30 min, respectively. The significant enhancement is due to both ligand-to-metal transfer of charges process, and this increased the process of rate determination through carrying electrons into the citrate and EDTA ligands to Fe(III), generating Fe(II). In addition, the 4-CP and 3-CB degradation facilitated with citrate/Fe(II)/PS and EDTA/Fe(II)/PS systems was efficiently degraded at acidic pH (2.0–6.0) conditions. The pseudo-first-order kinetics model accurately predicted 4-CP and 3-CB degradation in the organic ligand/Fe(II)/PS systems. The degradation percentage of 4-CP and 3-CB increased with increasing PS and Fe(II) concentrations. Moreover, both sulfate and hydroxyl radicals formed by citrate/Fe(II)/PS and EDTA/Fe(II)/PS systems were identified as major reactive oxygen species for 4-CP and 3-CB decomposition. The present investigation recommends an alternate strategy to enhance the Fe(II)-activated persulfate mechanisms.
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Materials
·
2025
·Vol. 18
·期 9
·1969
·
IF 3.2
Ruixia Chu,Hongtao Zhang,Wanyou Huang,Fangyuan Qiu,Yan Wang,Zhenyu Li,Xiaoyue Jin
Lithium-ion batteries (LIBs) with high power, high capacity, and support for fast charging are increasingly favored by consumers. As a commercial electrode material for power batteries, LiFePO4was limited from further wide application due to its low conductivity and lithium-ion diffusion rate. The development of advanced architectures integrating rational conductive networks with optimized ion transport pathways represents a critical frontier in optimizing the performance of cathode materials. In this paper, a novel self-supporting cathode material (designated as LFP@LVP-CES) was synthesized through an integrated coaxial electrospinning and controlled pyrolysis strategy. This methodology directly converts LiFePO4, Li3V2(PO4)3, and polyacrylonitrile (PAN)) into flexible, binder-free cathodes with a hierarchical structural organization. The 3D carbon nanofiber (CNF) matrix synergistically integrates LiFePO4(Li/Fe/POx) and Li3V2(PO4)3(Li/V/POx) nanoparticles, where CNFs act as a conductive scaffold to enhance electron transport, while the POxpolyanionic frameworks stabilize Li+diffusion pathways. Morphological characterizations (SEM and TEM) revealed a 3D cross-connected carbon nanofiber matrix (diameter: 250 ± 50 nm) uniformly embedded with active material particles. Electrochemical evaluations demonstrated that the LFP@LVP-CES cathode delivers an initial specific capacity of 165 mAh·g−1at 0.1 C, maintaining 80 mAh·g−1at 5 C. Notably, the material exhibited exceptional rate capability and cycling stability, demonstrating a 96% capacity recovery after high-rate cycling upon returning to 0.1 C, along with 97% capacity retention over 200 cycles at 1 C. Detailed kinetic analysis through EIS revealed significantly reduced Rctand increased Li+diffusion. This superior electrochemical performance can be attributed to the synergistic effects between the 3D conductive network architecture and dual active materials. Compared with traditional coating processes and high-temperature calcination, the preparation of controllable electrospinning and low-temperature pyrolysis to some extent avoid the introduction of harmful substances and reduce raw material consumption and carbon emissions. This original integration strategy establishes a paradigm for designing freestanding electrode architectures through 3D structural design combined with a bimodal active material, providing critical insights for next-generation energy storage systems.
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高影响因子
Materials Today Bio
·
2022
·
IF 10.761
Chenghua Song,Jia Zhang,Ruichao Wen,Qingshan Li,Jiaxuan Zhou,Xiaoli liu,Zheng Wu,Yi Lv,Rongqian Wu
Effective systemic treatment for hepatocellular carcinoma (HCC) remains urgently needed. Sorafenib is the first FDA-approved systemic treatment for HCC. However, individual HCC patents’ response to sorafenib varies greatly. How to enhance the anti-HCC effect of sorafenib is still a significant challenge. T cell immunoglobulin mucin-3 (Tim-3) is a newly identified immune checkpoint molecule and a promising target for HCC treatment. Herein, we developed a novel pH-triggered drug-eluting nanoparticle ( [email protected] & [email protected] ) for simultaneously delivery of Tim-3 siRNA and sorafenib to HCC in situ . By a single emulsification method, a representative HCC targeted-therapeutic drug sorafenib (SF) was encapsulated into the pH-triggered positive-charged mPEG5K-PAE10K (PP) nanoparticles, followed by condensing of negative-charged Tim-3 siRNA. Then, carboxymethyl chitosan (CMCS), an amphoteric polysaccharide with negative charge in the physiological pH and positive charge in the acidic environment of the tumor, was eventually adsorbed onto the surface of nanoparticles. This co-delivery nanoparticle rapidly and specifically accumulated in the tumor site of the liver and enhanced the targeted, specific and multiple release of siRNA and sorafenib. Enhanced Tim-3 siRNA transfected into tumor cells can not only directly inhibit the growth of tumor cells by knock down the expression Tim-3, but also induce the immune response and enhance the recruitment of cytotoxic T cells to kill tumor cells. The following pH-triggered sorafenib release from [email protected] NPs greatly inhibited the tumor proliferation and angiogenesis, resulting in remarkable tumor growth inhibition in a mouse hepatoma 22 (H22) orthotopic tumor model. Thus, co-delivery of Tim-3 siRNA and sorafenib via this novel pH triggered drug-eluting nanoparticle enhances their anti-tumor efficacy. We expect that such combination treatment strategy will have great potential in future clinical applications.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2014
·
IF 3.552
Qiang Zhang,Qinfu Zhao,Ying Zhang,Ning Han,Liang Hu,Chen Zhang,Tongying Jiang,Siling Wang
3-D ordered macroporous (3DOM) materials were customized for BSA adsorption and further oral immunization. These carriers have a high adsorption capacity and our customized carrier showed a distinctive double-plateau adsorption behavior. Different BSA release rates (between the two plateaus) could be obtained by adjusting the ratio of the protein adsorbed on the internal surface and the external surface. This suggests that the release pattern was determined by the adsorption state. One benefit is that the same carrier could have different release profiles making it possible to study the relationship between the release behavior and adjuvant effects without any distractions. Compared with free BSA alone, a significantly higher level of serum IgG, IgA induced by BSA/3DOM was observed and the release profile had an effect on the immunity. The IgG1 and IgG2a titers suggesting that both the Th1 and Th2 mediated immune response were induced. Therefore, this research could help in the development of a novel inorganic oral adjuvant and provide a new avenue for the administration of oral vaccine.
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Algal Research-Biomass Biofuels and Bioproducts
·
2019
·
IF 3.723
Linfei Huang,Lihua Yu,Zhongze Li,Yanhua Li,Kang-sup Yoon,Qiang Hu,Li Yuan,Danxiang Han
The plastidial lysophosphatidic acid acyltransferase of the unicellular green alga Chlamydomonas reinhardtii (CrLPAAT1) is a key enzyme involved in triacylglycerol biosynthesis . However, research on the biochemical characteristics of CrLPAAT1 has been impeded by its membrane-bound nature. In this study, the recombinant CrLPAAT1 was purified in a soluble form and was utilized for comprehensive biochemical characterization. The recombinant CrLPAAT1 favors the conditions of pH 6.5–7.5, 30 °C and the presence of magnesium ion in vitro . Similar with the CrLPAAT1 associated with the membranes, the purified CrLPAAT1 prefers to utilize C16:0-CoA over other acyl donors, whereas it showed broader substrate selectivity than the membrane-bound enzyme. By comparing the wild-type CrLPAAT1 and a transmembrane domain-truncated enzyme, it was uncovered in this study that the two transmembrane domains of CrLPAAT1 are involved in shaping its substrate preference for C16:0-CoA. Additionally, CrLPAAT1 was found to be interacting with the water-soluble plastidial glycerol-3-phosphate acyltransferase (CrGAPTcl) via its two transmembrane domains in vitro . The interaction between CrLPAAT1 and CrGPATcl can be negatively regulated by both the acyl-CoAs and lysophosphatidic acid in a dosage-dependent manner. Such a regulation pattern may represent a novel mechanism adopted by algal cells to control lipid metabolism homeostasis under various environmental conditions.
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高影响因子
Inorganic Chemistry Frontiers
·
2025
·Vol. 12
·期 23
·7566-7572
·
IF 6.4
Xiaodong Zhang,Bohui Xu,Deshuai Xiao,Xinyuan Zhang,Pifu Gong,Zheshuai Lin
Ultraviolet (UV) nonlinear optical (NLO) materials are critical for laser frequency conversion to extend wavelength ranges. Sulfates have emerged as a promising family of UV NLO materials, yet their NLO performance is constrained by the low optical anisotropy of the constituent [SO4]2− groups. In this study, we investigate the [C6H5SO3]− group, formed by substituting a ligand of the non-π-conjugated [SO4]2− unit with a π-conjugated benzene ring, and demonstrate that this group has a strong second harmonic generation (SHG) response and large birefringence. Leveraging this optimized structural unit, we successfully synthesize the first UV NLO benzenesulfonate, Y(C6H5SO3)3·9H2O. This compound exhibits enhanced UV optical properties, including a short cutoff edge of 280 nm, a relatively large SHG efficiency (0.8 × KDP), and a large birefringence of 0.16 at 1064 nm. This work not only presents Y(C6H5SO3)3·9H2O as a competitive UV NLO material, but also highlights the [C6H5SO3]− group as a highly effective structural motif for the future development of advanced UV NLO materials.
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Bioengineered
·
2021
·
IF 3.269
Yan Li,Nianling Yao,Yan Gao,Yunping Wang,Lu Bai,Jia Xu,Haixu Wang
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that poses a great threat to women's health. MiR-1224-5p is downregulated in the follicular fluid of patients with PCOS, but its role remains largely unknown. In this study, mice were treated with dehydroepiandrosterone (DHEA) to establish an in vivo model of PCOS. We found that enhanced activation of NLRP3 inflammasome was accompanied by downregulation of miR-1224-5p in ovarian tissue of PCOS mice. The effect of miR-1224-5p was further explored in TNF-α-treated human granulosa-like tumor (KGN) cells. Upregulation of miR-1224-5p suppressed TNF-α-induced secretion of DHEA and testosterone. MiR-1224-5p attenuated TNF-α-induced inflammation by inhibiting NLRP3 inflammasome activation, IL-1β synthesis, and nuclear factor kappa B (NF-κB) p65 nuclear translocation. Notably, miR-1224-5p decreased the expression of Forkhead box O 1 (FOXO1) and its downstream gene thioredoxin interaction protein (TXNIP). Luciferase reporter assay confirmed FOXO1 as a target of miR-1224-5p. Upregulation of FOXO1 abolished miR-1224-5p-induced activation of NLRP3 inflammasome, demonstrating that miR-1224-5p might inhibit NLRP3 inflammasome activation through regulating FOXO1. This study provided novel insights into the pathogenesis of PCOS and suggested that miR-1224-5p might be a promising target for treating PCOS.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2025
·
IF 2.1
Zhe Wu,Zhe Xue,Shaolan Zhuang,Yire Ma,Xiaofei Tang,Pengqi Hou,Qunsheng Li,Zhongqi Ren,Hongkang Zhao
The solubility of 3-methoxycinnamic acid was determined in nine pure solvents (methanol to ethyl acetate) and ethanol–ethyl acetate binary mixtures (293.15–333.15 K). Results demonstrate positive temperature dependence in all systems, with maximum solubility in binary solvent at ethanol volume fraction of 0.3, while benzene exhibited the lowest solubility. Solid–liquid equilibrium (SLE) data were correlated using five thermodynamic models (modified Apelblat, Van’t Hoff, Wilson, NRTL, UNIQUAC). The modified Apelblat equation showed superior accuracy for both solvent systems. KAT-LSER analysis revealed solvent hydrogen-bond acidity (α), basicity (β), and cohesive energy density (CED) (δH) as dominant molecular descriptors. Thermodynamic parameters (ΔGmix < 0) confirmed spontaneous dissolution, with enthalpy–entropy compensation revealed by Gibbs energy deconvolution. The obtained solubility and thermodynamic data may be useful for the design and optimization of crystallization processes of 3-methoxycinnamic acid.
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高影响因子
Journal of Biomaterials and Tissue Engineering
·
2022
·Vol. 12
·期 5
·926-932
·
IF 0.144
Guan Xin,Sun Ning
High expression of E74-like factor 3 (ELF3) has been reported in type 1 endometrial cancer (EC). Bioinformatics analysis predicted a positive correlation with ELF3 and mucin 1 (MUC1)/hypoxiainducible factor 1α (HIF-1α), a previously identified cancer-promoting
pathway. This study focused on the MUC1/HIF-1α-involved action mechanism of ELF3 in EC. ELF3 expression in EC cell lines was measured by RT-qPCR and western blot analysis. Following the expression of ELF3 was silent, cell proliferation was examined using CCK-8 and colony formation
assay, cell migration and invasion were observed using wound healing and transwell assays. The effect of ELF1 silencing on MUC1/HIF-1α expression was detected by western blot. Rescue experiments incorporating pcDNA3.1(+)/MUC1 explored the interaction between ELF3 and MUC1/HIF-1α
in EC cell proliferation, migration and invasion. ELF3 was found to be expressed at a high level in EC cell lines, and the silencing of it effectively inhibited EC cell proliferation. Moreover, ELF silencing also inhibited the migration and invasion of EC cells. Consistent with the database
prediction, a positive correlation between ELF3 and MUC1/HIF-1α was observed. More importantly, MUC1 overexpression abated the promotive effect of ELF3 silencing on EC cell proliferation, migration and invasion. ELF3 promotes EC cell proliferation, migration and invasion by regulating
MUC1/HIF-1α pathway. Thus, ELF3 as well as MUC1/HIF-1α pathway may be particle targets in the treatment of EC.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Jing Zeng,Dongzheng Wu,Xin Wang,Junnan Wu,Jiyang Li,Jing Wang,Jinbao Zhao
The high-voltage cathode material based on the sodium super ionic conductor (NASICON) structured Na 3 V 2 (PO 4 ) 3 (NVP) has been found to be a potential candidate for Mg storage. In this work, to improve its electrochemical performance, we construct honeycomb-like structured NVP/C/G with faster electronic and ionic transport by a convenient and universal spray-drying method for the first time. After electrochemically desodiating two Na from the NVP/C/G (ED-NVP/C/G), the ED-NVP/C/G is tested in highly anhydrous Mg electrolyte, and the insights into its Mg storage property and mechanism are carefully studied. An initial capacity of 87 mAh g −1 with a relatively high average discharge voltage of 2.47 V vs. Mg 2+ /Mg is obtained at 0.1 C. The X-ray diffraction (XRD) results show that the inserted Mg 2+ ions tend to occupy the Na2 (at 18e sites) vacant sites. The investigation of kinetic process by galvanostatic intermittent titration technique (GITT) reveals that the Mg diffusion kinetics is faster during the demagnesiation process. The electrochemical reaction bases on two-phase transition mechanism, and the R ct value shows a positive relationship to the formation of NaV 2 (PO 4 ) 3 phase. Finally, a Mg full cell prototype based on the ED-NVP/C/G cathode with Mg metal anode is built. The rational structure design of NVP/C/G improves the electrochemical performance for Mg storage, and our work also gives new understanding into the Mg storage mechanism in the ED-NVP/C/G structure.
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